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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Bosentan

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Bosentan 147536-97-8 API

Cas:147536-97-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Bosentan 147536-97-8 GMP Manufacturer

Cas:147536-97-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Bosentan

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Best Price Top Quality Bosentan CAS 147536-97-8

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 147536-97-8 with competitive price

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Cardiovascular Drug; for Pulmonary Hypertension;Vasodilator Transportation:By sea or by air Port:Qingdao Port

Bosentan

Cas:147536-97-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Bosentan 147536-97-8

Cas:147536-97-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Bosentan 99%

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $49.0 / 54.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Bosentan CAS147536-97-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Bosentan CAS147536-97-8

Cas:147536-97-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Bosentan

Cas:147536-97-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Bosentan

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

BOSENTAN

Cas:147536-97-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of APIs in China

supply Bosentan High quality Hot sale Bosentan price

Cas:147536-97-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Bosentan 147536-97-8

Cas:147536-97-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Bosentan

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D

Bosentan CAS NO.147536-97-8

Cas:147536-97-8

Min.Order:10 Gram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Bosentan

Cas:147536-97-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:pale yellow to off-white solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:

Bosentan

Cas:147536-97-8

Min.Order:50 Gram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply BOSENTAN

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Bosentan Basic information Product Name: Bosentan Synonyms: 2’-bipyrimidin)-4-yl)-enoxy)(;benzenesulfonamide,4-(1,1-dimethylethyl)-n-(6-(2-hydroxyethoxy)-5-(2-methoxyph;ro47-0203;ro47-0203/039;BOSENTAN;Ro-47-0203, 4-(1,1-dimethylethyl)-N-[6

TIANFU-CHEM Bosentan

Cas:147536-97-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferBosentan

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Bosentan

Cas:147536-97-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

147536-97-8 Bosentan

Cas:147536-97-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Bosentan

Cas:147536-97-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

147536-97-8 Bosentan

Cas:147536-97-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Bosentan

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Bosentan

Cas:147536-97-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

ethylene glycol
107-21-1

ethylene glycol

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide
150727-06-3

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: ethylene glycol; 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide With sodium hydroxide In tetrahydrofuran at 60 - 65℃; for 12h;
Stage #2: With tartaric acid In tetrahydrofuran; water at 5 - 10℃; for 1h;
95.7%
With sodium hydroxide In tetrahydrofuran at 50 - 65℃; for 7h; Time;92%
Stage #1: ethylene glycol; 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide With sodium hydroxide at 100℃; for 2h;
Stage #2: With DL-tartaric acid In tetrahydrofuran; water Reagent/catalyst; Cooling with ice;
88.3%
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butylbenzenesulphonamide sodium salt

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butylbenzenesulphonamide sodium salt

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20 - 30℃; for 3h;95%
With hydrogenchloride In ethanol; water pH=3;116 g
4-[(1,1-dimethylethyl)-N-[6-(2-formyloxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide

4-[(1,1-dimethylethyl)-N-[6-(2-formyloxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: 4-[(1,1-dimethylethyl)-N-[6-(2-formyloxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide With water; sodium hydroxide In ethanol at 25 - 30℃; for 1h;
Stage #2: With hydrogenchloride In ethanol; water for 1h; pH=5.5;
93%
Stage #1: 4-[(1,1-dimethylethyl)-N-[6-(2-formyloxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide With sodium hydroxide In water at 25℃; for 1h;
Stage #2: In ethanol Reflux;
91.2%
bosentan p-toluenesulfonate

bosentan p-toluenesulfonate

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water at 20 - 25℃; for 1h;93%
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide potassium salt

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide potassium salt

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 20℃; for 3h;90%
With hydrogenchloride In water; 4-methyl-2-pentanone at 75℃; Inert atmosphere;
With hydrogenchloride In water; 4-methyl-2-pentanone at 75℃;
With hydrogenchloride In water32 g
trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester
1334686-08-6

trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester With ethanol; sodium hydroxide at 20℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water at 0℃; pH=3 - 3.5;
90%
Stage #1: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester With sodium hydroxide In ethanol at 20℃; for 1h;
Stage #2: With hydrogenchloride In ethanol; dichloromethane; water pH=3 - 3.5;
90%
4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

ethylene glycol
107-21-1

ethylene glycol

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: ethylene glycol With potassium carbonate In acetonitrile for 0.25h;
Stage #2: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt In acetonitrile at 80 - 85℃; for 12h; Temperature; Time; Solvent;
89%
Stage #1: ethylene glycol With sodium hydroxide In acetonitrile at 75 - 80℃; for 8 - 12h;
Stage #2: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt In acetonitrile for 12 - 14h;
Stage #3: With hydrogenchloride; water In acetonitrile at 25℃; for 2h; pH=2 - 3; Product distribution / selectivity;
Stage #1: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt; ethylene glycol With barium(II) hydroxide In toluene at 110℃;
Stage #2: With hydrogenchloride In water pH=1 - 2; Product distribution / selectivity;
4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In methanol at 20℃; for 24h; Inert atmosphere;84%
bosentan potassium
1174918-31-0

bosentan potassium

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 20 - 30℃; pH=0.5 - 1;80.8%
4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide
1174918-30-9

4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 5℃; Solvent;80%
With sodium tetrahydroborate In methanol at 0 - 20℃;80%
With sodium tetrahydroborate In methanol at 0 - 5℃;75%
Stage #1: 4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide With sodium tetrahydroborate In methanol at 0 - 5℃; for 2h;
Stage #2: With hydrogenchloride In methanol; water pH=2; Product distribution / selectivity;
With methanol; sodium tetrahydroborate for 4h;
2,2-dimethyl-propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']-bipyrimidinyl-4-yloxy]-ethyl ester
1374293-39-6

2,2-dimethyl-propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']-bipyrimidinyl-4-yloxy]-ethyl ester

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: 2,2-dimethyl-propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']-bipyrimidinyl-4-yloxy]-ethyl ester With water; sodium hydroxide In ethanol at 10 - 25℃;
Stage #2: With hydrogenchloride In ethanol; water at 10 - 15℃; for 2h;
80%
ethyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

ethyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 5℃;80%
4-tert-butyl-N-[6-(2-hydroxyethoxy)-2-iodo-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide
1206769-86-9

4-tert-butyl-N-[6-(2-hydroxyethoxy)-2-iodo-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

2-(tributylstannyl)pyrimidine
153435-63-3

2-(tributylstannyl)pyrimidine

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With cesium fluoride; bis(tri-t-butylphosphine)palladium(0) In 1,4-dioxane at 100 - 110℃; for 16h; Inert atmosphere;70%
trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester
1334686-05-3

trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

2-(tributylstannyl)pyrimidine
153435-63-3

2-(tributylstannyl)pyrimidine

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide at 130℃; for 6h; Stille Coupling;70%
tetrakis(triphenylphosphine) palladium(0) In ISOPROPYLAMIDE at 130℃; for 6h;70%
N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide

N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide With formic acid at 85℃; for 1.5h;
Stage #2: With potassium carbonate In methanol for 1h;
70%
Stage #1: N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide With formic acid at 85℃; for 1.5h;
Stage #2: With potassium carbonate In methanol for 1h;
Stage #3: With hydrogenchloride In methanol; water; ethyl acetate pH=3 - 3.5;
70%
With phosphoric acid In acetonitrile at 25℃; Product distribution / selectivity; Reflux;
Multi-step reaction with 2 steps
1.1: 4 h / 85 °C
2.1: sodium hydroxide / water / 1 h / 25 °C
2.2: Reflux
View Scheme
N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
1206769-81-4

N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide

2-(tributylstannyl)pyrimidine
153435-63-3

2-(tributylstannyl)pyrimidine

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With cesium fluoride; bis(tri-t-butylphosphine)palladium(0) In N,N-dimethyl-formamide at 140 - 150℃; for 16h; Inert atmosphere;47%
2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy) ethanol
184779-15-5

2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy) ethanol

4-tert-butylbenzenesulphonamide
6292-59-7

4-tert-butylbenzenesulphonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; glycine In 1,4-dioxane at 120℃; for 44h; Product distribution / selectivity;31%
With potassium phosphate; copper(l) iodide; glycine In 1,4-dioxane at 120℃; for 44h; Product distribution / selectivity;31%
With potassium phosphate In N,N-dimethyl acetamide at 20 - 100℃; for 18h; Product distribution / selectivity;
With potassium carbonate; tetrabutylammomium bromide In toluene at 100 - 110℃; for 15h;
ethylene glycol
107-21-1

ethylene glycol

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
150728-13-5

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

potassium 4-tert-butylbenzenesulfonate

potassium 4-tert-butylbenzenesulfonate

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With sodium 1.) DMSO, rt, 2.) 100 deg C; Multistep reaction;
5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidine-4,6(1H, 5H)-dione
150728-12-4

5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidine-4,6(1H, 5H)-dione

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3, PCl5 / Heating
2: 2.) Na / 1.) DMSO, rt, 2.) 100 deg C
View Scheme
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 4 h / Reflux
2.1: potassium hydroxide / acetone / 0.08 h / 30 °C
2.2: 6.5 h / 30 °C / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 30 - 50 °C
3.2: 0.5 h / 30 °C
4.1: hydrogenchloride; water / 1 h
5.1: sodium tetrahydroborate; methanol / 4 h
View Scheme
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 90 - 105 °C
2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 50 °C / Reflux; Dean-Stark
3.1: sodium hydroxide / toluene / 55 °C
4.1: 4 h / 85 °C
5.1: sodium hydroxide / water / 1 h / 25 °C
5.2: Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: phosphorus pentachloride / toluene / 2 h / Reflux
2.1: sodium hydroxide
2.2: 3 h / 90 °C
3.1: sodium hydroxide / tetrahydrofuran / 7 h / 50 - 65 °C
View Scheme
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide
150727-06-3

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
In ethylene glycol
ethylene glycol
107-21-1

ethylene glycol

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide
150727-06-3

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

A

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
174227-14-6

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

B

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: ethylene glycol With sodium hydroxide In tetrahydrofuran at 50℃; for 0.5h;
Stage #2: 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide In tetrahydrofuran at 50 - 65℃; for 12h;
bosentan barium

bosentan barium

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water pH=1 - 2; Product distribution / selectivity;
p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
174227-14-6

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

2-chloro-ethanol
107-07-3

2-chloro-ethanol

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide With sodium carbonate In N,N-dimethyl-formamide at 110 - 115℃; for 4h;
Stage #2: 2-chloro-ethanol In N,N-dimethyl-formamide for 16h;
Stage #3: With hydrogenchloride; water In N,N-dimethyl-formamide pH=2; Product distribution / selectivity;
Stage #1: p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; 2-chloro-ethanol With potassium tert-butylate In N,N-dimethyl-formamide at 120℃; for 15h;
Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide at 20 - 25℃; pH=2;
Stage #1: p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide With sodium carbonate In dimethyl sulfoxide; toluene at 105 - 110℃;
Stage #2: 2-chloro-ethanol In dimethyl sulfoxide; toluene at 105 - 110℃;
Stage #3: With hydrogenchloride In water; dimethyl sulfoxide; toluene at 20℃;
bosentan hydrochloride
1196074-08-4

bosentan hydrochloride

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water for 2h; pH=7;
ethylene sulfite
3741-38-6

ethylene sulfite

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
174227-14-6

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: ethylene sulfite; p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide With potassium carbonate; tetrabutylammomium bromide In butanone Reflux;
Stage #2: With water; sodium hydroxide In ethyl acetate
N-(6-chloro-5-(2-methoxyphenoxy))-[2,2'-bipyrimidinyl]-4-t-butyl benzenesulfonamide cesium salt

N-(6-chloro-5-(2-methoxyphenoxy))-[2,2'-bipyrimidinyl]-4-t-butyl benzenesulfonamide cesium salt

ethylene glycol
107-21-1

ethylene glycol

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Stage #1: ethylene glycol With sodium carbonate; dmap at 60 - 65℃; for 3h;
Stage #2: N-(6-chloro-5-(2-methoxyphenoxy))-[2,2'-bipyrimidinyl]-4-t-butyl benzenesulfonamide cesium salt In tetrahydrofuran for 135h; Product distribution / selectivity; Reflux;
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide
150727-06-3

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

A

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
174227-14-6

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

B

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
In water; isopropyl alcohol at 115℃; for 5h;A 5.88 %Chromat.
B n/a
2-methoxy-phenol
90-05-1

2-methoxy-phenol

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / toluene / 20 °C / Reflux
1.2: 3.5 h / 60 °C / Reflux
2.1: sodium ethanolate / methanol / 6 h / 0 - 35 °C
3.1: trichlorophosphate / 4 h / 103 - 105 °C
3.2: 20 - 80 °C
4.1: potassium carbonate / tetrabutylammomium bromide / toluene / 2 h / Reflux
5.1: isopropyl alcohol; water / 5 h / 115 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide / toluene / 20 °C / Reflux
1.2: 3.5 h / 60 °C / Reflux
2.1: sodium ethanolate / methanol / 6 h / 0 - 35 °C
3.1: trichlorophosphate / 4 h / 103 - 105 °C
3.2: 20 - 80 °C
4.1: potassium carbonate / tetrabutylammomium bromide / toluene / 2 h / Reflux
5.1: water / 5 h / 115 °C
5.2: 1 h / 55 - 85 °C
6.1: hydrogenchloride / dichloromethane; water / 20 - 30 °C / pH 0.5 - 1
View Scheme
(2-methoxyphenoxy)-malonic acid dimethyl ester
150726-89-9

(2-methoxyphenoxy)-malonic acid dimethyl ester

bosentan
147536-97-8

bosentan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium ethanolate / methanol / 6 h / 0 - 35 °C
2.1: trichlorophosphate / 4 h / 103 - 105 °C
2.2: 20 - 80 °C
3.1: potassium carbonate / tetrabutylammomium bromide / toluene / 2 h / Reflux
4.1: isopropyl alcohol; water / 5 h / 115 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium ethanolate / methanol / 6 h / 0 - 35 °C
2.1: trichlorophosphate / 4 h / 103 - 105 °C
2.2: 20 - 80 °C
3.1: potassium carbonate / tetrabutylammomium bromide / toluene / 2 h / Reflux
4.1: water / 5 h / 115 °C
4.2: 1 h / 55 - 85 °C
5.1: hydrogenchloride / dichloromethane; water / 20 - 30 °C / pH 0.5 - 1
View Scheme
Multi-step reaction with 6 steps
1.1: sodium methylate / methanol / 3 h / 25 - 30 °C
1.2: 3 h / 25 - 30 °C
2.1: trichlorophosphate / 4 h / Reflux
3.1: potassium hydroxide / acetone / 0.08 h / 30 °C
3.2: 6.5 h / 30 °C / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 30 - 50 °C
4.2: 0.5 h / 30 °C
5.1: hydrogenchloride; water / 1 h
6.1: sodium tetrahydroborate; methanol / 4 h
View Scheme
pivaloyl chloride
3282-30-2

pivaloyl chloride

bosentan
147536-97-8

bosentan

2,2-dimethyl-propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']-bipyrimidinyl-4-yloxy]-ethyl ester
1374293-39-6

2,2-dimethyl-propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']-bipyrimidinyl-4-yloxy]-ethyl ester

Conditions
ConditionsYield
Stage #1: bosentan In dichloromethane at 20 - 25℃; for 1h;
Stage #2: pivaloyl chloride In dichloromethane at 20 - 25℃; for 15h;
97.5%
2,5-dihydroxybenzoic acid.
490-79-9

2,5-dihydroxybenzoic acid.

bosentan
147536-97-8

bosentan

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide gentisic acid cocrystal
1450829-49-8

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide gentisic acid cocrystal

Conditions
ConditionsYield
In n-heptane; acetone at 55℃; for 2.33333h; Concentration; Solvent; Temperature; Time; Sonication;96%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

bosentan
147536-97-8

bosentan

C32H32N6O10S

C32H32N6O10S

Conditions
ConditionsYield
In acetonitrile at 65℃; for 32h; Temperature; Solvent;95.5%
zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

ethanol
64-17-5

ethanol

bosentan
147536-97-8

bosentan

C54H56N10O12S2Zn*2.5C2H6O

C54H56N10O12S2Zn*2.5C2H6O

Conditions
ConditionsYield
With potassium hydroxide for 4h; Thermodynamic data; Reflux;74%
maleic acid
110-16-7

maleic acid

bosentan
147536-97-8

bosentan

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide maleic acid cocrystal

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide maleic acid cocrystal

Conditions
ConditionsYield
In ethyl acetate; acetone at 4 - 80℃; for 12h; Concentration; Time; Temperature; Solvent;63%
In acetonitrile at 4 - 20℃;
pentafluorophenol 4-nitroxybutyrate
838878-70-9

pentafluorophenol 4-nitroxybutyrate

bosentan
147536-97-8

bosentan

C31H34N6O10S

C31H34N6O10S

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0℃;57%
chloromethyl (4-(nitrooxy)butyl) carbonate
959639-85-1

chloromethyl (4-(nitrooxy)butyl) carbonate

bosentan
147536-97-8

bosentan

C33H38N6O12S

C33H38N6O12S

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide for 48h;38%
1-chloro-ethyl 4-nitooxy-butyl carbonate
959639-82-8

1-chloro-ethyl 4-nitooxy-butyl carbonate

bosentan
147536-97-8

bosentan

C34H40N6O12S

C34H40N6O12S

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide for 60h;30%
[4-(nitrooxy)methyl]benzoic acid pentafluorophenyl ester
874446-96-5

[4-(nitrooxy)methyl]benzoic acid pentafluorophenyl ester

bosentan
147536-97-8

bosentan

C35H34N6O10S

C35H34N6O10S

Conditions
ConditionsYield
With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at 0℃;23%
4-(nitrooxy)butyl 4-nitrophenyl carbonate
935472-60-9

4-(nitrooxy)butyl 4-nitrophenyl carbonate

bosentan
147536-97-8

bosentan

C32H36N6O11S

C32H36N6O11S

Conditions
ConditionsYield
With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at 0℃;15%
pyridine-2-carbonyl azide
4013-71-2

pyridine-2-carbonyl azide

bosentan
147536-97-8

bosentan

pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-yloxy]-ethyl ester

pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-yloxy]-ethyl ester

Conditions
ConditionsYield
With dmap In toluene at 100℃;
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