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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Piperazin-2-one Manufacturer/High quality/Best price/In stock

Cas:5625-67-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

1. high purity 2. able to provide COA/HNMR/HPLC 3. High quality 4. low price 5. Best service Appearance:white powder Storage:rm Package:bag/bottle/drum Application:pharmaceutical intermediate Transportation:common transportation Port:Shanghai

Piperazin-2-one

Cas:5625-67-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Product Name: Piperazin-2-one; 2-Oxopiperazine; 2-piperazone CAS No.: 5625-67-2 Molecular Formula: C4H8N2O Molecular Weight: 100.12 Purity: 98.0% Min. Appearance: White or off-white crystalline powder We are a professional chemi

Piperazin-2-one

Cas:5625-67-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply piperazin-2-one

Cas:5625-67-2

Min.Order:1

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Piperazin-2-one

Cas:5625-67-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Oxopiperazine

Cas:5625-67-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Piperazin-2-one_

Cas:5625-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-Piperazinone

Cas:5625-67-2

Min.Order:1 Kilogram

FOB Price: $2.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 5625-67-2 with best quality

Cas:5625-67-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Piperazinone 5625-67-2

Cas:5625-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Piperazin-2-one

Cas:5625-67-2

Min.Order:1 Kilogram

FOB Price: $85.0 / 99.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Piperazinone CAS:5625-67-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

2-Piperazinone CAS:5625-67-2

Cas:5625-67-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Piperazinone

Cas:5625-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Piperazinone

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

piperazin-2-one

Cas:5625-67-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

2-Piperazinone

Cas:5625-67-2

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

piperazin-2-one

Cas:5625-67-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packag

Best price/In stock 2-piperazone

Cas:5625-67-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Piperazinone

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Piperazin-2-one CAS NO.5625-67-2

Cas:5625-67-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

piperazin-2-one

Cas:5625-67-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity 2-Piperazinone

Cas:5625-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Piperazinone

Cas:5625-67-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Piperazinone Chemical Properties Melting point 136-140 °C (lit.) Boiling point 164°C/5mmHg(lit.) density 1.053±0.06 g/cm3(Predicted) form Crystalline Powder pka 15.47±0.20(Predicted) color White to tan S

Piperazin-2-one

Cas:5625-67-2

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Piperazin-2-one

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Piperazin-2-one

Cas:5625-67-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

5625-67-2 CAS NO.5625-67-2

Cas:5625-67-2

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2-Piperazinone

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Piperazin-2-one CAS NO.5625-67-2

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

piperazin-2-one

Cas:5625-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

ethylenediamine
107-15-3

ethylenediamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With meso-tetraphenylporphyrin iron(III) chloride In dichloromethane at 22℃; for 0.166667h; Inert atmosphere;86%
With [2-(4-hydroxymethyl)phenyl-4,4-(dimethyloxazole)Ru(CH3CN)4]PF6 In diethyl ether; water at 20℃;80%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

ethylenediamine
107-15-3

ethylenediamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
Stage #1: chloroacetic acid ethyl ester; ethylenediamine In methanol at 0 - 5℃; for 4h;
Stage #2: With sodium methylate In methanol at 20 - 25℃; Solvent; Reagent/catalyst;
85.4%
Stage #1: chloroacetic acid ethyl ester; ethylenediamine In ethanol at 20℃; for 5.5h;
Stage #2: With sodium ethanolate In ethanol
Stage #3: With N,N-dimethyl-formamide In ethanol at 20 - 70℃; for 24h;
82%
With potassium hydroxide In ethanol Heating;50%
Stage #1: chloroacetic acid ethyl ester; ethylenediamine In ethanol at 20℃; for 2h;
Stage #2: With sodium ethanolate In ethanol at 20℃; for 14h;
Stage #3: at 200℃; for 0.0833333h;
34.5%
With ethanol
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethylamine
109-89-7

diethylamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
Stage #1: chloroacetic acid ethyl ester; diethylamine With sodium ethanolate In ethanol at 20℃; for 5.5h;
Stage #2: In DMF (N,N-dimethyl-formamide) at 20 - 70℃; for 24h;
82%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethylenediamine
107-15-3

ethylenediamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
Stage #1: ethyl bromoacetate; ethylenediamine In ethanol at 20℃; for 2h;
Stage #2: With sodium ethanolate at 20℃;
79.84%
Stage #1: ethyl bromoacetate; ethylenediamine In ethanol at 0 - 23℃;
Stage #2: With sodium ethanolate In ethanol at 80℃; for 16h; Inert atmosphere;
64%
2-[(bromoacetyl)(2-phenylpropyl)amino]ethyl carbamic acid tert-butyl ester

2-[(bromoacetyl)(2-phenylpropyl)amino]ethyl carbamic acid tert-butyl ester

dichloromethane
75-09-2

dichloromethane

potassium carbonate
584-08-7

potassium carbonate

A

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

B

1-(2-phenylpropyl)piperazin-2-one

1-(2-phenylpropyl)piperazin-2-one

Conditions
ConditionsYield
With trifluoroacetic acid In ethanolA n/a
B 75%
bromoethyl acetate
927-68-4

bromoethyl acetate

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With ammonium hydroxide; sodium ethanolate; ethylenediamine In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide45%
With ammonium hydroxide; sodium ethanolate; ethylenediamine In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide45%
With ammonium hydroxide; sodium ethanolate; ethylenediamine In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide45%
CH2Cl2:MeOH

CH2Cl2:MeOH

bromoethyl acetate
927-68-4

bromoethyl acetate

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With ammonium hydroxide; sodium ethanolate; ethylenediamine In ethanol; N,N-dimethyl-formamide45%
With ammonium hydroxide; sodium ethanolate; ethylenediamine In ethanol; N,N-dimethyl-formamide45%
With ammonium hydroxide; sodium ethanolate; ethylenediamine In ethanol; N,N-dimethyl-formamide45%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

A

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

B

sodium chloride

sodium chloride

Conditions
ConditionsYield
With sodium ethanolate; ethylenediamine In ethanolA 34.5%
B n/a
ethylenediamine
107-15-3

ethylenediamine

Chloroacetamide
79-07-2

Chloroacetamide

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With potassium carbonate at 125℃;30%
ethanol
64-17-5

ethanol

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

ethylenediamine
107-15-3

ethylenediamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
at 25℃;
formaldehyd
50-00-0

formaldehyd

ethylenediamine
107-15-3

ethylenediamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With piperidine; hydrogen cyanide
ethylenediamine
107-15-3

ethylenediamine

glycolonitrile
107-16-4

glycolonitrile

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With water
N-(2-Aminoethyl)glycinethylester
24123-13-5

N-(2-Aminoethyl)glycinethylester

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60 - 70℃; Cyclization;
With sodium ethanolate In ethanol; toluene at 20℃; for 5h; Heating / reflux;
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With sodium ethanolate; ethylenediamine In ethanol; N,N-dimethyl-formamide
With NaOEt In ethanol; ethylenediamine; toluene
With sodium methylate In methanol; ethanol; chloroform; ethylenediamine
diethylamine
109-89-7

diethylamine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With acetyl chloride In methanol; 1,1-dichloroethane
tert-butoxide

tert-butoxide

4-(t-butyloxycarbonyl)piperazin-2-one
76003-29-7

4-(t-butyloxycarbonyl)piperazin-2-one

A

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

B

1-tert-butoxycarbonyl-4-(2-fluoroethyl)-3-oxopiperazine
194351-12-7

1-tert-butoxycarbonyl-4-(2-fluoroethyl)-3-oxopiperazine

Conditions
ConditionsYield
In N,N-dimethyl-formamide; isopropyl alcohol
C4H9ClN2O
1247428-43-8

C4H9ClN2O

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Conditions
ConditionsYield
With sodium methylate In methanol at 25 - 30℃; for 0.0833333h;
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-(t-butyloxycarbonyl)piperazin-2-one
76003-29-7

4-(t-butyloxycarbonyl)piperazin-2-one

Conditions
ConditionsYield
In dichloromethane for 3h;100%
In dichloromethane at 20℃; for 5h;100%
In dichloromethane at 20℃; Cooling with ice;100%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

trityl chloride
76-83-5

trityl chloride

4-tritylpiperazin-2-one
666853-55-0

4-tritylpiperazin-2-one

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at -10 - 20℃;100%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

4-nitrobenzyl chloroformate
4457-32-3

4-nitrobenzyl chloroformate

4-p-nitrobenzyloxycarbonyl-2-ketopiperazine
623564-23-8

4-p-nitrobenzyloxycarbonyl-2-ketopiperazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane at 0℃; for 0.5h;100%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane at 0℃; for 0.5h;100%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane at 0℃; for 0.5h;100%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane; water
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

tert-butyl 4-{[4-amino-6-formyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazine-1-carboxylate
1443531-81-4

tert-butyl 4-{[4-amino-6-formyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazine-1-carboxylate

tert-butyl 4-( {4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-[(3-oxopiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}methyl)piperazine-1-carboxylate

tert-butyl 4-( {4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-[(3-oxopiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}methyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 2h;100%
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 2h; Enzymatic reaction;100%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide
1353891-92-5

N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide
1353891-93-6

N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide

Conditions
ConditionsYield
Stage #1: N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1.5h;
Stage #2: 2-Ketopiperazine In dichloromethane at 20℃; for 18h;
99%
In dichloromethane at 20℃; for 2h;66%
In dichloromethane at 20℃;
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

piperazine

piperazine

Conditions
ConditionsYield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 160℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;99%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

benzyl chloroformate
501-53-1

benzyl chloroformate

4-benzyloxycarbonylpiperazin-2-one
78818-15-2

4-benzyloxycarbonylpiperazin-2-one

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate for 16h; Ambient temperature;98%
With potassium carbonate In water; ethyl acetate at 20℃; for 16h;93%
With sodium carbonate In water; ethyl acetate at 0 - 30℃; for 16h;84.93%
piperidine
110-89-4

piperidine

2-Ketopiperazine
5625-67-2

2-Ketopiperazine

9-fluorenylmethoxycarbonyl isothiocyanate
199915-38-3

9-fluorenylmethoxycarbonyl isothiocyanate

3-oxopiperazine-1-carbothionic acid amide
909292-42-8

3-oxopiperazine-1-carbothionic acid amide

Conditions
ConditionsYield
Stage #1: piperidine; 2-Ketopiperazine; 9-fluorenylmethoxycarbonyl isothiocyanate In chloroform at 20℃; for 2h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 6h;
98%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

N-((1S,2R)-2-amino-2-(4-chlorophenyl)-1-(3-methoxyphenyl)ethyl)-2-isopropoxy-4-methoxybenzamide

N-((1S,2R)-2-amino-2-(4-chlorophenyl)-1-(3-methoxyphenyl)ethyl)-2-isopropoxy-4-methoxybenzamide

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-((1R,2S)-1-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)-2-(3-methoxyphenyl)ethyl)-3-oxopiperazine-1-carboxamide

N-((1R,2S)-1-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)-2-(3-methoxyphenyl)ethyl)-3-oxopiperazine-1-carboxamide

Conditions
ConditionsYield
Stage #1: N-((1S,2R)-2-amino-2-(4-chlorophenyl)-1-(3-methoxyphenyl)ethyl)-2-isopropoxy-4-methoxybenzamide; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: 2-Ketopiperazine In dichloromethane at 20℃; for 15h; Inert atmosphere;
98%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

2-chloropyridine-5-sulfonyl chloride
6684-39-5

2-chloropyridine-5-sulfonyl chloride

4-((6-chloro-3-pyridinyl)sulfonyl)-2-piperazinone
1003767-51-8

4-((6-chloro-3-pyridinyl)sulfonyl)-2-piperazinone

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 0.5h; Inert atmosphere;97%
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;
Stage #1: 2-Ketopiperazine; 2-chloropyridine-5-sulfonyl chloride With triethylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: With sodium hydrogencarbonate In water at 20℃; for 24h;
1.12 g
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

methyl 2-chlorosulfonyl-6-nitrobenzoate
104898-55-7

methyl 2-chlorosulfonyl-6-nitrobenzoate

methyl 6-Nitro-2-[3-oxo-1-piperazinylsulfonyl]benzoate

methyl 6-Nitro-2-[3-oxo-1-piperazinylsulfonyl]benzoate

Conditions
ConditionsYield
With triethylamine In chloroform96.8%
With triethylamine In chloroform96.8%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

2,6-dichloro-4-cyclopropylpyridine-3,5-dicarbonitrile

2,6-dichloro-4-cyclopropylpyridine-3,5-dicarbonitrile

2-chloro-4-cyclopropyl-6-(3-oxopiperazin-1-yl)pyridine-3,5-dicarbonitrile

2-chloro-4-cyclopropyl-6-(3-oxopiperazin-1-yl)pyridine-3,5-dicarbonitrile

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;96%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

C5H11N3

C5H11N3

Conditions
ConditionsYield
With hydrazine hydrate In propan-1-ol Solvent; Reflux;95.9%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

2,2-diallylpiperazine
282089-93-4

2,2-diallylpiperazine

Conditions
ConditionsYield
In tetrahydrofuran for 2h; reductive diallylation; Heating;95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

allyl bromide
106-95-6

allyl bromide

2,2-diallylpiperazine
282089-93-4

2,2-diallylpiperazine

Conditions
ConditionsYield
Stage #1: allyl bromide With samarium In tetrahydrofuran at 20℃; for 1h;
Stage #2: 2-Ketopiperazine In tetrahydrofuran at 20℃; for 0.0666667h;
95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

C17H13ClF2N2O2
868552-03-8

C17H13ClF2N2O2

methyl 1-(4-fluorobenzyl)-3-((3-oxopiperazin-1-yl)methyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
868551-80-8

methyl 1-(4-fluorobenzyl)-3-((3-oxopiperazin-1-yl)methyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 50℃; for 4h;95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

chloroacetyl-piperazinone

chloroacetyl-piperazinone

Conditions
ConditionsYield
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
868552-11-8

methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

methyl 1-(4-fluorobenzyl)-3-((3-oxopiperazin-1-yl)methyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
868551-80-8

methyl 1-(4-fluorobenzyl)-3-((3-oxopiperazin-1-yl)methyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Conditions
ConditionsYield
Stage #1: methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate With chloroformic acid ethyl ester In dichloromethane at 20℃; Inert atmosphere;
Stage #2: 2-Ketopiperazine With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; Inert atmosphere;
95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide
1353891-92-5

N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide

N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide
1353891-93-6

N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide

Conditions
ConditionsYield
Stage #1: N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1.5h;
Stage #2: 2-Ketopiperazine In dichloromethane for 15h; Product distribution / selectivity;
95%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
139756-22-2

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

5-(2-ethoxy-5-((3-oxopiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

5-(2-ethoxy-5-((3-oxopiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Conditions
ConditionsYield
Stage #1: 2-Ketopiperazine With triethylamine In chloroform at 10℃; for 0.166667h;
Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In chloroform at 25℃; for 6h;
95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃;70%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(9H-fluoren-9-yl)methyl 3-oxopiperazine-1-carboxylate
1119449-40-9

(9H-fluoren-9-yl)methyl 3-oxopiperazine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In water; ethyl acetate at 20℃;94%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

7-(2-Chloro-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
1215167-26-2

7-(2-Chloro-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

4-[6-propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-thieno[2,3-d]pyrimidin-2-yl]-piperazin-2-one
1215167-27-3

4-[6-propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-thieno[2,3-d]pyrimidin-2-yl]-piperazin-2-one

Conditions
ConditionsYield
In butan-1-ol at 150℃; for 2h; Microwave irradiation;94%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

2-chloro-4-fluorobenzonitrile
60702-69-4

2-chloro-4-fluorobenzonitrile

2-chloro-4-(3-oxopiperazin-1-yl)benzonitrile
1372928-18-1

2-chloro-4-(3-oxopiperazin-1-yl)benzonitrile

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 80℃; for 24h;94%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

C18H20N2O5S2

C18H20N2O5S2

Conditions
ConditionsYield
With sodium t-butanolate In tetrahydrofuran at 80℃; for 24h;94%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

4-(4-bromobenzyl)piperazin-2-on
923674-86-6

4-(4-bromobenzyl)piperazin-2-on

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 16h;93%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

C16H12N2O2

C16H12N2O2

C14H14N4O2

C14H14N4O2

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 16h;93%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

7-bromo-5-cyclopropyl-6-methyl-oxazolo[4,5-c]quinolin-4-one

7-bromo-5-cyclopropyl-6-methyl-oxazolo[4,5-c]quinolin-4-one

4-{7-bromo-5-cyclopropyl-6-methyl-4-oxo-oxazolo[4,5-c]quinolin-2-yl}piperazin-2-one

4-{7-bromo-5-cyclopropyl-6-methyl-4-oxo-oxazolo[4,5-c]quinolin-2-yl}piperazin-2-one

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; acetic acid In acetonitrile at 80℃; for 16h; Inert atmosphere; Microwave irradiation;93%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

N-tert-butyloxycarbonyl-S-trityl-L-cysteine
21947-98-8, 87494-13-1

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

(R)-tert-butyl 1-oxo-1-(3-oxopiperazin-1-yl)-3-(tritylthio)propan-2-ylcarbamate

(R)-tert-butyl 1-oxo-1-(3-oxopiperazin-1-yl)-3-(tritylthio)propan-2-ylcarbamate

Conditions
ConditionsYield
Stage #1: N-tert-butyloxycarbonyl-S-trityl-L-cysteine With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2-Ketopiperazine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 48h; Inert atmosphere;
93%
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

2-Naphthalenesulfonyl chloride
93-11-8

2-Naphthalenesulfonyl chloride

4-(naphthalene-2-sulfonyl)-piperazin-2-one
239072-77-6

4-(naphthalene-2-sulfonyl)-piperazin-2-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.5h;92.5%
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide
2-Ketopiperazine
5625-67-2

2-Ketopiperazine

4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoic acid
1464155-72-3

4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoic acid

4-(6-(4-(3-oxopiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile
1464151-39-0

4-(6-(4-(3-oxopiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;92%
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;92%

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