As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryTianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiryChemical Name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Cas No.: 827026-45-9 Molecular Formula: C13H11N3O5 Molecular Weight: 289.24354 Molecular Structure: A
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
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inquiry3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione CAS:827026-45-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courier Dange
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryadvantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging
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inquiryAdvantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:827026-45-9
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiry3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Basic information Product Name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Synonyms: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione;3-(4-Nitro-1
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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inquiryrac-α-aminoglutarimide hydrochloride
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Stage #1: rac-α-aminoglutarimide hydrochloride With triethylamine In dimethyl sulfoxide for 0.166667h; Inert atmosphere; Stage #2: 2-bromomethyl-3-nitro-benzoic acid methyl ester In dimethyl sulfoxide at 50 - 55℃; for 12.3333h; Inert atmosphere; | 99.73% |
With sodium carbonate at 100℃; for 0.75h; Reagent/catalyst; Temperature; Inert atmosphere; | 98.5% |
With sodium carbonate In acetonitrile at 70℃; for 8h; Solvent; Reagent/catalyst; Temperature; | 98.8% |
2-bromomethyl-3-nitro-benzoic acid methyl ester
(+/-)-α-aminoglutarimide
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 3h; Reflux; | 96% |
Stage #1: 2-bromomethyl-3-nitro-benzoic acid methyl ester; (+/-)-α-aminoglutarimide With sodium carbonate In acetonitrile at 5℃; Inert atmosphere; Reflux; Large scale; Stage #2: With hydrogenchloride In water at 20 - 62℃; for 4h; pH=< 6; Large scale; | 79.5% |
With triethylamine In N,N-dimethyl-formamide at 25 - 100℃; for 7h; Inert atmosphere; | |
With potassium hydrogencarbonate In acetonitrile Reflux; | |
With triethylamine In N,N-dimethyl-formamide at 75℃; for 20h; |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ5-benzo[d][1,2]-iodoxol-1-ol anion In water at 50 - 70℃; | 94.1% |
With tert.-butylhydroperoxide; copper(ll) sulfate pentahydrate; oxygen In 1,4-dioxane at 70℃; for 3h; Temperature; Reagent/catalyst; Solvent; | 78% |
rac-α-aminoglutarimide hydrochloride
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 80℃; for 10h; | 93.2% |
2-methyl-3-nitro-benzoic acid methyl ester
(+/-)-α-aminoglutarimide
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With N,N,N,N,-tetramethylethylenediamine; zinc dibromide In 1,4-dioxane at 95℃; Temperature; | 90.7% |
2-amino-3-tert-butoxypropionic acid
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Stage #1: 2-amino-3-tert-butoxypropionic acid; 2-bromomethyl-3-nitro-benzoic acid methyl ester With sodium hydrogencarbonate In acetonitrile at 5 - 20℃; Reflux; Stage #2: With hydrogenchloride In water at 58 - 62℃; for 4.16667h; pH=< 6; Temperature; Time; | 79.5% |
4-carbamoyl-4-(4-nitro-1-oxo-1,3-dihydroisoindol-2-yl)butyric acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide at 0℃; | 78% |
(+/-)-α-aminoglutarimide
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With ammonium hydroxide In N,N-dimethyl-formamide for 2h; Reflux; | 75% |
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 20 - 50℃; for 40.5h; Inert atmosphere; | 73% |
3-aminopiperidine-2,6-dione hydrobromide
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20 - 80℃; for 10h; | 65.2% |
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl acetamide at 85℃; for 4h; | 56% |
2-methyl-3-nitro-benzoic acid methyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NBS / CCl4 / Heating; Irradiation 2: Et3N / dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 93 h / Reflux 2.1: acetonitrile / 0.25 h / 20 °C 2.2: 7 h / 20 °C / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / chlorobenzene / 6 h / 90 - 95 °C / Inert atmosphere 2: triethylamine / N,N-dimethyl-formamide / 7 h / 25 - 100 °C / Inert atmosphere View Scheme |
Cbz-L-Gln
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: Et3N / dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.5 h / 25 - 70 °C 2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 25 - 35 °C 2.2: 6 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 3 steps 1: dmap; 1,1'-carbonyldiimidazole / 1,4-dioxane / 15 h / 100 °C 2: hydrogen bromide; acetic acid / 1 h / 60 °C 3: triethylamine / acetonitrile / 10 h / 20 - 80 °C View Scheme |
3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 2: Et3N / dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen bromide; acetic acid / 1 h / 60 °C 2: triethylamine / acetonitrile / 10 h / 20 - 80 °C View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With formamide at 160 - 170℃; Product distribution / selectivity; |
2-(4-nitro-1-oxo-1,3-dihydroisoindol-2-yl)glutaric acid dimethyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With formamide at 160 - 170℃; Product distribution / selectivity; | |
With sodium amide In tetrahydrofuran; water at 20℃; Product distribution / selectivity; |
N-benzyloxycarbonyl-L-isoglutamine
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / Reflux 2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 23 h / 760.05 Torr 3.1: acetonitrile / 0.25 h / 20 °C 3.2: 7 h / 20 °C / Reflux View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 23 h / 760.05 Torr 2.1: acetonitrile / 0.25 h / 20 °C 2.2: 7 h / 20 °C / Reflux View Scheme |
2-bromomethyl-3-nitro-benzoic acid methyl ester
3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Stage #1: 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine With palladium 10% on activated carbon; hydrogen In methanol at 25 - 35℃; for 2h; Stage #2: 2-bromomethyl-3-nitro-benzoic acid methyl ester With triethylamine In N,N-dimethyl-formamide at 25 - 35℃; for 6h; | 77 g |
(S)-methyl 5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoate
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,1'-carbonyldiimidazole; dmap / tetrahydrofuran / 48 h / Reflux 2: water; sodium chloride / 4 h / Reflux 3: N,N-dimethyl-formamide / 3 h / Reflux View Scheme |
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; sodium chloride / 4 h / Reflux 2: N,N-dimethyl-formamide / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 20 °C 2: potassium hydrogencarbonate / acetonitrile / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; tert-butyl methyl ether / 0.33 h / 0 °C 2: ammonium hydroxide / N,N-dimethyl-formamide / 2 h / Reflux View Scheme |
Boc-Gln-OH
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / acetonitrile / 20 °C 2: trifluoroacetic acid / dichloromethane / 20 °C 3: potassium hydrogencarbonate / acetonitrile / Reflux View Scheme |
2-methyl-3-nitrobenzic acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / dichloromethane / Reflux 1.2: Reflux 2.1: bromine / tetrachloromethane / 20 °C 3.1: potassium hydrogencarbonate / acetonitrile / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: bis(trichloromethyl) carbonate / N,N-dimethyl-formamide / 6 h / Reflux 2: N-Bromosuccinimide; dibenzoyl peroxide / 8 h / Reflux 3: triethylamine / acetonitrile / 3 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: acetone / 0.17 h / 25 - 30 °C 1.2: 1.5 h / 25 - 30 °C 2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 12 h / 55 - 60 °C 3.1: triethylamine / dimethyl sulfoxide / 0.17 h / Inert atmosphere 3.2: 12.33 h / 50 - 55 °C / Inert atmosphere View Scheme |
L-glutamic acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water / 2 h / 0 °C 2: urea / dimethyl sulfoxide / 2 h / 150 °C 3: hydrogenchloride / dimethyl sulfoxide 4: triethylamine / acetonitrile / 3 h / Reflux View Scheme |
N-benzyloxycarbonyl-L-glutamic acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: urea / dimethyl sulfoxide / 2 h / 150 °C 2: hydrogenchloride / dimethyl sulfoxide 3: triethylamine / acetonitrile / 3 h / Reflux View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper(l) iodide; potassium carbonate / tetrahydrofuran / 6 h / 60 °C 2: 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ5-benzo[d][1,2]-iodoxol-1-ol anion / water / 50 - 70 °C View Scheme |
A
4-NT
B
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
C
3-(4-nitro-3-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With potassium permanganate In water at 50 - 70℃; |
isoindoline
A
4-NT
B
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
C
3-(4-nitro-3-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / 8.5 h / 20 °C / Cooling with ice 2: copper(l) iodide; potassium carbonate / tetrahydrofuran / 6 h / 60 °C 3: potassium permanganate / water / 50 - 70 °C View Scheme |
isoindoline
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / 8.5 h / 20 °C / Cooling with ice 2: copper(l) iodide; potassium carbonate / tetrahydrofuran / 6 h / 60 °C 3: 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ5-benzo[d][1,2]-iodoxol-1-ol anion / water / 50 - 70 °C View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Lenalidomide
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol at 40℃; under 3000.3 Torr; Pressure; Temperature; | 98.2% |
With sodium sulfide; ethanol at 20℃; for 1h; | 98% |
With sodium tetrahydroborate; ammonium chloride In ethanol; water at 90℃; for 1h; Reagent/catalyst; | 98% |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
4-nitro-1-thioxo-2-(2-oxo-6-thioxopiperidine-3-yl)phthalimidine
Conditions | Yield |
---|---|
With Lawessons reagent In toluene for 26h; Inert atmosphere; Reflux; | 85.8% |
With Lawessons reagent In 1,4-dioxane for 5h; Reflux; | 64% |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
(RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione With hydrogen; palladium 10% on activated carbon In methanol at 21 - 35℃; under 2400.24 Torr; for 18h; Stage #2: With hydrogenchloride In water | 83.5% |
methanesulfonic acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol under 4654.46 Torr; | |
With hydrogen; palladium 10% on activated carbon In methanol at 30℃; under 4654.46 Torr; for 3 - 4h; |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
methanesulfonic acid
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione methylsufonate
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol at 30℃; under 4654.46 Torr; | |
With palladium 10% on activated carbon; hydrogen In water at 25 - 30℃; under 4654.46 Torr; |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
(RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrogen sulfate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 42 h / 2362.74 Torr 2: sulfuric acid / water / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 21 - 35 °C / 2400.24 Torr 2: sodium hydrogencarbonate / water / 65 - 70 °C / pH 8 3: sulfuric acid / water / 50 °C View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 42 h / 2362.74 Torr 2: sulfuric acid / acetic acid / 0.75 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 21 - 35 °C / 2400.24 Torr 2: sodium hydrogencarbonate / water / 65 - 70 °C / pH 8 3: sulfuric acid / acetic acid / 0.75 h / 70 °C View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 42 h / 2362.74 Torr 2: sulfuric acid / water / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 21 - 35 °C / 2400.24 Torr 2: sodium hydrogencarbonate / water / 65 - 70 °C / pH 8 3: sulfuric acid / water / 50 °C View Scheme |
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
1,6′-dithiolenalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Lawessons reagent / toluene / 26 h / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; hydrogen / methanol / 69 h / 20 °C View Scheme |
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