(R)-(+)-1,1'-Bi-2-naphthol supplier

Name
(R)-(+)-1,1'-Bi-2-naphthol
EINECS 210-014-0
CAS No. 18531-94-7
Article Data152
CAS DataBase
Density 1.301 g/cm³
Solubility Dioxane: 50 mg/mL, clear
Melting Point 215-218 °C
Formula C₂₀H₁₄O₂
Boiling Point 388.69°C (rough estimate)
Molecular Weight 286.33
Flash Point
Transport Information UN 2811 6.1/PG 3
Appearance white to light yellow crystal powder
Safety 26-45-24/25-36
Risk Codes 25-36-36/37/38
Molecular Structure
Hazard Symbols T,Xi
Synonyms (R)-BINOLR-(-)-2,2'-Dihydroxy-1,1'-binaphthyl;(R)-(+)-BINOL18531-94-7;(R)-(+)-1,1\'-Bi-2-naphthol;R-(+)-1,1'-Bi-2-Naphthol;R(+)-1,1'- bi-2-naphthol;(R)-(+)-BINOL;(R)-(+)-1,1'-Bi(2-naphthol);(R)-(+)-1,1-Bi-2-naphthol;R-(+)-1,1'-binaphthyl-2,2'-diol;(R)-BINOL;R-Binol;
PSA 40.46000
LogP 5.07120

Synthetic route

: C25H22O3

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; water at 24℃; for 16h; Inert atmosphere;	A n/a B 98%

: 602-09-5
1,1'-bi-2-naphthol

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
Stage #1: 1,1'-bi-2-naphthol With copper(l) chloride; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine In methanol; dichloromethane at -20 - 20℃; for 24h; Inert atmosphere; Darkness; Stage #2: With sodium hydrogencarbonate In methanol; dichloromethane; water at -20℃; optical yield given as %ee; enantioselective reaction;	96%
Multistep reaction;	86%
Stage #1: 1,1'-bi-2-naphthol With (3R)-3-propyl-4-((S)-1'-phenylethylamino)butanoic acid; (3S)-3-propyl-4-((S)-1'-phenylethylamino)butanoic acid In methanol at 60℃; for 1h; Resolution of racemate; Stage #2: With (3R)-3-propyl-4-((R)-1'-phenylethylamino)butanoic acid; (3S)-3-propyl-4-((R)-1'-phenylethylamino)butanoic acid In methanol at 60℃; for 1h; Resolution of racemate; Stage #3: With hydrogenchloride In water; ethyl acetate	68%

: 6708-06-1, 19943-27-2, 20873-90-9, 36588-47-3, 36588-48-4, 53990-71-9, 53990-72-0
(5aS,10aS)-octahydrodipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-dione

: 602-09-5
1,1'-bi-2-naphthol

A: C20H14O2*C10H14N2O2

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
In ethyl acetate for 2h; Reflux; Resolution of racemate; Green chemistry;	A n/a B 96%

...Expand

: 602-09-5
1,1'-bi-2-naphthol

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol

Conditions

Conditions	Yield
With N-benzylcinchoninium chloride In acetonitrile for 4h; resolution of racemate; Heating;	A 95% B 95%
With (-)-N-benzylcinchonidinium chloride In acetonitrile for 4h; Heating;	A 83% B n/a
Stage #1: 1,1'-bi-2-naphthol With dimethylsulfide borane complex In tetrahydrofuran; toluene at 80℃; for 0.5h; Inert atmosphere; Stage #2: With Quinine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; Stage #3: With hydrogenchloride In water at 20℃; for 0.5h; Inert atmosphere;	A n/a B 46%

: 135-19-3
β-naphthol

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol

Conditions

Conditions	Yield
With oxygen; oxovanadium(IV) In tetrachloromethane at 20℃; for 144h;	A 94% B n/a
With dexamfetamine; copper dichloride In methanol Product distribution; Mechanism; stereoselectivity of the coupling reaction with various optically active amines; variation of the temperature;
With dexamfetamine; copper dichloride In methanol at 25℃; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: N-(2-((2'-hydroxy-[1,1'-binaphthalen]-2-yl)oxy)octyl)-3,5-dinitrobenzamide

A: N-(2-chlorooctyl)-3,5-dinitrobenzamide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With boron trichloride In n-heptane; dichloromethane at 25℃; for 24h; Inert atmosphere;	A 76% B 85%

: 135-19-3
β-naphthol

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With oxygen; C26H28N2O9V2 In tetrachloromethane at 0℃; for 168 - 192h; Product distribution / selectivity;	84%
With C34H36N2O10V2 In dichloromethane at 30℃; for 24h; enantioselective reaction;	100 %Spectr.
Multi-step reaction with 3 steps 1: iron(III) chloride / water / Reflux 2: triethylamine; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere; Resolution of racemate 3: potassium hydroxide / methanol; 1,4-dioxane / 20 °C View Scheme

: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate)

: 100-58-3
phenylmagnesium bromide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

B: 4850-72-0
(-)-(S)-tert-butyl phenyl sulfoxide

Conditions

Conditions	Yield
Stage #1: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate); phenylmagnesium bromide In tetrahydrofuran at -78 - -20℃; Inert atmosphere; Stage #2: With water; ammonium chloride In tetrahydrofuran at -20 - 20℃; Inert atmosphere; optical yield given as %ee;	A n/a B 84%

...Expand

: (R)-2'-hydroxy-[1,1'-binaphthalen]-2-yl (1R,4S)-1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; methanol at 20℃;	84%

: (R)-(+)-1-(2-hydroxynapthalen-1-yl)napthalen-2-yl acetate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With potassium carbonate In methanol at 20℃; for 0.166667h; Inert atmosphere;	83%
With methanol; potassium carbonate

: C26H24O5

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -78℃;	80%

: 96026-44-7
[1,1']Binaphthalenyl-2,2'-diol; compound with 1-((R)-methanesulfinyl)-3-methyl-benzene

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

B: 84413-69-4
(R)-1-methyl-3-(methylsulfinyl)benzene

Conditions

Conditions	Yield
In benzene	A 77% B 77%

: 147-85-3
L-proline

: 602-09-5
1,1'-bi-2-naphthol

: (S)-proline (S)-1,1'-bi-2-naphthol 1:2 complex

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
In acetonitrile for 3h; Reflux;	A 76% B 38%

...Expand

: 93274-50-1
C34H18N2O8

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 5457-32-9, 50573-78-9
6,6′-dinitro[1,1′-biphenyl]-2,2′-dicarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol	A 73% B 65%

: 124583-86-4, 124583-87-5, 124648-60-8
(+/-)-1,1'-Binaphthyl-2,2'-diyl phosphorochloridate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride	73%

: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate)

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

B: (-)-(S)-tert-butyl (4-methoxyphenyl) sulfoxide

Conditions

Conditions	Yield
Stage #1: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate); 4-methoxyphenyl magnesium bromide In tetrahydrofuran at -78 - -20℃; Inert atmosphere; Stage #2: With water; ammonium chloride In tetrahydrofuran at -20 - 20℃; Inert atmosphere; optical yield given as %ee;	A n/a B 73%

...Expand

: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate)

: 703-55-9
1-naphthylmagnesiumbromide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

B: 203503-64-4
(S)-1-<(2-Methylprop-2-yl)sulfinyl>naphthalene

Conditions

Conditions	Yield
Stage #1: (R,S(S),S(S))-1,1'-binaphthalene-2,2'-diyl bis-(tert-butylsulfinate); 1-naphthylmagnesiumbromide In tetrahydrofuran at -78 - -20℃; Inert atmosphere; Stage #2: With water; ammonium chloride In tetrahydrofuran at -20 - 20℃; Inert atmosphere; optical yield given as %ee;	A n/a B 71%

...Expand

: (R)-(+)-2'-Hydroxy-1,1'-binaphthyl-2-yl (4aS,9R,10aS)-1,2,3,4,4a,9,10,10a-octahydro-6-methoxy-1,1,4a-trimethylphenanthrene-9-carboxylate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

B: 303962-65-4
(4aS,9S,10aS)-1,2,3,4,4a,9,10,10a-Octahydro-6-methoxy-1,1,4a-trimethylphenanthrene-9-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 24h; Hydrolysis; Heating;	A n/a B 67%

: C26H29N2O(1+)*C20H14O2*Cl(1-)

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

Conditions

Conditions	Yield
With hydrogenchloride	60%

: 135-19-3
β-naphthol

A: 633-99-8
1-chloro-2-naphthol

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol

Conditions

Conditions	Yield
With L-proline; copper dichloride at 60℃; for 0.5h; Neat (no solvent); optical yield given as %ee; enantioselective reaction;	A 60% B n/a C n/a

...Expand

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 65283-60-5
(R)-6,6'-dibromo-1,1'-binaphth-2-ol

Conditions

Conditions	Yield
With bromine In dichloromethane at -78℃; Inert atmosphere;	100%
With bromine at -78℃;	99.9%
With bromine In dichloromethane at -75 - 20℃; for 3h;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 74-88-4
methyl iodide

: 35294-28-1
(R)-2,2'-dimethoxy-1,1'-dinaphthyl

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	100%
With potassium carbonate In acetone Reflux;	100%
With potassium carbonate In acetone for 20h; Schlenk technique; Inert atmosphere; Reflux;	100%

: 74-96-4
ethyl bromide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (R)-(+)-2,2'-diethoxy-1,1'-binaphthalene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 24h;	100%
With caesium carbonate In acetone at 25℃; for 3h;	99%
With potassium carbonate; sodium iodide	98%
With potassium carbonate In acetonitrile Reflux;	98%
With potassium carbonate In acetone at 90℃; for 24h;

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: [(R)-1,1'-binaphthyl-2,2'-diyl]chlorophosphite

Conditions

Conditions	Yield
With triethylamine; phosphorus trichloride In tetrahydrofuran at 0℃; for 6h;	100%
With phosphorus trichloride for 16h; Inert atmosphere; Reflux;	100%
With phosphorus trichloride Reflux; Inert atmosphere;	100%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 107-30-2
chloromethyl methyl ether

: (Ra)-2,2'-bis(methoxy-methyloxy)-1,1'-binaphthalene

Conditions

Conditions	Yield
Stage #1: (R)-1,1'-Bi-2-naphthol With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: chloromethyl methyl ether In tetrahydrofuran at 20℃; for 4.5h;	100%
Stage #1: (R)-1,1'-Bi-2-naphthol With sodium hydride In tetrahydrofuran at 0 - 20℃; activation; Stage #2: chloromethyl methyl ether In tetrahydrofuran at 20℃; for 4.5h; Condensation; Further stages.;	100%
Stage #1: (R)-1,1'-Bi-2-naphthol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 20h; Metallation; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide at 20℃; for 1h; Etherification; Further stages.;	100%

: 358-23-6
trifluoromethylsulfonic anhydride

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 128544-05-8, 128575-34-8, 141807-44-5, 126613-06-7
(R)-(-)-1,1'-bi-2-naphthol triflate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine	100%
With pyridine Inert atmosphere;	100%
With pyridine In dichloromethane at 20℃; for 5h; Inert atmosphere;	100%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 39648-74-3, 65355-00-2, 65355-14-8
(Ra)-5,6,7,8,5',6',7',8'-octahydro-[1,1']binaphthalenyl-2,2'-diol

Conditions

Conditions	Yield
With hydrogen; aluminum oxide; ruthenium In ethanol at 100℃; under 37503 - 45003.6 Torr; for 4h;	100%
With hydrogen; platinum(IV) oxide In acetic acid at 20℃; under 5168.35 Torr; for 72h;	100%
With palladium 10% on activated carbon; hydrogen In ethanol at 70℃; under 37503.8 Torr; for 16h; Autoclave;	100%

: 2969-81-5
4-bromoethylbutanoate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (R)-2,2'-bis(3-carboxypropoxy)-1,1-binaphthyl diethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Heating;	100%
With potassium carbonate In acetone for 96h; Heating / reflux;	68%
With potassium carbonate In acetone for 24h; Reflux;

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 1605-65-8
N,N,N',N'-Tetramethylphosphorodiamidic chloride

: C28H36N4O4P2

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 20℃;	100%
With sodium hydride In tetrahydrofuran at 0℃; for 3h;	99%

: 19438-10-9
methyl 3-hydroxybenzoate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (-)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-3-oxybenzoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (R)-1,1'-Bi-2-naphthol With triethylamine; phosphorus trichloride In tetrahydrofuran at -3 - 20℃; Stage #2: methyl 3-hydroxybenzoate With triethylamine In tetrahydrofuran at 20℃; for 24h; Further stages.;	100%

: 40138-16-7
2-formylbenzene boronic acid

: 2912-98-3
(R)-1-Phenylethylhydroxylamine

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: C35H26BNO3

Conditions

Conditions	Yield
With magnesium sulfate; caesium carbonate In chloroform-d1 at 20℃; for 0.25h;	100%

...Expand

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 581-96-4
2-naphthylacetic acid

: Naphthalen-2-yl-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 4h; Ambient temperature;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 106-95-6
allyl bromide

: (R)-(+)-2,2'-bis(2-propen-1-yloxy)-1,1'-dinaphthyl

Conditions

Conditions	Yield
With potassium carbonate In acetone for 70h; Heating;	99%
With potassium carbonate In acetone for 2h; Heating;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 65-85-0
benzoic acid

: (R)-2'-hydroxy-1,1'-binaphthalene-2-yl benzoate

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 15h; Esterification;	99%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (R)-2,2'-Bis[2-(trimethylsilyl)ethoxymethoxy]-1,1'-binaphthyl

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 2h;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 615257-62-0
C18H34N3P

: {1-[2-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-phenyl]-ethyl}-dimethyl-amine

Conditions

Conditions	Yield
In toluene at 80℃; for 2h;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 1499-21-4
Diphenylphosphinic chloride

: (Ra)-1,1'-binaphthalene-2,2'-bis(diphenylphosphinate)

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 3h;	99%
Stage #1: (R)-1,1'-Bi-2-naphthol With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere; Stage #2: Diphenylphosphinic chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.25h; Inert atmosphere;	96%
Stage #1: (R)-1,1'-Bi-2-naphthol With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Stage #2: Diphenylphosphinic chloride In tetrahydrofuran at 0 - 20℃;
With sodium hydride In tetrahydrofuran at 0 - 20℃;

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 814-49-3
diethyl chlorophosphate

: (R)-[1,1′-binaphthalene]-2,2′-diyl tetraethyl bis(phosphate)

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 3h;	99%
With sodium hydride In tetrahydrofuran at 0 - 20℃;

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 1,1'-binaphthyl-2,2'-diyl sulfite

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In diethyl ether at 0℃;	99%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: C29H22NO2P

Conditions

Conditions	Yield
Stage #1: 1,2,3,4-tetrahydroisoquinoline With triethylamine; phosphorus trichloride In toluene at 0 - 80℃; Inert atmosphere; Stage #2: (R)-1,1'-Bi-2-naphthol With triethylamine In tetrahydrofuran; toluene at -78 - 20℃; Inert atmosphere;	99%

: 1-[(1′S,2′R,5′S)-(+)-menthoxymethyl]-3-methylimidazolium bis(trifluoromethylsulfonyl)imide

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 1184-58-3
dimethylaluminum chloride

: C23H15AlF6NO6S2(1-)*C15H27N2O(1+)

Conditions

Conditions	Yield
In dichloromethane at -15℃; for 1h; Inert atmosphere;	99%

...Expand

: C14H19BrO3

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: C48H50O8

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h; Inert atmosphere;	99%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 77544-68-4
8-tosyloxy-3,6-dioxaoctanol

: (R)-2,2'-bis(8-hydroxy-3,6-dioxa-1-octyloxy)-1,1'-binaphthyl

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Heating;	98.4%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 70101-69-8, 70144-34-2, 70144-35-3
(R)-(-)-4-mercapto-4-sulfide-dinaphtho<2,1-d:1',2'-f><1,3,2>dioxaphosphepin

Conditions

Conditions	Yield
With tetraphosphorus decasulfide In m-xylene at 20℃; for 50h; Inert atmosphere; Reflux;	98%
With tetraphosphorus decasulfide In xylene 1.) reflux, 0.5 h, 2.) room temperature, 48 h;	70%
With diphosphorus pentasulfide In toluene for 24h; Heating;
With diphosphorus pentasulfide In toluene at 110℃; for 24h; Inert atmosphere;

: 111-25-1
1-bromo-hexane

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (R)-2,2'-dihexyloxybi-1,1'-naphthalene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	98%
With sodium hydroxide In water; acetone for 18h; Heating;	95.6%
With potassium carbonate In acetonitrile for 16h; Heating;	95%

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 1795-48-8
Isopropyl isocyanate

: (R)-O,O'-[1,1']-binaphthyl-2,2'-diyl di(N-isopropylcarbamate)

Conditions

Conditions	Yield
With dmap In tetrahydrofuran; dichloromethane at 60℃; for 48h;	98%

: 29841-69-8
(S,S)-1,2-diphenyl-1,2-diaminoethane

: 40138-16-7
2-formylbenzene boronic acid

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (4S,5S)-2-(2-((Ra)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaborepin-4-yl)phenyl)-4,5-diphenylimidazolidine

Conditions

Conditions	Yield
In chloroform at 20℃; for 1h;	98%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: C22H12F6O2

Conditions

Conditions	Yield
With pyridine In dichloromethane	98%

: 19694-02-1
Pyrene-1-carboxylic acid

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: C54H30O4

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;	98%
With 4-methyl-N-methylpyridinium p-toluenesulfonate salt; diisopropyl-carbodiimide In dichloromethane

(R)-(+)-1,1'-Bi-2-naphthol Specification

(R)-(+)-1,1'-Bi-2-naphthol with cas registry number of 18531-94-7 is white to light yellow crystal powder, also called beta-Binaphthol; 1,1'-Bi-2-naphthol; Chiral binaphthol; Bis-beta-naphtho ; 2,2'-Dinaphthol; .beta.-Binaphthol; 1,1'-Bis-2-naphthol; 2,2'-Dihydroxydinaphthyl; Bis-.beta.-naphthol; 2,2'-Dihydroxybinaphthalene. It is an organic compound that is often used as a ligand for transition-metal catalysed asymmetric synthesis.

Physical properties about (R)-(+)-1,1'-Bi-2-naphthol are: (1)ACD/LogP: 4.861; (2)ACD/LogD (pH 5.5): 4.86; (3)ACD/LogD (pH 7.4): 4.81; (4)ACD/BCF (pH 5.5): 2907.26; (5)ACD/BCF (pH 7.4): 2575.61; (6)ACD/KOC (pH 5.5): 10484.68; (7)ACD/KOC (pH 7.4): 9288.64; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.758 ; (12)Molar Refractivity: 90.293 cm³; (13)Molar Volume: 219.809 cm³; (14)Polarizability: 35.795 10-24cm³; (15)Surface Tension: 62.6150016784668 dyne/cm; (16)Density: 1.303 g/cm³; (17)Flash Point: 218.932 °C; (18)Enthalpy of Vaporization: 75.079 kJ/mol; (19)Boiling Point: 462.104 °C at 760 mmHg;

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
3. Avoid contact with skin and eyes;
4. Wear suitable protective clothing;

You can still convert the following datas into molecular structure:
(1)SMILES:c1ccc2c(c1)ccc(c2c3c4ccccc4ccc3O)O;
(2)Std. InChI:InChI=1S/C20H14O2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H;
(3)Std. InChIKey:PPTXVXKCQZKFBN-UHFFFAOYSA-N

Product Name

(R)-(+)-1,1'-Bi-2-naphthol

Synthetic route

(R)-(+)-1,1'-Bi-2-naphthol Specification

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