2-Hydroxynicotinic acid supplier

Name
2-Hydroxynicotinic acid
EINECS 210-198-2
CAS No. 609-71-2
Article Data47
CAS DataBase
Density 1.451 g/cm³
Solubility
Melting Point 258-261 °C(lit.)
Formula C₆H₅NO₃
Boiling Point 436 °C at 760 mmHg
Molecular Weight 139.111
Flash Point 217.5 °C
Transport Information
Appearance white to light yellow powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,2-Dihydro-2-oxonicotinic acid;2-Hydroxy-3-pyridinecarboxylic acid;2-Hydroxy-3-Pyridine Carboxylic acid;2-oxo-1H-pyridine-3-carboxylic acid;2-oxo-1H-pyridine-3-carboxylate;1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid;
PSA 70.42000
LogP 0.48540

Synthetic route

: 2942-59-8
2-chloronicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With hydrogenchloride; water for 6h; Heating;	92%
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere;	63%
Heating;
With sodium hydroxide In ethanol; water

: 13466-43-8
3-bromo-pyridin-2-ol

: 124-38-9
carbon dioxide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Stage #1: 3-bromo-pyridin-2-ol With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -20℃; for 0.5h;	79%

: 2398-81-4
Nicotinic acid N-oxide

: 108-24-7
acetic anhydride

A: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

B: 609-71-2
2-hydroxy-3-carboxypyridine

C: 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
for 6h; Heating;	A 1.5% B 5.4% C 62%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

A: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

B: 609-71-2
2-hydroxy-3-carboxypyridine

C: 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
With acetic anhydride for 6h; Heating;	A 1.5% B 5.4% C 62%

...Expand

: 2942-59-8
2-chloronicotinic acid

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 5345-47-1
2-aminopyridin-3-carboxylic acid

Conditions

Conditions	Yield
With ammonium hydroxide at 155℃; for 20h;	A n/a B 60%

: 83164-33-4
N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 98-17-9
3-Trifluoromethylphenol

C: 367-25-9
2,4-difluorophenylamine

D: 130191-66-1
N-(2,4-Difluorophenyl)-2-hydroxy-3-pyridinecarboxamide

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water for 48h; Heating;	A 57% B n/a C n/a D 28%
With hydrogenchloride; acetic acid In water for 48h; Product distribution; Mechanism; Heating;	A 57% B n/a C n/a D 28%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
at 125℃; for 6h;	A n/a B n/a C 12.9% D 54.2%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone

Conditions

Conditions	Yield
at 160℃; for 4h; Yield given. Further byproducts given;	A n/a B n/a C 39.8% D 16.4%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone

E: 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone 4-oxide

F: 115147-81-4
4-aza-3-ethyl-3,5-dipropionyloxy-1(3H)-isobenzofuranone

Conditions

Conditions	Yield
at 160℃; for 4h; Product distribution; Mechanism; various temperatures and times;	A n/a B n/a C 39.8% D 16.4% E 8.3% F 2.1%

...Expand

: 504-29-0
2-aminopyridine

: 2942-59-8
2-chloronicotinic acid

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 99973-09-8
2-hydroxy-nicotinic acid-[2]pyridylamide

C: 109255-91-6
2-(2-hydroxy-nicotinoylimino)-2H-[1,2']bipyridyl-3'-carboxylic acid

Conditions

Conditions	Yield
at 180 - 185℃;

...Expand

: 20577-27-9
2-hydroxy-3-cyanopyridine

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With hydrogenchloride

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With hydrogenchloride

: 35905-85-2
2-bromonicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With potassium hydroxide; water at 180℃;

: 10128-92-4
2-hydroxynicotinamide

: 609-71-2
2-hydroxy-3-carboxypyridine

: 59-67-6
nicotinic acid

A: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

B: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With potassium hydroxide; fluorine In water at 0℃; for 3.5h; Yield given. Yields of byproduct given;
With potassium hydroxide; fluorine In water at 0℃; Yield given. Yields of byproduct given;
With water; oxygen Quantum yield; Further Variations:; pH-values; Reagents; Irradiation;

: 91-22-5
quinoline

A: 500-22-1
3-pyridinecarboxaldehyde

B: 59-67-6
nicotinic acid

C: 609-71-2
2-hydroxy-3-carboxypyridine

D: 59-31-4
2-hydroxyquinoline

Conditions

Conditions	Yield
With oxygen at 260 - 280℃; under 15751.3 - 64505.2 Torr; pH=7; Kinetics; Further Variations:; pH-values; Temperatures; Oxidation;

...Expand

2-amino-pyridine-carboxylic acid-(3): 2-amino-pyridine-carboxylic acid-(3)

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite Diazotization;

: 7647-01-0
hydrogenchloride

: 393-55-5
2-fluoronicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

4-chloro-2-oxy-nicotinic acid: 4-chloro-2-oxy-nicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With Pd-BaSO4; ethanol Hydrogenation;

6-oxy-pyridine-dicarboxylic acid-(2.5): 6-oxy-pyridine-dicarboxylic acid-(2.5)

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With acetic anhydride; acetic acid at 210℃; im Rohr;

6--quinoline: 6--quinoline

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 10349-57-2
Quinoline-6-carboxylic acid

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid

: 504-29-0
2-aminopyridine

: 2942-59-8
2-chloronicotinic acid

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 99973-09-8
2-hydroxy-nicotinic acid-[2]pyridylamide

C 2-<2-hydroxy-nicotinoylimino>-2H-bipyridyl-3'-carboxylic acid: 2-<2-hydroxy-nicotinoylimino>-2H-bipyridyl-3'-carboxylic acid

Conditions

Conditions	Yield
at 180 - 185℃;

...Expand

: 59-67-6
nicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With sulfuric acid; quinolinium dichromate(VI); acetic acid at 50℃; for 24h; Kinetics;
With sulfuric acid; quinolinium dichromate(VI); acetic acid In water at 49.85℃; for 48h; Kinetics; Further Variations:; Solvents; Temperatures;
With quinolinium dichromate In water; acetic acid at 49.84℃; for 48h; Kinetics; Mechanism; Solvent; Temperature; Inert atmosphere;

: 59-67-6
nicotinic acid

phenyl-β-pyridyl ketone: phenyl-β-pyridyl ketone

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 2: PCl5, POCl3 3: conc. NH4OH / 20 h / 155 °C View Scheme
Multi-step reaction with 3 steps 1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C 2: 65 percent / POCl3, Et3N / 4 h / 100 °C 3: conc. NH4OH / 20 h / 155 °C View Scheme

: 2398-81-4
Nicotinic acid N-oxide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: PCl5, POCl3 2: conc. NH4OH / 20 h / 155 °C View Scheme
Multi-step reaction with 2 steps 1: 65 percent / POCl3, Et3N / 4 h / 100 °C 2: conc. NH4OH / 20 h / 155 °C View Scheme
Multi-step reaction with 2 steps 1: POCl3 / dimethylformamide 2: Heating View Scheme

: 1986-81-8
nicotinamide N-oxide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: PCl5; POCl3 / 115 - 120 °C 2: aqueous HCl View Scheme

: 364-22-7
2-fluoronicotinamide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH3I / 80 °C / Behandeln des Reaktionsprodukts mit H2O View Scheme

: 98-92-0
nicotinamide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous H2O2; acetic acid 2: PCl5; POCl3 / 115 - 120 °C 3: aqueous HCl View Scheme

: 100921-66-2
bromo-2 butyl-3 pyridine

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KMnO4; H2O 2: KOH; H2O / 180 °C View Scheme

: 609-71-2
2-hydroxy-3-carboxypyridine

: 49609-84-9
2-Chloronicotinoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	100%
With phosphorus pentachloride anschliessendes Erwaermen;
With phosphorus pentachloride anschliessendes Erwaermen;

: 609-71-2
2-hydroxy-3-carboxypyridine

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 183274-22-8
trimethylsilyl 2-(trimethylsilyloxy)nicotinate

Conditions

Conditions	Yield
at 150℃; for 7h;	100%
With chloro-trimethyl-silane In toluene Heating;

: 67-56-1
methanol

: 609-71-2
2-hydroxy-3-carboxypyridine

: 2-Hydroxy-nicotinic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
With acetyl chloride at 0 - 20℃;	100%

: 67-56-1
methanol

: 609-71-2
2-hydroxy-3-carboxypyridine

: 10128-91-3
methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

Conditions

Conditions	Yield
With sulfuric acid Heating / reflux;	100%
Stage #1: 2-hydroxy-3-carboxypyridine With thionyl chloride In dichloromethane at 0℃; Stage #2: In tetrahydrofuran; dichloromethane at 20℃; Stage #3: methanol In tetrahydrofuran; dichloromethane at 20℃;	81.8%
With sulfuric acid In toluene Dean-Stark; Reflux;	74%

: 67-56-1
methanol

: 609-71-2
2-hydroxy-3-carboxypyridine

: 203937-66-0
methyl 2-oxo-1,2-dihydropyridine-3-carboxylate hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-3-carboxypyridine With thionyl chloride In tetrahydrofuran; dichloromethane at 20℃; for 1h; Stage #2: methanol In tetrahydrofuran; dichloromethane at 20℃;	100%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 7732-18-5
water

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 956331-98-9
diaquabis(2-hydroxynicotinato(1-))cobalt(II)

Conditions

Conditions	Yield
With aq. ammonia In water soln. of ligand in H2O added to soln. of Co salt in H2O; pH adjusted to 8 (a few drops of concd. ammonia soln.); stored for a few d; filtered; ppt. washed with H2O; dried in dessicator over NaOH; elem. anal.;	100%

...Expand

: 609-71-2
2-hydroxy-3-carboxypyridine

: 14871-92-2
dichloro(2,2'-bipyridine)palladium(II)

: 503811-68-5
[Pd bis(2-hydroxynicotinate)(2,2'-bipyridine)

Conditions

Conditions	Yield
With triethylamine In methanol; ethanol stirred suspn. of Pd complex in methanol mixed with methanolic suspn. ofligand and triethylamine, stirred for 1 day; sentrifuged, washed with ethanol, dried (silica gel); elem. anal.;	99%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 530-62-1
1,1'-carbonyldiimidazole

: 211425-43-3
(2-Hydroxy-pyridin-3-yl)-imidazol-1-yl-methanone

Conditions

Conditions	Yield
In tetrahydrofuran for 19h; Heating;	98%
In tetrahydrofuran for 24h; Heating;
With Imidazole hydrochloride In tetrahydrofuran at 50℃; for 4h;

: 89430-08-0
C20H15N2PS2

: 609-71-2
2-hydroxy-3-carboxypyridine

: 2-thioxo-2,3-dihydro-4H-pyrido[3,2-e][1,3]oxazin-4-one

Conditions

Conditions	Yield
In dichloromethane	97%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 1416767-53-7
5,5-dibenzyl-2,3,4,5-tetrahydropyridine

: 1416767-45-7
10,10-dibenzyl-8,9,10,10a-tetrahydrodipyrido[2,1-b:3',2'-e][1,3]oxazin-5(7H)-one

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h; Inert atmosphere;	97%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h;	97%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 74-88-4
methyl iodide

: 15506-18-0
1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water for 2h; Methylation; Heating;	96%
With potassium hydroxide In methanol; water for 12h; Reflux; Inert atmosphere;	65%
With potassium hydroxide In methanol; water at 0 - 80℃; for 16h;	45%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 66158-41-6
1,2-dihydro-1-(4-fluorobenzyl)-2-oxopyridine-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-3-carboxypyridine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 1-chloromethyl-4-fluorobenzene In N,N-dimethyl-formamide at 50℃; for 12h; Stage #3: With sodium hydroxide In water for 4h; Reflux;	96%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 38076-80-1
5-chloro-2-hydroxypyridine-3-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium hypochlorite; chlorine; sodium hydrogensulfite In water; acetone	95.6%
With sodium hydroxide; chlorine In water at 0 - 35℃;	84%
Stage #1: 2-hydroxy-3-carboxypyridine With sodium hydroxide; sodium hypochlorite In water at 20℃; for 48h; Stage #2: With sodium sulfite In water at 20℃; for 0.5h;	78%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 42463-41-2
3-(hydroxymethyl)pyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-3-carboxypyridine With chloro-trimethyl-silane; 1,1,1,2,2,2-hexamethyldisilane In toluene at 110℃; for 0.5h; Stage #2: With diisobutylaluminium hydride In dichloromethane; toluene at -40 - 20℃; Stage #3: With hydrogenchloride; water In dichloromethane; toluene at -10℃; pH=4;	95%
Stage #1: 2-hydroxy-3-carboxypyridine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 2h; Heating / reflux; Stage #2: With diisobutylaluminium hydride In toluene at -78℃; for 4h; Stage #3: With methanol In toluene	59%

: 67-56-1
methanol

: 609-71-2
2-hydroxy-3-carboxypyridine

: 28966-81-6
trans-bis(triphenylphosphine)palladium dichloride

: trans-[PdCl(2-hydroxynicotinate)(PPh3)2

Conditions

Conditions	Yield
With triethylamine In methanol; ethanol stirred suspn. of Pd complex mixed with methanolic suspn. of ligand and triethylamine, stirred for 1 week; centrifuged, washed with ethanol, dried (silica gel); elem. anal., XRD;	94%

...Expand

: 609-71-2
2-hydroxy-3-carboxypyridine

: 100-39-0
benzyl bromide

: 89960-36-1
1-benzyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water for 8.5h; Heating;	93%
With potassium hydroxide In methanol; water for 12h; Reflux; Inert atmosphere;	71%
Stage #1: 2-hydroxy-3-carboxypyridine With potassium hydroxide In methanol; water for 0.25h; Heating / reflux; Stage #2: benzyl bromide In methanol; water for 1.5h; Heating / reflux; Stage #3: With hydrogenchloride; water	55%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 2-hydroxy-4-((triisopropylsilyl)ethynyl)nicotinic acid

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate at 90℃; for 14h;	92%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 7631-95-0
sodium molybdate dihydrate

: 7732-18-5
water

: Na2[Mo2O4 bis(2-hydroxynicotinate)]*5H2O

Conditions

Conditions	Yield
In water ligand added to soln. of Mo salt, suspn. refluxed for 6 h; filtered, washed with water, dried (silica gel);	91%

...Expand

: 609-71-2
2-hydroxy-3-carboxypyridine

: 371-40-4
4-fluoroaniline

: 951314-43-5
N-(4-fluorophenyl)-2-hydroxynicotinamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	91%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 20989-17-7
(2S)-2-phenylglycinol

: 2-hydroxy-N-[(1S)-2-hydroxy-1-phenylethyl]pyridine-3-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at -15 - 20℃; Inert atmosphere;	90%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 109-89-7
diethylamine

: 2-hydroxy-N,N-diethylnicotinamide

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-3-carboxypyridine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 70℃; for 24h; Stage #2: diethylamine In tetrahydrofuran at 70℃; for 18h;	90%
Stage #1: 2-hydroxy-3-carboxypyridine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: diethylamine In tetrahydrofuran at 60℃; for 2h; Inert atmosphere;	85%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 52462-31-4
[RuCl2(η(6)-1,3,5-C6H3Me3)]2

: 67-66-3
chloroform

: [Ru(CH3)3C6H3(C6H3NO3)]2*1.5CHCl3

Conditions

Conditions	Yield
With NaOMe In methanol byproducts: NaCl; suspn. of Ru-complex and ligand in MeOH was stirred at room temp. for 10min, soln. of NaOMe in MeOH was added, stirred for 30 min under N2; solvent was evapd. under reduced pressure, extd. with CH2Cl2, hexane wasadded, solvent was evapd.; elem. anal.;	89%

...Expand

: 609-71-2
2-hydroxy-3-carboxypyridine

: 6854-07-5
2-hydroxy-5-nitropyridine-3-carboxylic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 50℃; for 4h;	88%
With sulfuric acid; nitric acid 1.) RT, 16 h, 2.) from 50 deg C to 70 deg C, 1.5 h;	87%
With sulfuric acid; nitric acid	87%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 100-39-0
benzyl bromide

: 14178-18-8
2-(Benzyloxy)nicotinic acid

Conditions

Conditions	Yield
With n-Bu4POH In tetrahydrofuran; water at 0 - 20℃;	88%
Stage #1: 2-hydroxy-3-carboxypyridine; benzyl bromide With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; Stage #2: With sodium hydroxide Inert atmosphere;

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 609-71-2
2-hydroxy-3-carboxypyridine

: 1221489-81-1
2-hydroxy-N-(2-morpholinoethyl)nicotinamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	88%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 106-47-8
4-chloro-aniline

: 951314-44-6
N-(4-chlorophenyl)-2-hydroxynicotinamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	88%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 104612-36-4
5-bromo-2-hydroxynicotinic acid

Conditions

Conditions	Yield
Stage #1: With sodium hydroxide; bromine In water at 0℃; for 0.0833333h; Stage #2: 2-hydroxy-3-carboxypyridine With sodium hydroxide In water at 50℃; for 44h; Stage #3: With hydrogenchloride In water at 0℃; pH=2;	87%
With sodium hydroxide; bromine at 0 - 50℃; for 18h;	78%
With bromine In water; acetic acid	78%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 13965-31-6
dichloro(2,2'-bipyridine)platinum(II)

: 503811-71-0
[PtCl(2-hydroxynicotinate)(2,2'-bipyridine)

Conditions

Conditions	Yield
With triethylamine In methanol; ethanol stirred suspn. of Pt complex in methanol mixed with methanolic suspn. ofligand and triethylamine, stirred for 2 weeks; sentrifuged, washed with ethanol, dried (silica gel); elem. anal.;	87%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 106-49-0
p-toluidine

: 72646-01-6
2-hydroxy-N-(p-tolyl)nicotinamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	87%

2-Hydroxynicotinic acid Chemical Properties

Molecular Structure of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):

IUPAC Name: 2-Oxo-1H-pyridine-3-carboxylic acid
Molecular Formula: C₆H₅NO₃
Molecular Weight: 139.108800 g/mol
Index of Refraction: 1.579
Molar Refractivity: 31.84 cm³
Molar Volume: 95.8 cm³
Surface Tension: 61 dyne/cm
Density: 1.451 g/cm³
Flash Point: 217.5 °C
Enthalpy of Vaporization: 75.92 kJ/mol
Boiling Point: 436 °C at 760 mmHg
Vapour Pressure: 8.03E-09 mmHg at 25 °C
Melting Point: 258-261 °C(lit.)
BRN: 119028
EINECS: 210-198-2
Product Categories: blocks;Carboxes;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Organic acids;CHIRAL CHEMICALS

2-Hydroxynicotinic acid Safety Profile

Safety Information of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):
Hazard Codes: Xi
Hazard Note: Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
S37/39:Wear suitable gloves and eye/face protection
WGK Germany: 3
HazardClass: IRRITANT

2-Hydroxynicotinic acid Specification

2-Hydroxynicotinic acid with cas registry number of 609-71-2 is also called NSC 226152 ; 1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid ; 1,2-Dihydro-2-oxonicotinic acid .

Product Name

2-Hydroxynicotinic acid

Synthetic route

2-Hydroxynicotinic acid Chemical Properties

2-Hydroxynicotinic acid Safety Profile

2-Hydroxynicotinic acid Specification

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