Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryProduct Description Product website: http://www.finerchem.com Product Name Dimethyl acetylmethylphosphonate C
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With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryDimethyl acetylmethylphosphonate CAS:4202-14-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirySuperior quality Appearance:CLEAR COLOURLESS TO LIGHT BROWN LIQUID Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermed
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inquiryProduct Name Dimethyl acetylmethylphosphonate CAS No. 4202-14-6 Appearance Colorless liquid Assay ≥
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inquiryDimethyl acetylmethylphosphonate Chemical Properties Boiling point 76-79 °C3 mm Hg(lit.) density 1.202 g/mL at 25 °C(lit.) refractive index n20/D 1.439(lit.) Fp 200 °F storage temp. 2-8°C solubility Difficult
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
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Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
chloroacetone
phosphorous acid trimethyl ester
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
In toluene at 135℃; under 3750.38 - 15001.5 Torr; for 0.333333h; Arbuzov Reaction; Large scale; | 88% |
Stage #1: chloroacetone With potassium iodide In acetone; acetonitrile at 20℃; for 2h; Stage #2: phosphorous acid trimethyl ester In acetone; acetonitrile at 50℃; for 24h; | 82% |
Stage #1: chloroacetone With potassium iodide In acetone; acetonitrile at 20℃; for 2h; Irradiation; Stage #2: phosphorous acid trimethyl ester In acetone; acetonitrile at 50℃; for 24h; | 77% |
[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid dimethyl ester
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With hydrogenchloride; acetone for 3h; Ambient temperature; | 82% |
iodoacetone
phosphorous acid trimethyl ester
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
In toluene for 2h; Heating; | 74% |
In benzene | |
In acetone; acetonitrile at 20℃; for 12h; Michaelis-Arbuzov reaction; | 101.3 g |
In acetone; acetonitrile at 20 - 50℃; Inert atmosphere; | 41 g |
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 72% |
Conditions | Yield |
---|---|
With potassium iodide; phosphorous acid trimethyl ester In acetone; acetonitrile | 71% |
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; silver(I) acetate In water at 85℃; Inert atmosphere; Schlenk technique; chemoselective reaction; | 60% |
acetic acid methyl ester
dimethyl methane phosphonate
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃; Further stages.; | 56% |
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃; | 55% |
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; Stage #2: acetic acid methyl ester In tetrahydrofuran; hexane at -78 - 0℃; | |
With lithium diisopropyl amide In tetrahydrofuran at -5 - 0℃; Inert atmosphere; |
ethyl acetate
dimethyl methane phosphonate
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl methane phosphonate With n-butyllithium In hexane; toluene at -80℃; for 0.166667h; Inert atmosphere; Stage #2: ethyl acetate In hexane; toluene at -80℃; for 1h; Inert atmosphere; | 50% |
With n-butyllithium 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 30 min; Multistep reaction; |
4-chlorophenyl acetate
dimethyl (2-hydroxypropyl)phosphonate
A
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With (hydroxy)tetraphenylcyclopentadienyl-based ruthenium; Candida antarctica lipase B (Novozym-435) In toluene at 70℃; for 24h; | A 16% B 62 % Spectr. |
chloroacetone
phosphorous acid trimethyl ester
A
phosphoric acid isopropenyl ester dimethyl ester
B
dimethyl (2-oxopropyl)phosphonate
acetyl chloride
dimethyl methane phosphonate
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
(i) nBuLi, hexane, THF, (ii) Cu2I2, (iii) /BRN= 605303/, Et2O; Multistep reaction; |
1-bromoacetone
phosphorous acid trimethyl ester
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
In methanol Heating; | |
at 120℃; for 1.5h; |
methanol
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
A
dimethyl (2-oxopropyl)phosphonate
B
trimethyl 2-phosphonopropionate
Conditions | Yield |
---|---|
at 0℃; Irradiation; | A 12.3 % Chromat. B 87.5 % Chromat. |
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
A
dimethyl (2-oxopropyl)phosphonate
B
trimethyl 2-phosphonopropionate
Conditions | Yield |
---|---|
In methanol at 0℃; Irradiation; | A 12.3 % Chromat. B 87.5 % Chromat. |
1,2-propenephosphonic acid methyl ester
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With water; oxygen; p-benzoquinone; lithium chloride; palladium dichloride at 65℃; for 26h; Yield given; |
methyl 2-dimethoxyphosphoryl-3-oxobutyrate
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With water for 2.5h; Heating; Yield given; |
chloroacetone
phosphorous acid trimethyl ester
A
dimethyl (2-oxopropyl)phosphonate
1-bromoacetone
phosphorous acid trimethyl ester
A
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOtBu 2: LiCl, p-benzoquinone, O2, H2O / PdCl2 / 26 h / 65 °C View Scheme |
dimethyl (2-oxopropyl)phosphonate
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil; benzene at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: With 4-toluenesulfonyl azide In tetrahydrofuran; mineral oil; benzene at 20℃; Inert atmosphere; | 100% |
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; mineral oil; benzene at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: With 4-toluenesulfonyl azide In tetrahydrofuran; mineral oil; benzene at 20℃; Inert atmosphere; | 99% |
With 4-toluenesulfonyl azide In tetrahydrofuran; benzene at 0 - 20℃; for 2h; Substitution; | 98% |
dimethyl (2-oxopropyl)phosphonate
3,4-dichlorobenzaldehyde
(E)-4-(3,4-dichlorophenyl)but-3-en-2-one
Conditions | Yield |
---|---|
With potassium carbonate In water at 5℃; for 0.25h; | 100% |
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With potassium tert-butylate In tert-butyl alcohol at 20℃; for 0.5h; Stage #2: With acetyl hypofluorite In tert-butyl alcohol at 20℃; | 100% |
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With RuCl2((R)-binap)(dmf)n; hydrogen In methanol at 25℃; under 3040 Torr; for 72h; | 99% |
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere 1.2: 16 h / Inert atmosphere 2.1: BF4(1-)*C50H59IrO3P2(1+); hydrogen / dichloromethane / 24 h / 25 °C / 3040.2 Torr 3.1: sodium carbonate / methanol / 16 h View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere 1.2: 16 h / Inert atmosphere 2.1: BF4(1-)*C44H63IrO3P2(2+); hydrogen / dichloromethane / 24 h / 25 °C / 3040.2 Torr 3.1: sodium carbonate / methanol / 16 h View Scheme |
Martins sulfurane
dimethyl (2-oxopropyl)phosphonate
dimethyl 2-(diphenylsulfuranylidene)-2-oxopropylphosphonate
Conditions | Yield |
---|---|
In diethyl ether at 25℃; for 0.5h; Schlenk technique; Inert atmosphere; | 99% |
dimethyl (2-oxopropyl)phosphonate
4-nitrobenzaldehdye
(4-Nitrophenyl)acetylene
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; for 18h; Seyferth-Gilbert Homologation; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere; Stage #2: C32H42F2N2O6Si2 In methanol; acetonitrile at 25℃; for 12h; Inert atmosphere; | 98.2% |
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere; Stage #2: C32H42F2N2O6Si2 In methanol at 25℃; for 12h; Inert atmosphere; | 98.2% |
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 25℃; for 2h; Inert atmosphere; Stage #2: C32H42F2N2O6Si2 In methanol; acetonitrile at 25℃; for 12h; | 98.2% |
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran; benzene at 0℃; for 1h; Stage #2: 4-toluenesulfonyl azide In tetrahydrofuran; benzene at 20℃; for 2h; | 98% |
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.25h; Inert atmosphere; Stage #2: C28H30N2O5 In tetrahydrofuran; hexane at -70℃; for 2h; Inert atmosphere; | 98% |
dimethyl (2-oxopropyl)phosphonate
2-N,N-Dibenzylaminoacetaldehyde
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With lithium bromide In tetrahydrofuran at 20℃; for 0.0833333h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Stage #2: With triethylamine In tetrahydrofuran for 0.166667h; Inert atmosphere; Stage #3: 2-N,N-Dibenzylaminoacetaldehyde In tetrahydrofuran for 0.75h; Inert atmosphere; | 98% |
dimethyl (2-oxopropyl)phosphonate
2,3-isopropylidene-glyceraldehyde
(3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran; water at 0℃; for 1h; | 97% |
With sodium hydride 1.) THF 1.5h at room temp.; 2.) 2 h from 0 degC to 5 degC; Yield given. Multistep reaction; | |
With potassium carbonate at 0℃; for 3h; Yield given; | |
With potassium carbonate |
dimethyl (2-oxopropyl)phosphonate
(S)-2-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-2,5-dimethyl-hex-4-enal
(E)-(S)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propyl]-5,8-dimethyl-nona-3,7-dien-2-one
Conditions | Yield |
---|---|
With n-butyllithium In toluene Heating; | 97% |
4-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]benzenesulfonamide
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 0℃; for 0.333333h; Stage #2: 4-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]benzenesulfonamide In acetonitrile at 20℃; for 2h; | 97% |
trimethylsilyl cyanide
dimethyl (2-oxopropyl)phosphonate
(2-Cyano-2-methyl-2-trimethylsilanyloxy-ethyl)-phosphonic acid dimethyl ester
Conditions | Yield |
---|---|
With potassium cyanide; 18-crown-6 ether In dichloromethane for 2h; | 96% |
dimethyl (2-oxopropyl)phosphonate
4-(Tetrahydro-pyran-2-yloxy)-non-5-ynal
(E)-7-(Tetrahydro-pyran-2-yloxy)-dodec-3-en-8-yn-2-one
Conditions | Yield |
---|---|
With sodium hydride | 96% |
With sodium hydride | 92% |
(2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal
dimethyl (2-oxopropyl)phosphonate
(3E,5R,6R,7R)-5,6-bis-(p-methoxybenzyloxy)-7-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-oct-3-en-2-one
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With barium dihydroxide In tetrahydrofuran at 20℃; for 0.5h; Stage #2: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal In tetrahydrofuran; water at 20℃; for 4h; Horner-Wadsworth-Emmons chain extension; | 96% |
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With C48H44ClO4P2Ru(1+)*Cl(1-); hydrogen In methanol at 50℃; under 7500.75 Torr; for 19h; Inert atmosphere; enantioselective reaction; | 95.3% |
dimethyl (2-oxopropyl)phosphonate
ethyl (E)-3-((E)-carbamoyldiazenyl)but-2-enoate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature; | 95% |
dimethyl (2-oxopropyl)phosphonate
cyclohexanone
1-cyclohexylidene-2-propanone
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 20℃; for 28h; Wittig-Horner reaction; | 95% |
Tetrahydro-4H-pyran-4-one
dimethyl (2-oxopropyl)phosphonate
1-(dihydro-2H-pyran-4(3H)-ylidene)propan-2-one
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 0 - 20℃; for 5h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; | 95% |
With potassium hydroxide In ethanol; water at 20℃; for 5h; | 82% |
With potassium hydroxide In ethanol at 0 - 20℃; | |
With potassium hydroxide In ethanol; water at 0 - 20℃; | |
With potassium hydroxide In ethanol; water at 0℃; for 4h; |
Conditions | Yield |
---|---|
With tetramethylguanidinium acetate at 50℃; for 1.5h; Ionic liquid; | 95% |
Conditions | Yield |
---|---|
With C5H14N3(1+)*HO(1-) at 50℃; for 2h; Ionic liquid; | 95% |
dimethyl (2-oxopropyl)phosphonate
orthoformic acid triethyl ester
dimethyl 2-ethoxypropenylphosphonate
Conditions | Yield |
---|---|
With iron(III) chloride for 72h; Ambient temperature; | 94% |
With iron(III) chloride | |
With iron(III) chloride Substitution; |
dimethyl (2-oxopropyl)phosphonate
(R)-3-((tert-butyldimethylsilyl)oxy)-1-iodobutane
dimethyl (6R)-(6-[(tert-butyldimethylsilyl)oxy]-2-oxoheptyl)phosphonate
Conditions | Yield |
---|---|
With n-butyllithium; sodium hydride In tetrahydrofuran at 0℃; for 30h; | 94% |
4-[(2R,6R)-4-Methylene-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester
dimethyl (2-oxopropyl)phosphonate
4-[(2R,6S)-4-Methylene-6-((E)-4-oxo-pent-2-enyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With barium dihydroxide In tetrahydrofuran for 0.5h; Stage #2: 4-[(2R,6R)-4-Methylene-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-but-2-ynoic acid methyl ester In tetrahydrofuran; water for 1.75h; Horner-Wadsworth-Emmons reaction; | 94% |
dimethyl (2-oxopropyl)phosphonate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 24h; Reflux; Dean-Stark; | 94% |
dimethyl (2-oxopropyl)phosphonate
tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate
5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In toluene; acetonitrile at 20℃; for 2.5h; Stage #2: tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate In methanol; toluene; acetonitrile for 1.5h; | 93.4% |
Stage #1: dimethyl (2-oxopropyl)phosphonate With 4-toluenesulfonyl azide; potassium carbonate In acetonitrile at 20℃; for 2h; Stage #2: tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate In methanol; acetonitrile at 20℃; for 8h; | 84% |
tert-butyl 3-formylazetidine-1-carboxylate
dimethyl (2-oxopropyl)phosphonate
tert-butyl 3-ethynylazetidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium azide; caesium carbonate; methanesulfonyl chloride In acetonitrile at 0 - 20℃; for 3h; Stage #2: tert-butyl 3-formylazetidine-1-carboxylate With caesium carbonate In methanol; acetonitrile at 0℃; | 93% |
dimethyl (2-oxopropyl)phosphonate
methyl (E)-4,4-dimethyl-6-oxo-2-hexenoate
methyl (E,E)-4,4-dimethyl-8-oxo-2,6-nonadienoate
Conditions | Yield |
---|---|
Stage #1: dimethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: methyl (E)-4,4-dimethyl-6-oxo-2-hexenoate In tetrahydrofuran Horner-Wadsworth-Emmons olefination; Heating; Further stages.; | 92% |
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 0℃; Horner-Emmons olefination; | 92% |
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