1,4-dichlorobutane supplier

Name
1,4-dichlorobutane
EINECS 203-778-1
CAS No. 110-56-5
Article Data96
CAS DataBase
Density 1.16 g/cm³
Solubility 0.24 g/100 mL (20 °C) in water
Melting Point -38 °C
Formula C₄H₈Cl₂
Boiling Point 153.9 °C at 760 mmHg
Molecular Weight 127.014
Flash Point 40.8 °C
Transport Information UN 1993 3/PG 3
Appearance Colorless mobile liquid
Safety 26-36-45-36/37
Risk Codes 10-36/37/38-39/23/24/25-23/24/25
Molecular Structure
Hazard Symbols Xi,T
Synonyms Tetramethylene dichloride;NSC 6288;
PSA 0.00000
LogP 2.24420

Synthetic route

: 110-63-4
Butane-1,4-diol

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With hydrogenchloride; ammonium chloride In water at 56 - 105℃; for 3h;	97%
With hydrogenchloride In water at 20℃; for 24h;	94.7%
With hydrogenchloride In water at 20℃; for 24h;	94.7%

: 6334-96-9
bis-(4-chlorobutyl)ether

: 98-88-4
benzoyl chloride

A: 946-02-1
4-chlorobutyl benzoate

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With molybdenum(V) chloride In 1,2-dichloro-ethane at 80℃; for 24h;	A 95% B 60%

...Expand

: 75-44-5
phosgene

butane-1,4-diole: butane-1,4-diole

: 814-29-9
Tributylphosphine oxide

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
	95%

...Expand

: 2157-16-6
1,4-butanediol bis(chloroformate)

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With hexabutylguanidinium chloride at 120℃; for 4h;	91%

: 109-99-9
tetrahydrofuran

A: 6334-96-9
bis-(4-chlorobutyl)ether

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With molybdenum(V) chloride In 1,2-dichloro-ethane at 50℃; for 24h;	A 76% B 6%
With titanium tetrachloride 1.) 0 deg C; reflux, 2 h, 2.) 110 - 125 deg C, 1 h, 10 mmHg; Yield given. Multistep reaction. Yields of byproduct given;
With zinc(II) chloride; trichlorophosphate
With thionyl chloride

: 109-99-9
tetrahydrofuran

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate at 85 - 90℃; for 1h;	75.6%
With molybdenum(V) chloride In 1,2-dichloro-ethane at 50℃; for 1h;	70%
With hydrogenchloride

: 109-99-9
tetrahydrofuran

: 75-77-4
chloro-trimethyl-silane

A: 107-46-0
Hexamethyldisiloxane

B: 13617-19-1
1-chloro-4-trimethylsilanyloxy-butane

C: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With aluminum oxide In hexane at 50℃; for 90h; Product distribution; further reagents;	A 24% B 15% C 1%

...Expand

: 109-99-9
tetrahydrofuran

: 75-77-4
chloro-trimethyl-silane

A: 107-46-0
Hexamethyldisiloxane

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With silica gel In hexane at 50℃; for 72h;	A 20% B 5%

...Expand

: 109-99-9
tetrahydrofuran

: 75-54-7
Dichloromethylsilane

: 110-56-5
1,4-dichlorobutane

: 109-99-9
tetrahydrofuran

: 75-44-5
phosgene

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 110-56-5
1,4-dichlorobutane

...Expand

: 109-99-9
tetrahydrofuran

: 75-44-5
phosgene

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With zinc(II) chloride

: 109-99-9
tetrahydrofuran

: 75-44-5
phosgene

A: 6334-96-9
bis-(4-chlorobutyl)ether

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With zinc(II) chloride

...Expand

: 109-99-9
tetrahydrofuran

: 115-21-9
ethyltrichlorosilane

: 628-13-7
pyridine hydrochloride

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
at 180℃;

...Expand

: 109-99-9
tetrahydrofuran

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 75-78-5
dimethylsilicon dichloride

: 110-56-5
1,4-dichlorobutane

...Expand

: 3389-54-6
n-benzoylpyrrolidine

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With phosphorus pentachloride

: 109-69-3
n-Butyl chloride

: 78-00-2
tetraethyllead(IV)

A: 541-33-3
1,1-dichlorobutane

B: 1190-22-3
1,3-dichlorobutane

C: 616-21-7, 130232-87-0, 130232-88-1
1,2-dichlorobutane

D: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
at 202℃; Chlorierung im Stickstoffstrom;

...Expand

: 109-69-3
n-Butyl chloride

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With sulfuryl dichloride; dibenzoyl peroxide
With sulfuryl dichloride; dilauryl peroxide
Chlorierung im Tageslicht oder ultravioletten Licht(?);
With sulfuryl dichloride; dilauryl peroxide
With sulfuryl dichloride; dibenzoyl peroxide

: 109-69-3
n-Butyl chloride

A: 541-33-3
1,1-dichlorobutane

B: 1190-22-3
1,3-dichlorobutane

C: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
at 312℃; Chlorierung im Stickstoffstrom;
at 380℃; Chlorierung im Stickstoffstrom;

...Expand

: 3079-82-1
butane-1,4-disulfonyl chloride

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
at 200℃;

: 31991-78-3
uvariadiamide

: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With phosphorus pentachloride im Vakuum;

: 31991-78-3
uvariadiamide

A: 6345-94-4
N-(4-chlorobutyl)benzamide

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With phosphorus pentachloride under 3 - 4 Torr;

: 109-69-3
n-Butyl chloride

A: 541-33-3
1,1-dichlorobutane

B: 1190-22-3
1,3-dichlorobutane

C: 616-21-7, 130232-87-0, 130232-88-1
1,2-dichlorobutane

D: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With sulfuryl dichloride; zeolite NaX for 2h; Heating; Irradiation;	A 6 % Chromat. B 46 % Chromat. C 23 % Chromat. D 25 % Chromat.
With sulfuryl dichloride; zeolite NaX for 2h; Product distribution; Heating; Irradiation;	A 6 % Chromat. B 46 % Chromat. C 23 % Chromat. D 25 % Chromat.
With norborn-2-ene; N-chlorohexamethyldisilazane; trans-di-O-tert-butyl hyponitrite at 44.9℃; for 1h; Product distribution; Mechanism; further reagent, time;

...Expand

: 109-99-9
tetrahydrofuran

A: 60767-73-9
4-(4-chlorobutoxy)butan-1-ol

B: 6334-96-9
bis-(4-chlorobutyl)ether

C: 68936-07-2
14-chloro-5,10-dioxatetradecan-1-ol

D: 77920-58-2
19-chloro-5,10,15-trioxanonadecan-1-ol

E: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With titanium tetrachloride Mechanism; multistep reaction, ring-opening and ring-opening with simultaneous condensation to dimeric products, hydrolytic and non-hydrolytic work-up;

...Expand

: 67-56-1
methanol

: 74-85-1
ethene

A: 627-42-9
2-chloroethyl methyl ether

B: 107-06-2
1,2-dichloro-ethane

C: 111-44-4
3-oxa-1,5-dichloropentane

D: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With hydrogenchloride at 5 - 10℃; under 45003.6 Torr; electrolysis;	A 47 % Chromat. B 31 % Chromat. C 17 % Chromat. D 6 % Chromat.

...Expand

: 74-85-1
ethene

A: 107-06-2
1,2-dichloro-ethane

B: 111-44-4
3-oxa-1,5-dichloropentane

C: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With hydrogenchloride In water; acetonitrile at 5 - 10℃; under 45003.6 Torr; electrolysis, further solvent methanol;	A 82 % Chromat. B 17 % Chromat. C 6 % Chromat.

...Expand

: 74-85-1
ethene

A: 627-42-9
2-chloroethyl methyl ether

B: 107-06-2
1,2-dichloro-ethane

C: 111-44-4
3-oxa-1,5-dichloropentane

D: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 5 - 10℃; under 45003.6 Torr; electrolysis, further solvent aq. acetonitrile;	A 47 % Chromat. B 31 % Chromat. C 17 % Chromat. D 6 % Chromat.

...Expand

: 109-69-3
n-Butyl chloride

A: 1190-22-3
1,3-dichlorobutane

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With chlorinating agent; sulfuric acid In acetic acid at 30℃; Product distribution; Irradiation; various yield of products by various reagents;

: 75-09-2
dichloromethane

A: 23415-85-2
(dichloromethyl)phosphonous dichloride

B: 110-56-5
1,4-dichlorobutane

Conditions

Conditions	Yield
With n-butyllithium; zinc(II) chloride; phosphorus trichloride 1.) -95 to -80 deg C, 2.5 h; -80 deg C to r.t., 2.) THF, r.t., 30 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

: 617-86-7
triethylsilane

: 110-63-4
Butane-1,4-diol

A: 109-99-9
tetrahydrofuran

B: 110-56-5
1,4-dichlorobutane

C: (4-Chloro-butoxy)-triethyl-silane

Conditions

Conditions	Yield
With hexachloroethane; palladium dichloride at 60℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 110-63-4
Butane-1,4-diol

A: 109-99-9
tetrahydrofuran

B: 110-56-5
1,4-dichlorobutane

C: (4-Chloro-butoxy)-triethyl-silane

Conditions

Conditions	Yield
With triethylsilane; hexachloroethane; palladium dichloride at 60℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 110-56-5
1,4-dichlorobutane

: 61717-82-6
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione

: butane-1,4-diyl bis(2-iodobenzoate)

Conditions

Conditions	Yield
With tetrabutylammomium bromide In dimethyl sulfoxide at 80℃; for 2h;	100%

: 138434-76-1
1,20-Bis-(4-hydroxy-phenyl)-6,9,12,15-tetraoxa-3,18-diaza-tricyclo[16.3.1.13,20]tricosan-21-one

: 110-56-5
1,4-dichlorobutane

: 138434-81-8
1,20-Bis-[4-(4-chloro-butoxy)-phenyl]-6,9,12,15-tetraoxa-3,18-diaza-tricyclo[16.3.1.13,20]tricosan-21-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	99%

: 110-56-5
1,4-dichlorobutane

: 1,20-bis(4-hydroxyphenyl)-6,9,12,15-tetraoxa-3,18-diazatricyclo<16.3.1.13,20>tricosan-21-one

: 1,20-bis<4-(4-chlorobutyloxy)phenyl>-6,9,12,15-tetraoxa-3,18-diazatricyclo<16.3.1.13,20>tricosan-21-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h;	99%

: 616-47-7
1-methyl-1H-imidazole

: 110-56-5
1,4-dichlorobutane

: 1,1'-dimethyl-3,3'-(1,4-tetramethylene)bisimidazolium dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 3h; Pressure; Menshutkin Reaction; High pressure; Autoclave;	99%
In neat (no solvent) at 90℃; for 2h;	98%
In methanol for 24h; Reflux;	94%

: 1739-84-0
1,2-dimethyl-1H-imidazole

: 110-56-5
1,4-dichlorobutane

: 1,4-bis(1,2-dimethylimidazolium-3-yl)butane dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 24h; Kinetics; Pressure; Time; Menshutkin Reaction; High pressure; Autoclave;	99%
In isopropyl alcohol for 16h; Reflux;	60%

: 1739-83-9
1,2,4,5-tetramethylimidazole

: 110-56-5
1,4-dichlorobutane

: 1,4-bis(1,2,4,5-tetramethylimidazolium-3-yl)butane dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 3h; Pressure; Menshutkin Reaction; High pressure; Autoclave;	99%

: 7098-07-9
N-Ethylimidazole

: 110-56-5
1,4-dichlorobutane

: 1,4-bis(1-ethylimidazolium-3-yl)butane dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 24h; Pressure; Menshutkin Reaction; High pressure; Autoclave;	99%

: 110-56-5
1,4-dichlorobutane

: 110-01-0
thiophene

Conditions

Conditions	Yield
With sodium sulfide; N-benzyl-N,N,N-triethylammonium chloride In 1-methyl-pyrrolidin-2-one at 50 - 100℃; Solvent; Temperature; Reagent/catalyst; Concentration;	98.8%
With sodium sulfide; N,N-dimethyl-formamide
With sodium sulfide; ethylene glycol
With sodium sulfide; ethanol

: 25909-68-6
[13C]-potassium cyanide

: 110-56-5
1,4-dichlorobutane

: 109432-72-6
<1,6-(13)C2>-adiponitrile

Conditions

Conditions	Yield
18-crown-6 ether In acetonitrile for 16h; Heating;	98.8%

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 110-56-5
1,4-dichlorobutane

: 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) dichloride

Conditions

Conditions	Yield
In acetonitrile for 4h; Reflux;	98.7%
In neat (no solvent) at 80℃; for 4h;	98.7%
at 80℃; for 4h;	98.7%

: 110-86-1
pyridine

: 110-56-5
1,4-dichlorobutane

: 25057-79-8
1,1'-butylenebispyridinium dichloride

Conditions

Conditions	Yield
In acetonitrile for 48h; Reflux;	98.2%
In ethanol for 40h; Heating;

: 110-56-5
1,4-dichlorobutane

: 136975-73-0
7-propyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione

: 1-(4-chloro-butyl)-7-propyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;	98%

: 110-56-5
1,4-dichlorobutane

: 136975-53-6
7-butyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione

: 7-butyl-1-(4-chloro-butyl)-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;	98%

: 288-32-4
1H-imidazole

: 110-56-5
1,4-dichlorobutane

: 69506-86-1
1,1'-(1,4-butanediyl)bis(imidazole)

Conditions

Conditions	Yield
Stage #1: 1H-imidazole With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 2h; Stage #2: 1,4-dichlorobutane In dimethyl sulfoxide; mineral oil at 20℃;	98%
Stage #1: 1H-imidazole With sodium hydride In mineral oil at 20℃; for 2h; Stage #2: 1,4-dichlorobutane In mineral oil at 20℃;	98%
Stage #1: 1H-imidazole With sodium hydroxide In dimethyl sulfoxide at 60℃; for 1.5h; Stage #2: 1,4-dichlorobutane In dimethyl sulfoxide at 60℃; for 2.5h;	93%

: 1013-90-7
(c-C6H11)2SbLi

: 110-56-5
1,4-dichlorobutane

: 1058-87-3
{(c-C6H11)2Sb}2(CH2)4

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether addn. of 1,4-dichlorobutane in THF over 30 min to a (c-C6H11)2SbLi soln. in ether at -45°C; mixt. treated with aq. NH4Cl, evapn. of the ether;	97.6%
In tetrahydrofuran; diethyl ether addn. of 1,4-dichlorobutane in THF over 30 min to a (c-C6H11)2SbLi soln. in ether at -45°C; mixt. treated with aq. NH4Cl, evapn. of the ether;	97.6%

: 110-56-5
1,4-dichlorobutane

: 137003-97-5
7-methyl-6,7-dihydropyrrolo[2,3-c]-azepine-4,8(1H,5H)-dione

: 136975-57-0
1-(4-Chlorobutyl)-7-methyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;	97%
With hydrogenchloride; potassium carbonate In ethyl acetate; N,N-dimethyl-formamide; benzene	97%

: C18H20N2O8

: 110-56-5
1,4-dichlorobutane

: C22H27ClN2O8

Conditions

Conditions	Yield
Stage #1: C18H20N2O8 With sodium hydride In tetrahydrofuran Inert atmosphere; Reflux; Stage #2: 1,4-dichlorobutane In tetrahydrofuran for 30h; Inert atmosphere; Reflux;	96.6%

: 141-53-7
sodium formate

: 110-56-5
1,4-dichlorobutane

: 61836-76-8
1,4-butanediol diformate

Conditions

Conditions	Yield
tetrabutylammomium bromide at 115℃; for 1.5h;	96%

: 21502-53-4
lithium diisopropylphosphide

: 110-56-5
1,4-dichlorobutane

: 80499-19-0
1,4-bis(diisopropyl-phosphino)butane

Conditions

Conditions	Yield
In diethyl ether; hexane ice cooling, then Rt 10 h;	96%

: 39630-68-7
diethyl 5-hydroxyisophthalate

: 110-56-5
1,4-dichlorobutane

: 52739-96-5
tetraethyl 5,5′-(butane-1,4-diyl)-bis(oxy)-diisophthalate

Conditions

Conditions	Yield
Stage #1: diethyl 5-hydroxyisophthalate With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; Inert atmosphere; Stage #2: 1,4-dichlorobutane In N,N-dimethyl-formamide at 80℃; for 20h; Inert atmosphere;	96%

: Cd(2+)*2C12H22P(1-)

: 110-56-5
1,4-dichlorobutane

: 65038-36-0
1,4-bis(dicyclohexylphosphino)butane

Conditions

Conditions	Yield
at 60℃; for 12h;	96%

: 3-nitro-4-vinylphenol

: 110-56-5
1,4-dichlorobutane

: 4-(4-chlorobutoxy)-2-nitro-1-vinylbenzene

Conditions

Conditions	Yield
With potassium iodide; sodium hydroxide In acetonitrile at 30℃; for 16h; Reagent/catalyst; Temperature;	96%

: 4791-78-0, 856332-85-9
(t-C4H9)2SbLi*C4H8O2

: 110-56-5
1,4-dichlorobutane

: 4791-75-7
{(t-C4H9)2Sb}2

Conditions

Conditions	Yield
In 1,4-dioxane ratio of (t-C4H9)2SbLi * C4H8O2 and 1,4-dichlorobutane 1:2, at 65°C;	95.5%

: 123-75-1
pyrrolidine

: 110-56-5
1,4-dichlorobutane

: 90076-67-8
potassium bis(trifluoromethylsulfonyl)imide

: 5-azoniaspiro[4.4]nonane bis(trifluoromethanesulfonyl)imide

Conditions

Conditions	Yield
With sodium hydroxide In water at 10 - 60℃; for 7h;	95.5%

...Expand

: 110-56-5
1,4-dichlorobutane

: 109-99-9
tetrahydrofuran

Conditions

Conditions	Yield
With potassium hydroxide; sodium formate; Aliquat 336 at 105℃; for 0.25h;	95%

: 4316-42-1
1-Butylimidazole

: 110-56-5
1,4-dichlorobutane

: 1,4-bis(1-butylimidazolium-3-yl)butane dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 24h; Pressure; Time; Menshutkin Reaction; High pressure; Autoclave;	95%
In toluene at 95℃; for 24h;	72%
With calcium chloride In acetonitrile for 72h; Reflux;	72%

: 110-86-1
pyridine

: 110-56-5
1,4-dichlorobutane

: 10500-57-9
5,6,7,8-tetrahydroquinoline

Conditions

Conditions	Yield
With aluminum (III) chloride at 25℃; for 24h; Inert atmosphere;	95%
With aluminum (III) chloride for 24h;	95%
With aluminum (III) chloride for 24h;	95%

1,4-dichlorobutane Specification

The IUPAC name of this product is 1,4-dichlorobutane. With the CAS registry number 110-56-5, it is also named as Butane, 1,4-dichloro-. The product's categories are industrial / fine chemicals; alpha,omega-bifunctional alkanes; alpha,omega-dichloroalkanes; monofunctional & alpha,omega-bifunctional alkanes; method 8021; 500 series drinking water methods; 600 series wastewater methods; 8000 series solidwaste methods; alpha sort; method 502EPA; method 601EPA; volatiles / semivolatiles; method 601. It is colorless mobile liquid with a mild pleasant odor. In addition, it is stable, flammable and incompatible with strong bases, strong oxidizing agents. This chemical can react vigorously with oxidizing materials.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.24; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.24; (4)ACD/LogD (pH 7.4): 2.24; (5)ACD/BCF (pH 5.5): 29.65; (6)ACD/BCF (pH 7.4): 29.65; (7)ACD/KOC (pH 5.5): 393.85; (8)ACD/KOC (pH 7.4): 393.85; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.429; (13)Molar Refractivity: 30.27 cm³; (14)Molar Volume: 117.3 cm³; (15)Polarizability: 12×10^-24 cm³; (16)Surface Tension: 27.2 dyne/cm; (17)Enthalpy of Vaporization: 37.46 kJ/mol; (18)Vapour Pressure: 4.18 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Exact Mass: 126.000306; (21)MonoIsotopic Mass: 126.000306; (22)Heavy Atom Count: 6.

Preparation of 1,4-dichlorobutane: It can be obtained by butane-1,4-diol in solvent chlorotriphenylphosphonium dichlorophosphate at 20 °C. This reaction type is Arbuzov reaction and the yield is 65%.

Uses of 1,4-dichlorobutane: It is used as raw material and solvent for organic synthesis. And it is used for the synthesis of adiponitrile and drug carbetapentane. In addition, it can react with aniline to get 1-phenyl-pyrrolidine. This reaction needs reagent KF at temperature of 120 °C. The reaction time is 12 hours. The yield is 88%.

When you are using this chemical, please be cautious about it as the following:
It is flammable. And it is toxic by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. Smiles: C(CCCl)CCl;
2. InChI: InChI=1/C4H8Cl2/c5-3-1-2-4-6/h1-4H2.

Product Name

1,4-dichlorobutane

Synthetic route

1,4-dichlorobutane Specification

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