1-(2-Aminoethyl)-2-imidazolidone supplier

Name
1-(2-Aminoethyl)imidazolidin-2-one
EINECS 228-491-9
CAS No. 6281-42-1
Article Data20
CAS DataBase
Density 1.137 g/cm³
Solubility
Melting Point
Formula C₅H₁₁N₃O
Boiling Point 363.1 °C at 760 mmHg
Molecular Weight 129.162
Flash Point 173.4 °C
Transport Information
Appearance
Safety 22-26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols Xi,C
Synonyms 1-(2-Aminoethyl)-2-imidazolidinone;1-(b-Aminoethyl)-2-imidazolidone;3-(2-Aminoethyl)-2-imidazolidinone;N-(2-Aminoethyl)imidazolidin-2-one;N-(2-Aminoethyl)imidazolidinone;N-(b-Aminoethyl)-N,N'-ethyleneurea;NSC 5776;[2-(2-Oxoimidazolidino)ethyl]amine;
PSA 58.36000
LogP -0.06270

Synthetic route

: 111-40-0
1,5-diamino-3-azapentane

: 57-13-6
urea

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With ammonia at 125 - 160℃; Concentration; Temperature; Inert atmosphere; Large scale;	96%
at 210℃;
at 130 - 210℃; for 3h;

: 124-38-9
carbon dioxide

: 111-40-0
1,5-diamino-3-azapentane

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With cerium(IV) oxide In ethanol at 160℃; for 8h;	36%
With ethanolamine at 190℃; for 0.5h; Catalytic behavior; Reagent/catalyst;

: 6573-15-5
1,3,6-triazabicyclo[3.3.0]oct-4-ene

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With water

: 2387-20-4
1-(2-chloroethyl)imidazolidin-2-one

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With ammonium hydroxide at 100℃;

: 40778-59-4
1-(2-aminoethyl)-2-imidazolidinethione

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With ammonium hydroxide; dihydrogen peroxide
Multi-step reaction with 2 steps 1: chloroacetic acid 2: H2O View Scheme

: 2387-20-4
1-(2-chloroethyl)imidazolidin-2-one

: ammonium hydroxide

A: 98137-74-7
2-(2-amino-4,5-dihydro-imidazol-1-yl)-ethanol

B: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
at 100℃;

...Expand

: 111-40-0
1,5-diamino-3-azapentane

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With urea

: 757967-03-6
bis-(2-phenylacetylamino-ethyl)-carbamic acid 4-nitro-phenyl ester

A: 103-82-2
phenylacetic acid

B: 6281-42-1
2-aminoethylimidazolidone

C: 100-02-7
4-nitro-phenol

D: 623-05-2
(4-hydroxyphenyl)methanol

E: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With water; penicillin-G-amidase In Chremephor EL; dimethyl sulfoxide at 37℃; pH=7.4; Kinetics; Enzymatic reaction; Aqueous phosphate buffer;

...Expand

: 111-40-0
1,5-diamino-3-azapentane

: 616-38-6
carbonic acid dimethyl ester

: 6281-42-1
2-aminoethylimidazolidone

Conditions

Conditions	Yield
With sodium methylate In methanol at 23 - 120℃; for 4h; Inert atmosphere;
With sodium methylate In methanol at 23 - 120℃; for 4h; Concentration; Solvent; Inert atmosphere;

: 3699-54-5
2-oxo-imidazolidine-1-ethanol

: 111-40-0
1,5-diamino-3-azapentane

A: 6281-42-1
2-aminoethylimidazolidone

B: 111-41-1
2-(2-Aminoethylamino)ethanol

Conditions

Conditions	Yield
at 270℃; for 5h; Autoclave; Inert atmosphere;	A 30.5 %Chromat. B 16.8 %Chromat.

...Expand

: 120-93-4
imidazolidone

: 107-15-3
ethylenediamine

A: 6281-42-1
2-aminoethylimidazolidone

B: 623-76-7
N,N'-diethylurea

C: 166532-70-3
U2TETA

D: 24368-15-8
1,1'-(1,2-ethanediyl)di(2-imidazolidinone)

E: U1TETA

F: 111-40-0
1,5-diamino-3-azapentane

G: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With dimethylenecyclourethane at 260℃; for 1.5h; Inert atmosphere;

...Expand

: 120-93-4
imidazolidone

: 107-15-3
ethylenediamine

A: 6281-42-1
2-aminoethylimidazolidone

B: 166532-70-3
U2TETA

C: 24368-15-8
1,1'-(1,2-ethanediyl)di(2-imidazolidinone)

D: U1TETA

E: 111-40-0
1,5-diamino-3-azapentane

F: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With dimethylenecyclourethane at 250℃; for 5.5h; Microwave irradiation; Inert atmosphere;

...Expand

: 497-25-6
dimethylenecyclourethane

: 120-93-4
imidazolidone

: 107-15-3
ethylenediamine

A: 3699-54-5
2-oxo-imidazolidine-1-ethanol

B: 6281-42-1
2-aminoethylimidazolidone

C: 166532-70-3
U2TETA

D: 24368-15-8
1,1'-(1,2-ethanediyl)di(2-imidazolidinone)

E: U1TETA

F: 111-40-0
1,5-diamino-3-azapentane

G: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
at 250℃; for 5.5h; Inert atmosphere;

...Expand

: 497-25-6
dimethylenecyclourethane

: 120-93-4
imidazolidone

: 107-15-3
ethylenediamine

A: 3699-54-5
2-oxo-imidazolidine-1-ethanol

B: 6281-42-1
2-aminoethylimidazolidone

C: 111-41-1
2-(2-Aminoethylamino)ethanol

D: 111-40-0
1,5-diamino-3-azapentane

E: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
at 260℃; for 3h;

...Expand

: 120-93-4
imidazolidone

: 141-43-5
ethanolamine

: 107-15-3
ethylenediamine

A: 6281-42-1
2-aminoethylimidazolidone

B: 166532-70-3
U2TETA

C: 24368-15-8
1,1'-(1,2-ethanediyl)di(2-imidazolidinone)

D: U1TETA

E: 111-40-0
1,5-diamino-3-azapentane

F: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With dimethylenecyclourethane at 250℃; for 5h; Inert atmosphere;

...Expand

: 6281-42-1
2-aminoethylimidazolidone

: 71310-21-9
11-mercaptounadecanoic acid

: 11-mercapto-N-[2-(2-oxoimidazolidin-1-yl)ethyl]undecaneamide

Conditions

Conditions	Yield
at 160℃; for 6h; Inert atmosphere;	100%

: 6281-42-1
2-aminoethylimidazolidone

: 660870-46-2
1-(5-(methoxycarbonyl)-4-{[2-(trifluoromethyl)benzyl]oxy}thien-2-yl)-1H-benzimidazole-5-carboxylic acid

: methyl 5-[5-({[2-(2-oxoimidazolidin-1-yl)ethyl]amino}carbonyl)-1H-benzimidazol-1-yl]-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) for 2h;	95%

: 6281-42-1
2-aminoethylimidazolidone

: 5-(4-chlorophenyl)-2-{[1-(4-chloropyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 5-(4-chlorophenyl)-2-{[1-(4-{[2-(2-oxoimidazolidin-1-yl)ethyl]amino}pyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions

Conditions	Yield
In ethanol Reflux;	94%

: 6281-42-1
2-aminoethylimidazolidone

: 1034658-89-3
2-chloro-4-[7-(2-chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-pyrimidine

: 1034657-98-1
1-(2-{4-[7-(2-chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
In butan-1-ol at 120℃; for 5h;	93%

: 6281-42-1
2-aminoethylimidazolidone

: 1572-52-7
2,4-dicyano-1-butene

: C11H17N5O

Conditions

Conditions	Yield
In water at 75 - 80℃; Inert atmosphere;	89%

: 6281-42-1
2-aminoethylimidazolidone

: 106-93-4
ethylene dibromide

: ,4,7-triazacyclononan-1,4-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 100℃; for 60h; Reagent/catalyst; Solvent; Temperature;	87.09%

: 6281-42-1
2-aminoethylimidazolidone

: 82417-45-6
dichlorobenzenesulfonyl chloride

: 886236-60-8
2,3-dichloro-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzenesulphonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	87%

: 77-77-0
Divinyl sulfone

: 6281-42-1
2-aminoethylimidazolidone

: 85694-70-8
1-<2-N-(1,1-dioxidothiomorpholinoethyl)>-2-imidazolidinone

Conditions

Conditions	Yield
In ethanol for 3h; Ambient temperature;	83%

: 6281-42-1
2-aminoethylimidazolidone

: 90826-32-7
m-isopropenyl-α,α-dimethylbenzyl carbamic acid methyl ester

: 137559-77-4
m-TMU

Conditions

Conditions	Yield
1,3-diacetoxy-1,1,3,3-tetrabutyldistannoxane at 140℃; under 30 Torr; for 3h;	83%

: 6281-42-1
2-aminoethylimidazolidone

: 2946-89-6
3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

: N-nitro-N'-[2-(2-oxo-imidazolidin-3-yl)ethyl]guanidine

Conditions

Conditions	Yield
In methanol at 20℃;	80%

: 6281-42-1
2-aminoethylimidazolidone

: 4‐(3‐bromo‐4‐fluorophenyl)‐3‐(4‐nitro‐1,2,5‐oxadiazol‐3‐yl)‐4,5‐dihydro‐1,2,4‐oxadiazol‐5‐one

: 4‐(3‐bromo‐4‐fluorophenyl)‐3‐(4‐{[2‐(2‐oxoimidazolidin‐1‐yl)ethyl]amino}‐1,2,5‐oxadiazol‐3‐yl)‐1,2,4‐oxadiazol‐5‐one

Conditions

Conditions	Yield
In acetonitrile	78%

: 6281-42-1
2-aminoethylimidazolidone

: 79-10-7
acrylic acid

: 3,3'-{[2-(2-oxoimidazolidin-1-yl)ethyl]imino}dipropanoic acid

Conditions

Conditions	Yield
In isopropyl alcohol at 60℃; for 2h; Inert atmosphere;	75%

: 6281-42-1
2-aminoethylimidazolidone

: 893441-65-1
2-(methylsulfonyl)-4-(5-(morpholinosulfonyl)thiophen-2-yl)pyrimidine

: 1-(2-(4-(5-(morpholinosulfonyl)thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In toluene for 6h; Heating / reflux;	72%

: 6281-42-1
2-aminoethylimidazolidone

: 1367126-25-7
C18H12FNO2

: 1367124-97-7
1-(2-(((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)methyl)amino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
Stage #1: 2-aminoethylimidazolidone; C18H12FNO2 In tetrahydrofuran at 20℃; for 14h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 0.333333h;	72%

: 6281-42-1
2-aminoethylimidazolidone

: 1367126-49-5
C20H18FNO4S

: 1367124-99-9
1-(2-((2-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)ethyl)amino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 40℃; for 14h;	70%

: 6281-42-1
2-aminoethylimidazolidone

: 131022-68-9
4-(5'-bromo-2'-thienyl)-2-chloropyrimidine

: 1-(2-(4-(5-bromothiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol for 30h; Heating / reflux;	68%

: 6281-42-1
2-aminoethylimidazolidone

: 102-36-3
3,4-dichlorophenylisocyanate

: C12H14Cl2N4O2

Conditions

Conditions	Yield
With triethylamine In toluene at 5℃; for 24h;	68%

: 6281-42-1
2-aminoethylimidazolidone

: 50329-91-4
4-chloro-3-formylcoumarin

: C15H15N3O4

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.0833333h; Heating;	67%

: 6281-42-1
2-aminoethylimidazolidone

: C19H10(2)H3F3N2O2

: d-1-(2-(((6-(2-methyl-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl-3,5,6-d3)pyridin-2-yl)methyl)amino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
Stage #1: 2-aminoethylimidazolidone; C19H10(2)H3F3N2O2 In methanol at 20℃; for 1h; Stage #2: With 5%-palladium/activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 3h;	65%

: 6281-42-1
2-aminoethylimidazolidone

: 893434-89-4
4-(benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine

: 1-(2-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In 2-methoxy-ethanol at 100℃;	64%

: 6281-42-1
2-aminoethylimidazolidone

: 2-{[5-bromo-1-(2-chlorophenyl)-1H-1,2,4-triazol-3-yl]methyl}-5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-5-{[2-(2-oxoimidazolidin-1-yl)ethyl]amino}-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3 -one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 150℃; for 5h; Microwave irradiation;	64%

: 6281-42-1
2-aminoethylimidazolidone

: 1034468-08-0
{4-[2-(2-chloro-5-fluoro-pyrimidin-4-yl)-benzo[b]thiophen-7-yl]-6-fluoro-pyridin-3-ylmethyl}-dimethylamine

: 1034466-20-0
1-(2-{4-[7-(5-((dimethylamino)methyl)-2-fluoro-pyridin-4-yl)benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In butan-1-ol at 120℃; for 15h;	63%

: 6281-42-1
2-aminoethylimidazolidone

: 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl chloride

: 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	61%

: 6281-42-1
2-aminoethylimidazolidone

: 41848-21-9
S-allyl isothiouronium hydrobromide

: 123-31-9
hydroquinone

: 2-(allylthio)-5-((2-(2-oxoimidazolidin-1-yl)ethyl)amino)-2,5-cyclohexadiene-1,4-dione

Conditions

Conditions	Yield
With sodium iodide; sodium chloride In water; acetonitrile at 20℃;	58%

...Expand

: 6281-42-1
2-aminoethylimidazolidone

: 151608-48-9
N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine

: 1268157-54-5
N-acetyl-O-[bis(benzyloxy)phosphoryl]-N'-[2-(2-oxoimidazolidin-1-yl)ethyl]-L-tyrosinamide

Conditions

Conditions	Yield
Stage #1: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2-aminoethylimidazolidone In dichloromethane at 0 - 20℃; for 2.16667h; Inert atmosphere;	56%

: 6281-42-1
2-aminoethylimidazolidone

: 104-12-1
p-chlorphenylisocyanate

: 63874-81-7
1-[2-(2-Oxo-3-imidazolidinyl)-ethyl]-3-(4-chlorophenyl)urea

Conditions

Conditions	Yield
With triethylamine In toluene at 5℃; for 24h;	53%
In tetrahydrofuran

: 6281-42-1
2-aminoethylimidazolidone

: 1034468-28-4
4-(7-bromo-benzo[b]thiophen-2-yl)-2-chloro-5-fluoro-pyrimidine

: 1034468-55-7
1-{2-[4-(7-bromo-benzo[b]thiophen-2-yl)-5-fluoro-pyrimidin-2-ylamino]-ethyl}-imidazolidin-2-one

Conditions

Conditions	Yield
In 1,4-dioxane at 90℃; for 3h;	52%

: 6281-42-1
2-aminoethylimidazolidone

: 1034468-45-5
2-chloro-4-[7-(3-trimethylsilanylethynyl-pyridin-4-yl)-benzo[b]-thiophen-2-yl]-pyrimidine

: 1034468-65-9
1-(2-[4-[7-(3-trimethylsilylethynyl-pyridin-4-yl)-benzo[b]thiophen-2-yl]-pyrimidin-2-ylamino]-ethyl)-imidazolidin-2-one

Conditions

Conditions	Yield
In butan-1-ol at 120℃; for 4 - 5h;	49%

1-(2-Aminoethyl)-2-imidazolidone Chemical Properties

IUPAC Name: 1-(2-Aminoethyl)imidazolidin-2-one
Synonyms: 1-(2-Aminoethyl)imidazolidin-2-one ; 2-Imidazolidinone, 1-(2-aminoethyl)- ; 1-(.beta.-Aminoethyl)-2-imidazolidone
Product Categories: Imidazoles & Benzimidazoles;Imidazoles & Benzimidazoles
Molecular Structure of 1-(2-Aminoethyl)-2-imidazolidone (CAS NO.6281-42-1):
Molecular Formula of 1-(2-Aminoethyl)-2-imidazolidone (CAS NO.6281-42-1): C₅H₁₁N₃O
Molecular Weight of 1-(2-Aminoethyl)-2-imidazolidone (CAS NO.6281-42-1): 129.16
CAS NO: 6281-42-1
EINECS : 228-491-9
Index of Refraction: 1.506
Surface Tension: 42.6 dyne/cm
Density: 1.137 g/cm³
Flash Point: 173.4 °C
Enthalpy of Vaporization: 60.91 kJ/mol
Boiling Point: 363.1 °C at 760 mmHg
Vapour Pressure: 1.85E-05 mmHg at 25°C

1-(2-Aminoethyl)-2-imidazolidone Production

Raw materials: Urea-->Diethylenetriamine

1-(2-Aminoethyl)-2-imidazolidone Safety Profile

Hazard Codes Irritant Xi, Corrosive C
Risk Statements 34
R34:Causes burns.
Safety Statements 22-26-36/37/39-45
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Hazard Note Irritant

Product Name

1-(2-Aminoethyl)imidazolidin-2-one

Synthetic route

1-(2-Aminoethyl)-2-imidazolidone Chemical Properties

1-(2-Aminoethyl)-2-imidazolidone Production

1-(2-Aminoethyl)-2-imidazolidone Safety Profile

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