Product Name

  • Name

    1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene

  • EINECS 229-724-7
  • CAS No. 6683-48-3
  • Article Data46
  • CAS DataBase
  • Density 0.882 g/cm3
  • Solubility
  • Melting Point 31
  • Formula C15H22
  • Boiling Point 267.4 °C at 760 mmHg
  • Molecular Weight 202.34
  • Flash Point 112.5 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39
  • Risk Codes 20/21/22
  • Molecular Structure Molecular Structure of 6683-48-3 (1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene)
  • Hazard Symbols IrritantXi
  • Synonyms 1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHALENE;1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHYLENE;1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE;1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene;1,1,4,4,6-Pentamethyl-1,2,3,4-;1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTALENE: TECH.;1,1,4,4,6-Pentamethyltetralin;1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene
  • PSA 0.00000
  • LogP 4.34400

Synthetic route

2,5-dichloro-2,5-dimethyl hexane
6223-78-5

2,5-dichloro-2,5-dimethyl hexane

toluene
108-88-3

toluene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With aluminium trichloride for 12h; Heating;99%
With aluminium trichloride In dichloromethane at 20℃; Friedel-Crafts alkylation;99%
With aluminium trichloride In dichloromethane Friedel-Crafts alkylation; Heating;97%
2,5-dichloro-2,5-dimethyl hexane
6223-78-5

2,5-dichloro-2,5-dimethyl hexane

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With aluminum (III) chloride In toluene for 0.416667h;97%
1,1,4,4,6-pentamethyl-1,4-dihydronaphthalene
167958-79-4

1,1,4,4,6-pentamethyl-1,4-dihydronaphthalene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 1h;80%
toluene
108-88-3

toluene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Stage #1: 2,5-dimethyl-2,5-hexanediol With hydrogenchloride In water at 20℃; for 1h;
Stage #2: toluene With aluminum (III) chloride In dichloromethane at 20℃; for 3h;
76%
5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalene-1-carbaldehyde
127459-66-9

5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalene-1-carbaldehyde

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With Wilkinson's catalyst In toluene Heating;
2,5-dimethyl-2,5-hexanediol
110-03-2

2,5-dimethyl-2,5-hexanediol

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl conc. / 3 h / 20 °C
2: 99 percent / AlCl3 / CH2Cl2 / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 56 percent / HCl gas / ethanol
2: 91 percent / AlCl3 / CH2Cl2 / 1.) RT, 30 min, 2.) reflux, 15 min
View Scheme
Multi-step reaction with 2 steps
1: conc. HCl, HCl gas / 0.25 h / 0 °C
2: 80.4 percent / AlCl3 / 1 h / 0 °C
View Scheme
1,1,4,4,7-pentamethyl-2-oxo-1,2,3,4-tetrahydronaphthalene
29020-85-7

1,1,4,4,7-pentamethyl-2-oxo-1,2,3,4-tetrahydronaphthalene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
2: 79 percent / POCl3, pyridine / 100 °C
3: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
View Scheme
2,2,5,5-tetramethyltetrahydro-3-oxofuran
5455-94-7

2,2,5,5-tetramethyltetrahydro-3-oxofuran

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 45 percent / AlCl3 / 2 h / 0 - 20 °C
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 79 percent / POCl3, pyridine / 100 °C
4: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
View Scheme
toluene
108-88-3

toluene

(+-)-o-toluenesulfinic acid-chloride

(+-)-o-toluenesulfinic acid-chloride

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 45 percent / AlCl3 / 2 h / 0 - 20 °C
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 79 percent / POCl3, pyridine / 100 °C
4: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
View Scheme
1,1,4,4,7-pentamethyl-2-hydroxy-1,2,3,4-tetrahydronaphthalene
167958-78-3

1,1,4,4,7-pentamethyl-2-hydroxy-1,2,3,4-tetrahydronaphthalene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / POCl3, pyridine / 100 °C
2: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
View Scheme
1,2,3,4-tetrahydro-1,1,4,4,5,7-hexamethylnaphthalene
94374-39-7

1,2,3,4-tetrahydro-1,1,4,4,5,7-hexamethylnaphthalene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NBS, 2.) 1-methylpyrrolidin-2-one, 3.) PCC / 1.) CCl4, 77 deg C, 45 min, 2.) H2O, 100 h, 1h, 3.) CH2Cl2, 20 deg C, 2 h
2: 3)3> / toluene / Heating
View Scheme
m-xylene
108-38-3

m-xylene

benzene; toluene

benzene; toluene

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) H2SO4, 2.) Mg, 4.) H2SO4 / 1.) 20 deg C, 3 h, 2.) THF, 75 deg C, 30 min, 3.) THF, reflux, 30 min, 4.) petroleum ether, 5 - 10 deg C, 30 min
2: 1.) NBS, 2.) 1-methylpyrrolidin-2-one, 3.) PCC / 1.) CCl4, 77 deg C, 45 min, 2.) H2O, 100 h, 1h, 3.) CH2Cl2, 20 deg C, 2 h
3: 3)3> / toluene / Heating
View Scheme
2,5-dichloro-2,5-dimethyl hexane
6223-78-5

2,5-dichloro-2,5-dimethyl hexane

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran
96042-30-7

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With hydrogenchloride; AlCl3 In toluene
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

acetyl chloride
75-36-5

acetyl chloride

1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalenyl)ethanone
17610-24-1

1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalenyl)ethanone

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane for 1h; Ambient temperature;99%
aluminium trichloride In 1,2-dichloro-ethane99%
With aluminum (III) chloride In dichloromethane for 5h; Inert atmosphere; Reflux;96%
methyl 5-(chloromethyl)-2-furoate
2144-37-8

methyl 5-(chloromethyl)-2-furoate

Methyl 5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl) methyl]-2-furoate

Methyl 5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl) methyl]-2-furoate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

A

5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-N'-(2,4,6-trimethoxybenzyl)-2-furohydrazide
637012-34-1

5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-N'-(2,4,6-trimethoxybenzyl)-2-furohydrazide

B

5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furoic acid
263854-27-9

5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furoic acid

Conditions
ConditionsYield
With sodium hydroxide; aluminium trichloride In methanol; dichloromethane; water; ethyl acetateA 99%
B n/a
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

3-(methoxycarbonyl)benzoyl chloride
3441-03-0

3-(methoxycarbonyl)benzoyl chloride

methyl 3-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>benzoate

methyl 3-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminum (III) chloride Friedel Crafts Acylation;98%
With aluminium trichloride In dichloromethane for 0.166667h; Ambient temperature;80%
With aluminum (III) chloride In dichloromethane at 20℃; Friedel Crafts acylation; Reflux;2.21 g
Monomethyl terephthalate
1679-64-7

Monomethyl terephthalate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminum (III) chloride; thionyl chloride In dichloromethane at 20℃; for 4h; Temperature; Solvent; Reflux;95.3%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

(4-methoxy-phenyl)-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanone
544708-96-5

(4-methoxy-phenyl)-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane95%
With aluminium trichloride Friedel-Crafts acylation;70%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

phthalic monoacid monomethyl ester chloride
4397-55-1

phthalic monoacid monomethyl ester chloride

methyl 2-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>benzoate

methyl 2-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 0.166667h; Ambient temperature;91%
4-chlorosulfonylbenzoyl chloride
7516-60-1

4-chlorosulfonylbenzoyl chloride

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzene-1-sulfonyl chloride

4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzene-1-sulfonyl chloride

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 55℃; for 0.25h; Friedel-Crafts Acylation;86%
With aluminum (III) chloride In dichloromethane at 55℃; for 0.25h;2.3592 g
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

potassium p-carboxybenzenesulfonate
5399-63-3

potassium p-carboxybenzenesulfonate

4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzene-1-sulfonyl chloride

4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzene-1-sulfonyl chloride

Conditions
ConditionsYield
Stage #1: potassium p-carboxybenzenesulfonate With thionyl chloride; N,N-dimethyl-formamide at 85℃; for 1.66667h;
Stage #2: 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene With aluminum (III) chloride In dichloromethane at 55℃; for 0.25h;
86%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

2-bromo-3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene
119999-22-3

2-bromo-3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene

Conditions
ConditionsYield
With aluminium trichloride; bromine In dichloromethane85%
With bromine In tetrachloromethane for 0.25h; Ambient temperature;80%
With bromine In chloroform at 20℃; for 0.5h;60%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

4-Methoxycarbonylbenzoyl chloride
7377-26-6

4-Methoxycarbonylbenzoyl chloride

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminum (III) chloride Friedel Crafts Acylation;82%
With iron(III) chloride In 1,2-dichloro-ethane at 75℃; for 16h; Friedel-Crafts acylation;81%
With aluminium trichloride In dichloromethane for 0.25h; Heating;72%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxaldehyde
92654-79-0

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxaldehyde

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; acetic acid In water at 100℃; for 1h;78%
With ammonium cerium(IV) nitrate In acetic acid at 20℃; for 1h;78%
With ammonium cerium (IV) nitrate; acetic acid at 100℃; for 1h;77%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

A

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxaldehyde
92654-79-0

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxaldehyde

B

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid
103031-30-7

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; acetic acid at 100℃; for 0.25h;A 78%
B 14%
With ammonium cerium(IV) nitrate; acetic acid at 100℃; for 0.25h;A 78%
B 78%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-bromomethane
119435-90-4

(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-bromomethane

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 2.5h; Heating / reflux;72.5%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chloroform
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

1,1,4,4,6-pentamethyl-7-nitro-1,2,3,4-tetrahydronaphthalene
116233-16-0

1,1,4,4,6-pentamethyl-7-nitro-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With nitric acid; acetic anhydride72%
With sulfuric acid; nitric acid at 20℃; for 4h;62.1%
With sulfuric acid; nitric acid at -10℃;50%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

2-(4-iodophenyl)-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-methanone
926038-65-5

2-(4-iodophenyl)-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0℃; for 0.166667h;71%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

methyl 2-acetoxy-4-(chlorocarbonyl)benzoate

methyl 2-acetoxy-4-(chlorocarbonyl)benzoate

methyl 2-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoate

methyl 2-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoate

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 55℃; for 0.25h;70%
methyl 5-(chloromethyl)-2-furoate
2144-37-8

methyl 5-(chloromethyl)-2-furoate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

methyl 5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-methyl]-2-furoate
263854-26-8

methyl 5-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-methyl]-2-furoate

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane Friedel-Crafts alkylation; Heating;68%
aluminum (III) chloride In dichloromethane for 2h; Heating / reflux;46%
With aluminum (III) chloride In dichloromethane for 2h; Friedel Crafts Acylation; Heating / reflux;46%
methyl 2-(chlorocarbonyl)pyrimidine-5-carboxylate
1427690-41-2

methyl 2-(chlorocarbonyl)pyrimidine-5-carboxylate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

methyl 2-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]pyrimidine-5-carboxylate
1427690-40-1

methyl 2-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]pyrimidine-5-carboxylate

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; Reflux;68%
With aluminum (III) chloride In dichloromethane at 20℃; for 0.333333h; Friedel-Crafts Acylation; Reflux;1.677 g
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid
103031-30-7

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid

Conditions
ConditionsYield
With potassium permanganate; sodium hydroxide In water; chlorobenzene at 100℃; for 16h;63.3%
Stage #1: 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene With potassium permanganate; sodium hydroxide In pyridine; water at 95℃; for 16h;
Stage #2: With hydrogenchloride In pyridine; water at 1℃; pH=1;
57%
With potassium permanganate Alkaline conditions;57%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

trifluoromethyl 4-fluorobenzene-1-sulfonate

trifluoromethyl 4-fluorobenzene-1-sulfonate

1,1,4,4-tetramethyl-6-((trifluoromethoxy)methyl)-1,2,3,4-tetrahydronaphthalene

1,1,4,4-tetramethyl-6-((trifluoromethoxy)methyl)-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
Stage #1: 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene With 1,10-phenanthroline-5,6-dione; bathophenanthroline; silver trifluoromethanesulfonate; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(trifluoromethanesulfonate); cesium fluoride at 20℃; for 0.0833333h; Glovebox; Sealed tube; Inert atmosphere;
Stage #2: trifluoromethyl 4-fluorobenzene-1-sulfonate at 25℃; for 15h; Glovebox; Sealed tube; Inert atmosphere;
59%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

1,2,3,4-tetrahydro-1,1,4,4,6-pentamethyl-5,7-dinitronaphthalene
92649-05-3

1,2,3,4-tetrahydro-1,1,4,4,6-pentamethyl-5,7-dinitronaphthalene

Conditions
ConditionsYield
With sulfuric acid; nitric acid In 1,2-dichloro-ethane at 0℃; for 2h;57%
With sulfuric acid; nitric acid
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

6-chlorocarbonyl-nicotinic acid methyl ester
169124-35-0

6-chlorocarbonyl-nicotinic acid methyl ester

methyl 6-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>nicotinate
153559-92-3

methyl 6-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>nicotinate

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; Reflux;54%
With aluminium trichloride In dichloromethane for 0.166667h; Ambient temperature;50%
With aluminium trichloride In nitromethane; dichloromethane at 15 - 30℃; for 24h; Friedel-Crafts acylation;
With aluminum (III) chloride In dichloromethane at 20℃; for 0.333333h; Friedel-Crafts Acylation; Reflux;1.3 g
5-carbethoxythiophene-2-carbonyl chloride
156910-44-0

5-carbethoxythiophene-2-carbonyl chloride

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

ethyl 5-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>thiophene-2-carboxylate
156910-45-1

ethyl 5-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>thiophene-2-carboxylate

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane for 16h; Ambient temperature;50%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

benzoyl chloride
98-88-4

benzoyl chloride

ethyl 5-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>thiophene-2-carboxylate
156910-45-1

ethyl 5-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>thiophene-2-carboxylate

Conditions
ConditionsYield
aluminium trichloride In 1,2-dichloro-ethane50%
4-(1,3,2-dioxaborinan-2-yl)benzoyl chloride
481725-56-8

4-(1,3,2-dioxaborinan-2-yl)benzoyl chloride

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

C22H27BO3
926038-69-9

C22H27BO3

Conditions
ConditionsYield
With aluminum (III) chloride47%

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Chemical Properties

The Molecular Structure of 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene (CAS NO.6683-48-3):

Empirical Formula: C15H22
Molecular Weight: 202.3352
Nominal Mass: 202 Da
Average Mass: 202.3352 Da
Monoisotopic Mass: 202.172151 Da 
Index of Refraction: 1.491
Molar Refractivity: 66.5 cm3
Molar Volume: 229.3 cm3
Surface Tension: 30.1 dyne/cm
Density: 0.882 g/cm3
Flash Point: 112.5 °C
Enthalpy of Vaporization: 48.51 kJ/mol
Boiling Point: 267.4 °C at 760 mmHg
Melting Point: 31 °C 
Vapour Pressure: 0.0134 mmHg at 25°C 
IUPAC Name: 1,1,4,4,6-pentamethyl-2,3-dihydronaphthalene   
Product Categories: Fused Ring Systems
Synonyms: 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene ; 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthylene ; 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene ; 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene ; 1,1,4,4,6-Pentamethyl-1,2,3,4- ; 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene tech ; 1,1,4,4,6-Pentamethyltetralin ; 1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene       

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 20/21/22 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
Hazard Note: Irritant
HazardClass: IRRITANT

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