Product Name

  • Name

    (2-Bromoethyl)benzene

  • EINECS 203-130-8
  • CAS No. 103-63-9
  • Article Data128
  • CAS DataBase
  • Density 1.366 g/cm3
  • Solubility Miscible with ether, benzene, insoluble in water
  • Melting Point -56 °C
  • Formula C8H9Br
  • Boiling Point 220.5 °C at 760 mmHg
  • Molecular Weight 185.063
  • Flash Point 89.4 °C
  • Transport Information
  • Appearance Colourless to yellow liquid
  • Safety 26-37/39
  • Risk Codes 22-36-36/37/38
  • Molecular Structure Molecular Structure of 103-63-9 ((2-Bromoethyl)benzene)
  • Hazard Symbols HarmfulXn
  • Synonyms 2-Bromoethyl benzene;1-Bromo-2-phenylethane;1-Phenyl-2-bromoethane;2-Bromo-1-phenylethane;2-Phenethyl bromide;2-Phenyl-1-bromoethane;2-Phenylbromoethane;2-Phenylethylbromide;NSC 33926;Phenethyl bromide;Phenylethyl bromide;b-Bromoethylbenzene;b-Phenethyl bromide;b-Phenylethyl bromide;
  • PSA 0.00000
  • LogP 2.62400

Synthetic route

2-phenylethanol
60-12-8

2-phenylethanol

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With hydrogen bromide; Aliquat 336 In chlorobenzene at 85℃; without cat.;98.7%
With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation;97%
With Silphos; bromine In acetonitrile for 0.416667h; Heating;96%
2-phenylethyl mesylate
20020-27-3

2-phenylethyl mesylate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With 1-n-butyl-3-methylimidazolim bromide at 50℃; for 1h; Inert atmosphere; Green chemistry;97%
With lithium bromide In tetrahydrofuran Inert atmosphere; Reflux;94%
ethylbenzene
100-41-4

ethylbenzene

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; silica gel for 4h; UV-irradiation;94%
With dihydrogen peroxide; bromine In dichloromethane; water for 4h; Reagent/catalyst; Reflux;92%
1-fluoro-2-phenylethane
458-87-7

1-fluoro-2-phenylethane

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 0℃; for 0.0833333h;91%
With aluminum tri-bromide In chlorobenzene at 20℃; for 1h;
(2-(methoxymethoxy)ethyl)benzene
54673-12-0

(2-(methoxymethoxy)ethyl)benzene

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With phosphotungstic acid; tetrabutylammomium bromide at 130 - 142℃; for 0.0333333h; Microwave irradiation; Ionic liquid; chemoselective reaction;90%
With tetrabutylammomium bromide; 1-(n-butyl)-3-methylimidazolium tetrachloroindate at 135 - 140℃; for 0.0666667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;83%
4-(4-Chloro-phenyl)-1-phenethyl-2,3,5,6-tetraphenyl-pyridinium; bromide
76192-15-9

4-(4-Chloro-phenyl)-1-phenethyl-2,3,5,6-tetraphenyl-pyridinium; bromide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With 2,4,6-triphenylpyridine at 180 - 220℃; under 0.5 - 1.5 Torr;75%
4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane
165904-22-3

4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; 2-methoxybenzo[d][1,3,2]dioxaborole; benzenesulfonyl bromide In methanol; dichloromethane; benzene at 70℃; for 16h; Inert atmosphere;75%
2-phenylethanol
60-12-8

2-phenylethanol

triphenylphosphine
603-35-0

triphenylphosphine

A

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

B

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

Conditions
ConditionsYield
With carbon tetrabromide In 1,2-dichloro-ethaneA 72%
B n/a
2-phenylethyl mesylate
20020-27-3

2-phenylethyl mesylate

A

styrene
292638-84-7

styrene

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With lithium bromide In N,N-dimethyl-formamide at 120℃; Inert atmosphere;A 17%
B 72%
C22H17NO

C22H17NO

allyl bromide
106-95-6

allyl bromide

A

3,5-diphenyl-4-(2-propen-1-yl)isoxazole
1227781-92-1

3,5-diphenyl-4-(2-propen-1-yl)isoxazole

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With tetrabutylammomium bromide; palladium diacetate In N,N-dimethyl-formamide at 80℃; for 1h;A 68%
B 65 %Spectr.
1-p-Toluolsulfonyl-1-phenethyl-hydrazin
159690-31-0

1-p-Toluolsulfonyl-1-phenethyl-hydrazin

A

toluene-p-sulfonyl bromide
1950-69-2

toluene-p-sulfonyl bromide

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;A n/a
B 67%
2-phenylethanol
60-12-8

2-phenylethanol

A

dibenzyl ether
103-50-4

dibenzyl ether

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
Stage #1: 2-phenylethanol With N,N-dimethylthiourea In dichloromethane at 20℃;
Stage #2: With N-Bromosuccinimide In dichloromethane at 20℃; for 2h;
A n/a
B 64%
1-Phenethyl-2,3,4,5,6-pentaphenyl-pyridinium; bromide
71017-60-2

1-Phenethyl-2,3,4,5,6-pentaphenyl-pyridinium; bromide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With 2,4,6-triphenylpyridine at 180 - 220℃; under 0.5 - 2 Torr;60%
toluene
108-88-3

toluene

1,2-dibromomethane
74-95-3

1,2-dibromomethane

A

1,3-diphenylpropane
1081-75-0

1,3-diphenylpropane

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

C

1,1'-(1,2-ethanediyl)bisbenzene
103-29-7

1,1'-(1,2-ethanediyl)bisbenzene

Conditions
ConditionsYield
Stage #1: toluene With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 3h; Inert atmosphere; Schlenk technique;
Stage #2: 1,2-dibromomethane In tetrahydrofuran; hexane at 20℃; Inert atmosphere; Schlenk technique;
A 1%
B n/a
C n/a
styrene
292638-84-7

styrene

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With dilauryl peroxide; hydrogen bromide; pentane
With ethylbenzene; hydrogen bromide; dibenzoyl peroxide at 95℃;
With hydrogen bromide; nickel; Petroleum ether
bromocyane
506-68-3

bromocyane

N,N-diethylphenethylamine
5300-21-0

N,N-diethylphenethylamine

A

ethyl bromide
74-96-4

ethyl bromide

B

ethyl-phenethyl-carbamonitrile
860767-75-5

ethyl-phenethyl-carbamonitrile

C

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2-phenethoxybenzene
40515-89-7

2-phenethoxybenzene

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 120℃;
With water; boron tribromide In dichloromethane at 20℃; for 0.5h; Inert atmosphere;98 %Chromat.
5,8-Dibrom-1,3-cyclooctadien
53800-00-3

5,8-Dibrom-1,3-cyclooctadien

A

(1-bromoethyl)benzne
585-71-7, 38661-81-3

(1-bromoethyl)benzne

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
under 760 Torr; Erhitzen auf Siedetemperatur;
styrene oxide
96-09-3

styrene oxide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With chloro-trimethyl-silane; 1,1,3,3-Tetramethyldisiloxane; lithium bromide 1.) dry acetonitrile, 5-10 deg C, 2-3 min, 2.) reflux, 15 min; Yield given. Multistep reaction;
With chloro-trimethyl-silane; 1,1,3,3-Tetramethyldisiloxane; lithium bromide 1.) trifluoroacetic acid, 2.) 50 deg C, 15 h; Yield given. Multistep reaction;
ethylbenzene
100-41-4

ethylbenzene

A

2-phenylethyl chloride
622-24-2

2-phenylethyl chloride

B

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

Conditions
ConditionsYield
With bromine; chlorine In various solvent(s) Irradiation;
With bromine; chlorine In various solvent(s) Product distribution; Irradiation; hidrogen selectivity in various photoinitiated halogenations;
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

phenethyl azide
6926-44-9

phenethyl azide

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 80℃;100%
With sodium azide In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere;100%
With sodium azide In N,N-dimethyl-formamide at 85℃;100%
diphenyl diselenide
1666-13-3

diphenyl diselenide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

(2-phenyl-ethyl) phenyl selenide
65275-36-7

(2-phenyl-ethyl) phenyl selenide

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol for 2h; Ambient temperature;100%
With zinc In N,N-dimethyl-formamide at 100℃; for 2h; Inert atmosphere;94%
With indium iodide In dichloromethane at 20℃; for 1h;89%
With sodium tetrahydroborate In ethanol; 1,2-dichloro-ethane at 20℃; Reduction; alkylation;79%
With triphenylphosphine; 1-pentyl-3-methylimidazolium bromide at 75℃; for 5.5h;75%
potassium tert-butylate
865-47-4

potassium tert-butylate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

styrene
292638-84-7

styrene

Conditions
ConditionsYield
In tert-butyl alcohol at 40℃; Rate constant; Mechanism; secondary α-deuterium isotope effects investigated;100%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

SynPhase lantern-OC(O)-C6H4-(NC(O)C6H4NHC(S))

SynPhase lantern-OC(O)-C6H4-(NC(O)C6H4NHC(S))

4-(4-oxo-2-phenethylsulfanyl-4H-quinazolin-3-yl)-benzoic acid

4-(4-oxo-2-phenethylsulfanyl-4H-quinazolin-3-yl)-benzoic acid

Conditions
ConditionsYield
Stage #1: 1-phenyl-2-bromoethane; SynPhase lantern-OC(O)-C6H4-(NC(O)C6H4NHC(S)) With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine at 20℃; for 16h;
Stage #2: With water; trifluoroacetic acid at 20℃; for 1h;
100%
heptanethiol
1639-09-4

heptanethiol

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

(2-heptylsulfanyl-ethyl)-benzene

(2-heptylsulfanyl-ethyl)-benzene

Conditions
ConditionsYield
Stage #1: heptanethiol With tetra-(n-butyl)ammonium iodide; caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 1-phenyl-2-bromoethane In N,N-dimethyl-formamide at 0 - 20℃; for 1h;
100%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2,2-dimethyl-propionic acid 4-(2-phthalimido-ethyl)-imidazol-1-ylmethyl ester
51721-15-4

2,2-dimethyl-propionic acid 4-(2-phthalimido-ethyl)-imidazol-1-ylmethyl ester

1-pivaloyloxymethyl-3-(4-phenylethyl)-4-(2-phthalimidoethyl)imidazolium bromide
281197-46-4

1-pivaloyloxymethyl-3-(4-phenylethyl)-4-(2-phthalimidoethyl)imidazolium bromide

Conditions
ConditionsYield
In acetonitrile for 72h; Heating / reflux;100%
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

1-methyl-3-(2-phenylethyl)imidazolium bromide

1-methyl-3-(2-phenylethyl)imidazolium bromide

Conditions
ConditionsYield
at 140℃; Continuous flow; neat (no solvent);100%
In acetonitrile for 18h; Reflux; Schlenk technique;86%
In toluene for 24h; Reflux; Inert atmosphere;
In toluene for 24h; Reflux; Inert atmosphere;
2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

2,6-diisopropylphenyl isocyanate
28178-42-9

2,6-diisopropylphenyl isocyanate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

N-(2,6-diisopropylphenyl)-2-(2,6-dimethylphenylimino)-4-phenylbutanamide
1392826-44-6

N-(2,6-diisopropylphenyl)-2-(2,6-dimethylphenylimino)-4-phenylbutanamide

Conditions
ConditionsYield
Stage #1: 2,6-dimethylphenyl isonitrile; 1-phenyl-2-bromoethane With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -15℃; for 3h;
Stage #2: 2,6-diisopropylphenyl isocyanate In tetrahydrofuran at -78℃;
100%
2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

phenyl isocyanate
103-71-9

phenyl isocyanate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2-(2,6-dimethylphenylamino)-N,4-diphenylbutanamide
1392826-54-8

2-(2,6-dimethylphenylamino)-N,4-diphenylbutanamide

Conditions
ConditionsYield
Stage #1: 2,6-dimethylphenyl isonitrile; 1-phenyl-2-bromoethane With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -15℃; for 3h;
Stage #2: phenyl isocyanate In tetrahydrofuran at -78℃; for 0.5h;
100%
2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

phenyl isocyanate
103-71-9

phenyl isocyanate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2-(2,6-dimethylphenylimino)-N,4-diphenylbutanamide
1392826-40-2

2-(2,6-dimethylphenylimino)-N,4-diphenylbutanamide

Conditions
ConditionsYield
Stage #1: 2,6-dimethylphenyl isonitrile; 1-phenyl-2-bromoethane With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -15℃; for 3h;
Stage #2: phenyl isocyanate In tetrahydrofuran at -78℃;
100%
2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

4-Methoxyphenyl isocyanate
5416-93-3

4-Methoxyphenyl isocyanate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2-(2,6-dimethylphenylimino)-N-(4-methoxyphenyl)-4-phenylbutanamide
1392826-41-3

2-(2,6-dimethylphenylimino)-N-(4-methoxyphenyl)-4-phenylbutanamide

Conditions
ConditionsYield
Stage #1: 2,6-dimethylphenyl isonitrile; 1-phenyl-2-bromoethane With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -15℃; for 3h;
Stage #2: 4-Methoxyphenyl isocyanate In tetrahydrofuran at -78℃;
100%
phenyltin trichloride
1124-19-2

phenyltin trichloride

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

tri(2-phenylethyl)(phenyl)stannane
97664-42-1

tri(2-phenylethyl)(phenyl)stannane

Conditions
ConditionsYield
Stage #1: 1-phenyl-2-bromoethane With iodine; magnesium In diethyl ether Inert atmosphere; Reflux;
Stage #2: phenyltin trichloride In diethyl ether; n-heptane at 0 - 20℃; Inert atmosphere;
100%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

1-(2-bromophenyl)-3-phenylpropan-1-ol

1-(2-bromophenyl)-3-phenylpropan-1-ol

Conditions
ConditionsYield
Stage #1: 1-phenyl-2-bromoethane With iodine; magnesium In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;
Stage #2: ortho-bromobenzaldehyde In tetrahydrofuran for 4h; Inert atmosphere; Reflux;
100%
carbon dioxide
124-38-9

carbon dioxide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

diphenethyl carbonate
67879-62-3

diphenethyl carbonate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 80℃; under 760.051 Torr; for 18h; Temperature;99.5%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

1-benzylnicotinium bromide

1-benzylnicotinium bromide

C25H30N2(2+)*2I(1-)

C25H30N2(2+)*2I(1-)

Conditions
ConditionsYield
In diethylene glycol dimethyl ether; acetonitrile for 8h; Heating;99.1%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

1-(2-ethoxyethyl)-2-(1-piperazinyl)-1H-benzimidazole
87233-69-0

1-(2-ethoxyethyl)-2-(1-piperazinyl)-1H-benzimidazole

1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-1H-benzoimidazole
101954-16-9

1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-1H-benzoimidazole

Conditions
ConditionsYield
With potassium carbonate In ethanol at 65℃; for 5h;99%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

triphenylphosphine
603-35-0

triphenylphosphine

(2-phenylethyl)triphenylphosphonium bromide
53213-26-6

(2-phenylethyl)triphenylphosphonium bromide

Conditions
ConditionsYield
at 100℃; for 2h; Addition;99%
In neat (no solvent) at 120℃; for 22h;99%
In benzene for 24h; Heating;92%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

β-naphthaldehyde
66-99-9

β-naphthaldehyde

2,2,2-tris(methylthio)-1-(2-naphthyl)ethanol
170654-26-9

2,2,2-tris(methylthio)-1-(2-naphthyl)ethanol

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h;99%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

pyridine-3,4-dicarboxylic acid diisopropyl ester

pyridine-3,4-dicarboxylic acid diisopropyl ester

4-phenethyl-1,4-dihydro-pyridine-3,4-dicarboxylic acid diisopropyl ester

4-phenethyl-1,4-dihydro-pyridine-3,4-dicarboxylic acid diisopropyl ester

Conditions
ConditionsYield
Stage #1: pyridine-3,4-dicarboxylic acid diisopropyl ester With ammonia; sodium In tetrahydrofuran at -78℃; for 0.25h;
Stage #2: 1-phenyl-2-bromoethane In tetrahydrofuran for 10h;
99%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

α-bromoacetophenone
70-11-1

α-bromoacetophenone

Conditions
ConditionsYield
With Iron(III) nitrate nonahydrate; 1-hydroxy-pyrrolidine-2,5-dione; oxygen In benzonitrile at 90℃; for 20h;99%
With 3,6-bis(triphenylphosphonium)cyclohexene peroxodisulfate In water; acetonitrile for 0.416667h; Heating;84%
With 1,4-bis(triphenylphosphonium)butane cerium nitrate In water; acetic acid for 0.833333h; Reflux;75%
With oxygen; Langlois reagent In acetonitrile at 25℃; under 760.051 Torr; for 12h; Irradiation; Green chemistry;98 %Chromat.
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

diphenylphosphane
829-85-6

diphenylphosphane

(2-phenylethyl)diphenylphosphane
5952-49-8

(2-phenylethyl)diphenylphosphane

Conditions
ConditionsYield
With cesium hydroxide; 4 Angstroem MS In N,N-dimethyl-formamide at 23℃; for 29h;99%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

phenylacetylene
536-74-3

phenylacetylene

1-phenethyl-4-phenyl-1H-[1,2,3]triazole

1-phenethyl-4-phenyl-1H-[1,2,3]triazole

Conditions
ConditionsYield
With sodium azide In ethanol at 80℃; for 8h; regioselective reaction;99%
With sodium azide In ethanol at 80℃; for 8h;98%
With sodium azide In water at 60℃; for 5h; Temperature; Green chemistry; regioselective reaction;97%
2,5-dimethoxythiophenol
1483-27-8

2,5-dimethoxythiophenol

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

1,4-dimethoxy-2-(2-phenethyl)thiobenzene
849919-63-7

1,4-dimethoxy-2-(2-phenethyl)thiobenzene

Conditions
ConditionsYield
Stage #1: 2,5-dimethoxythiophenol With potassium hydroxide In methanol for 1h;
Stage #2: 1-phenyl-2-bromoethane In methanol for 0.5h; Heating;
99%
chlorodiisopropylsilane
2227-29-4

chlorodiisopropylsilane

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

diisopropyl(phenethyl)silane

diisopropyl(phenethyl)silane

Conditions
ConditionsYield
Stage #1: 1-phenyl-2-bromoethane With iodine; magnesium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: chlorodiisopropylsilane In tetrahydrofuran for 18h; Reflux; Inert atmosphere;
99%
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

N-phenylethylhydroxylamine
3217-93-4

N-phenylethylhydroxylamine

Conditions
ConditionsYield
With hydroxylamine monohydrate In methanol at 100℃; under 18100.7 Torr; for 0.166667h; Flow reactor; chemoselective reaction;99%
2-bromothiophenol
6320-02-1

2-bromothiophenol

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

(2-bromophenyl)(phenethyl)sulfane

(2-bromophenyl)(phenethyl)sulfane

Conditions
ConditionsYield
Stage #1: o-bromothiophenol With sodium hydride; potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.333333h;
Stage #2: 1-phenyl-2-bromoethane In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃;
99%

(2-Bromoethyl)benzene Specification

The 2-Phenylethyl bromide with CAS registry number of 103-63-9 is also known as Benzene,(2-bromoethyl)-. The IUPAC name is 2-Bromoethylbenzene. Its EINECS registry number is 203-130-8. In addition, the formula is C8H9Br and the molecular weight is 185.08. This chemical is a colourless to yellow liquid that miscible with ether, benzene but insoluble in water. It may cause damage to health and should be stored away from oxidants. What's more, this chemical is used as pharmaceutical and pesticide intermediates, and it is also used for organic synthesis.

Physical properties about 2-Phenylethyl bromide are: (1)ACD/LogP: 3.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.09; (4)ACD/LogD (pH 7.4): 3.09; (5)ACD/BCF (pH 5.5): 131.12; (6)ACD/BCF (pH 7.4): 131.12; (7)ACD/KOC (pH 5.5): 1141.38; (8)ACD/KOC (pH 7.4): 1141.38; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.556; (11)Molar Refractivity: 43.53 cm3; (12)Molar Volume: 135.4 cm3; (13)Surface Tension: 37.8 dyne/cm; (14)Density: 1.366 g/cm3; (15)Flash Point: 89.4 °C; (16)Enthalpy of Vaporization: 43.83 kJ/mol; (17)Boiling Point: 220.5 °C at 760 mmHg; (18)Vapour Pressure: 0.167 mmHg at 25 °C.

Preparation of 2-Phenylethyl bromide: it is prepared by reaction of phenylethanol with hydrogen bromide. Firstly, phenylethanol is heated to 110 °C and hydrogen bromide is slowly passed into for refluxing. After reaction, the reaction mixture is cooled, washed with water, 10% sodium carbonate solution and water by turns. At last, product is obtained by drying with anhydrous potassium carbonate, vacuum distillation and collecting distillate at 97-99 °C. The yield is about 90%.

Uses of 2-Phenylethyl bromide: it is used to produce 1-phenethyl-piperidine by reaction with piperidine. The reaction occurs with solvent toluene and other condition of heating for 24 hours. The yield is about 36%.

2-Phenylethyl bromide is used to produce 1-phenethyl-piperidine by reaction with piperidine.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, it is harmful if swallowed. During using it, wear suitable gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC=C(C=C1)CCBr
2. InChI: InChI=1S/C8H9Br/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2
3. InChIKey: WMPPDTMATNBGJN-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 811mg/kg (811mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. OTS0536710,

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