As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:1826-12-6
Min.Order:1 Kilogram
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inquiryNow we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti
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Cas:1826-12-6
Min.Order:1 Kilogram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:1826-12-6
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
4-phenyl-1,3-thiazole cas 1826-12-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:1826-12-6
Min.Order:10 Milligram
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Type:Lab/Research institutions
inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
Cas:1826-12-6
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inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por
FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 4-phenyl-1,3-thiazole, CAS:1826-12-6 with the most competitive price and the best qua
ProName: 4-phenyl-1,3-thiazole CasNo: 1826-12-6 Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clients requirement Port: Shanghai Purity: 98%
high purity Application:Drug intermediates Materials intermediates and active molecules
2-bromo-4-phenyl-1,3-thiazole
4-phenyl-thiazole
Conditions | Yield |
---|---|
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Time; Inert atmosphere; | 95% |
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 25℃; for 3h; Inert atmosphere; | 95% |
Multi-step reaction with 3 steps 1: N-chloro-succinimide / acetonitrile / 31 h / 20 °C / Inert atmosphere; Reflux 2: palladium diacetate; triphenylphosphine; N,N,N,N,-tetramethylethylenediamine; sodium tetrahydroborate / tetrahydrofuran / 9 h / 20 °C / Inert atmosphere 3: N,N,N,N,-tetramethylethylenediamine; sodium tetrahydroborate; PdCl2(1,1′-bis(di-tertbutylphosphino)ferrocene) / tetrahydrofuran / 20 h / 65 °C / Inert atmosphere View Scheme |
5-chloro-4-phenylthiazole
4-phenyl-thiazole
Conditions | Yield |
---|---|
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; PdCl2(1,1′-bis(di-tertbutylphosphino)ferrocene) In tetrahydrofuran at 65℃; for 20h; Reagent/catalyst; Time; Temperature; Inert atmosphere; | 95% |
With sodium tetrahydroborate; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 65℃; for 20h; Reagent/catalyst; Temperature; Inert atmosphere; | 95% |
4-phenyl-thiazole
Conditions | Yield |
---|---|
With caesium carbonate In m-xylene at 150℃; for 40h; regioselective reaction; | 95% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; for 20h; Reagent/catalyst; Temperature; Inert atmosphere; | 93% |
With sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 20℃; for 22h; Reagent/catalyst; Time; Inert atmosphere; | 92% |
2,5-dibromo-4-phenylthiazole
A
5-bromo-4-phenylthiazole
B
4-phenyl-thiazole
Conditions | Yield |
---|---|
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 0℃; for 14h; Reagent/catalyst; Time; Inert atmosphere; regioselective reaction; | A 84% B 6% |
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran for 14h; Reagent/catalyst; Temperature; Inert atmosphere; Overall yield = 90 %; regioselective reaction; |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; for 18h; Suzuki Coupling; Inert atmosphere; Sealed tube; | 62% |
Conditions | Yield |
---|---|
With tetrahydrofuran; oxygen; nitrogen(II) oxide for 8h; Ambient temperature; | 40% |
With copper(I) oxide; sulfuric acid; hypophosphorous acid; sodium nitrite 1.) 0 deg C, 2.) H2O, from -5 deg C to RT; Yield given. Multistep reaction; | |
Stage #1: 2-Amino-4-phenylthiazole With sulfuric acid; trifluoroacetic acid; sodium nitrite In water at -15℃; Sandmeyer Reaction; Stage #2: With phosphoric acid In water at -15 - 20℃; |
1,3-thiazole
2-methylmercapto-4-phenylthiazole
A
4-phenyl-thiazole
B
2-methylthio-1,3-thiazole
Conditions | Yield |
---|---|
With carbonylhydridetris(triphenylphosphine)rhodium(I); 1,3-bis(dicyclohexylphosphine)propane In 1,2-dichloro-benzene for 3h; Reflux; Inert atmosphere; | A 31% B 12% |
ethyl acrylate
2-bromo-4-phenyl-1,3-thiazole
A
4-phenyl-thiazole
B
4,4'-diphenyl-2,2'-bithiazole
C
(E)-3-(4-Phenyl-thiazol-2-yl)-acrylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 24h; sealed tube; | A 22% B 6% C 19% |
2-bromo-4-phenyl-1,3-thiazole
A
4-phenyl-thiazole
B
4,4'-diphenyl-2,2'-bithiazole
C
(E)-3-(4-Phenyl-thiazol-2-yl)-acrylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine; ethyl acrylate; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 24h; sealed tube; | A 22% B 6% C 19% |
4-deuterio-5-phenylisothiazole
A
5-phenylthiazole
B
4-phenyl-thiazole
C
3-phenylisothiazole
Conditions | Yield |
---|---|
In benzene for 0.5h; phototransposition; Irradiation; | A 19% B 8% C 9% |
Conditions | Yield |
---|---|
In methanol for 3h; phototransposition; Irradiation; | A 4.9% B 16.8% |
acrylonitrile
2-bromo-4-phenyl-1,3-thiazole
A
4-phenyl-thiazole
B
4,4'-diphenyl-2,2'-bithiazole
C
(E)-3-(4-Phenyl-thiazol-2-yl)-acrylonitrile
Conditions | Yield |
---|---|
With triethylamine; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 48h; sealed tube; | A 12% B 15% C 15% |
2-bromo-4-phenyl-1,3-thiazole
A
4-phenyl-thiazole
B
4,4'-diphenyl-2,2'-bithiazole
C
(E)-3-(4-Phenyl-thiazol-2-yl)-acrylonitrile
Conditions | Yield |
---|---|
With triethylamine; acrylonitrile; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 48h; sealed tube; | A 12% B 15% C 15% |
5-phenylisothiazole
A
5-phenylthiazole
B
4-phenyl-thiazole
C
3-phenylisothiazole
Conditions | Yield |
---|---|
With TEA In benzene for 0.5h; Product distribution; Further Variations:; Reagents; Solvents; phototransposition; Irradiation; | A 14% B 2% C 5% |
styrene
2-bromo-4-phenyl-1,3-thiazole
A
4-phenyl-thiazole
B
4-phenyl-2-styrylthiazole
Conditions | Yield |
---|---|
With triethylamine; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 48h; sealed tube; | A 7% B 5% |
4-phenylthiazole-2-carboxylic acid
4-phenyl-thiazole
(4-phenyl-thiazol-2-yl)hydrazine hydrochloride
4-phenyl-thiazole
Conditions | Yield |
---|---|
With ethanol; mercury(II) oxide |
formamide
1-chloroacetophenone
4-phenyl-thiazole
Conditions | Yield |
---|---|
With piperidine; tetraphosphorus decasulfide |
1,3-thiazole
A
5-phenylthiazole
B
2-phenylthiazole
C
4-phenyl-thiazole
Conditions | Yield |
---|---|
With dibenzoyl peroxide Further byproducts given; |
Conditions | Yield |
---|---|
In ethanol Heating; | |
In ethanol Irradiation; |
Conditions | Yield |
---|---|
With sodium thiophenolate In methanol for 1h; Heating; |
Conditions | Yield |
---|---|
(i) P2S5, dioxane, (ii) /BRN= 606474/; Multistep reaction; |
2-phenylthiazole
A
5-phenylisothiazole
B
4-phenyl-thiazole
C
3-phenylisothiazole
Conditions | Yield |
---|---|
In benzene for 7h; Product distribution; Mechanism; Irradiation; other phenylthiazoles and phenylisothiazoles; phototransposition and photodeuteration; | A n/a B 26 % Chromat. C 7 % Chromat. |
Conditions | Yield |
---|---|
With sulfur dioxide; soda-lime; zirconium(IV) oxide at 450℃; | 26 % Spectr. |
Conditions | Yield |
---|---|
With TEA In methanol for 0.5h; Irradiation; | 82 % Chromat. |
With TEA In cyclohexane Product distribution; Quantum yield; Irradiation; other solvents, bases; photochemistry of 4-substituted isothiazoles; effect of reaction conditions; trapping of intermediate species; mechanism; sensitized irradiation; |
4-phenyl-thiazole
Conditions | Yield |
---|---|
With ethanol |
4-phenylthiazole-2(3H)-thione
ammonia
A
4-phenyl-thiazole
B
acetophenone
2-bromo-5-chloro-4-phenylthiazole
4-phenyl-thiazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium diacetate; triphenylphosphine; N,N,N,N,-tetramethylethylenediamine; sodium tetrahydroborate / tetrahydrofuran / 9 h / 20 °C / Inert atmosphere 2: N,N,N,N,-tetramethylethylenediamine; sodium tetrahydroborate; PdCl2(1,1′-bis(di-tertbutylphosphino)ferrocene) / tetrahydrofuran / 20 h / 65 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine / tetrahydrofuran / 9 h / 25 °C / Inert atmosphere 2: sodium tetrahydroborate; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 20 h / 65 °C / Inert atmosphere View Scheme |
4-phenyl-thiazole
Bis(trimethylsilyl)ethyne
3,4-bis(trimethylsilyl)thiophene
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 325℃; for 144h; | 92% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 325℃; for 144h; | 92 % Turnov. |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 325 - 340℃; | 83% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 340℃; for 60h; | 83 % Turnov. |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphosphine)palladium(0); lithium tert-butoxide In 1,4-dioxane at 80℃; for 48h; regioselective reaction; | 78% |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphosphine)palladium(0); lithium tert-butoxide In 1,4-dioxane at 80℃; for 48h; regioselective reaction; | 77% |
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 80℃; for 36h; regioselective reaction; | 77% |
4-phenyl-thiazole
para-iodoanisole
5-(4-methoxyphenyl)-4-phenylthiazole
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 80℃; for 36h; regioselective reaction; | 75% |
4-phenyl-thiazole
2-methylthio-1,3-thiazole
A
2-methylmercapto-4-phenylthiazole
Conditions | Yield |
---|---|
With carbonylhydridetris(triphenylphosphine)rhodium(I); 1,3-bis(dicyclohexylphosphine)propane In 1,2-dichloro-benzene for 3h; Inert atmosphere; Reflux; | A 74% B 10% |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 325 - 340℃; | 73% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 330℃; for 168h; | 73 % Turnov. |
Conditions | Yield |
---|---|
In acetonitrile for 72h; Heating; | 72% |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphosphine)palladium(0); lithium tert-butoxide In 1,4-dioxane at 100℃; for 48h; regioselective reaction; | 72% |
4-phenyl-thiazole
4-tolyl iodide
5-(4-methylphenyl)-4-phenylthiazole
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 80℃; for 36h; regioselective reaction; | 69% |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphosphine)palladium(0); lithium tert-butoxide In 1,4-dioxane at 100℃; for 48h; regioselective reaction; | 68% |
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 80℃; for 36h; regioselective reaction; | 66% |
4-phenyl-thiazole
trimethylsilylacetylene
3-(trimethylsilyl)thiophene
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 325 - 340℃; | 65% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 340℃; for 48h; | 65 % Turnov. |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphosphine)palladium(0); lithium tert-butoxide In 1,4-dioxane at 80℃; for 48h; regioselective reaction; | 62% |
Conditions | Yield |
---|---|
With acetic acid; bis(dibenzylideneacetone)-palladium(0); tricyclohexylphosphine In N,N-dimethyl acetamide at 130℃; for 14h; Inert atmosphere; Glovebox; stereoselective reaction; | 61% |
4-phenyl-thiazole
1-bromo-3,4,5-trimethoxybenzene
4-phenyl-5-(3,4,5-trimethoxyphenyl)thiazole
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 100℃; for 18h; regioselective reaction; | 60% |
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 80℃; for 36h; regioselective reaction; | 59% |
Conditions | Yield |
---|---|
With 5-Nitro-1,10-phenanthroline; copper diacetate; palladium diacetate; caesium carbonate; dimethyl sulfoxide In tert-Amyl alcohol at 100℃; for 12h; Inert atmosphere; regioselective reaction; | 55% |
Conditions | Yield |
---|---|
With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate at 100℃; for 18h; regioselective reaction; | 49% |
Conditions | Yield |
---|---|
With selenium; potassium carbonate; copper dichloride In N,N-dimethyl-formamide at 150℃; for 24h; Schlenk technique; Inert atmosphere; | 40% |
4-phenyl-thiazole
2-methylmercaptobenzothiazole
2-methylmercapto-4-phenylthiazole
Conditions | Yield |
---|---|
With carbonylhydridetris(triphenylphosphine)rhodium(I); 1,3-bis(dicyclohexylphosphine)propane In chlorobenzene for 3h; Reflux; Inert atmosphere; | 36% |
4-bromo-1-methyl-1H-pyrazole
4-phenyl-thiazole
bicyclo[2.2.1]hepta-2,5-diene
Conditions | Yield |
---|---|
With copper(l) iodide; palladium diacetate; caesium carbonate; bis[2-(diphenylphosphino)phenyl] ether In 1,4-dioxane at 130℃; for 16h; Glovebox; Inert atmosphere; | 36% |
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