1,8-Dihydroxyanthraquinone supplier

Name
1,8-Dihydroxyanthraquinone
EINECS 204-173-5
CAS No. 117-10-2
Article Data56
CAS DataBase
Density 1.541 g/cm³
Solubility insoluble in water
Melting Point 191-193 °C
Formula C₁₄H₈O₄
Boiling Point 452.667 °C at 760 mmHg
Molecular Weight 240.215
Flash Point 241.691 °C
Transport Information
Appearance orange-brown or brown powder
Safety 36/37-22
Risk Codes 40
Molecular Structure
Hazard Symbols Xn
Synonyms Anthraquinone,1,8-dihydroxy- (8CI);1,8-Dihydroxy-9,10-anthracenedione;1,8-Dihydroxy-9,10-anthraquinone;1,8-Dioxyanthraquinone;Antrapurol;Chrysazin;Danthron;Danthrone;Diaquone;Laxanorm;Laxanthreen;
PSA 74.60000
LogP 1.87320

Synthetic route

: 1963-82-2
1,8-diacetoxy-9,10-anthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With water; trifluoroacetic acid at 65℃; for 1h;	100%

: 69043-83-0
1,4-dioxo-1,2,3,4-tetrahydro-5,9,10-trihydroxyanthracene(leuco 1,4,5-trihydroxy-9,10-anthraquinone)

A: 117-12-4
1,5-dihydroxyanthraquinone

B: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With pyrrolidine In toluene for 1.5h; Heating;	A 93% B n/a

: 1432067-68-9
1,8-bis(2-phenylselenoethoxy)anthracene-9,10-dione

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 1432067-84-9
1-hydroxy-8-(2-phenylselenoethoxy)anthracene-9,10-dione

Conditions

Conditions	Yield
With iron (III) perchlorate monohydrate In dichloromethane for 2h;	A n/a B 90%
With copper(II) perchlorate hexahydrate In dichloromethane for 2h;	A n/a B 70%

: 577975-52-1
4-hydroxy-10-imino-5-methoxymethoxy-10H-anthracen-9-one

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane; methanol at 20℃; for 96h;	86%

: 1182282-39-8
1,8-bis(prop-2-ynyloxy)anthracene-9,10-dione

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 2,10-dimethyl-6,12-dihydroanthra[1,2-b:8,7-b']difuran-6,12-dione

Conditions

Conditions	Yield
With iron at 160℃; for 0.0666667h; Claisen Rearrangement; Ionic liquid;	A 16% B 73%

: 1393091-17-2
1-hydroxy-8-(prop-2'-ynyloxy)anthraquinone

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 10-hydroxy-2-methyl-6,11-dihydroanthra[1,2-b]furan-6,11-dione

Conditions

Conditions	Yield
With iron at 160℃; for 0.2h; Claisen Rearrangement; Ionic liquid;	A 15% B 73%

: 84399-87-1
8-Hydroxy-1,1,4-trimethoxy-1,4,4a,9a-tetrahydro-anthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sulfuric acid	67%

: 78526-20-2
1,1-ethylenedioxy-6-hydroxy-1,4,4α,9aα-tetrahydro-9,10-anthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With acetic acid at 100℃; for 0.333333h;	40%

: 89646-25-3
3-Hydroxy-2-(2-hydroxybenzoyl)-benzoesaeure

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; boric acid at 120℃; for 0.5h;	38.4%
With boron trioxide; sulfuric acid at 100℃;

: 1',8',10'-trihydroxy-1,8-bis(methoxymethoxy)-[2,10'-bianthracen]-9'(10'H)-one

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 1',8',10'-trihydroxy-8-(methoxymethoxy)-[2,10'-bianthracene]-1,4,9'(10'H)-trione

Conditions

Conditions	Yield
With sodium acetate; pyridinium chlorochromate In dichloromethane at 20℃; for 26h; Inert atmosphere;	A n/a B 34%

: 1',8',10'-trihydroxy-1,8-bis(methoxymethoxy)-[2,10'-bianthracen]-9'(10'H)-one

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 1',8',10'-trihydroxy-[2,10'-bianthracene]-1,4,5,8,9'(10'H)-pentaone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid In water at 20℃; for 1.5h;	A n/a B 23%

: 5539-66-2
1-hydroxy-8-methoxyanthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid

: 1758-68-5
1,2-diamino-9,10-anthraquinone

A: 117-12-4
1,5-dihydroxyanthraquinone

B: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite at 90 - 120℃;

: 82-48-4
1,8-anthraquinonedisulphonic acid

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With potassium carbonate
With quicklime; water at 180 - 200℃;
With calcium hydroxide; calcium chloride at 195 - 200℃; Darstellung; im Autoklaven;

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 129-39-5
1,8-dinitroanthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With potassium acetate; acetic acid at 170℃;
Multi-step reaction with 2 steps 1: water; alkali sulfite 2: quicklime; water / 180 - 200 °C View Scheme
With pyridine
With quicklime; water at 190 - 200℃;

: 2,4,5,7-tetraamino-1,8-dihydroxy-anthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With mixture of gaseous nitrogen oxides; sulfuric acid Erwaermen das Diazoniumsulfat mit Alkohol auf 60grad;

: 52431-65-9
3-Bromojuglone

: 110362-30-6
1-<(trimethylsilyl)oxy>-1-methoxy-1,3-butadiene

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With hydrogenchloride 1) THF, -78 deg C, 6 h, 2) -78 deg C to r.t., 2 h; Yield given. Multistep reaction;

: 1143-38-0
1,8-dihydroxy-9(10H)-anthracenone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With oxygen In methanol for 1.5h; Rate constant; Mechanism; different pH; half lives of decomposition;
With oxygen In ethanol at 25℃; for 240h; Mechanism; other solvent; determinations of half-lives;
With pyridinum sulfonate fluorochromate for 0.0222222h; Neat (no solvent); Microwave irradiation;

: 1143-38-0
1,8-dihydroxy-9(10H)-anthracenone

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 31991-54-5
1,8,1',8'-tetrahydroxy-10,10'-bianthrone

Conditions

Conditions	Yield
With tetraphenylporphyrine; oxygen In methanol at -10℃; for 4h; Product distribution; Irradiation; other reagents, other solvents, other temp., no irradiation; inhibition by β-carotene;	A 67 % Chromat. B 19 % Chromat.
With 4-hydroxy-TEMPO benzoate; oxygen In dimethyl sulfoxide at 20℃; Kinetics; Further Variations:; Reagents;

: 1143-38-0
1,8-dihydroxy-9(10H)-anthracenone

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 31991-54-5
1,8,1',8'-tetrahydroxy-10,10'-bianthrone

C: 64817-79-4
1,8,10-Trihydroxy-9-anthron

Conditions

Conditions	Yield
With salcomine; oxygen In dichloromethane for 1h; Product distribution; Mechanism; in the dark; further complexes of transition metals, other solvents;

...Expand

: 59945-68-5
1,8,9,10-anthracenetetrol

: 121151-81-3
1,8-dihydroxy-9,10-anthraquinone semiquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
In isopropyl alcohol Rate constant; Equilibrium constant;

: 2891-30-7
10-bromo-1,8-dihydroxy-9(10H)-anthracenone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With rac-cysteine

: 75464-11-8
1,8-dihydroxy-10-(1'-oxobutyl)-9(10H)-anthracenone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With oxygen In methanol for 1.5h; Rate constant; Mechanism; different pH; half lives of decomposition;

: 84399-87-1
(4α,4aβ,9aβ)-8-hydroxy-1,1,4-trimethoxy-1,4,4a,9a-tetrahydroanthraquinone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sulfuric acid In tetrahydrofuran Ambient temperature;	1.4 mg

: 78112-67-1
1-Amino-4,5-dihydroxy-9,10-anthracenedione

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sodium hydroxide; hypophosphorous acid; sodium nitrite 1.) water, dioxan, 2.) 0 deg C, 20 min; 70 deg C, 2 h; room temperature, 10 h; Multistep reaction;

: (E)-1,8-dihydroxy-10-(1-oxo-3-phenyl-2-propenyl)-9(10H)-anthracenone

A: 140-10-3
(E)-3-phenylacrylic acid

B: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With oxygen In ethanol at 25℃; for 240h; Mechanism; other solvent; determinations of half-lives;

: 151562-41-3
1,8-dihydroxy-10-(1-oxo-2-phenylethy)-9(10H)-anthracenone

A: 103-82-2
phenylacetic acid

B: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

Conditions

Conditions	Yield
With oxygen In ethanol at 25℃; for 240h; Mechanism; other solvent; determinations of half-lives;

: 151562-48-0
1,8-Dihydroxy-10-(1-oxo-3-phenylpropyl)-9(10H)-anthracenone

A: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

B: 501-52-0
3-Phenylpropionic acid

Conditions

Conditions	Yield
With oxygen In ethanol at 25℃; for 240h; Mechanism; other solvent; determinations of half-lives;

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 79-03-8
propionyl chloride

: Propionic acid 9,10-dioxo-8-propionyloxy-9,10-dihydro-anthracen-1-yl ester

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	100%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 2094-72-6
1-Adamantanecarbonyl chloride

: C36H36O6

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	100%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 107-30-2
chloromethyl methyl ether

: 134112-14-4
1,8-bis(methoxymethoxy)-9,10-anthraquinone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In chloroform for 16h; Heating;	100%
With N-ethyl-N,N-diisopropylamine In chloroform; acetic acid methyl ester for 40h; Reflux;	99%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 75-36-5
acetyl chloride

: 1963-82-2
1,8-diacetoxy-9,10-anthraquinone

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	100%
With pyridine	87%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 141-75-3
butyryl chloride

: Butyric acid 8-butyryloxy-9,10-dioxo-9,10-dihydro-anthracen-1-yl ester

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	100%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 108-24-7
acetic anhydride

: 1963-82-2
1,8-diacetoxy-9,10-anthraquinone

Conditions

Conditions	Yield
With sodium acetate Reflux;	98%
at 170℃;
With sodium acetate

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 6046-93-1
copper(II) acetate monohydrate

: 83533-69-1
bis(1,8-dihydroanthraquinonato)dicopper(II)

Conditions

Conditions	Yield
In ethanol mixture was boiled for 10 min, left stirring for 1 h at room temp.; ppt. was filtered, washed several times with ethanol, acetone, finally diethyl ether, dried in vac. over P2O5; elem. anal.;	98%

: lead(II) nitrate

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 7732-18-5
water

: lead 1,8-dihydroxyanthraquinone monohydride

Conditions

Conditions	Yield
With sodium hydroxide at 70℃; for 2h; pH=9; Reagent/catalyst; Temperature;	97.8%

...Expand

: 64-67-5
diethyl sulfate

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 16294-26-1
1,8-diethoxyanthracene-9,10-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 2h;	97%
With potassium carbonate; acetone

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 156-87-6
propan-1-ol-3-amine

: 858519-37-6
11-hydroxy-2-(2-hydroxyethyl)anthra[9,1-de][1,3]oxazin-7(2H)-one

Conditions

Conditions	Yield
With pyridine; copper(I) bromide at 20 - 80℃;	97%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 80-48-8
methyl p-toluene sulfonate

: 6407-55-2
1,8-dimethoxy-9,10-anthracenedione

Conditions

Conditions	Yield
With sodium carbonate at 320℃; for 0.0833333h;	95%
With sodium carbonate In 1,2-dichloro-benzene Heating;	87%
With sodium carbonate In various solvent(s) Yield given;

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 100-39-0
benzyl bromide

: 22516-60-5
1-(benzyloxy)-8-hydroxyanthracene-9,10-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; butanone for 15h; Reflux;	94.8%
With potassium carbonate In N,N-dimethyl-formamide; butanone for 20h; Inert atmosphere; Reflux;

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 108-24-7
acetic anhydride

: 43101-75-3
8-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl acetate

Conditions

Conditions	Yield
With boric acid at 90℃; for 21h;	94%
With boric acid at 95℃; for 5h;	94%
With boric acid at 90℃;
With water; boric acid 1) 90 deg C, 10 h 2) room temp., 1 h; Yield given. Multistep reaction;
With boron trioxide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid 1) 3 h, 110 deg C; 2) 3 h; Yield given. Multistep reaction;

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1,8-bis((tert-butyldimethylsilyl)oxy)-9,10-anthraquinone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 45h; Reflux; Inert atmosphere;	94%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 1.25h; silylation;	73%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 1143-38-0
1,8-dihydroxy-9(10H)-anthracenone

Conditions

Conditions	Yield
	93.7%
With hydrogenchloride; acetic acid; tin(ll) chloride In water at 60 - 65℃; for 3h;	92%
With hydrogenchloride; tin(ll) chloride In acetic acid Heating;	90%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 1,8-bis((tert-butyldimethylsilyl)oxy)-9,10-anthraquinone

Conditions

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile at 80℃; for 0.333333h; silylation;	93%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 80-48-8
methyl p-toluene sulfonate

: 5539-66-2
1-hydroxy-8-methoxyanthraquinone

Conditions

Conditions	Yield
With sodium carbonate In various solvent(s) for 2h; Heating;	93%
With sodium carbonate In various solvent(s) at 120℃; for 2h;	81%
With sodium carbonate	75%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 77-78-1
dimethyl sulfate

: 6407-55-2
1,8-dimethoxy-9,10-anthracenedione

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Heating;	92%
With potassium carbonate In acetone for 24.5h; Reflux; Inert atmosphere;	90%
Stage #1: 1,8-dihydroxy-9,10-anthracenedione With potassium carbonate In acetone Reflux; Stage #2: dimethyl sulfate In acetone for 54h; Reflux;	85%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1018327-05-3
diethyl 2-(9,10-dihydro-1,8-dihydroxy-9,10-dioxo-anthracen-2-yl)fumarate

Conditions

Conditions	Yield
With triphenylphosphine In toluene for 24h; Heating;	92%

: copper(II) choride dihydrate

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: C28H14CuO8*2H2O

Conditions

Conditions	Yield
Stage #1: copper(II) choride dihydrate; 1,8-dihydroxy-9,10-anthracenedione In methanol at 60℃; for 1h; Stage #2: With potassium hydroxide In methanol for 4h; Reflux;	91.7%

: 66086-33-7
Di-tert-butyl acetylenedicarboxylate

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 1018327-07-5
di-tert-butyl 2-(9,10-dihydro-1,8-dihydroxy-9,10-dioxo-anthracen-2-yl)fumarate

Conditions

Conditions	Yield
With triphenylphosphine In toluene for 24h; Heating;	91%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 106-96-7
propargyl bromide

: 1182282-39-8
1,8-bis(prop-2-ynyloxy)anthracene-9,10-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h;	91%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	89%
With sodium carbonate In N,N-dimethyl-formamide at 20℃;	88%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 143-15-7
1-dodecylbromide

: 1429868-49-4
C38H56O4

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide; acetone for 120h; Inert atmosphere; Reflux;	91%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 106-95-6
allyl bromide

A: 10-[1-(prop-2-enyl)]-1,8,10-trihydroxy-9(10H)-anthracenone

B: 9-[1-(prop-2-enyl)]-1,8,9-trihydroxy-10(9H)-anthracenone

Conditions

Conditions	Yield
With indium; water In tetrahydrofuran; methanol at 30 - 32℃; Barbier allylation;	A 90% B 4%

...Expand

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 106-95-6
allyl bromide

: 10-[1-(prop-2-enyl)]-1,8,10-trihydroxy-9(10H)-anthracenone

Conditions

Conditions	Yield
With indium In tetrahydrofuran; methanol; water at 29.85 - 31.85℃;	90%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 119-26-6
(2,4-dinitro-phenyl)-hydrazine

: 156383-28-7
10-[(2,4-dinitrophenyl)hydrazono]-1,8-dihydroxy-10H-anthracen-9-one

Conditions

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 0.5h;	90%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 6046-93-1
copper(II) acetate monohydrate

: 109837-65-2, 109837-66-3, 58806-62-5
bis(1,8-dihydroanthraquinonato)copper(II)

Conditions

Conditions	Yield
In ethanol 1,8-DHAQ was dissolved in abs. ethanol, warmed to boiling, filtered, slow addn. of ethanolic soln. of Cu(CH3COO)2*H2O, mixture was stirred at room temp. for 1 h, kept in refrigerator overnight; ppt. was washed with ethanol, acetone, finally diethyl ether, dried in vac. over P2O5; elem. anal.;	90%

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 64817-82-9
1,8-dihydroxy-9,10-dihydroanthracene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 4.25h; Reflux;	90%
With aluminum (III) chloride; lithium aluminium tetrahydride In tetrahydrofuran Cooling with ice; Reflux;	80%
With water; sodium hydroxide; zinc
With aluminum (III) chloride; lithium aluminium tetrahydride In tetrahydrofuran Reflux;
Multi-step reaction with 2 steps 1.1: acetic acid; potassium iodide; iodine / 2 h / 80 °C / Large scale 1.2: 8.5 h / 85 - 115 °C / Large scale 2.1: sodium tetrahydroborate; trifluoroacetic acid / tert-butyl methyl ether / -15 °C / Reflux View Scheme

1,8-Dihydroxyanthraquinone Uses

The major use of 1,8-Dihydroxyanthraquinone (117-10-2) is as an intermediate in the production of alizarin and indanthrene dyestuffs.

1,8-Dihydroxyanthraquinone Consensus Reports

NTP 10th Report on Carcinogens. Reported in EPA TSCA Inventory.

1,8-Dihydroxyanthraquinone Specification

The 1,8-Dihydroxyanthraquinone, with the CAS registry number 117-10-2, is also known as 1,8-Dihydroxy-9,10-anthraquinone. It belongs to the product categories of Intermediates of Dyes and Pigments; Anthraquinones; Hydroxyanthraquinones; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 204-173-5. This chemical's molecular formula is C₁₄H₈O₄ and molecular weight is 240.21. What's more, its IUPAC name is called 1,8-Dihydroxyanthracene-9,10-dione. It should be stored in a cool, dry and well-ventilated place.

Physical properties about 1,8-Dihydroxyanthraquinone are: (1)ACD/LogP: 4.003; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.93; (4)ACD/LogD (pH 7.4): 2.43; (5)ACD/BCF (pH 5.5): 551.84; (6)ACD/BCF (pH 7.4): 17.35; (7)ACD/KOC (pH 5.5): 3049.70; (8)ACD/KOC (pH 7.4): 95.86; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 74.6 Å²; (13)Index of Refraction: 1.733; (14)Molar Refractivity: 62.432 cm³; (15)Molar Volume: 155.926 cm³; (16)Polarizability: 24.75×10^-24cm³; (17)Surface Tension: 79.282dyne/cm; (18)Density: 1.541 g/cm³; (19)Flash Point: 241.691 °C; (20)Enthalpy of Vaporization: 73.928 kJ/mol; (21)Boiling Point: 452.667 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

Preparation of 1,8-Dihydroxyanthraquinone: this chemical can be prepared by 3-hydroxy-2-salicyloyl-benzoic acid. This reaction needs reagent H₂SO₄ at temperature of 120 °C. The reaction time is 30 min. The yield is 38.4 %.

1,8-Dihydroxyanthraquinone can be prepared by 3-hydroxy-2-salicyloyl-benzoic acid.

Uses of 1,8-Dihydroxyanthraquinone: (1) it is used as a stimulant laxative and used as intermediates in the production of alizarin and indanthrene dyestuffs; (2) it is used to produce other chemicals. For example, it can react with sulfuric acid dimethyl ester to get 1,8-dimethoxy-anthraquinone. The reaction occurs with reagent K₂CO₃ and other condition of heating for 48 hours. The yield is 77 %.

1,8-Dihydroxyanthraquinone can react with sulfuric acid dimethyl ester to get 1,8-dimethoxy-anthraquinone.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health and it has limited evidence of a carcinogenic effect. Therefore, you should wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1) SMILES: c1cc2c(c(c1)O)C(=O)c3c(cccc3O)C2=O
(2) InChI: InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
(3) InChIKey: QBPFLULOKWLNNW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	> 10gm/kg (10000mg/kg)		Pharmacology and Toxicology Vol. 61, Pg. 153, 1987.
mouse	LD50	oral	> 7gm/kg (7000mg/kg)		Drug and Chemical Toxicology. Vol. 1, Pg. 89, 1977/1978.
rat	LD50	intraperitoneal	1110mg/kg (1110mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(12), Pg. 93, 1987.

Product Name

1,8-Dihydroxyanthraquinone

Synthetic route

1,8-Dihydroxyanthraquinone Uses

1,8-Dihydroxyanthraquinone Consensus Reports

1,8-Dihydroxyanthraquinone Specification

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