1-Bromo-4-phenylbutane supplier

Name
1-Bromo-4-phenylbutane
EINECS
CAS No. 13633-25-5
Article Data71
CAS DataBase
Density 1.265 g/cm³
Solubility Slightly soluble in water.
Melting Point 52 °C
Formula C₁₀H₁₃Br
Boiling Point 265.2 °C at 760 mmHg
Molecular Weight 213.117
Flash Point 142.5 °C
Transport Information
Appearance cream
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (4-Bromobutyl)benzene;1-Phenyl-4-bromobutane;4-Bromo-1-phenylbutane;4-Phenyl-1-bromobutane;4-Phenylbutyl bromide;NSC 89816;
PSA 0.00000
LogP 3.40420

Synthetic route

: 558-13-4
carbon tetrabromide

: 3360-41-6
4-phenyl-butan-1-ol

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane; hexane-diethyl ether	100%

: 3360-41-6
4-phenyl-butan-1-ol

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With hydrogen bromide for 12h; Reagent/catalyst; Irradiation; Reflux;	99.6%
With allyl bromide; 1,1'-carbonyldiimidazole In acetonitrile for 1h; Heating;	98%
With carbon tetrabromide; triphenylphosphine In dichloromethane at 25℃;	95%

: 1229444-44-3
N-methyl-N-[4-(diphenylphosphino)benzyl]pyrrolidinium bromide

: 3360-41-6
4-phenyl-butan-1-ol

A: 1229444-42-1
Br(1-)*C24H27NOP(1+)

B: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With carbon tetrabromide In 1,2-dichloro-ethane at 40℃; for 2h;	A n/a B 97%

...Expand

: 1821-12-1
4-Phenylbutyric acid

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With trimethylsilyl bromide; 1,1,3,3-Tetramethyldisiloxane; indium tribromide In chloroform at 60℃; for 4h; Sealed tube; Inert atmosphere;	97%
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane; trimethylsilyl cyanide In chloroform at 60℃; Inert atmosphere;
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere 2: triphenylphosphine; carbon tetrabromide / acetonitrile / 3 h / 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C 2: triphenylphosphine; carbon tetrabromide / acetonitrile / 3 h / 20 °C View Scheme

: 5558-00-9, 7515-41-5, 73611-78-6
(4-bromo-1-buten-1-yl)benzene

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol; water under 225.023 Torr; for 5h;	93%

: 1229444-43-2
4-(diphenylphosphino)-benzyltrimethylammonium bromide

: 3360-41-6
4-phenyl-butan-1-ol

A: 1268610-56-5
Br(1-)*C22H25NOP(1+)

B: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With carbon tetrabromide In 1,2-dichloro-ethane at 60℃; for 2h;	A n/a B 91%

...Expand

: 110-52-1
1,4-dibromo-butane

: 71-43-2
benzene

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
at 5℃; for 2h; Temperature;	85.8%

: 110-52-1
1,4-dibromo-butane

: phenylmagnesium bromide

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With copper(I) bromide; lithium bromide In tetrahydrofuran at 50 - 55℃; for 1h;	85%

: 369-57-3
benzenediazonium tetrafluoroborate

: 142172-51-8
4-bromo-1-butylboronic acid catechol ester

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; palladium diacetate In tetrahydrofuran at 20℃; for 4.5h; Sizuki-Miyaura cross coupling;	61%

: 3360-41-6
4-phenyl-butan-1-ol

: 603-35-0
triphenylphosphine

A: 13633-25-5
1-Bromo-4-phenylbutane

B: 791-28-6
Triphenylphosphine oxide

Conditions

Conditions	Yield
With carbon tetrabromide In 1,2-dichloro-ethane	A 53% B n/a

...Expand

: 2270-20-4
5-Phenylpentanoic acid

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; caesium carbonate; Diethyl 2-bromomalonate In chlorobenzene at 20℃; for 4h; Inert atmosphere; Irradiation;	45%

: 3360-41-6
4-phenyl-butan-1-ol

: 100-39-0
benzyl bromide

A: 13633-25-5
1-Bromo-4-phenylbutane

B: 4-phenylbutyl formate

C: 4-phenylbutyl butyl ether

D: carbonic acid butyl ester 4-phenyl-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 23h;	A 11% B 21% C 44% D 3%
With rubidium carbonate In N,N-dimethyl-formamide at 95℃; for 23h; Product distribution; other reag;	A 12% B 34% C 20% D 18%

...Expand

: 110-52-1
1,4-dibromo-butane

: 108-86-1
bromobenzene

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether; hexane for 2h; Heating;	42%

: 767-99-7, 768-00-3, 2082-61-3
2-phenylbut-2-ene

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With hydrogen bromide; dihydrogen peroxide

: 124-38-9
carbon dioxide

: 637-59-2
1-Bromo-3-phenylpropane

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multistep reaction;

: 7492-40-2
4-phenylbutyl acetate

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With hydrogen bromide Heating; Yield given;

: 768-56-9
4-Phenyl-1-butene

peroxide/s: peroxide/s

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Anlagerung von HBr;

methyl-<δ-phenyl-butyl>-ether: methyl-<δ-phenyl-butyl>-ether

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With hydrogen bromide at 130 - 140℃; im Rohr;

: 6921-34-2
benzylmagnesium chloride

p-toluenesulfonic acid-<3-bromo-propyl ester>: p-toluenesulfonic acid-<3-bromo-propyl ester>

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With diethyl ether

: 10229-11-5
4-phenyl-but-3-yn-1-ol

(hexacarbonyl)chromium: (hexacarbonyl)chromium

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / Pd-CaCO3 2: PBr3 View Scheme

: 536-74-3
phenylacetylene

tungsten 4-hexynyl complex (9b): tungsten 4-hexynyl complex (9b)

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) EtMgBr, (ii) /BRN= 102378/ 2: H2 / Pd-CaCO3 3: PBr3 View Scheme

: 1821-12-1
4-Phenylbutyric acid

4.5-dihydroxy-4.5-diphenyl-octanedioic acid-1->4:8->5-dilactone: 4.5-dihydroxy-4.5-diphenyl-octanedioic acid-1->4:8->5-dilactone

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 79 percent / LiAlH4 2: 61 percent / PBr3 View Scheme

: 2046-17-5
methyl 3-(benzyl)propanoate

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LAH 2: PBr3 View Scheme
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: (i) TsCl, Py, Et2O, (ii) LiBr, acetone View Scheme

: 10031-93-3
ethyl 4-phenylbutyrate

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium; alcohol 2: fuming hydrobromic acid / 100 °C View Scheme

: 1462-75-5
3-phenylpropylmagnesium bromide

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: fuming hydrobromic acid / 100 °C View Scheme
Multi-step reaction with 2 steps 2: phosphorus pentabromide View Scheme

: 103-63-9
1-phenyl-2-bromoethane

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Mg, Et2O, (ii) /BRN= 102378/ 2: HBr / benzene View Scheme
Multi-step reaction with 2 steps 2: aq. HBr, aq. H2SO4 View Scheme
Multi-step reaction with 2 steps 1: Mg / diethyl ether 2: PBr3 View Scheme

: 3360-41-6
4-phenyl-butan-1-ol

A: 13633-25-5
1-Bromo-4-phenylbutane

B: 84473-31-4, 53118-87-9
4-(Bromobutyl)benzene

Conditions

Conditions	Yield
With phosphorus tribromide; sodium hydrogencarbonate In 1,4-dioxane; n-heptane; water; ethyl acetate

: 10041-02-8
p-imidazo-1-ylphenol

: 13633-25-5
1-Bromo-4-phenylbutane

Conditions

Conditions	Yield
With NaH In N,N-dimethyl-formamide

: 13633-25-5
1-Bromo-4-phenylbutane

: 7332-01-6
1-(4-azidobutyl)benzene

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 80℃;	100%
With sodium azide In N,N-dimethyl-formamide at 70℃; for 9h; Inert atmosphere;	99%
With sodium azide In dimethyl sulfoxide at 20℃; for 36h;	85%

: 13633-25-5
1-Bromo-4-phenylbutane

: 65864-64-4
trimethyl(difluoromethyl)silane

: 1,1-difluoro-5-phenylpentane

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; cesium fluoride; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 50℃; for 6h; Inert atmosphere; Glovebox; Schlenk technique;	100%

: 13633-25-5
1-Bromo-4-phenylbutane

: 603-35-0
triphenylphosphine

: 37748-19-9
(4-phenylbut-1-yl)triphenylphosphonium bromide

Conditions

Conditions	Yield
In toluene Reflux;	99%
In toluene at 110℃; for 20h; Inert atmosphere;	63%
In toluene Heating;

: 13633-25-5
1-Bromo-4-phenylbutane

: 154848-44-9
4'-hydroxy-3-biphenylcarbonitrile

: 1593090-71-1
4'-(4-phenylbutoxy)-[1,1'-biphenyl]-3-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate at 20 - 40℃; Inert atmosphere;	99%

: 13633-25-5
1-Bromo-4-phenylbutane

: 19438-10-9
methyl 3-hydroxybenzoate

: methyl 3-(4-phenylbutoxy)benzoate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide for 12h; Williamson Ether Synthesis; Inert atmosphere; Reflux;	99%

: 13633-25-5
1-Bromo-4-phenylbutane

: 75-31-0
isopropylamine

: 179742-05-3
N-isopropyl-4-phenylbutan-1-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 24h;	99%

polymer; monomer(s): 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 5 mol percent; styrene, 95 mol percent: polymer; monomer(s): 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 5 mol percent; styrene, 95 mol percent

: 13633-25-5
1-Bromo-4-phenylbutane

A polymer, CH2Cl2-insoluble; monomer(s): 1-bromo-4-phenylbutane; 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 1 molar part; styrene, 19 molar parts: polymer, CH2Cl2-insoluble; monomer(s): 1-bromo-4-phenylbutane; 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 1 molar part; styrene, 19 molar parts

B polymer, CH2Cl2-soluble; monomer(s): 1-bromo-4-phenylbutane; 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 1 molar part; styrene, 19 molar parts: polymer, CH2Cl2-soluble; monomer(s): 1-bromo-4-phenylbutane; 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 1 molar part; styrene, 19 molar parts

Conditions

Conditions	Yield
Stage #1: polymer; monomer(s): 5-(4-(4-ethenylphenyl)butoxy)methyl-1,3-dithiane, 5 mol percent; styrene, 95 mol percent With n-butyllithium In tetrahydrofuran; hexane at -40 - -30℃; Stage #2: 1-Bromo-4-phenylbutane In tetrahydrofuran; hexane at -30 - -10℃;	A 0.7% B 98.9%

...Expand

: 13633-25-5
1-Bromo-4-phenylbutane

: 99-76-3
methyl 4-hydroxylbenzoate

: 30131-16-9
4-(4-phenyl-1-butoxy)benzoic acid

Conditions

Conditions	Yield
Stage #1: 1-Bromo-4-phenylbutane; methyl 4-hydroxylbenzoate With potassium carbonate In N,N-dimethyl-formamide at 115℃; for 11h; Stage #2: With water; sodium hydroxide In ethanol for 3h; Reflux; Stage #3: With hydrogenchloride In ethanol; water pH=2; Reagent/catalyst; Concentration;	98.7%

: 13633-25-5
1-Bromo-4-phenylbutane

: 116956-35-5
sodium 4-phenylbutane-1-sulfonate

Conditions

Conditions	Yield
With sodium sulfite In water for 24h; Heating;	96%
With sodium sulfite In tetrahydrofuran; ethanol; water at 160℃; for 0.25h; Microwave irradiation;

: 13633-25-5
1-Bromo-4-phenylbutane

: 331-98-6, 83306-62-1, 83306-65-4
N-benzylidene-4-fluoroaniline

: N-(1,5-diphenylpentyl)-4-fluoroaniline

Conditions

Conditions	Yield
Stage #1: 1-Bromo-4-phenylbutane With lithium In diethyl ether at -40 - 0℃; for 2h; Inert atmosphere; Stage #2: N-benzylidene-4-fluoroaniline In diethyl ether at -78 - 20℃; for 3h; Inert atmosphere;	96%

: 13633-25-5
1-Bromo-4-phenylbutane

: 24028-79-3
4-methoxy-N-[(3-methoxyphenyl)methylene]benzenamine

: 4-methoxy-N-(1-(3-methoxyphenyl)-5-phenylpentyl)aniline

Conditions

Conditions	Yield
Stage #1: 1-Bromo-4-phenylbutane With lithium In diethyl ether at -40 - 0℃; for 2h; Inert atmosphere; Stage #2: 4-methoxy-N-[(3-methoxyphenyl)methylene]benzenamine In diethyl ether at -78 - 20℃; for 3h; Inert atmosphere;	94%

: 13633-25-5
1-Bromo-4-phenylbutane

: 3-azabicyclo[3.2.1]octane

: C17H25N

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 18h; Reflux;	93%

: 13633-25-5
1-Bromo-4-phenylbutane

: 98-89-5
Cyclohexanecarboxylic acid

: C17H24O

Conditions

Conditions	Yield
With 6,6'-dimethyl-2,2'-bipyridine; nickel(II) bromide trihydrate; di-tert-butyl dicarbonate; sodium iodide; magnesium chloride; zinc In N,N-dimethyl acetamide at 30℃; for 24h; regioselective reaction;	93%

: 13633-25-5
1-Bromo-4-phenylbutane

: 139-85-5
3,4-dihydroxybenzaldehyde

: 3,4-bis(4-phenylbutoxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	93%

: 13633-25-5
1-Bromo-4-phenylbutane

: N-(3-methylbenzylidene)-4-methoxybenzenamine

: 4-methoxy-N-(5-phenyl-1-(m-tolyl)pentyl)aniline

Conditions

Conditions	Yield
Stage #1: 1-Bromo-4-phenylbutane With lithium In diethyl ether at -40 - 0℃; for 2h; Inert atmosphere; Stage #2: N-(3-methylbenzylidene)-4-methoxybenzenamine In diethyl ether at -78 - 20℃; for 3h; Inert atmosphere;	93%

: 13633-25-5
1-Bromo-4-phenylbutane

: 1335557-88-4
(3S)-1-(pent-4-enyl)-[(1R)-hydroxyethyl]azetidin-2-one

: 1335557-82-8
(3S)-1-(pent-4-enyl)-[(1R)-(4-phenylbutoxy)ethyl]azetidin-2-one

Conditions

Conditions	Yield
Stage #1: (3S)-1-(pent-4-enyl)-[(1R)-hydroxyethyl]azetidin-2-one With sodium hydride In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #2: 1-Bromo-4-phenylbutane With potassium iodide In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	92%

: 13633-25-5
1-Bromo-4-phenylbutane

: tert-butyl (R)-3-(3-(4-(1-(hydroxyimino)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboxylate

: tert-butyl (R)-3-(3-(4-(1-((4-phenylbutoxy)imino)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tert-butyl (R)-3-(3-(4-(1-(hydroxyimino)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboxylate With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 1-Bromo-4-phenylbutane In tetrahydrofuran for 16h; Reflux;	92%

: 13633-25-5
1-Bromo-4-phenylbutane

: 66943-05-3
1,4,7,10-tetraoxa-15-azacyclopentadecane

: N-(4-phenylbutyl)-aza-15-crown-5

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 80℃; for 20h;	91.4%

: 13633-25-5
1-Bromo-4-phenylbutane

: 1335557-90-8
(3S)-1-(4-methoxybenzyl)-[(1R)-hydroxyethyl]azetidin-2-one

: 1335557-91-9
(3S)-1-(4-methoxybenzyl)-[(1R)-(4-phenylbutoxy)ethyl]azetidin-2-one

Conditions

Conditions	Yield
Stage #1: (3S)-1-(4-methoxybenzyl)-[(1R)-hydroxyethyl]azetidin-2-one With sodium hydride In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #2: 1-Bromo-4-phenylbutane With potassium iodide In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	91%

: 13633-25-5
1-Bromo-4-phenylbutane

: 68-11-1
mercaptoacetic acid

: 945414-39-1
((4-phenylbutyl)sulfanyl)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃;	91%

: 616-45-5
2-pyrrolidinon

: 13633-25-5
1-Bromo-4-phenylbutane

: 1616591-75-3
1-[4-phenylbutyl]pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 2-pyrrolidinon With sodium hydride In toluene; paraffin oil for 10h; Inert atmosphere; Reflux; Stage #2: 1-Bromo-4-phenylbutane In 5,5-dimethyl-1,3-cyclohexadiene; toluene; paraffin oil for 4h; Inert atmosphere; Reflux;	91%

: 3721-95-7
Cyclobutanecarboxylic acid

: 13633-25-5
1-Bromo-4-phenylbutane

: C15H20O

Conditions

Conditions	Yield
With 6,6'-dimethyl-2,2'-bipyridine; nickel(II) bromide trihydrate; di-tert-butyl dicarbonate; sodium iodide; magnesium chloride; zinc In N,N-dimethyl acetamide at 30℃; for 24h; regioselective reaction;	91%

: 13633-25-5
1-Bromo-4-phenylbutane

: 2365-48-2
Methyl thioglycolate

: 945414-38-0
methyl 2-[(4-phenylbutyl)thio]acetate

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide; acetone at 25℃; for 30h;	90%
With potassium carbonate In dimethyl sulfoxide; acetone at 25℃; for 30h;	90%
Stage #1: Methyl thioglycolate With potassium carbonate In acetone for 0.25h; Stage #2: 1-Bromo-4-phenylbutane In acetone for 21h; Reflux;

1-Bromo-4-phenylbutane Chemical Properties

Product Name:1-Bromo-4-phenylbutane
CAS No:13633-25-5
Synonyms:RARECHEM AH CK 0044;1-BROMO-4-PHENYLBUTANE;(4-BROMOBUTYL)BENZENE;4-PHENYLBUTYL BROMIDE;4-PHENYL 1-BUTYL BROMIDE;4-Bromo-1-phenyl butane;1-BROMO-4-PHENYLBUTANE 99%;1-BROMO-4-PHENYL-BUTANE >97%
Molecular Formula:C₁₀H₁₃Br
Formula Weight:213.11
Density:1.214
Boiling Point:131-133°C/12mm
Flash Point:131-133°C/12mm
Molecular Structure:

1-Bromo-4-phenylbutane Safety Profile

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
Hazard Note Irritant

Product Name

1-Bromo-4-phenylbutane

Synthetic route

1-Bromo-4-phenylbutane Chemical Properties

1-Bromo-4-phenylbutane Safety Profile

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