Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:609-71-2
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1301.html Product Name 2-Hydroxynicotinic acid CAS No. 609-71-2
Cas:609-71-2
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: 2-Hydroxynicotinic acid Synonyms: 2-Hydroxypyridine-3-carboxylic acid CAS:609-71-2 MF: C6H4NO3 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Pharmaceutical intermediate Tra
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
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inquiry2-Hydroxynicotinic acid CAS:609-71-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:609-71-2
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:609-71-2
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inquiryPRODUCT DETAILS 2-Hydroxynicotinic acid Basic information Product Name: 2-Hydr
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Cas:609-71-2
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:609-71-2
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inquirySuperior quality, moderate price & quick delivery. Appearance:White to light yellow powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Intermediat
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
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inquiryProduct name: 2-Hydroxynicotinic Acid CAS No.:609-71-2 Molecule Formula:C6H5NO3 Molecule Weight:139.11 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:609-71-2
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inquiry2-Hydroxynicotinic acid Chemical Properties Melting point 258-261 °C(lit.) Boiling point 255.04°C (rough estimate) density 1.4429 (rough estimate) refractive index 1.5423 (estimate) storage temp. Store below +30°C. sol
Cas:609-71-2
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Conditions | Yield |
---|---|
With hydrogenchloride; water for 6h; Heating; | 92% |
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere; | 63% |
Heating; | |
With sodium hydroxide In ethanol; water |
Conditions | Yield |
---|---|
Stage #1: 3-bromo-pyridin-2-ol With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -20℃; for 0.5h; | 79% |
Nicotinic acid N-oxide
acetic anhydride
A
6-hydroxy-3-pyridinecarboxylic acid
B
2-hydroxy-3-carboxypyridine
C
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
Conditions | Yield |
---|---|
for 6h; Heating; | A 1.5% B 5.4% C 62% |
Nicotinic acid N-oxide
A
6-hydroxy-3-pyridinecarboxylic acid
B
2-hydroxy-3-carboxypyridine
C
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
Conditions | Yield |
---|---|
With acetic anhydride for 6h; Heating; | A 1.5% B 5.4% C 62% |
2-chloronicotinic acid
A
2-hydroxy-3-carboxypyridine
B
2-aminopyridin-3-carboxylic acid
Conditions | Yield |
---|---|
With ammonium hydroxide at 155℃; for 20h; | A n/a B 60% |
N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide
A
2-hydroxy-3-carboxypyridine
B
3-Trifluoromethylphenol
C
2,4-difluorophenylamine
D
N-(2,4-Difluorophenyl)-2-hydroxy-3-pyridinecarboxamide
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid In water for 48h; Heating; | A 57% B n/a C n/a D 28% |
With hydrogenchloride; acetic acid In water for 48h; Product distribution; Mechanism; Heating; | A 57% B n/a C n/a D 28% |
Nicotinic acid N-oxide
propionic acid anhydride
A
2-hydroxy-3-carboxypyridine
C
5-aza-3-methyl-4-propionyloxyisocoumarin
Conditions | Yield |
---|---|
at 125℃; for 6h; | A n/a B n/a C 12.9% D 54.2% |
Nicotinic acid N-oxide
propionic acid anhydride
A
2-hydroxy-3-carboxypyridine
C
5-aza-3-methyl-4-propionyloxyisocoumarin
D
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone
Conditions | Yield |
---|---|
at 160℃; for 4h; Yield given. Further byproducts given; | A n/a B n/a C 39.8% D 16.4% |
Nicotinic acid N-oxide
propionic acid anhydride
A
2-hydroxy-3-carboxypyridine
C
5-aza-3-methyl-4-propionyloxyisocoumarin
D
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone
F
4-aza-3-ethyl-3,5-dipropionyloxy-1(3H)-isobenzofuranone
Conditions | Yield |
---|---|
at 160℃; for 4h; Product distribution; Mechanism; various temperatures and times; | A n/a B n/a C 39.8% D 16.4% E 8.3% F 2.1% |
2-aminopyridine
2-chloronicotinic acid
A
2-hydroxy-3-carboxypyridine
B
2-hydroxy-nicotinic acid-[2]pyridylamide
C
2-(2-hydroxy-nicotinoylimino)-2H-[1,2']bipyridyl-3'-carboxylic acid
Conditions | Yield |
---|---|
at 180 - 185℃; |
2-hydroxy-3-cyanopyridine
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With hydrogenchloride |
2-bromonicotinic acid
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With potassium hydroxide; water at 180℃; |
2-hydroxynicotinamide
2-hydroxy-3-carboxypyridine
nicotinic acid
A
6-hydroxy-3-pyridinecarboxylic acid
B
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With potassium hydroxide; fluorine In water at 0℃; for 3.5h; Yield given. Yields of byproduct given; | |
With potassium hydroxide; fluorine In water at 0℃; Yield given. Yields of byproduct given; | |
With water; oxygen Quantum yield; Further Variations:; pH-values; Reagents; Irradiation; |
quinoline
A
3-pyridinecarboxaldehyde
B
nicotinic acid
C
2-hydroxy-3-carboxypyridine
D
2-hydroxyquinoline
Conditions | Yield |
---|---|
With oxygen at 260 - 280℃; under 15751.3 - 64505.2 Torr; pH=7; Kinetics; Further Variations:; pH-values; Temperatures; Oxidation; |
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite Diazotization; |
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With Pd-BaSO4; ethanol Hydrogenation; |
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
With acetic anhydride; acetic acid at 210℃; im Rohr; |
A
2-hydroxy-3-carboxypyridine
B
Quinoline-6-carboxylic acid
Conditions | Yield |
---|---|
With potassium permanganate; sulfuric acid |
2-aminopyridine
2-chloronicotinic acid
A
2-hydroxy-3-carboxypyridine
B
2-hydroxy-nicotinic acid-[2]pyridylamide
Conditions | Yield |
---|---|
at 180 - 185℃; |
Conditions | Yield |
---|---|
With sulfuric acid; quinolinium dichromate(VI); acetic acid at 50℃; for 24h; Kinetics; | |
With sulfuric acid; quinolinium dichromate(VI); acetic acid In water at 49.85℃; for 48h; Kinetics; Further Variations:; Solvents; Temperatures; | |
With quinolinium dichromate In water; acetic acid at 49.84℃; for 48h; Kinetics; Mechanism; Solvent; Temperature; Inert atmosphere; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 2: PCl5, POCl3 3: conc. NH4OH / 20 h / 155 °C View Scheme | |
Multi-step reaction with 3 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 2: 65 percent / POCl3, Et3N / 4 h / 100 °C 3: conc. NH4OH / 20 h / 155 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PCl5, POCl3 2: conc. NH4OH / 20 h / 155 °C View Scheme | |
Multi-step reaction with 2 steps 1: 65 percent / POCl3, Et3N / 4 h / 100 °C 2: conc. NH4OH / 20 h / 155 °C View Scheme | |
Multi-step reaction with 2 steps 1: POCl3 / dimethylformamide 2: Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PCl5; POCl3 / 115 - 120 °C 2: aqueous HCl View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CH3I / 80 °C / Behandeln des Reaktionsprodukts mit H2O View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aqueous H2O2; acetic acid 2: PCl5; POCl3 / 115 - 120 °C 3: aqueous HCl View Scheme |
bromo-2 butyl-3 pyridine
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KMnO4; H2O 2: KOH; H2O / 180 °C View Scheme |
2-hydroxy-3-carboxypyridine
2-Chloronicotinoyl chloride
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; | 100% |
With phosphorus pentachloride anschliessendes Erwaermen; | |
With phosphorus pentachloride anschliessendes Erwaermen; |
2-hydroxy-3-carboxypyridine
1,1,1,3,3,3-hexamethyl-disilazane
trimethylsilyl 2-(trimethylsilyloxy)nicotinate
Conditions | Yield |
---|---|
at 150℃; for 7h; | 100% |
With chloro-trimethyl-silane In toluene Heating; |
Conditions | Yield |
---|---|
With acetyl chloride at 0 - 20℃; | 100% |
methanol
2-hydroxy-3-carboxypyridine
methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Conditions | Yield |
---|---|
With sulfuric acid Heating / reflux; | 100% |
Stage #1: 2-hydroxy-3-carboxypyridine With thionyl chloride In dichloromethane at 0℃; Stage #2: In tetrahydrofuran; dichloromethane at 20℃; Stage #3: methanol In tetrahydrofuran; dichloromethane at 20℃; | 81.8% |
With sulfuric acid In toluene Dean-Stark; Reflux; | 74% |
methanol
2-hydroxy-3-carboxypyridine
methyl 2-oxo-1,2-dihydropyridine-3-carboxylate hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-3-carboxypyridine With thionyl chloride In tetrahydrofuran; dichloromethane at 20℃; for 1h; Stage #2: methanol In tetrahydrofuran; dichloromethane at 20℃; | 100% |
2-hydroxy-3-carboxypyridine
water
cobalt(II) diacetate tetrahydrate
diaquabis(2-hydroxynicotinato(1-))cobalt(II)
Conditions | Yield |
---|---|
With aq. ammonia In water soln. of ligand in H2O added to soln. of Co salt in H2O; pH adjusted to 8 (a few drops of concd. ammonia soln.); stored for a few d; filtered; ppt. washed with H2O; dried in dessicator over NaOH; elem. anal.; | 100% |
2-hydroxy-3-carboxypyridine
dichloro(2,2'-bipyridine)palladium(II)
[Pd bis(2-hydroxynicotinate)(2,2'-bipyridine)
Conditions | Yield |
---|---|
With triethylamine In methanol; ethanol stirred suspn. of Pd complex in methanol mixed with methanolic suspn. ofligand and triethylamine, stirred for 1 day; sentrifuged, washed with ethanol, dried (silica gel); elem. anal.; | 99% |
2-hydroxy-3-carboxypyridine
1,1'-carbonyldiimidazole
(2-Hydroxy-pyridin-3-yl)-imidazol-1-yl-methanone
Conditions | Yield |
---|---|
In tetrahydrofuran for 19h; Heating; | 98% |
In tetrahydrofuran for 24h; Heating; | |
With Imidazole hydrochloride In tetrahydrofuran at 50℃; for 4h; |
C20H15N2PS2
2-hydroxy-3-carboxypyridine
Conditions | Yield |
---|---|
In dichloromethane | 97% |
2-hydroxy-3-carboxypyridine
5,5-dibenzyl-2,3,4,5-tetrahydropyridine
10,10-dibenzyl-8,9,10,10a-tetrahydrodipyrido[2,1-b:3',2'-e][1,3]oxazin-5(7H)-one
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h; Inert atmosphere; | 97% |
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h; | 97% |
2-hydroxy-3-carboxypyridine
methyl iodide
1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 2h; Methylation; Heating; | 96% |
With potassium hydroxide In methanol; water for 12h; Reflux; Inert atmosphere; | 65% |
With potassium hydroxide In methanol; water at 0 - 80℃; for 16h; | 45% |
2-hydroxy-3-carboxypyridine
1-chloromethyl-4-fluorobenzene
1,2-dihydro-1-(4-fluorobenzyl)-2-oxopyridine-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-3-carboxypyridine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 1-chloromethyl-4-fluorobenzene In N,N-dimethyl-formamide at 50℃; for 12h; Stage #3: With sodium hydroxide In water for 4h; Reflux; | 96% |
2-hydroxy-3-carboxypyridine
5-chloro-2-hydroxypyridine-3-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium hypochlorite; chlorine; sodium hydrogensulfite In water; acetone | 95.6% |
With sodium hydroxide; chlorine In water at 0 - 35℃; | 84% |
Stage #1: 2-hydroxy-3-carboxypyridine With sodium hydroxide; sodium hypochlorite In water at 20℃; for 48h; Stage #2: With sodium sulfite In water at 20℃; for 0.5h; | 78% |
2-hydroxy-3-carboxypyridine
3-(hydroxymethyl)pyridin-2(1H)-one
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-3-carboxypyridine With chloro-trimethyl-silane; 1,1,1,2,2,2-hexamethyldisilane In toluene at 110℃; for 0.5h; Stage #2: With diisobutylaluminium hydride In dichloromethane; toluene at -40 - 20℃; Stage #3: With hydrogenchloride; water In dichloromethane; toluene at -10℃; pH=4; | 95% |
Stage #1: 2-hydroxy-3-carboxypyridine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 2h; Heating / reflux; Stage #2: With diisobutylaluminium hydride In toluene at -78℃; for 4h; Stage #3: With methanol In toluene | 59% |
methanol
2-hydroxy-3-carboxypyridine
trans-bis(triphenylphosphine)palladium dichloride
Conditions | Yield |
---|---|
With triethylamine In methanol; ethanol stirred suspn. of Pd complex mixed with methanolic suspn. of ligand and triethylamine, stirred for 1 week; centrifuged, washed with ethanol, dried (silica gel); elem. anal., XRD; | 94% |
2-hydroxy-3-carboxypyridine
benzyl bromide
1-benzyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 8.5h; Heating; | 93% |
With potassium hydroxide In methanol; water for 12h; Reflux; Inert atmosphere; | 71% |
Stage #1: 2-hydroxy-3-carboxypyridine With potassium hydroxide In methanol; water for 0.25h; Heating / reflux; Stage #2: benzyl bromide In methanol; water for 1.5h; Heating / reflux; Stage #3: With hydrogenchloride; water | 55% |
2-hydroxy-3-carboxypyridine
1-bromo-2-(triisopropylsilyl)acetylene
Conditions | Yield |
---|---|
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate at 90℃; for 14h; | 92% |
Conditions | Yield |
---|---|
In water ligand added to soln. of Mo salt, suspn. refluxed for 6 h; filtered, washed with water, dried (silica gel); | 91% |
2-hydroxy-3-carboxypyridine
4-fluoroaniline
N-(4-fluorophenyl)-2-hydroxynicotinamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux; | 91% |
2-hydroxy-3-carboxypyridine
(2S)-2-phenylglycinol
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at -15 - 20℃; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-3-carboxypyridine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 70℃; for 24h; Stage #2: diethylamine In tetrahydrofuran at 70℃; for 18h; | 90% |
Stage #1: 2-hydroxy-3-carboxypyridine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: diethylamine In tetrahydrofuran at 60℃; for 2h; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
With NaOMe In methanol byproducts: NaCl; suspn. of Ru-complex and ligand in MeOH was stirred at room temp. for 10min, soln. of NaOMe in MeOH was added, stirred for 30 min under N2; solvent was evapd. under reduced pressure, extd. with CH2Cl2, hexane wasadded, solvent was evapd.; elem. anal.; | 89% |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at 0 - 50℃; for 4h; | 88% |
With sulfuric acid; nitric acid 1.) RT, 16 h, 2.) from 50 deg C to 70 deg C, 1.5 h; | 87% |
With sulfuric acid; nitric acid | 87% |
Conditions | Yield |
---|---|
With n-Bu4POH In tetrahydrofuran; water at 0 - 20℃; | 88% |
Stage #1: 2-hydroxy-3-carboxypyridine; benzyl bromide With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; Stage #2: With sodium hydroxide Inert atmosphere; |
4-(2-AMINOETHYL)MORPHOLINE
2-hydroxy-3-carboxypyridine
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux; | 88% |
2-hydroxy-3-carboxypyridine
4-chloro-aniline
N-(4-chlorophenyl)-2-hydroxynicotinamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux; | 88% |
2-hydroxy-3-carboxypyridine
5-bromo-2-hydroxynicotinic acid
Conditions | Yield |
---|---|
Stage #1: With sodium hydroxide; bromine In water at 0℃; for 0.0833333h; Stage #2: 2-hydroxy-3-carboxypyridine With sodium hydroxide In water at 50℃; for 44h; Stage #3: With hydrogenchloride In water at 0℃; pH=2; | 87% |
With sodium hydroxide; bromine at 0 - 50℃; for 18h; | 78% |
With bromine In water; acetic acid | 78% |
2-hydroxy-3-carboxypyridine
dichloro(2,2'-bipyridine)platinum(II)
[PtCl(2-hydroxynicotinate)(2,2'-bipyridine)
Conditions | Yield |
---|---|
With triethylamine In methanol; ethanol stirred suspn. of Pt complex in methanol mixed with methanolic suspn. ofligand and triethylamine, stirred for 2 weeks; sentrifuged, washed with ethanol, dried (silica gel); elem. anal.; | 87% |
2-hydroxy-3-carboxypyridine
p-toluidine
2-hydroxy-N-(p-tolyl)nicotinamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux; | 87% |
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