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Greenutra Resource Inc

Product Name : Fructus Cnidii Extract Latin Name :Cnidium monnieri (L.) Cuss Used part: seed Quality data Identification Standardization Aspect

Fructus Cnidii Extract

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $15.5

Type:Trading Company

inquiry

Weihai Moochun Bio-Tech Co., Ltd.

.english name: cnidium fruit extract latin name:c.monnieri (l.) cusson source:the fruit of the cnidium monnieri (l.) cusson. ingredients:containing pinene,bornyl isovalarate,osthol,berapt

Cnidium Fruit Extract

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $1119.0 / 1139.0

Type:Trading Company

inquiry

SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD

Natural product : 100% natural product, without any synthetic ingredients. Manufacturer : China's leading manufacturer of plant extracts. Quality : Our products have undergone comprehensive inspection and all have passed strict testing. In s

Fructus Cnidii Extract Manufacturer/ In stock CAS NO.484-12-8

Cas:484-12-8

Min.Order:5 Gram

Negotiable

Type:Trading Company

inquiry

shanghai Tauto Biotech Co., Ltd

The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysis me

E-0091 Osthole

Cas:484-12-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Osthole Manufacturer/High quality/Best price/In stock

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Province,

Osthole Powder CAS 484-12-8

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 100.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb

Osthole

Cas:484-12-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Best service,high quality and cheap price. Appearance:Powder Storage:Stored in a cool and dry well-closed container,keep away from moisture and strong light/heat Package:25kg/drum,1kg/bag Application:Mainly used in medicine, health food, tobacco, c

Osthole

Cas:484-12-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Osthole 484-12-8 GMP Manufacturer

Cas:484-12-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

Our Advantages: 1. Free samples and unconditional hypothetical responses. 2.100% natural product, without any synthetic ingredients. 3. Direct sales from manufacturers, providing OEM and R&D services. 4. Complete certificates. 5. China's lead

Osthole, Cnidium monnieric

Cas:484-12-8

Min.Order:25 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

Product Name: Osthole Powder CAS: 484-12-8 Source: Cnidium Seed Extract Appearance: White Powder Test method: HPLC Grade: Food Grade Assay: 98% Used Part: Whole Herb Solubility: Soluble in hot water,hot ethanol Sample: Available Shelf Life:

Factory Supply Cnidium Seed Extract 98% Osthole

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $2.0 / 8.0

Type:Lab/Research institutions

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Osthole

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Osthole

Cas:484-12-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Osthole

Cas:484-12-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name: Osthole Alias: Common Cnidium Fruit Extract English Name: Common Cnidium Fruit Extract, Osthole Plant sources:Cnidium monnieric(L.)Cuss. CAS No.484-12-8 Molecular formula:C15H16O3 Molecular weight: 244.29 Packaging Specification: 25kg/d

Osthole Manufacturer /CAS:484-12-8/Chinese suppliers/Content is 98%

Cas:484-12-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Osthole

Cas:484-12-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 484-12-8 10%-98% Osthole Common Cnidium Extract

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 484-12-8 with best quality

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Common Cnidium Fruit Extract Spec./Purity: 5%~98% Osthole 10:1 ,20:1 powdered extract Straight powder Appearance: Brown Powder-yellow green powder-w

Osthole

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Herb Cnidium Monnieri Extract Osthole 10% 30% 98% HPLC

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia

High quality Osthole maen sex

Cas:484-12-8

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Osthole

Cas:484-12-8

Min.Order:5 Gram

FOB Price: $100.0 / 600.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Osthole CAS:484-12-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ster

Osthole CAS:484-12-8

Cas:484-12-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Osthole

Cas:484-12-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Why Choose Us 1. Quality Price We are the manufacturer, so we can provide the competitive price and high quality product. 2. Packing Products could be packaged according to customer's specializedrequirements. 3. Transport The products can be tr

Manufactory supply Fructus Cnidii with best price CAS No:484-12-8

Cas:484-12-8

Min.Order:1000 Kilogram

FOB Price: $70.0 / 75.0

Type:Other

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory Supply Fructus Cnidii/Osthole CAS 484-12-8

Cas:484-12-8

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Osthole

Cas:484-12-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Cnidium Monnieri Extract

Cas:484-12-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Osthol

Cas:484-12-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

7-methoxy-8-iodo-2H-chromen-2-one
65763-01-1

7-methoxy-8-iodo-2H-chromen-2-one

prenyl bromide
870-63-3

prenyl bromide

osthole
484-12-8

osthole

Conditions
ConditionsYield
Stage #1: 7-methoxy-8-iodo-2H-chromen-2-one With isopropylmagnesium chloride In tetrahydrofuran at -20℃; for 1h; Schlenk technique; Inert atmosphere; Green chemistry;
Stage #2: prenyl bromide With copper(l) iodide; lithium chloride In tetrahydrofuran at -20 - 20℃; for 10.5h; Reagent/catalyst; Schlenk technique; Inert atmosphere; Green chemistry;
80%
8-allyl-7-methoxy-2H-chromen-2-one
55136-74-8

8-allyl-7-methoxy-2H-chromen-2-one

3-chloro-3-methyl-1-butene
2190-48-9

3-chloro-3-methyl-1-butene

osthole
484-12-8

osthole

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 45℃; for 2h; Inert atmosphere;77.65%
4-methoxy-2-((2-methylbut-3-en-2-yl)oxy)benzaldehyde

4-methoxy-2-((2-methylbut-3-en-2-yl)oxy)benzaldehyde

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

osthole
484-12-8

osthole

Conditions
ConditionsYield
With N,N-diethylaniline at 250℃; for 1h; Microwave irradiation; Sealed tube;68%
7-methoxy-8-iodo-2H-chromen-2-one
65763-01-1

7-methoxy-8-iodo-2H-chromen-2-one

prenyl tributylstannane
104108-29-4

prenyl tributylstannane

osthole
484-12-8

osthole

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; lithium chloride In N,N-dimethyl-formamide at 80℃; for 6h; Stille Cross Coupling; Inert atmosphere; Schlenk technique;66.1%
prenyl tributylstannane
104108-29-4

prenyl tributylstannane

8-bromo-7-methoxy-2H-chromen-2-one

8-bromo-7-methoxy-2H-chromen-2-one

osthole
484-12-8

osthole

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In N,N-dimethyl-formamide at 125℃; for 5h; Stille Cross Coupling; Schlenk technique; Inert atmosphere;32%
2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)benzaldehyde
37761-53-8

2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)benzaldehyde

acetic anhydride
108-24-7

acetic anhydride

osthole
484-12-8

osthole

Conditions
ConditionsYield
With sodium acetate at 160℃;
osthenol

osthenol

osthole
484-12-8

osthole

Conditions
ConditionsYield
With diethyl ether
2-Hydroxy-4-methoxybenzaldehyde
673-22-3

2-Hydroxy-4-methoxybenzaldehyde

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium; benzene / anschliessend mit 4-Brom-2-methyl-buten-(2)
2: sodium acetate / 160 °C
View Scheme
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 0.25 h / -20 °C
1.2: -20 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux
2.2: 12 h / 0 °C
3.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate / acetonitrile / 16 h / 85 °C
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 5 h / 125 °C / Schlenk technique; Inert atmosphere
View Scheme
7-hydroxy-2H-chromen-2-one
93-35-6

7-hydroxy-2H-chromen-2-one

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; potassium iodide / acetone / 22 h / 60 °C
2: ethylene glycol / 6 h / Reflux
3: potassium carbonate; potassium iodide / acetone / 5 h / 20 °C
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: iodine; potassium iodide; ammonium hydroxide / water / 24.5 h
2.1: potassium carbonate / acetone / 5 h / Reflux
3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C / Schlenk technique; Inert atmosphere; Green chemistry
3.2: 10.5 h / -20 - 20 °C / Schlenk technique; Inert atmosphere; Green chemistry
View Scheme
7-hydroxy-8-allylcoumarin
55136-72-6

7-hydroxy-8-allylcoumarin

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / acetone / 5 h / 20 °C
2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
View Scheme
7-allyloxycoumarin
31005-03-5

7-allyloxycoumarin

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethylene glycol / 6 h / Reflux
2: potassium carbonate; potassium iodide / acetone / 5 h / 20 °C
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
View Scheme
(ethoxycarbonylmethyl)triphenylphosphonium chloride
17577-28-5

(ethoxycarbonylmethyl)triphenylphosphonium chloride

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium hydroxide / ethanol / 1.5 h / 80 °C
2: potassium carbonate; potassium iodide / acetone / 22 h / 60 °C
3: ethylene glycol / 6 h / Reflux
4: potassium carbonate; potassium iodide / acetone / 5 h / 20 °C
5: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
View Scheme
triphenylphosphine
603-35-0

triphenylphosphine

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: ethanol / 4 h / 80 °C
2: potassium hydroxide / ethanol / 1.5 h / 80 °C
3: potassium carbonate; potassium iodide / acetone / 22 h / 60 °C
4: ethylene glycol / 6 h / Reflux
5: potassium carbonate; potassium iodide / acetone / 5 h / 20 °C
6: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
View Scheme
7-hydroxy-8-iodocoumarin
65763-00-0

7-hydroxy-8-iodocoumarin

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 5 h / Reflux
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C / Schlenk technique; Inert atmosphere; Green chemistry
2.2: 10.5 h / -20 - 20 °C / Schlenk technique; Inert atmosphere; Green chemistry
View Scheme
4-methoxy-2-((2-methylbut-3-en-2-yl)oxy)benzaldehyde

4-methoxy-2-((2-methylbut-3-en-2-yl)oxy)benzaldehyde

methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

osthole
484-12-8

osthole

Conditions
ConditionsYield
In toluene at 220℃; for 1h; Inert atmosphere; Microwave irradiation; Sealed tube;928 mg
C13H14O3

C13H14O3

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr
2: toluene / 1 h / 220 °C / Inert atmosphere; Microwave irradiation; Sealed tube
View Scheme
3-bromo-2-hydroxy-4-methoxybenzaldehyde
63638-85-7

3-bromo-2-hydroxy-4-methoxybenzaldehyde

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / Reflux
1.2: 12 h / 0 °C
2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate / acetonitrile / 16 h / 85 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 5 h / 125 °C / Schlenk technique; Inert atmosphere
View Scheme
2-bromo-3-methoxy-6-vinylphenol
1358063-31-6

2-bromo-3-methoxy-6-vinylphenol

osthole
484-12-8

osthole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate / acetonitrile / 16 h / 85 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 5 h / 125 °C / Schlenk technique; Inert atmosphere
View Scheme
osthole
484-12-8

osthole

methyl iodide
74-88-4

methyl iodide

(Z)-2,4-dimethoxy-3-prenyl cinnamalic acid
73490-51-4

(Z)-2,4-dimethoxy-3-prenyl cinnamalic acid

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran 1.) 15 min, 2.) 10 h;98%
With potassium hydroxide 1.) DMSO, 1 h, 2.) (Osthol : CH3I = 1:1) 12 h; Yield given. Multistep reaction;
Stage #1: osthole; methyl iodide With potassium hydroxide In ethanol at 90℃; for 24h;
Stage #2: With hydrogenchloride In ethanol; water pH=3 - 4;
Stage #1: osthole; methyl iodide With ethanol; potassium hydroxide at 90℃;
Stage #2: With hydrogenchloride In ethanol; water pH=3 - 4;
osthole
484-12-8

osthole

8-(3-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
69219-24-5

8-(3-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one

Conditions
ConditionsYield
Stage #1: osthole With mercury(II) diacetate; water In tetrahydrofuran; dichloromethane for 3h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; dichloromethane
97%
With sulfuric acid; water In acetic acid at 0 - 5℃; for 1h;80%
With iron(III)-acetylacetonate; methyl 4-nitrobenzenesulfonate; phenylsilane; sodium hydrogencarbonate In methanol at 0 - 20℃; for 12h; Schlenk technique; Inert atmosphere; regioselective reaction;71%
With boron trifluoride diethyl etherate; water In dichloromethane Ambient temperature;52%
osthole
484-12-8

osthole

propargyl bromide
106-96-7

propargyl bromide

(Z)-3-(4-methoxy-3-(3-methylbut-2-enyl)-2-(prop-2-ynyloxy)phenyl)acrylic acid

(Z)-3-(4-methoxy-3-(3-methylbut-2-enyl)-2-(prop-2-ynyloxy)phenyl)acrylic acid

Conditions
ConditionsYield
Stage #1: osthole With sodium hydroxide In dimethyl sulfoxide at 25℃; for 0.5h;
Stage #2: propargyl bromide In dimethyl sulfoxide at 20℃; for 2h;
96%
osthole
484-12-8

osthole

7-methoxy-8-((3,3-dimethyloxiran-2-yl)methyl)-2H-chromen-2-one
489-53-2

7-methoxy-8-((3,3-dimethyloxiran-2-yl)methyl)-2H-chromen-2-one

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at -5℃; for 2h;93%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃;88%
With Perbenzoic acid; chloroform
Multi-step reaction with 2 steps
1: 180 mg / N-bromosuccinimide, DMSO, water / 1 h / Ambient temperature
2: 120 mg / sodium borohydride / dimethylsulfoxide / Ambient temperature
View Scheme
osthole
484-12-8

osthole

8-isopentyl-7-methoxy-chroman-2-one
181303-71-9

8-isopentyl-7-methoxy-chroman-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; under 760.051 Torr; for 16h;92%
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; under 760.051 Torr; for 16h;92%
With palladium on activated charcoal; acetic acid Hydrogenation;
osthole
484-12-8

osthole

8-isopentyl-7-methoxy-2H-chromen-2-one
6619-22-3

8-isopentyl-7-methoxy-2H-chromen-2-one

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In ethanol at 20℃;91%
With palladium; ethyl acetate Hydrogenation;
With acetic acid Hydrogenation;
Multi-step reaction with 2 steps
1: 66 percent / H2 / Pd/C / CH2Cl2; ethanol
2: 72 percent / Pd/C / 1,3,5-trimethyl-benzene / Heating
View Scheme
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C / 760.05 Torr
2: palladium 10% on activated carbon / 1,3,5-trimethyl-benzene / 16 h / 166 °C / Inert atmosphere
View Scheme
osthole
484-12-8

osthole

7-methoxy-8-(2',3'-dihydroxy-3'-methylbutyl)coumarin
5673-37-0

7-methoxy-8-(2',3'-dihydroxy-3'-methylbutyl)coumarin

Conditions
ConditionsYield
Stage #1: osthole With methanesulfonamide; AD-mix β In water; tert-butyl alcohol at 20℃; for 12h;
Stage #2: With sodium sulfite In water; tert-butyl alcohol at 20℃; for 0.5h;
90%
Multi-step reaction with 2 steps
1: 88 percent / m-chloroperbenzoic acid / CH2Cl2 / 0 °C
2: 73 percent / H2O, H2SO4 / tetrahydrofuran / Ambient temperature
View Scheme
osthole
484-12-8

osthole

N'-(3-methoxybenzylidene)-2-nitrobenzenesulfonohydrazide

N'-(3-methoxybenzylidene)-2-nitrobenzenesulfonohydrazide

7-methoxy-8-((3-(3-methoxyphenyl)-2,2-dimethylcyclopropyl)methyl)-2H-chromen-2-one

7-methoxy-8-((3-(3-methoxyphenyl)-2,2-dimethylcyclopropyl)methyl)-2H-chromen-2-one

Conditions
ConditionsYield
Stage #1: N'-(3-methoxybenzylidene)-2-nitrobenzenesulfonohydrazide With sodium hydride In dichloromethane at 20℃; for 1h; Inert atmosphere; Sealed tube;
Stage #2: osthole With silver trifluoromethanesulfonate In dichloromethane at 40℃; for 18h; Inert atmosphere; Sealed tube;
85%
osthole
484-12-8

osthole

tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

(E)-tert-butyl 4-(7-methoxy-2-oxo-2H-chromen-8-yl)but-2-enoate
1299490-72-4

(E)-tert-butyl 4-(7-methoxy-2-oxo-2H-chromen-8-yl)but-2-enoate

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide In diethyl ether at 35℃; for 24h; Inert atmosphere; diastereoselective reaction;81%
osthole
484-12-8

osthole

ethyl iodide
75-03-6

ethyl iodide

3-(2-ethoxy-4-methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic acid
73490-52-5

3-(2-ethoxy-4-methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic acid

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran 1.) 15 min, 2.) heating;80%
With potassium hydroxide 1.) DMSO, 1 h, 2.) (Osthol : C2H5I = 1:1) 12 h; Yield given. Multistep reaction;
osthole
484-12-8

osthole

osthenol
484-14-0

osthenol

Conditions
ConditionsYield
With L-Cysteine; sodium hydride In N,N-dimethyl-formamide for 3h; Reflux;77%
With aluminium trichloride; dimethylsulfide In dichloromethane at 30℃; for 24h;62%
Stage #1: osthole With aluminum (III) chloride; dimethylsulfide In dichloromethane at 0 - 30℃;
Stage #2: With hydrogenchloride In dichloromethane; water
62%
With aluminum (III) chloride; dimethylsulfide In dichloromethane at 0 - 30℃; for 24h;59%
osthole
484-12-8

osthole

7,8-(11,11-dimethyl pyrano)coumarin
2221-66-1

7,8-(11,11-dimethyl pyrano)coumarin

Conditions
ConditionsYield
With aluminium trichloride; ethanethiol In dichloromethane at 30℃; for 24h;76%
With phosphorus; hydrogen bromide
osthole
484-12-8

osthole

thioosthole

thioosthole

Conditions
ConditionsYield
With Lawessons reagent In tetrahydrofuran for 24h; Reflux;76%
With Lawessons reagent In tetrahydrofuran at 66℃; for 24h;351 mg
osthole
484-12-8

osthole

A

8-isopentyl-7-methoxy-2H-chromen-2-one
6619-22-3

8-isopentyl-7-methoxy-2H-chromen-2-one

B

8-isopentyl-7-methoxy-chroman-2-one
181303-71-9

8-isopentyl-7-methoxy-chroman-2-one

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; dichloromethaneA 21%
B 66%
osthole
484-12-8

osthole

(E)-2-hydroxy-4-methoxy-3-isopentenyl-cinnamic acid

(E)-2-hydroxy-4-methoxy-3-isopentenyl-cinnamic acid

Conditions
ConditionsYield
Stage #1: osthole With water; sodium hydroxide for 8h; Reflux;
Stage #2: With hydrogenchloride In water at 20℃; pH=2 - 3;
65.7%
osthole
484-12-8

osthole

(2E)-4-(7-methoxy-2-oxo-2H-chromen-8-yl)-2-methylbut-2-enal
73292-92-9

(2E)-4-(7-methoxy-2-oxo-2H-chromen-8-yl)-2-methylbut-2-enal

Conditions
ConditionsYield
With selenium(IV) oxide; acetic acid for 3h;60%
osthole
484-12-8

osthole

dimethyl sulfate
77-78-1

dimethyl sulfate

(Z)-2,4-dimethoxy-3-isopentenyl-cinnamic acid

(Z)-2,4-dimethoxy-3-isopentenyl-cinnamic acid

Conditions
ConditionsYield
Stage #1: osthole With water; sodium hydroxide for 0.5h; Reflux;
Stage #2: dimethyl sulfate With sodium hydroxide In water at 20℃; for 1.5h; Reflux;
Stage #3: With hydrogenchloride In water at 20℃; pH=2 - 3;
55.4%
osthole
484-12-8

osthole

A

(2E)-4-(7-methoxy-2-oxo-2H-chromen-8-yl)-2-methylbut-2-enal
73292-92-9

(2E)-4-(7-methoxy-2-oxo-2H-chromen-8-yl)-2-methylbut-2-enal

B

4'-hydroxylosthole
73292-93-0

4'-hydroxylosthole

Conditions
ConditionsYield
With selenium(IV) oxide In ethanol for 0.75h; Heating;A 22%
B 55%
osthole
484-12-8

osthole

dimethyl sulfate
77-78-1

dimethyl sulfate

(E)-2,4-dimethoxy-3-isopentenyl-cinnamic acid

(E)-2,4-dimethoxy-3-isopentenyl-cinnamic acid

Conditions
ConditionsYield
Stage #1: osthole With water; sodium hydroxide Reflux;
Stage #2: dimethyl sulfate With sodium hydroxide In water at 20℃; for 3.5h; Reflux;
Stage #3: With hydrogenchloride In water at 20℃; pH=2 - 3;
52.2%
osthole
484-12-8

osthole

7-methoxy-8-(3'-formylbut-2'-enyl) coumarin

7-methoxy-8-(3'-formylbut-2'-enyl) coumarin

Conditions
ConditionsYield
With selenium(IV) oxide; acetic acid for 3h;50%
With selenium(IV) oxide In ethanol at 65℃; for 10h; Inert atmosphere;
With selenium(IV) oxide In 1,4-dioxane at 60 - 80℃; for 1.5h;
osthole
484-12-8

osthole

sodium difluoromethanesulfinate
275818-95-6

sodium difluoromethanesulfinate

3-difluoromethyl-7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

3-difluoromethyl-7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

Conditions
ConditionsYield
With eosin y In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; Irradiation;47%
osthole
484-12-8

osthole

1,1,1-trifluoro-2-iodoethane
353-83-3

1,1,1-trifluoro-2-iodoethane

7-methoxy-8-(3-methylbut-2-en-1-yl)-3-(2,2,2-trifluoroethyl)-2H-chromen-2-one

7-methoxy-8-(3-methylbut-2-en-1-yl)-3-(2,2,2-trifluoroethyl)-2H-chromen-2-one

Conditions
ConditionsYield
With tris[2-phenylpyridinato-C2,N]iridium(III); potassium carbonate In dimethyl sulfoxide at 20℃; for 12h; Schlenk technique; Irradiation; Inert atmosphere;43%
osthole
484-12-8

osthole

ethanethiol
75-08-1

ethanethiol

A

7,8-(11,11-dimethyl pyrano)coumarin
2221-66-1

7,8-(11,11-dimethyl pyrano)coumarin

B

7-hydroxy-8-(3-methyl-3-thioethylbutyl)-coumarin

7-hydroxy-8-(3-methyl-3-thioethylbutyl)-coumarin

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane at 30℃; for 12h;A 20%
B 40%
osthole
484-12-8

osthole

8-(2,3-dibromo-3-methyl-butyl)-7-methoxy-coumarin

8-(2,3-dibromo-3-methyl-butyl)-7-methoxy-coumarin

Conditions
ConditionsYield
With bromine In dichloromethane at 0℃;34%
With tetrachloromethane; bromine
osthole
484-12-8

osthole

dimethyl sulfate
77-78-1

dimethyl sulfate

2,4-dimethoxy-3-isopentenyl-cinnamic acid

2,4-dimethoxy-3-isopentenyl-cinnamic acid

Conditions
ConditionsYield
Stage #1: osthole With water; sodium hydroxide at 20℃; Reflux;
Stage #2: dimethyl sulfate In water at 20℃; for 3h; Reflux;
Stage #3: With hydrogenchloride In water at 20℃; pH=2 - 3;
31.25%
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