Spironolactone supplier | CasNO.52-01-7

Name
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
EINECS 200-133-6
CAS No. 52-01-7
Article Data15
CAS DataBase
Density 1.24 g/cm³
Solubility practically insoluble in water
Melting Point 207-208 °C(lit.)
Formula C₂₄H₃₂O₄S
Boiling Point 597 °C at 760 mmHg
Molecular Weight 416.582
Flash Point 302.3 °C
Transport Information
Appearance White to Off White Solid
Safety 53-22-36/37/39-45-36-26
Risk Codes 60-40-36/37/38
Molecular Structure
Hazard Symbols T, Xn, Xi
Synonyms Alderon;3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alph a.-yl)propionic acid lactone;Uractone;Spiro(17H-cyclopenta(a)phenauthrene-17,2-(3H)-furan);Xenalon;Pregn-4-ene-21-carboxylic acid,7-(acetylthio)-17-hydroxy-3-oxo-,?- lactone,(7R,17R)-;Aldactone;17.alpha.-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7.alpha.-mercapto-3-oxo-, .gamma.-lactone, acetate;Euteberol;Prestwick_449;Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-;Spironolactone A;Urusonin;Verospirone;SC 9420;SC 15983;Spiro(17H-cyclopenta(a)phenanthrene-17,2(5H)-furan), pregn-4-ene-21-carboxylic acid deriv.;Spiro-Tablinen;Spirolang;Spironolactone [BAN:INN:JAN];7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone;7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone (9CI);496916-40-6;Spironolactonum [INN-Latin];Aldactone A;Aldactazide (TN);Spiroctan;3-(3-Oxo-7-alpha-acetylthio-17-beta-hydroxyandrost-4-en-17-beta-yl)propionic acid lactone;7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone;Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, g-lactone, (7a,17a)-;Verospiron;
PSA 85.74000
LogP 4.85230

Synthetic route

: 976-71-6
canrenone

: 507-09-5
thioacetic acid

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Stage #1: tiolacetic acid With trifluoromethylsulfonic anhydride In tetrahydrofuran Stage #2: canrenone In tetrahydrofuran at 20℃; for 1h;	76%
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at 20℃; for 3h;	60%
In water at 20℃; for 2h; Michael addition;

: 976-71-6
canrenone

: 507-09-5
thioacetic acid

A: 33784-05-3
β-spironolactone

B: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yields of byproduct given;	A n/a B 64%
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yield given;	A n/a B 64%

...Expand

17α-(2-carboxyethyl-17β-hydroxyandrosta-4,6-dien-3-one lactone: 17α-(2-carboxyethyl-17β-hydroxyandrosta-4,6-dien-3-one lactone

: 976-71-6
canrenone

: 507-09-5
thioacetic acid

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
In toluene

...Expand

: 976-70-5
3-oxopregn-4-ene-21,17α-carbolactone

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 2: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: tetrachloro-<1,4>benzoquinone; xylene; toluene-4-sulfonic acid-monohydrate View Scheme

: 434-03-7
levonorgestrel

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 98 percent / trimethyl orthoformate, p-toluenesulfonic acid / methanol / 3 h / 50 °C 2: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 3: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 4: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 5: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 6: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

Yield

Multi-step reaction with 6 steps
1: 98 percent / trimethyl orthoformate, p-toluenesulfonic acid / methanol / 3 h / 50 °C
2: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr
3: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h
4: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
5: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
6: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme

: 50407-76-6
17α-ethynyl-17β-hydroxy-5-androsten-3-one ethylene ketal

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 2: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 3: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 4: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 5: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

Yield

Multi-step reaction with 5 steps
1: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr
2: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h
3: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h
4: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating
5: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature
View Scheme

: 121936-43-4
5'-hydroxyspiro-5-en-3-one

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 2: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 3: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 4: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

: 75219-50-0
C24H34O4

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 2: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 3: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

: 972-46-3
3-ethoxyandrosta-3,5-dien-17-one

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: lithium bromide; C30H31Cl3N3(1+)*BF4(1-); triethylamine / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere; Sealed tube 2.1: chloranil / 1,2-dichloro-ethane; methanol; water / 1 h / 20 °C 3.1: trifluoromethylsulfonic anhydride / tetrahydrofuran 3.2: 1 h / 20 °C View Scheme

: 53-43-0
dehydroepiandrosterone

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: iodine; mercury dichloride; magnesium / diethyl ether / 0.5 h / 40 °C 1.2: 2.5 h / 0 - 20 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 2.2: 2 h / 0 - 20 °C 2.3: 1 h / 0 - 20 °C 3.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 4.1: chloranil / tert-butyl alcohol / 3 h / 80 °C 5.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: iodine; mercury dichloride; magnesium / diethyl ether / 0.5 h / 40 °C
1.2: 2.5 h / 0 - 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
2.2: 2 h / 0 - 20 °C
2.3: 1 h / 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C
4.1: chloranil / tert-butyl alcohol / 3 h / 80 °C
5.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C
View Scheme

: 156894-83-6
21,24-dinor-3β,17β-dihydroxy-chol-5-en-22-yne

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 1.2: 2 h / 0 - 20 °C 1.3: 1 h / 0 - 20 °C 2.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 3.1: chloranil / tert-butyl alcohol / 3 h / 80 °C 4.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C View Scheme

: 13934-61-7
3β,17β-Dihydroxy-5-androsten-17α-propanoic Acid γ-Lactone

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 2: chloranil / tert-butyl alcohol / 3 h / 80 °C 3: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C View Scheme

: C22H30O3

: 52-01-7
SPIRONOLACTONE

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chloranil / tert-butyl alcohol / 3 h / 80 °C 2: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 3 h / 20 °C View Scheme

: 507-09-5
thioacetic acid

: 976-71-6
canrenone

: 52-01-7
SPIRONOLACTONE

: 52-01-7
SPIRONOLACTONE

: 976-71-6
canrenone

Conditions

Conditions	Yield
With mercury dichloride In ethanol Ambient temperature;	95%
With sodium methylate In tetrahydrofuran at 20℃; for 18h; Elimination;	72%
With potassium dihydrogenphosphate In ethanol at 40℃; Rate constant; Kinetics; Thermodynamic data; var. buffers, pH, temp., ionic strengh, spironolactone and buffer conc.; energy of activation;

: 52-01-7
SPIRONOLACTONE

: 7α-Acetylthio-2α,6β-dibrom-3-oxo-17α-pregn-4-en-21,17-carbolacton

Conditions

Conditions	Yield
With pyridinium hydrobromide perbromide In acetic acid for 1.5h; Ambient temperature;	87%

: 52-01-7
SPIRONOLACTONE

: 38753-76-3
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone

Conditions

Conditions	Yield
Stage #1: SPIRONOLACTONE With sodium methylate In methanol at 20℃; for 0.666667h; Stage #2: With acetic acid In methanol; water pH=7;	69%
With β‐cyclodextrin In phosphate buffer at 25℃; pH=7.0; Deacetylation;
With sodium methylate In methanol for 0.666667h; Inert atmosphere; Cooling with ice;

: 52-01-7
SPIRONOLACTONE

: C24H34O4S

Conditions

Conditions	Yield
With sodium tetrahydroborate; activated acidic alumina Brockmann II In ethyl acetate at 20℃; for 2h;	66%

: 52-01-7
SPIRONOLACTONE

A: 976-71-6
canrenone

B: 79327-11-0
Chloronone

Conditions

Conditions	Yield
With mercury dichloride In ethanol for 2h; Heating;	A 38% B 54%

: 108-24-7
acetic anhydride

: 52-01-7
SPIRONOLACTONE

: 75-36-5
acetyl chloride

: 3-Acetoxy-7α-acetylthio-17α-pregna-3,5-dien-21,17-carbolacton

Conditions

Conditions	Yield
for 5h; Heating;	44%

...Expand

: 52-01-7
SPIRONOLACTONE

: 7585-39-9
β‐cyclodextrin

: 85819-38-1, 86583-62-2, 86583-64-4, 97453-59-3
2C42H70O35*C24H32O4S

Conditions

Conditions	Yield
In water-d2 Product distribution;

: 52-01-7
SPIRONOLACTONE

: 7585-39-9
β‐cyclodextrin

S-deacylated (and partially oxidized to disulfide) spironolactone-βCD complexes: S-deacylated (and partially oxidized to disulfide) spironolactone-βCD complexes

Conditions

Conditions	Yield
In dimethylsulfoxide-d6 Product distribution;

: 52-01-7
SPIRONOLACTONE

: 17-hydroxy-7α-thioethyl-3-oxo-4-androstene-17α-pr0pi0nic acid, γ-lactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 59 percent / sodium metal / 24 h / 60 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(propylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 72 percent / sodium metal / 24 h / 60 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(phenylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 59 percent / sodium metal / 24 h / 60 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(benzylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 74 percent / sodium metal / 24 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium methylate / methanol / 0.67 h / 20 °C 1.2: pH 7 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(hexylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 62 percent / sodium metal / 24 h / 60 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(benzoylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 40 percent / 3 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium methylate / methanol / 0.67 h / 20 °C 1.2: pH 7 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-(4-hydroxy-benzylthia)-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 91 percent / sodium / 0.75 h / 45 °C 3: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / -78 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 245076-30-6
3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 91 percent / sodium / 0.75 h / 45 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium methylate / methanol / 0.67 h / 20 °C 1.2: pH 7 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C View Scheme

: 52-01-7
SPIRONOLACTONE

: 3-oxo-17α-pregna-4-ene-7α-{4-[2-(1-piperidinyl)-ethoxy]benzylthia}-21,17-carbolactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C 2: 82 percent / sodium / 1 h / 45 °C View Scheme

Spironolactone Specification

The Spironolactone, with the cas registry number 52-01-7, has the IUPAC name of S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate. This is a kind of white to off white solid, and is practically insoluble. Its product categories are including Active Pharmaceutical Ingredients; Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals; API's. As to its usage, it is a kind of diuretic and also used as an antiandrogen.

The physical properties of this chemical are as follows: (1)ACD/LogP: 3.12; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.12; (4)ACD/LogD (pH 7.4): 3.12; (5)ACD/BCF (pH 5.5): 139.34; (6)ACD/BCF (pH 7.4): 139.34; (7)ACD/KOC (pH 5.5): 1192.14; (8)ACD/KOC (pH 7.4): 1192.14; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 85.74; (13)Index of Refraction: 1.585; (14)Molar Refractivity: 112.68 cm³; (15)Molar Volume: 335.7 cm³; (16)Polarizability: 44.67 ×10^-24 cm³; (17)Surface Tension: 50.8 dyne/cm; (18)Density: 1.24 g/cm³; (19)Flash Point: 302.3 °C; (20)Enthalpy of Vaporization: 88.93 kJ/mol; (21)Boiling Point: 597 °C at 760 mmHg; (22)Vapour Pressure: 3.24E-14 mmHg at 25°C; (23)Exact Mass: 416.20213; (24)MonoIsotopic Mass: 416.20213; (25)Topological Polar Surface Area: 85.7; (26)Heavy Atom Count: 29; (27)Formal Charge: 0; (28)Complexity: 818.

When you are dealing with this chemical, you should be very cautious. For being a kind of irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes. Then it is harmful which may cause damage to health. What's more, it is even toxic which could at low levels cause damage to health. This chemical may have impair fertility and may have limited evidence of a carcinogenic effect.

Therefore, you should take the following instructions to protect yourself. Wear suitable protective clothing, gloves and eye/face protection and avoid exposure - obtain special instructions before use. If in case of accident or if you feel unwell seek medical advice immediately (show the label where possible), and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Then do remember not breathe dust. When store it, keep in a dry, cool and well-ventilated place, away from the food raw material.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C
(2)Isomeric SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
(3)InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
(4)InChIKey: LXMSZDCAJNLERA-ZHYRCANASA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	5600mg/kg (5600mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Journal of Laboratory and Clinical Medicine. Vol. 80, Pg. 224, 1972.
man	TDLo	oral	5714ug/kg/4D- (5.714mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" BLOOD: AGRANULOCYTOSIS BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 974, 1987.
man	TDLo	oral	7500ug/kg/3W- (7.5mg/kg)	BLOOD: AGRANULOCYTOSIS	Australian and New Zealand Journal of Medicine. Vol. 30, Pg. 515, 2000.
man	TDLo	oral	7500ug/kg/3W- (7.5mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Australian and New Zealand Journal of Medicine. Vol. 30, Pg. 515, 2000.
mouse	LD50	intraperitoneal	260mg/kg (260mg/kg)		Drugs in Japan Vol. 6, Pg. 381, 1982.
mouse	LD50	intravenous	260mg/kg (260mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)		Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
rabbit	LD50	intraperitoneal	866mg/kg (866mg/kg)		Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
rabbit	LD50	oral	> 1gm/kg (1000mg/kg)		Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
rat	LD50	intraperitoneal	277mg/kg (277mg/kg)		Drugs in Japan Vol. 6, Pg. 381, 1982.
rat	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. 6, Pg. 381, 1982.
women	TDLo	oral	70mg/kg/5W-I (70mg/kg)	BLOOD: AGRANULOCYTOSIS	British Medical Journal. Vol. 289, Pg. 731, 1984.
women	TDLo	oral	122mg/kg/61D- (122mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	New Zealand Medical Journal. Vol. 83, Pg. 147, 1976.

Product Name

17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate

Synthetic route

Spironolactone Specification

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