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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 1-BOC-3-METHYL-PIPERIDIN-4-ONE Synonyms: N-TERT-BUTOXYCARBONYL-3-METHYL-4-PIPERIDONE;1-BOC-3-METHYL-PIPERIDIN-4-ONE;tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate;N-Boc-3-methyl-4-piperidone;3-Methyl-4-oxo-piperidine-1

181269-69-2 1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

1-BOC-3-METHYL-PIPERIDIN-4-ONE Basic information Product Name: 1-BOC-3-METHYL-PIPERIDIN-4-ONE Synonyms: N-TERT-BUTOXYCARBONYL-3-METHYL-4-PIPERIDONE;1-BOC-3-METHYL-PIPERIDIN-4-ONE;tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate;N-Boc-3-methyl-

Factory Supply N-Boc-3-methyl-4-piperidone

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 181269-69-2 with competitive price

Cas:181269-69-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

1-BOC-3-METHYL-PIPERIDIN-4-ONE CAS:181269-69-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o

1-BOC-3-METHYL-PIPERIDIN-4-ONE CAS:181269-69-2

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Piperidinecarboxylicacid, 3-methyl-4-oxo-, 1,1-dimethylethyl ester

Cas:181269-69-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Piperidinecarboxylicacid, 3-methyl-4-oxo-, 1,1-dimethylethyl ester

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Piperidinecarboxylicacid, 3-methyl-4-oxo-, 1,1-dimethylethyl ester

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-Methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Cas:181269-69-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 1-BOC-3-METHYL-PIPERIDIN-4-ONE Synonyms: N-TERT-BUTOXYCARBONYL-3-METHYL-4-PIPERIDONE;1-BOC-3-METHYL-PIPERIDIN-4-ONE;tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate;N-Boc-3-methyl-4-piperidone;3-Methyl-4-oxo-piperidine-1-carboxyl

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

N-Boc-3-methyl-4-piperidone

Cas:181269-69-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

ProductName:tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate Synonyms:N-Boc-3-methyl-4-piperidone;1-BOC-3-METHYL-PIPERIDIN-4-ONE; CAS:181269-69-2 Molecular Formula: C11H19NO3 Molecular Weight:213.27300 Purity:≥98% Appearance: light

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize in manufacturing high quality of Advanced Intermediates, Sp

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate cas no. 181269-69-2 98%

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

1-BOC-3-METHYL-PIPERIDIN-4-ONE

Cas:181269-69-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Cas:181269-69-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec tert-Butyl 3-methyl-4-oxo-1-piperidinecarboxylate 25g

Cas:181269-69-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-Benzyl-3-methyl-4-piperidon
34737-89-8

1-Benzyl-3-methyl-4-piperidon

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
With hydrogen; palladium dihydroxide In ethyl acetate under 2068.65 Torr; for 24h;100%
With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 2585.81 Torr; for 4h;97%
With hydrogen; palladium(II) hydroxide In methanol at 20℃; under 2844.39 Torr;95%
N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

methyl iodide
74-88-4

methyl iodide

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at -78 - 20℃; for 3h;
45%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 3h;
28%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With potassium hexamethylsilazane In tetrahydrofuran; toluene at 20℃; for 2h;
Stage #2: methyl iodide In tetrahydrofuran; toluene at 20℃;
22.5%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With sodium hydride In tetrahydrofuran; mineral oil at 20℃;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil
16%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With sodium hydride In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 18h;
10%
3-methyl-4-piperidone
5773-58-0

3-methyl-4-piperidone

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
With N,N-dimethylethylenediamine In dichloromethane at 20℃; for 2.5h;
With dmap; triethylamine In tetrahydrofuran; water at 20℃; for 18h;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 1-Benzyl-3-methyl-4-piperidon With hydrogenchloride; hydrogen; palladium dihydroxide In 1,4-dioxane; methanol under 2585.81 Torr;
Stage #2: di-tert-butyl dicarbonate With triethylamine In tetrahydrofuran for 2h;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C14H23NO5
1159982-52-1

C14H23NO5

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: C14H23NO5 With hydrogenchloride In water for 48h; Reflux;
Stage #2: di-tert-butyl dicarbonate With sodium carbonate In tetrahydrofuran; water
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate
181269-70-5

tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 20℃; for 3.5h;100%
With methanol; sodium tetrahydroborate at 0 - 25℃; for 3.5h;100%
With sodium tetrahydroborate In ethanol at 0℃; for 0.5h;88%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
1240971-20-3

3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.5h;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 25℃; for 2.5h;
97%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.5h;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at 20℃; for 16h;
78%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 0℃; for 1h;
61%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 25℃; for 3h;
198 mg
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 1h; Inert atmosphere;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -70 - 0℃; for 4h;
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

(S)-2-(2-(methylsulfonyl)ethyl)pyrrolidine hydrochloride

(S)-2-(2-(methylsulfonyl)ethyl)pyrrolidine hydrochloride

C13H26N2O2S*ClH

C13H26N2O2S*ClH

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; (S)-2-(2-(methylsulfonyl)ethyl)pyrrolidine hydrochloride With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 6h;
Stage #2: With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 4h;
96%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

diethyl {3-[(5-chloropyridin-2-yl)oxy]benzyl}phosphonate
1191250-62-0

diethyl {3-[(5-chloropyridin-2-yl)oxy]benzyl}phosphonate

5-chloro-2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}pyridine

5-chloro-2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}pyridine

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h;90%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h;
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

2-(5-methoxy-2-nitrophenyl)-ethylamine
180149-25-1

2-(5-methoxy-2-nitrophenyl)-ethylamine

tert-butyl 4-[2-(5-methoxy-2-nitro-phenyl)-ethylamino]-3-methyl-piperidine-1-carboxylate
1146733-30-3

tert-butyl 4-[2-(5-methoxy-2-nitro-phenyl)-ethylamino]-3-methyl-piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 3h;90%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

tert-butyl 4-methyl-1-oxa-6-azaspiro[2.5]octane-6-carboxylate

tert-butyl 4-methyl-1-oxa-6-azaspiro[2.5]octane-6-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In 1,2-dimethoxyethane; dimethyl sulfoxide at 0 - 5℃; for 1h;90%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

tert-butyl 4-hydroxy-3-methyl-4-phenylpiperidine-1-carboxylate

tert-butyl 4-hydroxy-3-methyl-4-phenylpiperidine-1-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 24h;84%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

tert-butyl 3-methyl-4-methylidenepiperidine-1-carboxylate
336182-47-9

tert-butyl 3-methyl-4-methylidenepiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In tetrahydrofuran at 20℃; for 1h;
83%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;
60%
With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 16h;
bromochlorobenzene
106-39-8

bromochlorobenzene

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

4-(4-chloro-phenyl)-4-hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

4-(4-chloro-phenyl)-4-hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: bromochlorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In tetrahydrofuran; hexane at -78 - -20℃;
Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water
83%
Stage #1: bromochlorobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 0.75h;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In tetrahydrofuran; hexanes at -78℃; for 2h;
79%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

sodium methylate
124-41-4

sodium methylate

4-methoxycarbonylmethylene-3-methylpiperidine-1-carboxylic acid t-butyl ester
502609-65-6

4-methoxycarbonylmethylene-3-methylpiperidine-1-carboxylic acid t-butyl ester

Conditions
ConditionsYield
In tetrahydrofuran; methanol at 20℃; for 4h;82.5%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

tert-butyl 4-amino-3-methylpiperidine-1-carboxylate
900642-17-3

tert-butyl 4-amino-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
With ammonium formate; sodium cyanoborohydride In methanol at 30℃; for 16h; Temperature; Molecular sieve;80%
With ammonium formate; sodium cyanoborohydride In methanol at 20℃; for 3h; Molecular sieve;60%
With formic acid; ammonium formate; sodium cyanoborohydride In methanol at 20℃; for 2h;
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine
1020325-38-5

2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine

2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}-5-(trifluoromethyl)pyridine
1191288-06-8

2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; 2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
79%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; 2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
79%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

3-methyl-4-piperidone
5773-58-0

3-methyl-4-piperidone

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
Stage #2: With water In dichloromethane; water
75%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

1,1-dimethylethyl 4-methyl-1-oxa-6-azaspiro[2.5]octane-6-carboxylate
862669-17-8

1,1-dimethylethyl 4-methyl-1-oxa-6-azaspiro[2.5]octane-6-carboxylate

Conditions
ConditionsYield
Stage #1: trimethylsulfoxonium iodide With sodium hydride In dimethyl sulfoxide; mineral oil at 0 - 20℃; for 2h;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In dimethyl sulfoxide; mineral oil at 0 - 20℃; for 2h;
75%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

methyl (S)-3-(pyrrolidin-2-yl)propanoate
689303-75-1

methyl (S)-3-(pyrrolidin-2-yl)propanoate

tert-butyl 4-((S)-2-(3-methoxy-3-oxopropyl)pyrrolidin-1-yl)-3-methylpiperidine-1-carboxylate

tert-butyl 4-((S)-2-(3-methoxy-3-oxopropyl)pyrrolidin-1-yl)-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 16h;75%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; methyl (S)-3-(pyrrolidin-2-yl)propanoate In 1,2-dichloro-ethane at 20℃; for 0.5h;
Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;
37%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Diethyl 3-(5-bromopyridin-2-yloxy)benzylphosphonate
1020326-79-7

Diethyl 3-(5-bromopyridin-2-yloxy)benzylphosphonate

5-bromo-2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}pyridine
1191250-55-1

5-bromo-2-{3-[(3-methylpiperidin-4-ylidene)methyl]phenoxy}pyridine

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h;72%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; Diethyl 3-(5-bromopyridin-2-yloxy)benzylphosphonate With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
72%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

benzyltriphenylphosphonium bromide
1449-46-3

benzyltriphenylphosphonium bromide

tert-butyl 4-benzylidene-3-methylpiperidine-1-carboxylate

tert-butyl 4-benzylidene-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: benzyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate In tetrahydrofuran at 20℃; for 3h;
63%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

2-propynamide
7341-96-0

2-propynamide

tert-butyl 8-methyl-2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
1401034-50-1

tert-butyl 8-methyl-2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With pyrrolidine In toluene for 5h; Reflux;
Stage #2: 2-propynamide In toluene Reflux;
55%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

p-tolylsulfonylmethyl isocyanide
5697-44-9

p-tolylsulfonylmethyl isocyanide

tert-butyl 4-cyano-3-methylpiperidine-1-carboxylate

tert-butyl 4-cyano-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In 1,2-dimethoxyethane at 0 - 25℃; for 16h; Inert atmosphere;50.4%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide
145100-51-2

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
1240971-20-3

3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With potassium hexamethylsilazane In tetrahydrofuran at -78 - 20℃; for 3.5h;
Stage #2: N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide In tetrahydrofuran at -78 - 20℃;
47%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

tert-butyl 3-(2-ethoxy-2-oxoacetyl)-5-methyl-4-oxopiperidine-1-carboxylate

tert-butyl 3-(2-ethoxy-2-oxoacetyl)-5-methyl-4-oxopiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: oxalic acid diethyl ester In tetrahydrofuran at 20℃; for 2h;
45.6%
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate With lithium hexamethyldisilazane In tetrahydrofuran at -60℃; for 0.5h;
Stage #2: oxalic acid diethyl ester at -60 - 20℃; for 1h;
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

2-iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine

2-iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine

tert-butyl 4-((2-iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-yl)amino)-3-methylpiperidine-1-carboxylate

tert-butyl 4-((2-iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-yl)amino)-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; 2-iodo-1-(2,2,2-trifluoroethyl)-1H-indol-4-amine With chloro-trimethyl-silane In N,N-dimethyl-formamide at 0℃; for 2h;
Stage #2: With borane-THF In N,N-dimethyl-formamide at 0 - 25℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;
45.28%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

tert-butyl 4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methylpiperidine-1-carboxylate

tert-butyl 4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methylpiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 16h;40%
2-cyanomethylbenzothiazole
56278-50-3

2-cyanomethylbenzothiazole

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

tert-butyl 2-amino-3-(benzo[d]thiazol-2-yl)-4-methyl-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate

tert-butyl 2-amino-3-(benzo[d]thiazol-2-yl)-4-methyl-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate

Conditions
ConditionsYield
With morpholine; sulfur at 85℃; for 12h;39%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

2-methyl-2-thiopseudouronium sulfate

2-methyl-2-thiopseudouronium sulfate

tert-butyl 8-methyl-2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
1567965-66-5

tert-butyl 8-methyl-2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; N,N-dimethyl-formamide dimethyl acetal at 80℃; for 12h;
Stage #2: 2-methyl-2-thiopseudouronium sulfate With sodium ethanolate In ethanol at 80℃; for 12.5h;
36%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

CYANAMID
420-04-2

CYANAMID

C12H19N3O2S
1253415-55-2

C12H19N3O2S

Conditions
ConditionsYield
With pyridine; sulfur at 100℃; for 3h;31.3%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

(S)-2-(pyrrolidin-2-yl)ethane-1-sulfonamide

(S)-2-(pyrrolidin-2-yl)ethane-1-sulfonamide

2-((S)-1-((3R,4S)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)ethane-1-sulfonamide

2-((S)-1-((3R,4S)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)ethane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; (S)-2-(pyrrolidin-2-yl)ethane-1-sulfonamide With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 16h;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
22%
tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate
181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

(3R,4R)-3-methyl-4-(1-(S)-phenyl-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester
723308-56-3

(3R,4R)-3-methyl-4-(1-(S)-phenyl-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With sodium triacetoxyborohydride In dichloromethane at 20℃;10%
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃;10%

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