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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Amino-3-Chloro-5-Trifluoromethylpyridine supplier in China

Cas:79456-26-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

3-chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience 2. Free samples will be provided,ensure specifications and quality are right for customer 3. Customers will receive the most professional techn

Large Stock 99.0% 3-Chloro-5-(trifluoromethyl)pyridin-2-amine 79456-26-1 Producer

Cas:79456-26-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-chloro-5-trifluoromethyl-2-pyridylamine

Cas:79456-26-1

Min.Order:1

Negotiable

Type:Other

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine

Cas:79456-26-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Amino-3-chloro-5-(trifluoromethyl)-pyridine

Cas:79456-26-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name 2-Amino-3-Chloro-5-(trifluoromethyl)pyridine CAS No 79456-26-1 MF C6H4ClF3N2 MW 196.56 Appearance

2-Amino-3-Chloro-5-(trifluoromethyl)pyridine

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 79456-26-1 with fast shipping

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Chloro-5-(trifluoromethyl)pyridin-2-amine 79456-26-1

Cas:79456-26-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Chloro-5-(trifluoromethyl)pyridin-2-amine CAS: 79456-26-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in h

3-Chloro-5-(trifluoromethyl)pyridin-2-amine CAS: 79456-26-1

Cas:79456-26-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Chloro-5-(trifluoroMethyl)pyridin-2-aMine

Cas:79456-26-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine Synonyms: TIMTEC-BB SBB003584;LABOTEST-BB LT00012608;2-AMINO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;2,3,5-actf;3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINAMINE;3-Chloro-5-(trifluoromethyl)-2

TIANFU-CHEM 3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine CAS No.:79456-26-1 Molecule Formula:C6H4ClF3N2 Molecule Weight:196.55 Purity: 98% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

High Quality 2-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine in stock

Cas:79456-26-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Chemical Properties Melting point 86-90 °C (lit.) Boiling point 205°C density 1.4650 (estimate) form Crystalline Powder pka 1.79±0.49(Predicted) color White to off-whit

2-Amino-3-chloro-5-trifluoromethylpyridine

Cas:79456-26-1

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-Chloro-5-(trifluoromethyl)pyridin-2-amine CAS NO.79456-26-1 from Jilin Tely with High Purity CAS NO.79456-26-1

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

Cas:79456-26-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Amino-3-chloro-5-trifluoromethylpyridine

Cas:79456-26-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ammonia In tetrahydrofuran at 35℃; under 1950.2 Torr; for 28h; Product distribution / selectivity; Autoclave; Inert atmosphere;99.5%
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;94%
With ammonia In tetrahydrofuran at 30℃; under 3750.38 - 6750.68 Torr; for 30h; Temperature; Pressure; Autoclave; Inert atmosphere;
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ammonia In water at 80℃; under 13501.4 - 16501.7 Torr; for 9h; Autoclave;90%
With ammonium hydroxide at 100℃; for 12h; Sealed tube;90%
With ammonium hydroxide at 100 - 125℃; under 1520 Torr; for 29h;82.9%
With ammonium hydroxide
With ammonia In tetrahydrofuran at 100℃; under 4500.45 - 12001.2 Torr; for 28h; Pressure; Temperature; Autoclave; Inert atmosphere;
5-bromo-3-chloropyridin-2-ylamine
38185-55-6

5-bromo-3-chloropyridin-2-ylamine

potassium trifluoro(methyl)boranuide

potassium trifluoro(methyl)boranuide

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 55 - 105℃; for 6h; Temperature;76%
2-amino-5-trifluoromethylpyridine
74784-70-6

2-amino-5-trifluoromethylpyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With hydrogenchloride; chlorine at 50 - 60℃;
2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 39 percent / aq. ammonia / 8 h / 180 °C
2: chlorine, conc.HCl / 50 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1: 75 percent / aq. ammonia / 24 h / 135 °C
2: chlorine, conc.HCl / 50 - 60 °C
View Scheme
2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating
2: 39 percent / aq. ammonia / 8 h / 180 °C
3: chlorine, conc.HCl / 50 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating
2: 75 percent / aq. ammonia / 24 h / 135 °C
3: chlorine, conc.HCl / 50 - 60 °C
View Scheme
2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation
2: 82.9 percent / aq. ammonia / 29 h / 100 - 125 °C / 1520 Torr
View Scheme
Multi-step reaction with 2 steps
1: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
2: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

2-amino-5-trifluoromethylpyridine
74784-70-6

2-amino-5-trifluoromethylpyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In toluene
ammonium hydroxide

ammonium hydroxide

2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

3-trichloromethyl-pyridine
3099-50-1

3-trichloromethyl-pyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
Multi-step reaction with 4 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: phosphorus pentachloride / 16 h / 210 °C / Autoclave
3: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
4: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
5-chloro-3-trichloromethyl pyridine

5-chloro-3-trichloromethyl pyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 16 h / 210 °C / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
nicotinic acid
59-67-6

nicotinic acid

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 14 h / 210 °C / 1500.15 - 27752.8 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 64 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 72 h / 185 °C / 18751.9 - 30003 Torr / Autoclave
2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave
3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave
View Scheme
3,6-dichloro-5-(trifluoromethyl)pyridin-2-amine
79456-29-4

3,6-dichloro-5-(trifluoromethyl)pyridin-2-amine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With sulfuric acid; tetrabutylammomium bromide; dipotassium dicarbonochloridate; zinc at 30℃; for 7h; Temperature; Reagent/catalyst;23.8 g
2-aminopyridine
504-29-0

2-aminopyridine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / tetrahydrofuran / -5 - 5 °C
2: N-chloro-succinimide / tetrahydrofuran / 15 h / 80 - 90 °C
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 6 h / 55 - 105 °C
View Scheme
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 20 deg C, 1 h;99%
With pyridine; hydrogen fluoride; sodium nitrite 1.) 0 deg C, 30 min; 2.) 20 deg C, 1 h; Yield given. Multistep reaction;
2,4-dichloro-3,5-dinitro-benzotrifluoride
29091-09-6

2,4-dichloro-3,5-dinitro-benzotrifluoride

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

fluazinam
79622-59-6

fluazinam

Conditions
ConditionsYield
With potassium hydroxide In 2-methyltetrahydrofuran at 20℃; for 4h; Concentration; Temperature; Solvent;98%
Stage #1: 2,4-dichloro-3,5-dinitro-benzotrifluoride; 2-amino-3-chloro-5-(trifluoromethyl)pyridine With methoxybenzene; potassium hydroxide at 55℃; for 6h;
Stage #2: With hydrogenchloride at 85℃; pH=3.7; Temperature; Reagent/catalyst; pH-value;
98.5%
With edetate disodium; potassium hydroxide In acetonitrile at 0 - 5℃; for 3h; Reagent/catalyst; Temperature;97.5%
2,4-di-tert-Butylphenol
96-76-4

2,4-di-tert-Butylphenol

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxy-3,5-(di-tert-butyl)benzene

1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxy-3,5-(di-tert-butyl)benzene

Conditions
ConditionsYield
With potassium tert-butylate In ammonia at -78℃; for 2.5h; Irradiation;98%
2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
784144-05-4

5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Conditions
ConditionsYield
With potassium phosphate; magnesium sulfate; acetic acid; bis(tri-t-butylphosphine)palladium(0) In N,N-dimethyl acetamide at 140℃; for 4h;97%
3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

5-(trifluoromethyl)-[3,3']bipyridinyl-2-ylamine

5-(trifluoromethyl)-[3,3']bipyridinyl-2-ylamine

Conditions
ConditionsYield
With potassium phosphate; XPhos; tris(dibenzylideneacetone)dipalladium (0) In butan-1-ol at 120℃; for 24h; Suzuki-Miyaura cross-coupling;95%
With potassium phosphate; 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; tris(dibenzylideneacetone)dipalladium (0) In butan-1-ol at 120℃; for 24h; Suzuki-Miyaura reaction;95%
2-formylthiophene-3-boronic acid
4347-31-3

2-formylthiophene-3-boronic acid

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

C11H5F3N2S

C11H5F3N2S

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 75℃; for 0.583333h; Suzuki-Miyaura Coupling; Microwave irradiation; Green chemistry;95%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

8-chloro-6-(trifluoromethyl)imidazo[1,2,a]pyridine-2-carboxylic acid ethyl ester
353258-31-8

8-chloro-6-(trifluoromethyl)imidazo[1,2,a]pyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
In ethanol at 20 - 80℃; for 12h;93%
In ethanol at 80℃; for 48h;86%
In ethanol at 80℃; for 48h;86%
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

Benzoyl isothiocyanate
532-55-8

Benzoyl isothiocyanate

N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamothioyl)benzamide

N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamothioyl)benzamide

Conditions
ConditionsYield
In acetone at 56℃; for 48h;93%
In tetrahydrofuran at 60℃; for 15h;21%
cyclohexanone
108-94-1

cyclohexanone

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

4-chloro-2-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

4-chloro-2-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With iodine; oxygen In 1,1,2,2-tetrachloroethane at 160℃; for 24h; Green chemistry;92%
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

β-naphthol
135-19-3

β-naphthol

1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxynaphthalene

1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxynaphthalene

Conditions
ConditionsYield
With potassium tert-butylate In ammonia at -78℃; for 4h; Irradiation;90%
formaldehyd
50-00-0

formaldehyd

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

(3aR,10aR)-6-Chloro-8-trifluoromethyl-3a,10a-dihydro-3H,4H-cyclopenta[e]pyrido[1,2-a]pyrimidine

(3aR,10aR)-6-Chloro-8-trifluoromethyl-3a,10a-dihydro-3H,4H-cyclopenta[e]pyrido[1,2-a]pyrimidine

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile for 1h; Heating;90%
4-hydroxycoumarin-3-carboxaldehyde
51751-34-9

4-hydroxycoumarin-3-carboxaldehyde

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

3-(3-(tert-butylamino)-8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

3-(3-(tert-butylamino)-8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

Conditions
ConditionsYield
With acetic acid In methanol at 70℃; for 2h; Sealed tube;90%
formaldehyd
50-00-0

formaldehyd

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

1-indene
95-13-6

1-indene

(6aS,11bR)-4-Chloro-2-trifluoromethyl-6,6a,7,11b-tetrahydro-5,11c-diaza-benzo[c]fluorene

(6aS,11bR)-4-Chloro-2-trifluoromethyl-6,6a,7,11b-tetrahydro-5,11c-diaza-benzo[c]fluorene

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile for 1h; Heating;88%
4-hydroxycoumarin-3-carboxaldehyde
51751-34-9

4-hydroxycoumarin-3-carboxaldehyde

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

3-(8-chloro-6-(trifluoromethyl)-3-((2,4,4-trimethylpentan-2-yl)amino)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

3-(8-chloro-6-(trifluoromethyl)-3-((2,4,4-trimethylpentan-2-yl)amino)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

Conditions
ConditionsYield
With acetic acid In methanol at 70℃; for 2h; Sealed tube;88%
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

2-<2-amino-5-(trifluoromethyl)pyridin-3-ylsulfanyl>ethanol

2-<2-amino-5-(trifluoromethyl)pyridin-3-ylsulfanyl>ethanol

Conditions
ConditionsYield
With potassium tert-butylate for 1h; Irradiation;85%
formaldehyd
50-00-0

formaldehyd

cyclohexa-1,3-diene
1165952-91-9

cyclohexa-1,3-diene

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

(6aR,10aR)-4-Chloro-2-trifluoromethyl-6a,7,8,10a-tetrahydro-6H-pyrido[1,2-a]quinazoline

(6aR,10aR)-4-Chloro-2-trifluoromethyl-6a,7,8,10a-tetrahydro-6H-pyrido[1,2-a]quinazoline

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile for 1h; Heating;85%
2-methyl-benzyl alcohol
89-95-2

2-methyl-benzyl alcohol

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol

2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol

Conditions
ConditionsYield
at 20℃; for 0.0666667h; microwave irradiation;76%
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

bromoacetaldehyde
17157-48-1

bromoacetaldehyde

8-Chloro-6-trifluoromethyl-imidazo[1,2-a]pyridine
178488-36-3

8-Chloro-6-trifluoromethyl-imidazo[1,2-a]pyridine

Conditions
ConditionsYield
In ethanol Heating;75%
ethyl 4,4,4-trifluoro-2-butynate
79424-03-6

ethyl 4,4,4-trifluoro-2-butynate

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

9-chloro-4,7-bistrifluoromethylpyrido[1,2-a]pyrimidin-2-one

9-chloro-4,7-bistrifluoromethylpyrido[1,2-a]pyrimidin-2-one

Conditions
ConditionsYield
In ethanol at 20℃; for 20h; Inert atmosphere;75%
2-Picolinic acid
98-98-6

2-Picolinic acid

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)picolinamide
1210410-12-0

N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)picolinamide

Conditions
ConditionsYield
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 24h; Reflux;74%
2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

propargyl bromide
106-96-7

propargyl bromide

5-trifluoromethyl-3-chloro-2-amino-1-(2-propynyl)pyridinium bromide

5-trifluoromethyl-3-chloro-2-amino-1-(2-propynyl)pyridinium bromide

Conditions
ConditionsYield
In isopropyl alcohol; toluene at 80℃; for 2h;74%
styrene
292638-84-7

styrene

formaldehyd
50-00-0

formaldehyd

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

9-Chloro-4-phenyl-7-trifluoromethyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine

9-Chloro-4-phenyl-7-trifluoromethyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile for 1h; Heating;70%
formaldehyd
50-00-0

formaldehyd

1-Phenylcyclohexene
771-98-2

1-Phenylcyclohexene

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

(6aS,10aS)-4-Chloro-10a-phenyl-2-trifluoromethyl-6a,7,8,9,10,10a-hexahydro-6H-pyrido[1,2-a]quinazoline

(6aS,10aS)-4-Chloro-10a-phenyl-2-trifluoromethyl-6a,7,8,9,10,10a-hexahydro-6H-pyrido[1,2-a]quinazoline

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile for 1h; Heating;70%
2,2-dihydroxy-1-phenyl-ethanone
1075-06-5

2,2-dihydroxy-1-phenyl-ethanone

dimedone
126-81-8

dimedone

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

2-(8-chloro-2-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-3-hydroxy-5,5-dimethylcyclohex-2-enone

2-(8-chloro-2-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-3-hydroxy-5,5-dimethylcyclohex-2-enone

Conditions
ConditionsYield
With iodine In ethanol at 130℃; for 0.25h; Microwave irradiation;68%
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

2,2-dihydroxy-1-phenyl-ethanone
1075-06-5

2,2-dihydroxy-1-phenyl-ethanone

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

3-(8-chloro-2-phenyl-6-(triuoromethyl)imidazo[1,2-a]pyridin-3-yl)-4-hydroxy-2H-chromen-2-one

3-(8-chloro-2-phenyl-6-(triuoromethyl)imidazo[1,2-a]pyridin-3-yl)-4-hydroxy-2H-chromen-2-one

Conditions
ConditionsYield
With iodine In ethanol at 130℃; for 0.25h; Microwave irradiation;65%
hexafluoroacetone ethoxycarbonylimine
19846-30-1

hexafluoroacetone ethoxycarbonylimine

2-amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1

2-amino-3-chloro-5-(trifluoromethyl)pyridine

9-chloro-2,2,7-tris(trifluoromethyl)-2,3-dihydropyrido[1,2-a][1,3,5]triazin-4(3H)-one

9-chloro-2,2,7-tris(trifluoromethyl)-2,3-dihydropyrido[1,2-a][1,3,5]triazin-4(3H)-one

Conditions
ConditionsYield
Stage #1: hexafluoroacetone ethoxycarbonylimine; 2-amino-3-chloro-5-(trifluoromethyl)pyridine In N,N-dimethyl-formamide
Stage #2: With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 1h; Heating;
63%

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