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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Dimethyl acetylmethylphosphonate Manufacturer/High quality/Best price/In stock

Cas:4202-14-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Dimethyl Acetylmethylphosphonate with high purity

Cas:4202-14-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name Dimethyl acetylmethylphosphonate C

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

DiMethyl (2-Oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Dimethyl Acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2-Oxopropyl)-phosphonic acid dimethyl ester

Cas:4202-14-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

4202-14-6

Cas:4202-14-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 4202-14-6 with best quality

Cas:4202-14-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-(2-oxopropyl)-, dimethyl ester 4202-14-6

Cas:4202-14-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Dimethyl acetylmethylphosphonate CAS:4202-14-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o

Dimethyl acetylmethylphosphonate CAS:4202-14-6

Cas:4202-14-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-(2-oxopropyl)-, dimethyl ester

Cas:4202-14-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:4202-14-6

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Dimethyl Acetylmethylphosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Dimethyl 2-oxopropylphosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dimethyl Acetylmethylphosphonate

Cas:4202-14-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:CLEAR COLOURLESS TO LIGHT BROWN LIQUID Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermed

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Dimethyl acetylmethylphosphonate CAS No. 4202-14-6 Appearance Colorless liquid Assay ≥

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Minstar Chemical Co., Ltd

Dimethyl acetylmethylphosphonate Chemical Properties Boiling point 76-79 °C3 mm Hg(lit.) density 1.202 g/mL at 25 °C(lit.) refractive index n20/D 1.439(lit.) Fp 200 °F storage temp. 2-8°C solubility Difficult

Dimethyl (2-Oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4202-14-6 CAS NO.4202-14-6

Cas:4202-14-6

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Dimethyl acetylmethylphosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Dimethyl 2-oxopropylphosphonate cas no. 4202-14-6 98%

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Dimethyl (2-oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Dimethyl (2-oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Phosphonic acid,P-(2-oxopropyl)-, dimethyl ester

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Dimethyl Acetylmethylphosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Dimethyl (2-oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Manufacturers

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Dimethyl (2-oxopropyl)phosphonate

Cas:4202-14-6

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

chloroacetone
78-95-5

chloroacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
In toluene at 135℃; under 3750.38 - 15001.5 Torr; for 0.333333h; Arbuzov Reaction; Large scale;88%
Stage #1: chloroacetone With potassium iodide In acetone; acetonitrile at 20℃; for 2h;
Stage #2: phosphorous acid trimethyl ester In acetone; acetonitrile at 50℃; for 24h;
82%
Stage #1: chloroacetone With potassium iodide In acetone; acetonitrile at 20℃; for 2h; Irradiation;
Stage #2: phosphorous acid trimethyl ester In acetone; acetonitrile at 50℃; for 24h;
77%
[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid dimethyl ester
103517-85-7, 103538-61-0

[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid dimethyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With hydrogenchloride; acetone for 3h; Ambient temperature;82%
iodoacetone
3019-04-3

iodoacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
In toluene for 2h; Heating;74%
In benzene
In acetone; acetonitrile at 20℃; for 12h; Michaelis-Arbuzov reaction;101.3 g
In acetone; acetonitrile at 20 - 50℃; Inert atmosphere;41 g
Dimethyl phosphite
868-85-9

Dimethyl phosphite

acetylacetone
123-54-6

acetylacetone

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;72%
chloroacetone
78-95-5

chloroacetone

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With potassium iodide; phosphorous acid trimethyl ester In acetone; acetonitrile71%
Dimethyl phosphite
868-85-9

Dimethyl phosphite

acetone
67-64-1

acetone

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water at 85℃; Inert atmosphere; Schlenk technique; chemoselective reaction;60%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃; Further stages.;
56%
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃;
55%
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h;
Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃;
With lithium diisopropyl amide In tetrahydrofuran at -5 - 0℃; Inert atmosphere;
ethyl acetate
141-78-6

ethyl acetate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In hexane; toluene at -80℃; for 0.166667h; Inert atmosphere;
Stage #2: ethyl acetate In hexane; toluene at -80℃; for 1h; Inert atmosphere;
50%
With n-butyllithium 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 30 min; Multistep reaction;
4-chlorophenyl acetate
876-27-7

4-chlorophenyl acetate

dimethyl (2-hydroxypropyl)phosphonate
54731-75-8

dimethyl (2-hydroxypropyl)phosphonate

A

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

B

(R)-dimethyl 2-acetyloxypropylphosphonate

(R)-dimethyl 2-acetyloxypropylphosphonate

Conditions
ConditionsYield
With (hydroxy)tetraphenylcyclopentadienyl-based ruthenium; Candida antarctica lipase B (Novozym-435) In toluene at 70℃; for 24h;A 16%
B 62 % Spectr.
chloroacetone
78-95-5

chloroacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

phosphoric acid isopropenyl ester dimethyl ester
4185-82-4

phosphoric acid isopropenyl ester dimethyl ester

B

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

acetyl chloride
75-36-5

acetyl chloride

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
(i) nBuLi, hexane, THF, (ii) Cu2I2, (iii) /BRN= 605303/, Et2O; Multistep reaction;
1-bromoacetone
598-31-2

1-bromoacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
In methanol Heating;
at 120℃; for 1.5h;
methanol
67-56-1

methanol

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

A

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

B

trimethyl 2-phosphonopropionate
26530-60-9

trimethyl 2-phosphonopropionate

Conditions
ConditionsYield
at 0℃; Irradiation;A 12.3 % Chromat.
B 87.5 % Chromat.
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

A

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

B

trimethyl 2-phosphonopropionate
26530-60-9

trimethyl 2-phosphonopropionate

Conditions
ConditionsYield
In methanol at 0℃; Irradiation;A 12.3 % Chromat.
B 87.5 % Chromat.
1,2-propenephosphonic acid methyl ester
56504-60-0

1,2-propenephosphonic acid methyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With water; oxygen; p-benzoquinone; lithium chloride; palladium dichloride at 65℃; for 26h; Yield given;
methyl 2-dimethoxyphosphoryl-3-oxobutyrate
58393-50-3

methyl 2-dimethoxyphosphoryl-3-oxobutyrate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With water for 2.5h; Heating; Yield given;
chloroacetone
78-95-5

chloroacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

B

phosphonic acid isopropenyl ester-dimethyl ester

phosphonic acid isopropenyl ester-dimethyl ester

1-bromoacetone
598-31-2

1-bromoacetone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

B

phosphonic acid isopropenyl ester-dimethyl ester

phosphonic acid isopropenyl ester-dimethyl ester

allylphosphonic acid dimethyl ester
757-54-0

allylphosphonic acid dimethyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOtBu
2: LiCl, p-benzoquinone, O2, H2O / PdCl2 / 26 h / 65 °C
View Scheme
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil; benzene at 20℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: With 4-toluenesulfonyl azide In tetrahydrofuran; mineral oil; benzene at 20℃; Inert atmosphere;
100%
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil; benzene at 20℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: With 4-toluenesulfonyl azide In tetrahydrofuran; mineral oil; benzene at 20℃; Inert atmosphere;
99%
With 4-toluenesulfonyl azide In tetrahydrofuran; benzene at 0 - 20℃; for 2h; Substitution;98%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

3,4-dichlorobenzaldehyde
6287-38-3

3,4-dichlorobenzaldehyde

(E)-4-(3,4-dichlorophenyl)but-3-en-2-one
55420-70-7

(E)-4-(3,4-dichlorophenyl)but-3-en-2-one

Conditions
ConditionsYield
With potassium carbonate In water at 5℃; for 0.25h;100%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

Dimethyl-1,1-difluoro-2-oxypropyl phosphonate

Dimethyl-1,1-difluoro-2-oxypropyl phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With potassium tert-butylate In tert-butyl alcohol at 20℃; for 0.5h;
Stage #2: With acetyl hypofluorite In tert-butyl alcohol at 20℃;
100%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(R)-2-hydroxy-1-dimethoxyphosphorylpropane

(R)-2-hydroxy-1-dimethoxyphosphorylpropane

Conditions
ConditionsYield
With RuCl2((R)-binap)(dmf)n; hydrogen In methanol at 25℃; under 3040 Torr; for 72h;99%
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere
1.2: 16 h / Inert atmosphere
2.1: BF4(1-)*C50H59IrO3P2(1+); hydrogen / dichloromethane / 24 h / 25 °C / 3040.2 Torr
3.1: sodium carbonate / methanol / 16 h
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere
1.2: 16 h / Inert atmosphere
2.1: BF4(1-)*C44H63IrO3P2(2+); hydrogen / dichloromethane / 24 h / 25 °C / 3040.2 Torr
3.1: sodium carbonate / methanol / 16 h
View Scheme
Martins sulfurane
32133-82-7

Martins sulfurane

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

dimethyl 2-(diphenylsulfuranylidene)-2-oxopropylphosphonate
1433220-51-9

dimethyl 2-(diphenylsulfuranylidene)-2-oxopropylphosphonate

Conditions
ConditionsYield
In diethyl ether at 25℃; for 0.5h; Schlenk technique; Inert atmosphere;99%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

(4-Nitrophenyl)acetylene
937-31-5

(4-Nitrophenyl)acetylene

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 18h; Seyferth-Gilbert Homologation; Inert atmosphere;99%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

C32H42F2N2O6Si2

C32H42F2N2O6Si2

C33H42F2N2O5Si2

C33H42F2N2O5Si2

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere;
Stage #2: C32H42F2N2O6Si2 In methanol; acetonitrile at 25℃; for 12h; Inert atmosphere;
98.2%
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere;
Stage #2: C32H42F2N2O6Si2 In methanol at 25℃; for 12h; Inert atmosphere;
98.2%
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere;
Stage #2: C32H42F2N2O6Si2 In methanol; acetonitrile at 25℃; for 12h;
98.2%
4-toluenesulfonyl azide
941-55-9

4-toluenesulfonyl azide

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

dimethyl (1-diazo-2-oxopropyl)phosphonate

dimethyl (1-diazo-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; benzene at 0℃; for 1h;
Stage #2: 4-toluenesulfonyl azide In tetrahydrofuran; benzene at 20℃; for 2h;
98%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

C28H30N2O5

C28H30N2O5

benzyl ((S)-1-(((S)-1-(dimethoxyphosphoryl)-2-oxo-5-phenylpentan-3-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

benzyl ((S)-1-(((S)-1-(dimethoxyphosphoryl)-2-oxo-5-phenylpentan-3-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.25h; Inert atmosphere;
Stage #2: C28H30N2O5 In tetrahydrofuran; hexane at -70℃; for 2h; Inert atmosphere;
98%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

2-N,N-Dibenzylaminoacetaldehyde
106889-84-3

2-N,N-Dibenzylaminoacetaldehyde

(E)-5-(dibenzylamino)pent-3-en-2-one

(E)-5-(dibenzylamino)pent-3-en-2-one

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With lithium bromide In tetrahydrofuran at 20℃; for 0.0833333h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: With triethylamine In tetrahydrofuran for 0.166667h; Inert atmosphere;
Stage #3: 2-N,N-Dibenzylaminoacetaldehyde In tetrahydrofuran for 0.75h; Inert atmosphere;
98%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

2,3-isopropylidene-glyceraldehyde
15186-48-8

2,3-isopropylidene-glyceraldehyde

(3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one
64482-41-3

(3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 0℃; for 1h;97%
With sodium hydride 1.) THF 1.5h at room temp.; 2.) 2 h from 0 degC to 5 degC; Yield given. Multistep reaction;
With potassium carbonate at 0℃; for 3h; Yield given;
With potassium carbonate
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(S)-2-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-2,5-dimethyl-hex-4-enal
226065-51-6

(S)-2-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-2,5-dimethyl-hex-4-enal

(E)-(S)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-5,8-dimethyl-nona-3,7-dien-2-one
226065-52-7

(E)-(S)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-5,8-dimethyl-nona-3,7-dien-2-one

Conditions
ConditionsYield
With n-butyllithium In toluene Heating;97%
4-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]benzenesulfonamide
887113-19-1

4-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]benzenesulfonamide

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(S,E)-4-methyl-N-(2-methyl-6-oxohept-4-en-3-yl)benzenesulfonamide

(S,E)-4-methyl-N-(2-methyl-6-oxohept-4-en-3-yl)benzenesulfonamide

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 0℃; for 0.333333h;
Stage #2: 4-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]benzenesulfonamide In acetonitrile at 20℃; for 2h;
97%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(2-Cyano-2-methyl-2-trimethylsilanyloxy-ethyl)-phosphonic acid dimethyl ester
88631-43-0

(2-Cyano-2-methyl-2-trimethylsilanyloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With potassium cyanide; 18-crown-6 ether In dichloromethane for 2h;96%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

4-(Tetrahydro-pyran-2-yloxy)-non-5-ynal
139338-88-8

4-(Tetrahydro-pyran-2-yloxy)-non-5-ynal

(E)-7-(Tetrahydro-pyran-2-yloxy)-dodec-3-en-8-yn-2-one
139338-89-9

(E)-7-(Tetrahydro-pyran-2-yloxy)-dodec-3-en-8-yn-2-one

Conditions
ConditionsYield
With sodium hydride96%
With sodium hydride92%
(2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal
862509-80-6

(2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(3E,5R,6R,7R)-5,6-bis-(p-methoxybenzyloxy)-7-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-oct-3-en-2-one
392692-56-7

(3E,5R,6R,7R)-5,6-bis-(p-methoxybenzyloxy)-7-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-oct-3-en-2-one

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With barium dihydroxide In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal In tetrahydrofuran; water at 20℃; for 4h; Horner-Wadsworth-Emmons chain extension;
96%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

dimethyl (S)-(2-hydroxypropyl)phosphonate

dimethyl (S)-(2-hydroxypropyl)phosphonate

Conditions
ConditionsYield
With C48H44ClO4P2Ru(1+)*Cl(1-); hydrogen In methanol at 50℃; under 7500.75 Torr; for 19h; Inert atmosphere; enantioselective reaction;95.3%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

ethyl (E)-3-((E)-carbamoyldiazenyl)but-2-enoate
146000-77-3

ethyl (E)-3-((E)-carbamoyldiazenyl)but-2-enoate

4-(Dimethoxy-phosphoryl)-2,5-dimethyl-1-ureido-1H-pyrrole-3-carboxylic acid ethyl ester

4-(Dimethoxy-phosphoryl)-2,5-dimethyl-1-ureido-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;95%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

cyclohexanone
108-94-1

cyclohexanone

1-cyclohexylidene-2-propanone
874-68-0

1-cyclohexylidene-2-propanone

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 28h; Wittig-Horner reaction;95%
Tetrahydro-4H-pyran-4-one
29943-42-8

Tetrahydro-4H-pyran-4-one

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

1-(dihydro-2H-pyran-4(3H)-ylidene)propan-2-one
912441-79-3

1-(dihydro-2H-pyran-4(3H)-ylidene)propan-2-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 0 - 20℃; for 5h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;95%
With potassium hydroxide In ethanol; water at 20℃; for 5h;82%
With potassium hydroxide In ethanol at 0 - 20℃;
With potassium hydroxide In ethanol; water at 0 - 20℃;
With potassium hydroxide In ethanol; water at 0℃; for 4h;
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

3-trifluoromethylphenylazide
22001-17-8

3-trifluoromethylphenylazide

C12H13F3N3O3P

C12H13F3N3O3P

Conditions
ConditionsYield
With tetramethylguanidinium acetate at 50℃; for 1.5h; Ionic liquid;95%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

1-azido-4-bromobenzene
2101-88-4

1-azido-4-bromobenzene

C11H13BrN3O3P

C11H13BrN3O3P

Conditions
ConditionsYield
With C5H14N3(1+)*HO(1-) at 50℃; for 2h; Ionic liquid;95%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

dimethyl 2-ethoxypropenylphosphonate
73542-47-9

dimethyl 2-ethoxypropenylphosphonate

Conditions
ConditionsYield
With iron(III) chloride for 72h; Ambient temperature;94%
With iron(III) chloride
With iron(III) chloride Substitution;
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

(R)-3-((tert-butyldimethylsilyl)oxy)-1-iodobutane
109613-36-7

(R)-3-((tert-butyldimethylsilyl)oxy)-1-iodobutane

dimethyl (6R)-(6-[(tert-butyldimethylsilyl)oxy]-2-oxoheptyl)phosphonate
121484-92-2

dimethyl (6R)-(6-[(tert-butyldimethylsilyl)oxy]-2-oxoheptyl)phosphonate

Conditions
ConditionsYield
With n-butyllithium; sodium hydride In tetrahydrofuran at 0℃; for 30h;94%
4-[(2R,6R)-4-Methylene-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester
799852-58-7

4-[(2R,6R)-4-Methylene-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

4-[(2R,6S)-4-Methylene-6-((E)-4-oxo-pent-2-enyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester
799852-60-1

4-[(2R,6S)-4-Methylene-6-((E)-4-oxo-pent-2-enyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With barium dihydroxide In tetrahydrofuran for 0.5h;
Stage #2: 4-[(2R,6R)-4-Methylene-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester In tetrahydrofuran; water for 1.75h; Horner-Wadsworth-Emmons reaction;
94%
ethyl 2-amino-4-benzyl-5-phenylthiophene-3-carboxylate

ethyl 2-amino-4-benzyl-5-phenylthiophene-3-carboxylate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

C23H22NO4PS

C23H22NO4PS

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 24h; Reflux; Dean-Stark;94%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate
364631-73-2

tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate

5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine
364631-74-3

5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In toluene; acetonitrile at 20℃; for 2.5h;
Stage #2: tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate In methanol; toluene; acetonitrile for 1.5h;
93.4%
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 20℃; for 2h;
Stage #2: tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate In methanol; acetonitrile at 20℃; for 8h;
84%
tert-butyl 3-formylazetidine-1-carboxylate
177947-96-5

tert-butyl 3-formylazetidine-1-carboxylate

dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

tert-butyl 3-ethynylazetidine-1-carboxylate
287193-01-5

tert-butyl 3-ethynylazetidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium azide; caesium carbonate; methanesulfonyl chloride In acetonitrile at 0 - 20℃; for 3h;
Stage #2: tert-butyl 3-formylazetidine-1-carboxylate With caesium carbonate In methanol; acetonitrile at 0℃;
93%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

methyl (E)-4,4-dimethyl-6-oxo-2-hexenoate
132298-32-9

methyl (E)-4,4-dimethyl-6-oxo-2-hexenoate

methyl (E,E)-4,4-dimethyl-8-oxo-2,6-nonadienoate
72808-49-2

methyl (E,E)-4,4-dimethyl-8-oxo-2,6-nonadienoate

Conditions
ConditionsYield
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: methyl (E)-4,4-dimethyl-6-oxo-2-hexenoate In tetrahydrofuran Horner-Wadsworth-Emmons olefination; Heating; Further stages.;
92%
dimethyl (2-oxopropyl)phosphonate
4202-14-6

dimethyl (2-oxopropyl)phosphonate

C15H18O5
1108588-18-6

C15H18O5

C18H22O5
1108588-22-2

C18H22O5

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0℃; Horner-Emmons olefination;92%

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