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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory supply 99% Spironolactone GMP CAS 52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $250.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbo

Spironolactone CAS 52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Spironolactone Synonyms: a-lactone,acetate;Aldace;Aldactide;Aldactone A;aldactonea;Alderon;Aldopur;Almatol CAS: 52-01-7 MF: C24H32O4S MW: 416.57 EINECS: 200-133-6 Mol File: 52-01-7.mol Appearance:White Solid Storage:Store

Spironolactone 99% Manufactuered in China high quality

Cas:52-01-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance White or yellowish-white powder white powder Solubility

High purity Various Specifications Spironolactone CAS:52-01-7

Cas:52-01-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Kono Chem Co.,Ltd

Product name: Spironolactone CAS#: 52-01-7 EINECS#: 200-133-6 Molecular formula: C24H32O4S Molecular weight:416.57 Items S

CAS:52-01-7 Spironolactone lower price

Cas:52-01-7

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Spironolactone CAS 52-01-7 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing

Spironolactone CAS 52-01-7

Cas:52-01-7

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Spironolactone CAS No.:52-01-7 Name: Spironolactone Synonyms: 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate Molecular Structure Molecula

High purity Spironolactone CAS No.:52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Spironolactone

Cas:52-01-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Spironolactone 52-01-7 ISO Producer

Cas:52-01-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Aldactone

Cas:52-01-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Spironolactone CAS NO:52-01-7 Grade:Medical scientific research and export Molecular formula:C24H32O4S Molecular weight:416.5735 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat

Spironolactone/ CAS:52-01-7/Spironolactone raw material/ high-quality

Cas:52-01-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Spironolactone 52-01-7 powder

Cas:52-01-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Spironolactone/ LIDE PHARMA- Factory supply / Best price

Cas:52-01-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate CAS52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:R.T Package:25kg/drum Application:Diuretics Transportation:Express/Sea/Air Port:Any port in China

API Spironolactone cas 52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Male Sexual Dysfunction Treatment Steroid Aldactone CAS 52-01-7

Cas:52-01-7

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia

high-purity Spironolactone 52-01-7 (single impurity:NMT1.0%)

Cas:52-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Pharmaceutical Raw Material Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Spirolactone antisterone aldactone BP EP USP grade CAS:52-01-7

Cas:52-01-7

Min.Order:1 Kilogram

FOB Price: $352.0 / 363.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Spironolactone CAS:52-01-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Spironolactone CAS:52-01-7

Cas:52-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 52-01-7 Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Spironolactone

Cas:52-01-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

High quality Spironolactone powder with factory price

Cas:52-01-7

Min.Order:0

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Spironolactone

Cas:52-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

SC9420 Spironolactone 52-01-7

Cas:52-01-7

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

canrenone
976-71-6

canrenone

thioacetic acid
507-09-5

thioacetic acid

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Stage #1: tiolacetic acid With trifluoromethylsulfonic anhydride In tetrahydrofuran
Stage #2: canrenone In tetrahydrofuran at 20℃; for 1h;
76%
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at 20℃; for 3h;60%
In water at 20℃; for 2h; Michael addition;
canrenone
976-71-6

canrenone

thioacetic acid
507-09-5

thioacetic acid

A

β-spironolactone
33784-05-3

β-spironolactone

B

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yields of byproduct given;A n/a
B 64%
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yield given;A n/a
B 64%
17α-(2-carboxyethyl-17β-hydroxyandrosta-4,6-dien-3-one lactone

17α-(2-carboxyethyl-17β-hydroxyandrosta-4,6-dien-3-one lactone

canrenone
976-71-6

canrenone

thioacetic acid
507-09-5

thioacetic acid

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
In toluene
3-oxopregn-4-ene-21,17α-carbolactone
976-70-5

3-oxopregn-4-ene-21,17α-carbolactone

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
2: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: tetrachloro-<1,4>benzoquinone; xylene; toluene-4-sulfonic acid-monohydrate
View Scheme
levonorgestrel
434-03-7

levonorgestrel

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 98 percent / trimethyl orthoformate, p-toluenesulfonic acid / methanol / 3 h / 50 °C
2: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr
3: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h
4: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
5: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
6: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
17α-ethynyl-17β-hydroxy-5-androsten-3-one ethylene ketal
50407-76-6

17α-ethynyl-17β-hydroxy-5-androsten-3-one ethylene ketal

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr
2: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h
3: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
4: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
5: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
5'-hydroxyspiro-5-en-3-one
121936-43-4

5'-hydroxyspiro-5-en-3-one

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h
2: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
3: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
4: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
C24H34O4
75219-50-0

C24H34O4

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
2: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
3: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
3-ethoxyandrosta-3,5-dien-17-one
972-46-3

3-ethoxyandrosta-3,5-dien-17-one

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium bromide; C30H31Cl3N3(1+)*BF4(1-); triethylamine / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere; Sealed tube
2.1: chloranil / 1,2-dichloro-ethane; methanol; water / 1 h / 20 °C
3.1: trifluoromethylsulfonic anhydride / tetrahydrofuran
3.2: 1 h / 20 °C
View Scheme
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iodine; mercury dichloride; magnesium / diethyl ether / 0.5 h / 40 °C
1.2: 2.5 h / 0 - 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
2.2: 2 h / 0 - 20 °C
2.3: 1 h / 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C
4.1: chloranil / tert-butyl alcohol / 3 h / 80 °C
5.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C
View Scheme
21,24-dinor-3β,17β-dihydroxy-chol-5-en-22-yne
156894-83-6

21,24-dinor-3β,17β-dihydroxy-chol-5-en-22-yne

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
1.2: 2 h / 0 - 20 °C
1.3: 1 h / 0 - 20 °C
2.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C
3.1: chloranil / tert-butyl alcohol / 3 h / 80 °C
4.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C
View Scheme
3β,17β-Dihydroxy-5-androsten-17α-propanoic Acid γ-Lactone
13934-61-7

3β,17β-Dihydroxy-5-androsten-17α-propanoic Acid γ-Lactone

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C
2: chloranil / tert-butyl alcohol / 3 h / 80 °C
3: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C
View Scheme
C22H30O3

C22H30O3

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chloranil / tert-butyl alcohol / 3 h / 80 °C
2: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C
View Scheme
thioacetic acid
507-09-5

thioacetic acid

canrenone
976-71-6

canrenone

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

canrenone
976-71-6

canrenone

Conditions
ConditionsYield
With mercury dichloride In ethanol Ambient temperature;95%
With sodium methylate In tetrahydrofuran at 20℃; for 18h; Elimination;72%
With potassium dihydrogenphosphate In ethanol at 40℃; Rate constant; Kinetics; Thermodynamic data; var. buffers, pH, temp., ionic strengh, spironolactone and buffer conc.; energy of activation;
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

7α-Acetylthio-2α,6β-dibrom-3-oxo-17α-pregn-4-en-21,17-carbolacton

7α-Acetylthio-2α,6β-dibrom-3-oxo-17α-pregn-4-en-21,17-carbolacton

Conditions
ConditionsYield
With pyridinium hydrobromide perbromide In acetic acid for 1.5h; Ambient temperature;87%
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
38753-76-3

3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone

Conditions
ConditionsYield
Stage #1: SPIRONOLACTONE With sodium methylate In methanol at 20℃; for 0.666667h;
Stage #2: With acetic acid In methanol; water pH=7;
69%
With β‐cyclodextrin In phosphate buffer at 25℃; pH=7.0; Deacetylation;
With sodium methylate In methanol for 0.666667h; Inert atmosphere; Cooling with ice;
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

C24H34O4S

C24H34O4S

Conditions
ConditionsYield
With sodium tetrahydroborate; activated acidic alumina Brockmann II In ethyl acetate at 20℃; for 2h;66%
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

A

canrenone
976-71-6

canrenone

B

Chloronone
79327-11-0

Chloronone

Conditions
ConditionsYield
With mercury dichloride In ethanol for 2h; Heating;A 38%
B 54%
acetic anhydride
108-24-7

acetic anhydride

SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

acetyl chloride
75-36-5

acetyl chloride

3-Acetoxy-7α-acetylthio-17α-pregna-3,5-dien-21,17-carbolacton

3-Acetoxy-7α-acetylthio-17α-pregna-3,5-dien-21,17-carbolacton

Conditions
ConditionsYield
for 5h; Heating;44%
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

Conditions
ConditionsYield
In water-d2 Product distribution;
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

S-deacylated (and partially oxidized to disulfide) spironolactone-βCD complexes

S-deacylated (and partially oxidized to disulfide) spironolactone-βCD complexes

Conditions
ConditionsYield
In dimethylsulfoxide-d6 Product distribution;
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

17-hydroxy-7α-thioethyl-3-oxo-4-androstene-17α-pr0pi0nic acid, γ-lactone

17-hydroxy-7α-thioethyl-3-oxo-4-androstene-17α-pr0pi0nic acid, γ-lactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 59 percent / sodium metal / 24 h / 60 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(propylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(propylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 72 percent / sodium metal / 24 h / 60 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(phenylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(phenylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 59 percent / sodium metal / 24 h / 60 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(benzylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(benzylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 74 percent / sodium metal / 24 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.67 h / 20 °C
1.2: pH 7
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(hexylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(hexylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 62 percent / sodium metal / 24 h / 60 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(benzoylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(benzoylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 40 percent / 3 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.67 h / 20 °C
1.2: pH 7
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-(4-hydroxy-benzylthia)-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-(4-hydroxy-benzylthia)-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 91 percent / sodium / 0.75 h / 45 °C
3: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / -78 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone
245076-30-6

3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 91 percent / sodium / 0.75 h / 45 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.67 h / 20 °C
1.2: pH 7
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C
View Scheme
SPIRONOLACTONE
52-01-7

SPIRONOLACTONE

3-oxo-17α-pregna-4-ene-7α-{4-[2-(1-piperidinyl)-ethoxy]benzylthia}-21,17-carbolactone

3-oxo-17α-pregna-4-ene-7α-{4-[2-(1-piperidinyl)-ethoxy]benzylthia}-21,17-carbolactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C
2: 82 percent / sodium / 1 h / 45 °C
View Scheme

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