1-(4-Methoxyphenyl)-2-phenylethanone supplier

Name
4'-METHOXY-2-PHENYLACETOPHENONE
EINECS
CAS No. 1023-17-2
Article Data207
CAS DataBase
Density 1.1 g/cm³
Solubility
Melting Point 77-78 °C
Formula C₁₅H₁₄O₂
Boiling Point 380 °C at 760 mmHg
Molecular Weight 226.275
Flash Point 173.2 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Acetophenone,4'-methoxy-2-phenyl- (6CI,7CI,8CI);Acetophenone, p-methoxy-a-phenyl- (3CI);2-Phenyl-p-methoxyacetophenone;4-Methoxy-a-phenylacetophenone;4-Methoxydeoxybenzoin;4-Methoxydesoxybenzoin;4-Methoxyphenyl benzyl ketone;4'-Methoxy-2-phenylacetophenone;Benzyl 4-methoxyphenyl ketone;Benzylp-methoxyphenyl ketone;NSC 26658;p-Anisyl benzyl ketone;a-Phenyl-4'-methoxyacetophenone;4-Methoxy phenyl Acetofenone;
PSA 26.30000
LogP 3.12060

Synthetic route

: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

: 108-90-7
chlorobenzene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
Stage #1: rac-1-(4-methoxyphenyl)-ethanol With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); para-chlorotoluene; potassium tert-butylate In toluene at 40℃; for 3h; Inert atmosphere; Stage #2: chlorobenzene In toluene at 80℃; for 4h; Inert atmosphere;	99%

: 103-82-2
phenylacetic acid

: 100-66-3
methoxybenzene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride In dichloromethane Friedel-Crafts Acylation; Cooling with ice;	98%
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 2h;	94%
With pyrographite; toluene-4-sulfonic acid at 90℃; for 3.5h; Friedel-Crafts reaction;	92%

: 100-66-3
methoxybenzene

: 103-80-0
phenylacetyl chloride

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With zinc(II) oxide at 20℃; for 0.0833333h; Friedel-Crafts acylation;	98%
With zinc oxide nanoparticles supported on polyaniline at 20℃; for 0.166667h; Friedel Crafts acylation; Neat (no solvent);	96%
With iron(III) oxide at 20℃; for 0.166667h; Friedel Crafts acylation; regioselective reaction;	91%

: 908094-04-2
phenyldiazomethane

: 123-11-5
4-methoxy-benzaldehyde

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In toluene at -78℃; for 0.166667h; Inert atmosphere;	97%
cyclopentadienyldicarbonyl(tetrahydrofuran)iron(II) tetrafluoroborate In dichloromethane at 20℃; for 12.5h; insertion;	55%
With lithium bromide In diethyl ether at -5 - 0℃; protected from light;	90 % Spectr.

: 7380-78-1
4-(phenylethynyl)anisole

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol at 120℃; for 0.5h; microwave irradiation;	96%
With toluene-4-sulfonic acid In ethanol at 78℃; for 72h;	80%
With silver hexafluoroantimonate; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I) In 1,4-dioxane; water at 80℃; for 16h;	74%
With 1,10-Phenanthroline; copper(II) choride dihydrate; silver trifluoromethanesulfonate; aniline; 1,2-bis-(diphenylphosphino)ethane; palladium dichloride In 1,4-dioxane; water at 100℃; for 24h;	22%
With hydrogenchloride; water; cetyltrimethylammonim bromide In isopropyl alcohol at 140℃; for 10h;

: 5720-07-0
4-methoxyphenylboronic acid

: 140-29-4
phenylacetonitrile

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With [2,2]bipyridinyl; palladium diacetate; trifluoroacetic acid In tetrahydrofuran; water at 80℃; for 36h; Inert atmosphere; Schlenk technique;	96%
With ammonium chloride; bipyridine-cyclopalladated ferrocenylimine complex In water at 100℃; for 24h;	92%
[Pd(μ-OH)(2,2'-bipyridine)]2(OSO2CF3)2 In nitromethane for 24h; Heating;	87%

: α-benzyl-4,4'-dimethoxybenzoin

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With potassium cyanide In N,N-dimethyl-formamide at 80℃; for 1h;	95%

: 1401229-25-1
1-(1-(4-methoxyphenyl)-2-phenylethoxy)-2,2,6,6-tetramethylpiperidine

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane	95%

: 121-98-2
methyl 4-methoxybenzoate

: (phenylmethylene)bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane)

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at 23℃; for 3h; Glovebox;	95%

: 5720-07-0
4-methoxyphenylboronic acid

: 103-80-0
phenylacetyl chloride

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With (BeDABCO)2Pd2Cl6; potassium carbonate In toluene at 20℃; for 0.583333h; Suzuki Coupling;	91%

: 696-62-8
para-iodoanisole

: 100-44-7
benzyl chloride

Fe(CO)5: Fe(CO)5

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With (2,2'-bipyridine)nickel(II) dibromide; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide Electrochemical reaction;	88%

...Expand

: 108-86-1
bromobenzene

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With C16H14N6O4Pd; potassium tert-butylate In acetonitrile at 82℃; for 2h; Schlenk technique; Reflux;	88%
With tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In tetrahydrofuran at 70℃; for 3h; Schlenk technique; Inert atmosphere;	71%
With potassium tert-butylate In acetonitrile at 81℃; for 2h; Inert atmosphere; Schlenk technique;	92 %Chromat.

: 201230-82-2
carbon monoxide

: 696-62-8
para-iodoanisole

: 100-44-7
benzyl chloride

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With palladium diacetate; 1,4-di(diphenylphosphino)-butane; zinc In 1,4-dioxane at 100℃; under 7500.75 Torr; for 16h; Negishi coupling reaction; Inert atmosphere; Autoclave;	85%

...Expand

: 93011-61-1
3-(4-methoxyphenyl)-3-oxo-2-phenylpropanal

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With ethylenediamine In tetrahydrofuran for 4h; Heating;	84%

: 696-62-8
para-iodoanisole

: 62673-31-8
benzyl(bromo)zinc

: 13939-06-5, 199620-15-0
molybdenum hexacarbonyl

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With palladium diacetate; 1,4-di(diphenylphosphino)-butane In tetrahydrofuran at 90℃; under 1500.15 Torr; for 1h; Sealed tube; Microwave irradiation; chemoselective reaction;	84%

...Expand

: 637-69-4
4-Methoxystyrene

: 100-63-0
phenylhydrazine

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; 3,7-bis(dimethylamine)phenothiazonium In acetonitrile at 25℃; Irradiation; Green chemistry;	84%
With 1,4-diaza-bicyclo[2.2.2]octane; water; oxygen In acetonitrile at 80℃; under 760.051 Torr; for 12h; chemoselective reaction;	63%

: 2613-89-0
phenylmalonic acid

: 100-66-3
methoxybenzene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With PPA at 60 - 80℃; for 2h; Acylation; Friedel-Crafts acylation;	83%

: 2-[Benzyloxy-(4-methoxy-phenyl)-methyl]-1,3-dimethyl-3H-imidazol-1-ium; iodide

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With caesium carbonate In tetrahydrofuran for 3h; Heating;	81%

: 104-92-7
1-bromo-4-methoxy-benzene

: 62673-31-8
benzyl(bromo)zinc

: 13939-06-5, 199620-15-0
molybdenum hexacarbonyl

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate In tetrahydrofuran at 120℃; under 2250.23 Torr; for 0.5h; Microwave irradiation; Sealed tube; chemoselective reaction;	81%

...Expand

: benzylic zinc mesylate

: 100-07-2
4-methoxy-benzoyl chloride

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With copper(l) cyanide; lithium chloride In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;	81%

: 79606-43-2
N,N-diisopropyl-4-methoxybenzamide

: 108-88-3
toluene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at 60℃; for 12h;	81%

: 187336-14-7
1-(4-methoxyphenyl)-2-phenyl-1-(quinazoline-4-yl)ethanol

A: 1023-17-2
4-methoxyphenyl benzyl ketone

B: 36082-71-0
quinazoline-4-carbonitrile

Conditions

Conditions	Yield
With potassium cyanide In N,N-dimethyl-formamide at 80℃; for 1.5h;	A 78% B 6%

: 187336-14-7
1-(4-methoxyphenyl)-2-phenyl-1-(quinazoline-4-yl)ethanol

A: 253-82-7
quinazoline

B: 1023-17-2
4-methoxyphenyl benzyl ketone

C: 16499-37-9
quinazoline-4-carbonamide

Conditions

Conditions	Yield
With potassium cyanide In N,N-dimethyl-formamide at 80℃; for 1h;	A 6% B 78% C 27%

...Expand

: 70263-71-7
2-hydroxy-1.3-diphenyl-2-(4-methoxy-phenyl)-propane

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In water; acetonitrile at 50 - 55℃; for 0.166667h;	77%

: 146767-33-1
phenylazo tert-butyl sulfide

: 1-(4-Methoxy-phenyl)-ethenol anion

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
In dimethyl sulfoxide Ambient temperature;	77%

: 187336-05-6
1-(4-Methoxy-phenyl)-2-phenyl-1-(2-phenyl-quinazolin-4-yl)-ethanol

A: 25855-20-3
2-phenylquinazoline

B: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With potassium cyanide In N,N-dimethyl-formamide for 1h; Heating;	A 68% B 77%
With tetra-n-butylammonium cyanide In tetrahydrofuran for 1h; Heating; Yield given. Yields of byproduct given;

: 874394-52-2
1-methoxy-4-(1-methoxy-2-phenylvinyl)benzene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water at 25℃;	77%

: 104-92-7
1-bromo-4-methoxy-benzene

: 4747-15-3
1-(2-methoxyvinyl)benzene

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
Stage #1: 1-bromo-4-methoxy-benzene; 1-(2-methoxyvinyl)benzene With sodium hydrogencarbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane In N,N-dimethyl-formamide at 150℃; for 20h; Heck reaction; Stage #2: With hydrogenchloride In tetrahydrofuran at 25℃; Further stages.;	77%

: 14310-21-5
1-(4-methoxyphenyl)-2-phenylethane

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 23℃; for 3h; Sealed tube;	77%
Multi-step reaction with 2 steps 1: S2O8(2-), HClO4 / Cu(ClO4)2 / acetonitrile; H2O / 0.42 h / 83 °C / other reaction conditions, other substrate 2: pyridine-chlorochromate View Scheme
Multi-step reaction with 3 steps 1: S2O8(2-), HClO4 / Cu(ClO4)2 / acetonitrile; H2O / 0.42 h / 83 °C / other reaction conditions, other substrate 3: pyridine-chlorochromate View Scheme
With ketoreductase-P1-B12; oxygen; NADPH; 9-(2-mesityl)-10-methylacridinium perchlorate In water; acetonitrile at 23℃; for 24h; Irradiation; Enzymatic reaction;

: 140-29-4
phenylacetonitrile

: 6462-50-6
sodium 4-methoxybenzenesulfinate

: 1023-17-2
4-methoxyphenyl benzyl ketone

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; trifluoroacetic acid; 6-methyl-2,2'-bipyridine In tetrahydrofuran; water at 100℃; for 1h; Microwave irradiation;	77%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 22711-21-3
4-methoxybenzil

Conditions

Conditions	Yield
With selenium(IV) oxide In dimethyl sulfoxide at 170℃; for 0.0166667h; Microwave irradiation;	98%
With potassium hydrogencarbonate; dimethyl sulfoxide at 80℃; Reagent/catalyst; Temperature; Pressure;	96%
With N-Bromosuccinimide; dimethyl sulfoxide for 72h; Ambient temperature;	93%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 104-88-1
4-chlorobenzaldehyde

: 17356-08-0
thiourea

: 1207548-68-2
4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol at 20 - 70℃; Biginelli type reaction;	98%

...Expand

: 524-38-9
N-hydroxyphthalimide

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 2-[2-(4-methoxyphenyl)-2-oxo-1-phenylethoxy]isoindoline-1,3-dione

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene In dichloromethane at 20℃; for 4h; Sealed tube;	98%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 105-36-2
ethyl bromoacetate

: 171818-87-4
3-hydroxy-3-(4-methoxy-phenyl)-4-phenyl-butyric acid ethyl ester

Conditions

Conditions	Yield
With iodine; zinc In benzene for 1h; Reformatsky reaction; Heating;	97%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 104-88-1
4-chlorobenzaldehyde

: 57-13-6
urea

: 1207548-70-6
4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol at 20 - 70℃; Biginelli type reaction;	97%

...Expand

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 5422-47-9
1-(4-methoxyphenyl)-2-phenylethan-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol	96%
Reduktion nach Meerwein-Ponndorf;
With sodium tetrahydroborate In isopropyl alcohol
With sodium tetrahydroborate In tetrahydrofuran; water at 20℃;
With sodium tetrahydroborate In methanol at 0 - 20℃;

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 881-43-6
2-bromo-1-(4-methoxyphenyl)butan-1-one

: 381229-25-0
2-ethyl-1,4-bis(4-methoxyphenyl)-3-phenyl-butane-1,4-dione

Conditions

Conditions	Yield
Stage #1: 4-methoxyphenyl benzyl ketone With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 1h; Stage #2: 2-bromo-1-(4-methoxyphenyl)butan-1-one In tetrahydrofuran; toluene at -78 - 20℃; Further stages.;	96%

: 75-77-4
chloro-trimethyl-silane

: 1023-17-2
4-methoxyphenyl benzyl ketone

: ((1-(4-methoxyphenyl)-2-phenylvinyl)oxy)trimethylsilane

Conditions

Conditions	Yield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃;	96%

: 74-96-4
ethyl bromide

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 78423-10-6
1-(4-methoxyphenyl)-2-phenylbutan-1-one

Conditions

Conditions	Yield
Stage #1: 4-methoxyphenyl benzyl ketone With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Stage #2: ethyl bromide With potassium iodide In tetrahydrofuran; mineral oil at 20℃; for 12h;	95%
With potassium tert-butylate In diethyl ether Heating;

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 62-53-3
aniline

A: 100-52-7
benzaldehyde

B: 7465-88-5
4-methoxy-N-phenylbenzamide

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(II) chloride dihydrate; oxygen In acetonitrile under 760.051 Torr; for 36h; Reflux;	A n/a B 93%

...Expand

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 1694-19-5
E-1-(phenyl)-2-(4'-methoxyphenyl)ethene

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; sodium 2,2,2-trifluoroacetate; diphenyl(methyl)phosphine; bis(pinacol)diborane In tetrahydrofuran at 70℃; for 10h; Glovebox; Sealed tube; Inert atmosphere; stereoselective reaction;	92%
Multi-step reaction with 2 steps 1: Reduktion nach Meerwein-Ponndorf 2: acetic acid; H2SO4 View Scheme
Multi-step reaction with 2 steps 1: sodium-amalgam 2: acetic acid; concentrated aqueous HCl View Scheme

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 1779-49-3
Methyltriphenylphosphonium bromide

: 22927-03-3
1-methoxy-4-(3-phenylprop-1-en-2-yl)benzene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Wittig Olefination; Inert atmosphere; Stage #2: 4-methoxyphenyl benzyl ketone In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;	92%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.75h; Stage #2: 4-methoxyphenyl benzyl ketone In tetrahydrofuran at 20℃; for 16h;

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 30839-20-4
1,4-bis(4-methoxyphenyl)-2,3-diphenylbutane-1,4-dione

Conditions

Conditions	Yield
With silver fluoride In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 10h;	91%
With copper(II) acetate monohydrate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 6h;	83%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 119-53-9
2-hydroxy-2-phenylacetophenone

: 22394-06-5
2-(4-methoxyphenyl)-3,4,5-triphenyl-1H-pyrrole

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 100℃; for 12h; Schlenk technique; Inert atmosphere;	91%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 17356-08-0
thiourea

: 91069-96-4
4-(4-methoxyphenyl)-5-phenyl-2-aminothiazole

Conditions

Conditions	Yield
With cesium bicarbonate; Bromotrichloromethane In acetonitrile at 80℃; for 2h;	91%

: 1023-17-2
4-methoxyphenyl benzyl ketone

Br2: Br2

: 1889-77-6
2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone

Conditions

Conditions	Yield
With aluminium trichloride In diethyl ether at 0℃; for 2h;	90%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 1119194-75-0
C21H18N2O3

: 1119194-84-1
C35H30N2O2

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; regioselective reaction;	90%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 3-(dimethylamino)-1-(4-methoxyphenyl)-2-phenyl-2-propen-1-one

Conditions

Conditions	Yield
In toluene at 50 - 80℃;	89.9%
In N,N-dimethyl-formamide at 100℃; for 2h; Microwave irradiation;	85%
In 5,5-dimethyl-1,3-cyclohexadiene for 2h; Reflux;	57%
for 12h; Heating;

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 85678-42-8
2-(bromomethyl)-3-(phenylthio)-1-(phenylsulfonyl)-1H-indole

: 3-(1-benzenesulfonyl-3-phenylsulfanyl-1H-indol-2-yl)-1-(4-methoxyphenyl)-2-phenylpropan-1-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h;	89.4%

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 1266134-54-6
2-azido-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate (V)

: 1309977-01-2
C20H23N3O2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; acetonitrile at 20℃; for 2h;	89%

1-(4-Methoxyphenyl)-2-phenylethanone Specification

The 1-(4-Methoxyphenyl)-2-phenylethanone with cas registry number of 1023-17-2 belongs to the categorie of Aromatic Ketones (substituted). It has its own systematic name and IUPAC name which are the same called 1-(4-methoxyphenyl)-2-phenylethanone.

The physical properties about this chemical are: (1)ACD/LogP: 3.25; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 4; (6)Index of Refraction: 1.569; (7)Molar Refractivity: 67.44 cm³; (8)Molar Volume: 205.6 cm³; (9)Surface Tension: 41.2 dyne/cm; (10)Density: 1.1 g/cm³; (11)Flash Point: 173.2 °C; (12)Enthalpy of Vaporization: 62.81 kJ/mol; (13)Boiling Point: 380 °C at 760 mmHg; (14)Vapour Pressure: 5.61E-06 mmHg at 25°C.

Preparation: There are several methods to prepare this chemical. Here is one example. It can be made by reaction of methoxybenzene with phenylacetic acid at temperature of 50 - 60 ℃. It also needs reagents: methanesulfonic acid, P2O5 with reaction time of 90 min.

Uses of 1-(4-Methoxyphenyl)-2-phenylethanone: it can be used for the synthesis of (4-methoxy-phenyl)-phenyl-ethanedione by using reagent SeO₂ and aqueous dioxane.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccc(OC)cc1)Cc2ccccc2;
(2)InChI: InChI=1/C15H14O2/c1-17-14-9-7-13(8-10-14)15(16)11-12-5-3-2-4-6-12/h2-10H,11H2,1H3;
(3)InChIKey: PLALKSRAHVYFOH-UHFFFAOYAT

Product Name

4'-METHOXY-2-PHENYLACETOPHENONE

Synthetic route

1-(4-Methoxyphenyl)-2-phenylethanone Specification

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