1,3-Dioxolane supplier | CasNO.646-06-0

Name
1,3-Dioxolane
EINECS 211-463-5
CAS No. 646-06-0
Article Data54
CAS DataBase
Density 1.046 g/cm³
Solubility Soluble in water
Melting Point -95 °C(lit.)
Formula C₃H₆O₂
Boiling Point 75.6 °C at 760 mmHg
Molecular Weight 74.0794
Flash Point 1.7 °C
Transport Information UN 1166 3/PG 2
Appearance Colourless liquid
Safety 16
Risk Codes 11
Molecular Structure
Hazard Symbols F
Synonyms 1,3-Dioxolan;1,3-Dioxole, dihydro-;Ethylene glycol formal;5-Crown-2;Glycol methylene ether;Formal glycol;Dioxolan [Czech];Dioxolane;Glycol formal;1,3-Dioxacyclopentane;
PSA 18.46000
LogP -0.00930

Synthetic route

: 50-00-0
formaldehyd

: 64-17-5
ethanol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With C13H22N4O6S2(2+)*2CF3O3S(1-) In water at 130℃; for 2h; Reagent/catalyst;	95.4%

: 50-00-0
formaldehyd

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
at 60 - 95℃; for 3h; Concentration; Temperature;	94.3%
With phosphoric acid
With phosphoric acid; water

: 107-21-1
ethylene glycol

paraformaldehyde: paraformaldehyde

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With sulfur dioxide at 105 - 164℃; for 4h;	85%

: 50-00-0
formaldehyd

: 1124-68-1
(CH2CH2O2)B(O-n-C4H9)

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With zinc(II) chloride at 130 - 150℃;	77%

: 67-56-1
methanol

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate; sodium nitrite at 50℃; for 24h; UV-irradiation;	71%

: 75-07-0
acetaldehyde

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
In toluene	69%

: 107-21-1
ethylene glycol

polyoxymethylene: polyoxymethylene

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In 1,4-dioxane at 100℃; for 3h; Sealed tube;	66%
With iron(III) chloride
With phosphoric acid at 100℃; im Rohr;
With hydrogenchloride at 100℃;

: 4544-20-1
2-ethoxy-1,3-dioxolane

A: 646-06-0
1,3-DIOXOLANE

B: 64-17-5
ethanol

C: 4468-92-2
2-ethoxymethoxy-ethanol

Conditions

Conditions	Yield
With diisobutylaluminium hydride In hexane at 35 - 40℃;	A 45% B n/a C 45%

...Expand

: 50-00-0
formaldehyd

: 1309123-32-7
C9H19BO3

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With zinc(II) chloride at 130 - 150℃;	31%

: Fe(CO)4(COCH2CH2O)

A: 646-06-0
1,3-DIOXOLANE

B: 7439-89-6
iron

Conditions

Conditions	Yield
With H2 In decalin High Pressure; 71.5 atm H2 at room temp., heated to 200°C and stirred for 24 h; pressure realesed, detn. by GC and GC-MS;	A 27% B n/a

: 50-00-0
formaldehyd

: 92673-07-9
(CH2CH2O2)B(O-n-C6H13)

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With zinc(II) chloride at 130 - 150℃;	27%

: 50-00-0
formaldehyd

: 118685-83-9
2-(3-methyl-butoxy)-[1,3,2]dioxaborolane

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With zinc(II) chloride at 130 - 150℃;	24%

: 75-21-8
oxirane

: 50-00-0
formaldehyd

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With sulfuric acid; water Erhitzen des mit Calciumchlorid versetzten Reaktionsgemisches mit Aethylenglykol unter Zusatz von wss. Salzsaeure;
With sulfuric acid; water Erhitzen des mit Calciumchlorid versetzten Reaktionsgemisches mit Aethylenglykol unter Zusatz von wss. Salzsaeure;

: 20757-83-9
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With water

: 4544-20-1
2-ethoxy-1,3-dioxolane

: 617-86-7
triethylsilane

A: 646-06-0
1,3-DIOXOLANE

B: 597-67-1
ethoxytriethylsilane

C: 13175-68-3
1,2-bis (triethylsilyloxy) ethane

D: (2-Ethoxymethoxy-ethoxy)-triethyl-silane

Conditions

Conditions	Yield
With nickel at 65℃; for 2h; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 4544-19-8
1,2-di(1,3-dioxolan-2-yloxy)ethane

A: 646-06-0
1,3-DIOXOLANE

B: 4544-20-1
2-ethoxy-1,3-dioxolane

C: 96-49-1
[1,3]-dioxolan-2-one

D: 85533-22-8
(1,3-dioxolan-2-yloxy)ethanal

E: 85533-21-7
2-(1,3-dioxolan-2-yloxy)ethyl carbonate

F: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 130℃; for 0.5h; Product distribution;	A 0.01 mol B 0.08 mol C 0.08 mol D 0.02 mol E 0.009 mol F 0.01 mol

...Expand

: 201230-82-2
carbon monoxide

A: 646-06-0
1,3-DIOXOLANE

B: 71-23-8
propan-1-ol

C: 64-17-5
ethanol

D: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With 2-hydroxypyridin; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 230℃; under 1499480 Torr; for 4.5h; Further byproducts given. Title compound not separated from byproducts;	A 2 mmol B 121 mmol C 191 mmol D 1000 mmol

...Expand

: 107-21-1
ethylene glycol

A: 646-06-0
1,3-DIOXOLANE

B: 497-26-7
2-methyl-1,3-dioxolane

C: 5694-68-8
2-hydroxymethyl-1,3-dioxolane

D: 64-18-6
formic acid

E: 64-19-7
acetic acid

Conditions

Conditions	Yield
With iron(III)-acetylacetonate; oxygen In water at 150℃; for 100h; Product distribution; other acetloacetonates, also in basic solution;

...Expand

: trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene-1,3-dioxolane

A: 646-06-0
1,3-DIOXOLANE

B: 36164-98-4
trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene

Conditions

Conditions	Yield
at 55℃; under 60 Torr; Thermodynamic data; ΔE(act.), var. temp and pressure;

: 75-21-8
oxirane

: 110-88-3
1,3,5-Trioxan

A: 646-06-0
1,3-DIOXOLANE

B: 5981-06-6
1,3,5-trioxepane

C: 1,3,5,7-tetraoxacyclononane

Conditions

Conditions	Yield
With boron trifluoride-butyl ether complex In cyclohexane at 70℃; Title compound not separated from byproducts;
With boron trifluoride-butyl ether complex In cyclohexane at 70℃; Kinetics;
With boron trifluoride-butyl ether complex In cyclohexane at 70℃;	A n/a B n/a C 33 % Chromat.

...Expand

: 75-21-8
oxirane

: 50-00-0
formaldehyd

: 7664-93-9
sulfuric acid

: 646-06-0
1,3-DIOXOLANE

...Expand

: 50-00-0
formaldehyd

: 7664-93-9
sulfuric acid

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
at 140℃;

...Expand

: 20757-83-9
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

: 7732-18-5
water

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

...Expand

: 50-00-0
formaldehyd

: 107-21-1
ethylene glycol

NaHSO4: NaHSO4

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
at 140℃;

...Expand

: [1,3]Dioxolane; compound with iodine

A: 646-06-0
1,3-DIOXOLANE

B iodine: iodine

Conditions

Conditions	Yield
In n-heptane at 20℃; Equilibrium constant; Thermodynamic data; 1/K=0.85 l/mole ΔH=3.0 kcal/mole;

: Fe(CO)4(COCH2CH2O)

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With CO; H2 In decalin in presence of 34 atm CO;	0%

: 107-21-1
ethylene glycol

A: 646-06-0
1,3-DIOXOLANE

B: 628-35-3
ethylene glycol monoformate

Conditions

Conditions	Yield
With H5V2Mo10O40*34H2O In sulfolane Kinetics; Mechanism; Temperature; Time; Inert atmosphere;

: 124-38-9
carbon dioxide

: 107-21-1
ethylene glycol

A: 646-06-0
1,3-DIOXOLANE

B: 2565-36-8
2,2'-methanediyldioxy-bis-ethanol

C: 628-35-3
ethylene glycol monoformate

Conditions

Conditions	Yield
With aluminium(III) triflate; [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 80℃; under 60006 Torr; for 18h; Catalytic behavior; Solvent; Autoclave; Schlenk technique;

...Expand

: 124-38-9
carbon dioxide

: 107-21-1
ethylene glycol

: 646-06-0
1,3-DIOXOLANE

Conditions

Conditions	Yield
With aluminium(III) triflate; [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 80℃; under 60006 Torr; for 18h; Catalytic behavior; Autoclave; Schlenk technique;

: 646-06-0
1,3-DIOXOLANE

: 75-36-5
acetyl chloride

: 40510-88-1
1-acetoxy-2-chloromethoxyethane

Conditions

Conditions	Yield
With zinc(II) chloride In diethyl ether at 19 - 27℃; for 5.33333h;	100%
Stage #1: 1,3-DIOXOLANE With zinc(II) chloride at 20℃; for 0.5h; Inert atmosphere; Stage #2: acetyl chloride at 20 - 80℃; for 22h; Inert atmosphere;	92%
With zinc(II) chloride	83%

: 646-06-0
1,3-DIOXOLANE

: 506-96-7
Acetyl bromide

: 81777-40-4
2-acetoxyethoxymethyl bromide

Conditions

Conditions	Yield
at 0 - 20℃;	100%
for 2h;	93%
at 0℃;	88%

: 646-06-0
1,3-DIOXOLANE

: 64723-93-9
acetaldehyde enolate

Conditions

Conditions	Yield
With amide at 24.9℃; OH-;	100%

: 646-06-0
1,3-DIOXOLANE

: 216249-59-1
(S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride

: 444728-17-0
(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Conditions

Conditions	Yield
at 90℃; for 11h;	100%

: 646-06-0
1,3-DIOXOLANE

: 635-85-8
homoveratrylamine hydrochloride

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
With hydrogenchloride	99.8%

: 646-06-0
1,3-DIOXOLANE

: 207983-95-7
(S,E)-3-(p-tolylsulfinyl)-3-pentene-2-one

: 5,5-ethylenedioxy-4-methyl-3-(p-tolylsulfinyl)-2-pentanone

Conditions

Conditions	Yield
With benzophenone for 0.166667h; Addition; Irradiation;	99%

: 646-06-0
1,3-DIOXOLANE

: 5535-48-8
PVS

: 56161-51-4
2-<2-(phenylsulfonyl)ethyl>-1,3-dioxolane

Conditions

Conditions	Yield
With (Bu4N)2S2O8 at 25℃; for 3h; Inert atmosphere; regioselective reaction;	99%
With 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one at 50℃; for 24h;	76%

: 646-06-0
1,3-DIOXOLANE

: 2009-97-4
ethyl 2-diazo-3-oxobutanoate

: ethyl (4Z)-4-methyl-7,8-dihydro-1,3,6-trioxocine-5-carboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In benzene at 80℃; for 4h;	99%
With dirhodium tetraacetate at 60℃; for 2h; Inert atmosphere;	90%

: 646-06-0
1,3-DIOXOLANE

: 10294-34-5
boron trichloride

: ClCH2CO(CH2)2OBCl2

Conditions

Conditions	Yield
-80°C;	98.8%

: 646-06-0
1,3-DIOXOLANE

: 207983-99-1
(S,E)-3-[(2,4,6-triisopropylphenyl)sulfinyl]-3-pentene-2-one

: 220077-33-8
(3R,4R,RS)-5,5-ethylenedioxy-4-methyl-3-[(2,4,6-triisopropylphenyl)sulfinyl]-2-pentanone

Conditions

Conditions	Yield
With benzophenone for 0.166667h; Addition; Irradiation;	98%

: 646-06-0
1,3-DIOXOLANE

: 623-43-8, 4358-59-2, 18707-60-3, 130981-57-6
methyl crotonate

: 77878-20-7
methyl 4,4-ethylenedioxy-3-methyl-butanoate

Conditions

Conditions	Yield
With (Bu4N)2S2O8 at 25℃; for 15h; Inert atmosphere; regioselective reaction;	98%

: 646-06-0
1,3-DIOXOLANE

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 88820-09-1
2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester

Conditions

Conditions	Yield
With (Bu4N)2S2O8 at 25℃; for 1.5h; Inert atmosphere; regioselective reaction;	98%
With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal at 20℃; for 3h; Irradiation; Sealed tube; Inert atmosphere;	96%

: 646-06-0
1,3-DIOXOLANE

: 23055-10-9
1,4-dimethyl but-2-enedioate

: 88820-09-1
2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester

Conditions

Conditions	Yield
With (Bu4N)2S2O8 at 25℃; for 1.5h; Inert atmosphere; regioselective reaction;	98%

: 646-06-0
1,3-DIOXOLANE

: 617-86-7
triethylsilane

: 73993-16-5
1-methoxy-2-(triethylsiloxy)-ethane

Conditions

Conditions	Yield
nickel at 80 - 100℃; for 1h;	97%
zinc(II) chloride at 140℃; for 12h;	62%
With zinc(II) chloride at 140℃; Product distribution; Rate constant;

: 646-06-0
1,3-DIOXOLANE

: 14187-32-7
dibenzo-18-crown-6

: 540-72-7
sodium thiocyanide

: C20H24O6*C3H6O2*CNS(1-)*Na(1+)

Conditions

Conditions	Yield
for 1h; Ambient temperature;	97%

...Expand

: 646-06-0
1,3-DIOXOLANE

: 930-30-3
cyclopent-2-enone

: 3-[1,3]Dioxolan-2-yl-cyclopentanone

Conditions

Conditions	Yield
With (Bu4N)2S2O8 at 20 - 25℃;	97%
With (Bu4N)2S2O8 at 25℃; for 18h; Inert atmosphere; regioselective reaction;	97%
With (Bu4N)2S2O8 at 25℃; Yield given;

: 646-06-0
1,3-DIOXOLANE

: 151951-76-7
(S)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-2-cyclopentenone

: 220077-00-9
(2R,3R,RS)-3-(1,3-dioxolan-2-yl)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-1-cyclopentanone

Conditions

Conditions	Yield
With benzophenone for 0.166667h; Addition; Irradiation;	97%

: 646-06-0
1,3-DIOXOLANE

: (E)-N-(4-bromophenyl)-1-(2,4-dichlorophenyl)methanimine

: 4-bromo-N-((2,4-dichlorophenyl)(1,3-dioxolan-2-yl)methyl)aniline

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol at 80℃; for 10h; Sealed tube; Molecular sieve;	97%

: 646-06-0
1,3-DIOXOLANE

: 6626-84-2
dimethyl 2-benzylidenepropanedioate

: dimethyl 2-((1,3-dioxolan-2-yl)(phenyl)methyl)malonate

Conditions

Conditions	Yield
With fac-tris[2-phenylpyridinato-C2,N]iridium(III); (Bu4N)2S2O8 at 30℃; for 24h; Reagent/catalyst; Inert atmosphere; Sealed tube; Irradiation;	97%

: 646-06-0
1,3-DIOXOLANE

: 5337-93-9
4'-methylpropiophenone

: 6091-44-7
piperidine hydrochloride

: Tolperisone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 90℃; for 8h;	96%

...Expand

: 646-06-0
1,3-DIOXOLANE

: 99315-76-1
(5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone

: (4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-dihydro-furan-2-one

Conditions

Conditions	Yield
With (Bu4N)2S2O8	96%
With (Bu4N)2S2O8 at 30℃; for 0.25h;	96%

: 646-06-0
1,3-DIOXOLANE

: 79681-26-8
2-[(S)-(4-methylphenyl)sulfinyl]cyclopent-2-en-1-one

: (2R*,3R*,RS)-3-(1,3-dioxolan-2-yl)-2-(p-tolylsulfinyl)-1-cyclopentanone

Conditions

Conditions	Yield
With benzophenone for 0.166667h; Addition; Irradiation;	96%

: 646-06-0
1,3-DIOXOLANE

: 856611-83-1
dichloro-(2-chloromethoxy-ethoxy)-borane

: 89582-76-3
bis(chloromethoxyethoxy)chloroborane

Conditions

Conditions	Yield
	96%

: 646-06-0
1,3-DIOXOLANE

: 1185869-40-2, 955280-09-8
C17H13ClN2O2

: 1185869-41-3
6-chloro-1-[(2'-hydroxyethoxy)methyl]-N-[(phenyl)methyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Conditions

Conditions	Yield
Stage #1: C17H13ClN2O2 With chloro-trimethyl-silane; N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile for 4h; Inert atmosphere; Reflux; Stage #2: 1,3-DIOXOLANE With chloro-trimethyl-silane; potassium iodide In acetonitrile at 20℃; for 24h; Stage #3: With water; sodium hydrogencarbonate In acetonitrile	96%

: 646-06-0
1,3-DIOXOLANE

: 924-44-7
glyoxylic acid ethyl ester

: 62-53-3
aniline

: ethyl 2-(1,3-dioxolan-2-yl)-2-(phenylamino)acetate

Conditions

Conditions	Yield
Stage #1: 1,3-DIOXOLANE; glyoxylic acid ethyl ester; aniline In toluene at 20℃; for 1h; Sealed tube; Molecular sieve; Stage #2: With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol In toluene at 80℃; for 12h; Sealed tube; Molecular sieve; regioselective reaction;	96%

...Expand

: 646-06-0
1,3-DIOXOLANE

: 924-44-7
glyoxylic acid ethyl ester

: 104-94-9
4-methoxy-aniline

: ethyl 2-(1,3-dioxolan-2-yl)-2-((4-methoxyphenyl)amino)acetate

Conditions

Conditions	Yield
Stage #1: 1,3-DIOXOLANE; glyoxylic acid ethyl ester; 4-methoxy-aniline In toluene at 20℃; for 1h; Sealed tube; Molecular sieve; Stage #2: With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol In toluene at 80℃; for 12h; Sealed tube; Molecular sieve;	96%

...Expand

: 646-06-0
1,3-DIOXOLANE

: 2,2,2-trifluoro-N-hexylethan-1-imine

: C11H20F3NO2

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal at 20℃; Molecular sieve; Irradiation; Inert atmosphere;	96%

: 646-06-0
1,3-DIOXOLANE

: 6065-67-4
formic acid-(2-bromo-ethyl ester)

Conditions

Conditions	Yield
With Bromoform; (RCO2)2 at 20 - 60℃; for 3h; Irradiation;	95%
With 1,4-Dioxane Dibromide In tetrachloromethane at 29.9℃; Rate constant; Thermodynamic data; Mechanism; ΔH(excit.), ΔS(excit.), ΔG(excit.), lg A; further temp., kinetics;

: 646-06-0
1,3-DIOXOLANE

: 27465-51-6
1-(4-ethylphenyl)-1-propanone

: 6091-44-7
piperidine hydrochloride

: 56839-43-1
eperisone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 90℃; for 6.5h;	95%

...Expand

1,3-Dioxolane Specification

The 1,3-Dioxolane, with the cas registry number 646-06-0, is a kind of clear colourless liquid. This is completely soluble in water and soluble in alcohol, ether, and benzene. And it could be easily ignited by heat, sparks or flames, and the vapor may form explosive mixtures with air. In addition, its product categories are various, including Dioxanes & Dioxolanes; Dioxolanes; Intermediates & Fine Chemicals; Pharmaceuticals.It is highly flammable. When exposed to air 1,3-Dioxolane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. Soluble in water.

Properties of 1,3-Dioxolane:
The characteristics of this chemical are as follows: (1)ACD/LogP: -0.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.73; (4)ACD/LogD (pH 7.4): -0.73; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 9.61; (8)ACD/KOC (pH 7.4): 9.61; (9)#H bond acceptors: 2; (10)Polar Surface Area: 18.46; (11)Index of Refraction: 1.396; (12)Molar Refractivity: 17.04 cm³; (13)Molar Volume: 70.8 cm³; (14)Polarizability: 6.75 ×10^-24 cm³; (15)Surface Tension: 32.7 dyne/cm; (16)Density: 1.046 g/cm³; (17)Flash Point: 1.7 °C; (18)Enthalpy of Vaporization: 30.36 kJ/mol; (19)Boiling Point: 75.6 °C at 760 mmHg; (20)Vapour Pressure: 115 mmHg at 25°C; (21)Exact Mass: 74.036779; (22)MonoIsotopic Mass: 74.036779; (23)Topological Polar Surface Area: 18.5; (24)Heavy Atom Count: 5; (25)Formal Charge: 0; (26)Complexity: 24.1.

Structure Descriptors of 1,3-Dioxolane:
(1)Canonical SMILES: C1COCO1
(2)InChI: InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2
(3)InChIKey: WNXJIVFYUVYPPR-UHFFFAOYSA-N

Toxicity of 1,3-Dioxolane is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	10500mg/m3/2H (10500mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 70, 1982.
mouse	LD50	oral	3200mg/kg (3200mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 70, 1982.
rabbit	LCLo	inhalation	32000ppm/4H (32000ppm)		Union Carbide Data Sheet. Vol. 12/17/1971,
rabbit	LD50	oral	5200mg/kg (5200mg/kg)		National Technical Information Service. Vol. OTS0537791,
rabbit	LD50	skin	8480uL/kg (8.48mL/kg)		Union Carbide Data Sheet. Vol. 12/17/1971,
rat	LC50	inhalation	20650mg/m3/4H (20650mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 70, 1982.
rat	LD50	oral	3gm/kg (3000mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 60, 1949.
rat	LD50	skin	15gm/kg (15000mg/kg)		National Technical Information Service. Vol. OTS0537791,
rat	LDLo	intraperitoneal	500mg/kg (500mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED	Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

Preparation of 1,3-Dioxolane
The first way: have the reaction of paraformaldehyde and ethylene glycol. The second way: paraformaldehyde could react with ethylene glycol with the existence of concentrated sulfuric acid, and then go through salting out with sodium chloride, soild sodium hydroxide and drying, and then rectifying to get this chemical.

Use of 1,3-Dioxolane
The production methods of 1,3-Dioxolane are as below: As to its usage, it is widely applied in many ways. It could be used as the solvent and extractant for oil and axunge, and as the silk finishing agent or sealing rubber; It could also be used as the galvanolysis solvent of lithium battery, stabilizing agent, and the intermediate for Acyclovir-d4.

Product Name

1,3-Dioxolane

Synthetic route

1,3-Dioxolane Specification

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