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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

1-Chloro-1,1-difluoroethane Manufacturer/High quality/Best price/In stock

Cas:75-68-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM_ 1-Chloro-1,1-difluoroethane,75-68-3

Cas:75-68-3

Min.Order:10 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:75-68-3

Cas:75-68-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

1-chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers298.Safe and fa

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

1-Chloro-1,1-Difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Fandachem Co.,Ltd

1-Chloro-1,1-difluoroethane;HCFC-142b.;Ethane, 1-chloro-1,1-difluoro-;R142b ,cas;75-68-3 from fandachem Package:as customers' requirements Application:fine chemical Transportation:by air,by sea,by express Port:Shanghai, China

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

1-Chloro-1,1-difluoroethane manufacture

Cas:75-68-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

1-Chloro-1,1-difluoroethane 75-68-3

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Chlorodifluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Amadis Chemical offer CAS#75-68-3;CAT#A838484

Cas:75-68-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

1-Chloro-1,1-difluoroethane Basic information Product Name: 1-Chloro-1,1-difluoroethane Synonyms: 1,1,1-chlorodifluoroethane;1-Chlor-1,1-difluorethan;1-chloro-1,1-difluor

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen BaiFuchem Co.,Ltd

BaiFuChem is a Professional chemical raw material supplier in China, our main products include Biochemical , Pharma Intermediate and Organic chemical etc. BaiFuChem have wealth of products,experience , expertise and state-of-the-art

Best price 1-Chloro-1,1-Difluoroethane

Cas:75-68-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

ORCHID CHEMICAL SUPPLIES LTD

Good quality, Competitive price

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Yierdechem Co. Ltd

With about ten years experiences in the field of pharmaceutical chemicals, Yierdechem has established solid business cooperation relationships with many large companys worldwide.As a leading supplier of API and pharmaceutical intermediates, holds its

1-Chloro-1,1-difluoroethane (HCFC-142B)

Cas:75-68-3

Min.Order:0

Negotiable

Type:Other

inquiry

Pure Chemistry Scientific Inc.

1-Chloro-1,1-difluoroethane Application:80062495

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:1 Gram

FOB Price: $500.0

Type:Trading Company

inquiry

Weihai Moochun Bio-Tech Co., Ltd.

high quality;competitive priceAppearance:gas Storage:keep sealed and keep from direct light Package:Sample: 50g/ bottle 100g/ bottle 1000g/ bottle bulk: 25kg/drum 50kg/drum 363kg/drum Application:Scientific research Transportation:For small batc

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuxi Morality Chemical Co., Ltd

Do best quality products, erect the morality model Application:please email us, thanks

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai chemrole co.,ltd

R142BAppearance:CHLORODIFLUOROETHANE

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

QUZHOU ZIO I/E CO.;LTD

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

1-Chloro-1,1-difluorothane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

1-Chloro-1,1-difluoroethane

Cas:75-68-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

Conditions
ConditionsYield
With hydrogen fluoride; SbCl5 on Carbon at 100℃; under 760.051 Torr; for 0.00277778h;A 80%
B n/a
C n/a
1,1-difluoroethane
75-37-6

1,1-difluoroethane

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
With chlorine In gas at 21.9℃; under 760 Torr; for 0.000666667h; Irradiation; time history of ignition;
bei der Photochlorierung;
beim Chlorieren im Sonnenlicht;
1,1-difluoroethane
75-37-6

1,1-difluoroethane

A

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

B

1,2-dichloro-1,1-difluoroethane
1649-08-7

1,2-dichloro-1,1-difluoroethane

Conditions
ConditionsYield
beim Chlorieren im Sonennlicht;
1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
With hydrogen fluoride at 200℃; under 175051 Torr;
With antimony dichloride trifluoride; antimony(III) fluoride
1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
With hydrogen fluoride; diphenylamine at 180 - 195℃; unter Druck;
1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
With hydrogen fluoride; diphenylamine at 140℃; im Autoklaven;
HCFC-141b
1717-00-6

HCFC-141b

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

D

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

E

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
fluorinated γ-alumina at 300℃; Product distribution; other temperatures; also with HCl or HF as reagents;
1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

Vinylidene fluoride
75-38-7

Vinylidene fluoride

D

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
fluorinated γ-alumina at 300℃; Product distribution; other temperatures;
1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

Vinylidene fluoride
75-38-7

Vinylidene fluoride

D

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

E

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With hydrogenchloride; fluorinated γ-alumina at 300℃; Product distribution; other temperatures;
HCFC-141b
1717-00-6

HCFC-141b

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
With hydrogen fluoride Heating;
1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

D

chlorotrifluoromethane
75-72-9

chlorotrifluoromethane

E

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

Conditions
ConditionsYield
With fluorinated indium(III) oxide Product distribution; Ambient temperature; further reagent: fluorinated gallium(III) oxide;
1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

A

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

B

HCFC-141b
1717-00-6

HCFC-141b

C

chlorotrifluoromethane
75-72-9

chlorotrifluoromethane

Conditions
ConditionsYield
With fluorinated gallium(III) oxide Product distribution; Ambient temperature;
1,1-dichloro-1-nitroethane
594-72-9

1,1-dichloro-1-nitroethane

hydrogen fluoride
7664-39-3

hydrogen fluoride

antimony dichloride trifluoroide

antimony dichloride trifluoroide

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
at 115℃;
1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

diphenylamine
122-39-4

diphenylamine

HF (6 mol)

HF (6 mol)

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

Conditions
ConditionsYield
at 140 - 210℃; unter Druck;entstehen je nach der Reaktionsdauer wechselnde Mengen;
1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

hydrogen fluoride
7664-39-3

hydrogen fluoride

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

hydrogen fluoride
7664-39-3

hydrogen fluoride

antimonypentachloride
7647-18-9

antimonypentachloride

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

antimony(III) fluoride
7783-56-4

antimony(III) fluoride

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

chlorinated SbF3

chlorinated SbF3

A

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

B

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C

HCFC-141b
1717-00-6

HCFC-141b

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

HF (4 mol)

HF (4 mol)

A

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

B

HCFC-141b
1717-00-6

HCFC-141b

C

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

Conditions
ConditionsYield
at 65℃; unter Druck;
dichloromethane
75-09-2

dichloromethane

A

pentaerythrityl tetrachloride
3228-99-7

pentaerythrityl tetrachloride

B

Isobutane
75-28-5

Isobutane

C

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

D

HCFC-141b
1717-00-6

HCFC-141b

E

1,2-dichloro-1,1-difluoroethane
1649-08-7

1,2-dichloro-1,1-difluoroethane

F

pentachloroethane
76-01-7

pentachloroethane

G

(ClCH2)3CCl

(ClCH2)3CCl

Conditions
ConditionsYield
With fluorinated gallium(III) oxide Product distribution; Mechanism; Ambient temperature;
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

2,2,2-trifluoroethanol
420-46-2

2,2,2-trifluoroethanol

Conditions
ConditionsYield
at 200℃; for 2h; Conversion of starting material;100%
With hydrogen fluoride; chlorine; antimonypentachloride at 15 - 20℃; under 6750.68 Torr;97%
With hydrogen fluoride; chromium(III) water-soluble salt; graphite; magnesium oxide; water; mixture of, dried at 150 C, hydrofluorinated at 200-350 C at 200℃; under 7500.75 Torr; Continious process;
With neodymium(III) oxide; hydrogen fluoride; antimony pentafluoride at 10℃; under 2250.23 Torr; Reagent/catalyst; Large scale;
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

5-Bromo-1-indanone
34598-49-7

5-Bromo-1-indanone

5-(1,1-difluoroethyl)-2,3-dihydro-1H-inden-1-one

5-(1,1-difluoroethyl)-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;83%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-bromoohenyl methyl sulfone
3466-32-8

4-bromoohenyl methyl sulfone

1-(1,1-difluoroethyl)-4-(methylsulfonyl)benzene

1-(1,1-difluoroethyl)-4-(methylsulfonyl)benzene

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;80%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

1-(4-(1,1-difluoroethyl)phenyl)ethan-1-one

1-(4-(1,1-difluoroethyl)phenyl)ethan-1-one

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;78%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-iodo-biphenyl
1591-31-7

4-iodo-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;74%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

(4-bromophenyl)(phenyl)methanone
90-90-4

(4-bromophenyl)(phenyl)methanone

(4-(1,1-difluoroethyl)phenyl)(phenyl)methanone

(4-(1,1-difluoroethyl)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;73%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-bromo-1,1'-biphenyl
92-66-0

4-bromo-1,1'-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;72%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-biphenylboronic acid
5122-94-1

4-biphenylboronic acid

4-(1,1-difluoroethyl)-1,1’-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

Conditions
ConditionsYield
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Reagent/catalyst; Schlenk technique; Inert atmosphere;70%
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Suzuki-Miyaura Coupling;70%
4-(carbazol-9-yl)phenylboronic acid
419536-33-7

4-(carbazol-9-yl)phenylboronic acid

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

9-(4-(1,1-difluoroethyl)phenyl)-9H-carbazole

9-(4-(1,1-difluoroethyl)phenyl)-9H-carbazole

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;62%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;59%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

fenofibrate
49562-28-9

fenofibrate

2-(4-(4-(1,1-difluoroethyl)benzoyl)phenoxy)-2-methylpropionoic acid isopropyl ester

2-(4-(4-(1,1-difluoroethyl)benzoyl)phenoxy)-2-methylpropionoic acid isopropyl ester

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;62%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

(4'-ethyl[1,1'-biphenyl]-4-yl)boronic acid
153035-62-2

(4'-ethyl[1,1'-biphenyl]-4-yl)boronic acid

4-(1,1-difluoroethyl)-4'-ethyl-1,1'-biphenyl

4-(1,1-difluoroethyl)-4'-ethyl-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;61%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;58%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-(4-bromophenyl)-4-oxobutanoic acid ethyl ester
30913-87-2

4-(4-bromophenyl)-4-oxobutanoic acid ethyl ester

4-(4-(1,1-difluoroethyl)phenyl)-4-oxobutanoic acid ethyl ester

4-(4-(1,1-difluoroethyl)phenyl)-4-oxobutanoic acid ethyl ester

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;61%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

1-bromo-4-(4'-ethylphenyl)benzene
58743-79-6

1-bromo-4-(4'-ethylphenyl)benzene

4-(1,1-difluoroethyl)-4'-ethyl-1,1'-biphenyl

4-(1,1-difluoroethyl)-4'-ethyl-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;58%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-bromo-4'-pentyloxybiphenyl
63619-51-2

4-bromo-4'-pentyloxybiphenyl

4-(1,1-difluoroethyl)-4'-(pentyloxy)-1,1'-biphenyl

4-(1,1-difluoroethyl)-4'-(pentyloxy)-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;56%
4-(naphthalene-2-yl)phenylboronic acid pinacol ester
918655-03-5

4-(naphthalene-2-yl)phenylboronic acid pinacol ester

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

2-(4-(1,1-difluoroethyl)phenyl)naphthalene

2-(4-(1,1-difluoroethyl)phenyl)naphthalene

Conditions
ConditionsYield
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;55%
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;55%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

3-Biphenylboronic acid
5122-95-2

3-Biphenylboronic acid

3-(1,1-difluoroethyl)-1,1'-biphenyl

3-(1,1-difluoroethyl)-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;54%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;49%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

N-(4-bromophenyl)carbazole
57102-42-8

N-(4-bromophenyl)carbazole

9-(4-(1,1-difluoroethyl)phenyl)-9H-carbazole

9-(4-(1,1-difluoroethyl)phenyl)-9H-carbazole

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;54%
4-(4-n-pentyloxyphenyl)phenylboronic acid
158937-25-8

4-(4-n-pentyloxyphenyl)phenylboronic acid

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-(1,1-difluoroethyl)-4'-(pentyloxy)-1,1'-biphenyl

4-(1,1-difluoroethyl)-4'-(pentyloxy)-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;51%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;48%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4'-biphenyl chloride
2051-62-9

4'-biphenyl chloride

4-(1,1-difluoroethyl)-1,1’-biphenyl

4-(1,1-difluoroethyl)-1,1’-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;49%
6-bromo-isoquinoline
34784-05-9

6-bromo-isoquinoline

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

6-(1,1-difluoroethyl)isoquinoline

6-(1,1-difluoroethyl)isoquinoline

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;46%
6-bromoquinoline
5332-25-2

6-bromoquinoline

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

6-(1,1-difluoroethyl)quinoline

6-(1,1-difluoroethyl)quinoline

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;44%
2-bromodibenzothiophene
22439-61-8

2-bromodibenzothiophene

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

2-(1,1-difluoroethyl)dibenzo[b,d]thiophene

2-(1,1-difluoroethyl)dibenzo[b,d]thiophene

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;43%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

3-bromobiphenyl
2113-57-7

3-bromobiphenyl

3-(1,1-difluoroethyl)-1,1'-biphenyl

3-(1,1-difluoroethyl)-1,1'-biphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;40%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

3,5-diphenylphenylboronic acid
128388-54-5

3,5-diphenylphenylboronic acid

5'-(1,1-difluoroethyl)-1,1':3',1"-terphenyl

5'-(1,1-difluoroethyl)-1,1':3',1"-terphenyl

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;39%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;34%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

1-bromo-3,5-diphenylbenzene
103068-20-8

1-bromo-3,5-diphenylbenzene

5'-(1,1-difluoroethyl)-1,1':3',1"-terphenyl

5'-(1,1-difluoroethyl)-1,1':3',1"-terphenyl

Conditions
ConditionsYield
With dmap; bis(tricyclohexylphosphine)nickel(II) dichloride; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; zinc In dimethyl sulfoxide at 110℃; for 10h; Schlenk technique;39%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

4-(4-morpholinyl)phenylboronic acid
186498-02-2

4-(4-morpholinyl)phenylboronic acid

4-(4-(1,1-difluoroethyl)phenyl)morpholine

4-(4-(1,1-difluoroethyl)phenyl)morpholine

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;28%
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;22%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

(3-(naphthalen-1-yl)phenyl)boronic acid
881913-20-8

(3-(naphthalen-1-yl)phenyl)boronic acid

1-(3-(1,1-difluoroethyl)phenyl)naphthalene

1-(3-(1,1-difluoroethyl)phenyl)naphthalene

Conditions
ConditionsYield
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;26%
(4-(naphthalen-1-yl)phenyl)boronic acid
870774-25-7

(4-(naphthalen-1-yl)phenyl)boronic acid

1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

C18H14F2

C18H14F2

Conditions
ConditionsYield
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;26%
1-Chloro-1,1-difluoroethane
75-68-3

1-Chloro-1,1-difluoroethane

(4-(1-phenyl-1H-benzo [d]imidazole-2-yl) phenyl)boronic acid
952514-79-3

(4-(1-phenyl-1H-benzo [d]imidazole-2-yl) phenyl)boronic acid

2-(4-(1,1-difluoroethyl)phenyl)-1-phenyl-1H-benzo[d]imidazole

2-(4-(1,1-difluoroethyl)phenyl)-1-phenyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With dmap; bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Schlenk technique; Inert atmosphere;16%
With dmap; trans-[Ni(Cl)2(PPh3)2]; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In 1,2-dimethoxyethane at 110℃; for 5h; Suzuki-Miyaura Coupling;16%

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