1-Chloro-2-nitrobenzene supplier

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Name
2-Nitrochlorobenzene
EINECS 201-854-9
CAS No. 88-73-3
Article Data188
CAS DataBase
Density 1.391 g/cm³
Solubility 0.43 g/L (20 °C) in water
Melting Point 31-33 °C(lit.)
Formula C₆H₄ClNO₂
Boiling Point 245.5 °C at 760 mmHg
Molecular Weight 157.556
Flash Point 96.5 °C
Transport Information UN 1578 6.1/PG 2
Appearance yellow solid with a characteristic odour
Safety 36/37/39-45-60-38-28A
Risk Codes 22-24-52-53-52/53
Molecular Structure
Hazard Symbols
Synonyms 1-Chloro-2-nitrobenzene;1-Nitro-2-chlorobenzene;2-Chloro-1-nitrobenzene;2-Chloronitrobenzene;2-Nitro-1-chlorobenzene;2-Nitrophenyl chloride;NSC36934;ONCB;o-Chloronitrobenzene;o-Nitrochlorobenzene;2-Nitrochlorobenzene;
PSA 45.82000
LogP 2.77140

Synthetic route

: 95-51-2
2-Chloroaniline

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane for 10h; Reflux;	78%
With dihydrogen peroxide; acetonitrile In aq. buffer at 20℃; for 1h; pH=11; Green chemistry;	78%
With dihydrogen peroxide; potassium carbonate In water; acetonitrile at 20℃;	65%

: 577-19-5
2-nitrophenyl bromide

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With CuCl-alumina In various solvent(s) at 150℃; for 6h;	75%
With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 36h; Finkelstein Reaction; Schlenk technique; Inert atmosphere;	70%

: 552-16-9
ortho-nitrobenzoic acid

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With oxygen; silver carbonate; potassium hydroxide; copper dichloride In dimethyl sulfoxide; N,N-dimethyl-formamide at 130 - 140℃;	83%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper (I) acetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; for 24h; Schlenk technique;	45%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper diacetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 20h; Schlenk technique;	45%
With copper(l) iodide; oxygen; copper(l) chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 30h; Schlenk technique; Sealed tube;	35%

: 3900-89-8
2-Chlorobenzeneboronic acid

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With zirconium(IV) oxynitrate hydrate; iodine In toluene at 20℃; for 16h; Inert atmosphere;	84%
With Iron(III) nitrate nonahydrate In toluene at 80℃; for 18h; Inert atmosphere;	70%
With nitric acid; trifluoroacetic acid In water at 80℃; for 18h; regioselective reaction;	61%

: 88-74-4
2-nitro-aniline

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With p-toluenesulfonyl nitrite; copper dichloride In acetonitrile at 25℃; for 0.0166667h;	87%
With hydrogenchloride; potassium nitrite; dimethyl sulfoxide In water at 35℃; for 0.5h;	73%
With tert.-butylnitrite; N-benzyl-N,N,N-triethylammonium chloride; copper dichloride; 10-camphorsulfonic acid In neat (no solvent) Time; Solvent;	59%

: 89-61-2
2,5-dichloronitrobenzene

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With ammonia at 125℃; under 15001.5 Torr; for 1h; Autoclave;	99.85%

: 88-72-2
1-methyl-2-nitrobenzene

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With bromine; iodine; chlorine at 140℃; for 2h; Reagent/catalyst; Temperature;	86.1%

: 108-90-7
chlorobenzene

A: 121-73-3
3-Chloronitrobenzene

B: 100-00-5
4-chlorobenzonitrile

C: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With dinitrogen tetraoxide; N,N,N,N-tetraethylammonium tetrafluoroborate In sulfolane at 30℃; electrochemical process; Yield given. Yields of byproduct given;
With zeolite H-beta; Nitrogen dioxide at 150℃; Yield given. Yields of byproduct given;
With zeolite FeAl-ZSM-5; Nitrogen dioxide at 150℃; Yield given. Yields of byproduct given;

...Expand

: 108-90-7
chlorobenzene

A: 100-00-5
4-chlorobenzonitrile

B: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With nickel ammonium sulfate; nitric acid In chloroform; water at 20℃; for 3h;	A 86% B 14%
With ammonium molybdate; water; nitric acid In chloroform for 6h; Nitration; Heating;	A 82% B 16%
With ammonium nitrate; trifluoroacetic anhydride at 25℃; for 2h;	A 80% B 20%

: 2-nitrobenzenediazonium o-benzenedisulfonamide

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride In acetonitrile at 60℃; for 0.75h; Substitution;	77%
With N-benzyl-N,N,N-triethylammonium chloride; copper In acetonitrile at 20℃; for 0.75h; Substitution;	74%

: 108-90-7
chlorobenzene

A: 100-00-5
4-chlorobenzonitrile

B: 88-73-3
2-Chloronitrobenzene

C: 97-00-7
1-chloro-2,4-dinitro-benzene

Conditions

Conditions	Yield
With nitric acid; acetic anhydride at 0 - 20℃; for 0.166667h; Overall yield = 76 %;

...Expand

2-nitro-benzenediazonium acetate: 2-nitro-benzenediazonium acetate

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With hydrogenchloride; copper(l) chloride at 0 - 5℃; oder bei 100-105grad;

<2-chloro-phenyl>-mercury acetate: <2-chloro-phenyl>-mercury acetate

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With nitric acid at 65℃;

: 1-(2-nitro-phenyl)-2-phenoxy-ethanol

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 36h; Autoclave;	62 %Chromat.

: 612-25-9
2-Nitrobenzyl alcohol

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 18h; Autoclave;	96 %Chromat.

: 15121-84-3
2-nitro-benzeneethanol

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 18h; Autoclave;	95 %Chromat.

: 80379-10-8, 108530-03-6, 142631-59-2, 3205-25-2
1-(2-nitrophenyl)ethan-1-ol

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 18h; Reagent/catalyst; Solvent; Time; Autoclave;	87 %Chromat.

: 552-89-6
2-nitro-benzaldehyde

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; oxygen; potassium carbonate In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 18h; Reagent/catalyst; Autoclave; Molecular sieve;	84 %Chromat.

: 90972-31-9
2-(1-Hydroxypropyl)nitrobenzene

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 18h; Autoclave;	92 %Chromat.

: 88057-15-2
2-bromo-1-(2-nitro-phenyl)-ethanol

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 36h; Autoclave;	98 %Chromat.

: 108-90-7
chlorobenzene

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid

: 100-00-5
4-chlorobenzonitrile

A: 121-73-3
3-Chloronitrobenzene

B: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With gold at -256.16℃;

: 108-90-7
chlorobenzene

A: 121-73-3
3-Chloronitrobenzene

B: 88-87-9
4-chloro-2,6-dinitrophenol

C: 100-00-5
4-chlorobenzonitrile

D: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With oxygen; Nitrogen dioxide; iron(III)-acetylacetonate In 1,2-dichloro-ethane at 0℃; for 36h; Yield given. Yields of byproduct given;

...Expand

: 528-29-0
1,2-Dinitrobenzene

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
Stage #1: 1,2-Dinitrobenzene With perchloric acid; sulfuric acid; sodium nitrite In water; ethyl acetate Electrochemical reaction; Stage #2: With hydrogenchloride; copper In water Sandmeyer Reaction; Electrochemical reaction;	63%

2-chloro-benzenediazonium-(1)-tetrafluoroborate: 2-chloro-benzenediazonium-(1)-tetrafluoroborate

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With water; copper; sodium nitrite

2-nitro-benzenediazonium-(1)-sulfate: 2-nitro-benzenediazonium-(1)-sulfate

A: 2436-96-6
1-nitro-2-(2-nitrophenyl)benzene

B: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With hydrogen bromide; copper(l) chloride

: 142-04-1
aniline hydrochloride

A: 611-06-3
2,4-dichloronitrobenzene

B: 100-00-5
4-chlorobenzonitrile

C: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In acetone at 20℃;	A 12% B 36% C 23%

...Expand

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper acetylacetonate; copper(l) cyanide; sodium carbonate In 1,4-dioxane at 130℃; for 24h; Sealed tube; Air;

: 108-90-7
chlorobenzene

A: 121-73-3
3-Chloronitrobenzene

B: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With poly(4-vinylpyridine)-nitrating mixture complex In dichloromethane at 20℃; for 2h; Green chemistry; Overall yield = 81 %;

: 100-66-3
methoxybenzene

A: 121-73-3
3-Chloronitrobenzene

B: 100-00-5
4-chlorobenzonitrile

C: 88-73-3
2-Chloronitrobenzene

Conditions

Conditions	Yield
With N-nitro-2,4,6-trimethylpyridinium tetrafluoroborate In nitromethane at 25℃; Rate constant; competitive nitration with benzene;

...Expand

: 110-91-8
morpholine

: 88-73-3
2-Chloronitrobenzene

: 5320-98-9
N-(2-nitrophenyl)morpholine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	99%
With potassium phosphate; Al2O3#dotCo(2+) In water at 100℃; for 7h;	90%

: 88-73-3
2-Chloronitrobenzene

: 95-51-2
2-Chloroaniline

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol; water at 80℃; for 1h; chemoselective reaction;	100%
With [1-butyl-2,3-dimethylimidazolium][tppm] stabilized rhodium nanoarticles at 50℃; under 22502.3 Torr; for 5h; Ionic liquid; Autoclave; chemoselective reaction;	100%
With hydrogen at 50℃; under 22502.3 Torr; for 5h; Autoclave; Sealed tube; Ionic liquid; chemoselective reaction;	100%

: 123-75-1
pyrrolidine

: 88-73-3
2-Chloronitrobenzene

: 40832-79-9
1-(2-nitrophenyl)pyrrolidine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 6375510 Torr; for 20h;	100%
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
at 108℃; for 2h; Neat (no solvent);	98%

: 75-61-6
dibromodifluoromethane

: 88-73-3
2-Chloronitrobenzene

: 384-22-5
2-nitrobenzotrifluoride

Conditions

Conditions	Yield
With ISOPROPYLAMIDE; copper at 100℃; for 16h;	100%
With copper In N,N-dimethyl acetamide at 100℃; for 4h; Product distribution; with or without charcoal;	89%
With copper; pyrographite In N,N-dimethyl acetamide at 100℃; for 2h;	89 % Turnov.
With copper In N,N-dimethyl acetamide at 100℃; for 8h;	59 % Chromat.

: 13616-82-5
2,4-dimethyl-thiophenol

: 88-73-3
2-Chloronitrobenzene

: 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 50℃; for 5h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 2.5h; Inert atmosphere;	99.79%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;	97%

: 105969-16-2
3,5-Difluoro-4-methoxybenzylamine

: 88-73-3
2-Chloronitrobenzene

: 105969-11-7
N-(3,5-difluoro-4-methoxybenzyl)-2-nitroaniline

Conditions

Conditions	Yield
With ammonium acetate at 100℃; for 24h;	100%

: 108-24-7
acetic anhydride

: 88-73-3
2-Chloronitrobenzene

: 533-17-5
N-(2-chlorophenyl)acetamide

Conditions

Conditions	Yield
With indium; acetic acid In methanol at 20℃; for 1.5h;	100%
With samarium; acetic acid In methanol at 20℃; for 1.5h;	80%
With aluminum oxide; zinc In dichloromethane at 20℃; for 12h; Acetylation; reduction;	75%

: 108847-20-7
4-dibenzothiophene boronic acid

: 88-73-3
2-Chloronitrobenzene

: 530403-00-0
4-(2-nitrophenyl)dibenzo[b,d]thiophene

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In methanol; benzene at 70℃; for 7h;	100%
With potassium phosphate tribasic trihydrate; (2-(anthracen-9-yl)-1H-inden-3-yl)dicyclohexylphosphine; palladium diacetate In water; isopropyl alcohol; toluene at 90℃; for 16h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere;	87%

: 88-73-3
2-Chloronitrobenzene

: 530403-10-2
dibenzoselenophene-4-boronic acid

: 530403-13-5
4-(2-nitrophenyl)dibenzoselenophene

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In methanol; benzene at 70℃;	100%

: 108-98-5
thiophenol

: 88-73-3
2-Chloronitrobenzene

: 4171-83-9
2-nitrophenyl phenyl sulfide

Conditions

Conditions	Yield
With potassium hydroxide In water; N,N-dimethyl-formamide 1.) between -3 and +2 deg C, 40 min, 2.) 80 deg C, 1 h;	99.9%
With C40H30Cl2N2NiO2S2; sodium hydroxide In N,N-dimethyl-formamide at 70℃; for 2h;	96%
With potassium fluoride impregnated on clinoptilolite; air In dimethyl sulfoxide at 115 - 120℃; for 4h;	95%

: 88-73-3
2-Chloronitrobenzene

: 74-89-5
methylamine

: 612-28-2
2-nitro-N-methylaniline

Conditions

Conditions	Yield
With copper In water at 100℃; for 12h; Ullmann reaction;	99.3%
In water at 130℃; for 24h; Autoclave;	99%
With copper In water at 100℃; for 8h; Sealed tube;	95%

: 108-91-8
cyclohexylamine

: 88-73-3
2-Chloronitrobenzene

: 6373-71-3
N-cyclohexyl-2-nitroaniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	99%
With potassium carbonate; Cu/Al-HTB at 100℃; for 8h;	91%
With 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide; caesium carbonate; copper(I) bromide at 115℃; for 24h; Inert atmosphere; Schlenk technique;	81%
With ethanol at 150℃;
With potassium carbonate In dimethyl sulfoxide at 60℃; for 17h;

: 75-04-7
ethylamine

: 88-73-3
2-Chloronitrobenzene

: 10112-15-9
N-Ethyl-2-nitroaniline

Conditions

Conditions	Yield
In water at 105℃; for 24h; Sealed vessel;	99%
In dimethyl sulfoxide	85%
With ethanol at 170℃;

: 109-96-6
3-Pyrroline

: 88-73-3
2-Chloronitrobenzene

: 113342-92-0
1-(2-Nitro-phenyl)-2,5-dihydro-1H-pyrrole

Conditions

Conditions	Yield
at 70℃; for 0.75h;	99%

: 124-22-1
n-Dodecylamine

: 88-73-3
2-Chloronitrobenzene

: 94208-22-7
N-Monododecyl-o-nitraniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	99%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	95%
In nitrobenzene at 190 - 200℃; for 6h;	46%

: 111-86-4
n-Octylamine

: 88-73-3
2-Chloronitrobenzene

: 22100-61-4
N-Monooctyl-o-nitraniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	99%
In nitrobenzene at 190 - 200℃; for 6h;	64%

: 7205-98-3
chloromethyl phenyl sulfone

: 88-73-3
2-Chloronitrobenzene

: 86434-29-9
1-benzenesulfonylmethyl-3-chloro-2-nitro-benzene

Conditions

Conditions	Yield
With potassium tert-butylate; acetic acid In tetrahydrofuran at -50 - 20℃; for 0.5h;	99%

: 32121-27-0
α-phenoxy-α-phenylacetonitrile

: 88-73-3
2-Chloronitrobenzene

: 89278-13-7
α-(3-Chloro-4-nitrophenyl)phenylacetonitrile

Conditions

Conditions	Yield
Stage #1: α-phenoxy-α-phenylacetonitrile; 2-Chloronitrobenzene With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at -78℃; for 0.25h; Stage #2: With hydrogenchloride In water at -78℃;	99%
With sodium hydroxide In dimethyl sulfoxide for 1h; Ambient temperature;	55%

: 90390-27-5
3,5-difluorobenzylamine

: 88-73-3
2-Chloronitrobenzene

: 105969-13-9
N-(3,5-difluorobenzyl)-2-nitroaniline

Conditions

Conditions	Yield
With ammonium acetate at 100℃; for 24h;	99%

: 88-73-3
2-Chloronitrobenzene

: 98-80-6
phenylboronic acid

: 86-00-0
2-nitrobiphenyl

Conditions

Conditions	Yield
With caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane for 1h; Suzuki-Miyaura coupling; Heating;	99%
With C12H10N3OPol; tetrabutylammomium bromide; palladium diacetate; potassium carbonate In water at 100℃; for 15h; Suzuki-Miyaura reaction;	99%
With potassium carbonate In water; isopropyl alcohol at 100℃; for 18h; Catalytic behavior; Suzuki-Miyaura Coupling; Inert atmosphere;	99%

: 288-32-4
1H-imidazole

: 88-73-3
2-Chloronitrobenzene

: 23309-16-2
1-(2-nitrophenyl)-1H-imidazole

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃;	99%
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 2h; Inert atmosphere; Green chemistry;	99%
With potassium carbonate; bis(μ-iodo)bis[(-)-sparteine]dicopper(I) In dimethyl sulfoxide at 125℃; for 12h;	92%

: 6783-05-7
trans-2-phenylvinylboronic acid

: 88-73-3
2-Chloronitrobenzene

: 4264-29-3
(E)-2-nitrostilbene

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); caesium carbonate In 1,4-dioxane for 1h; Suzuki-Miyaura cross-coupling; Heating;	99%

: 4381-25-3
S-methyl-S-phenylsulfoximine

: 88-73-3
2-Chloronitrobenzene

: rac-N-[2-(nitro)phenyl]-S-methyl-S-phenylsulfoximine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 135℃; for 24h; Buchward-Hartwig coupling;	99%

: 108-39-4
3-methyl-phenol

: 88-73-3
2-Chloronitrobenzene

: 54495-62-4
2-(3'-methylphenoxy)nitrobenzene

Conditions

Conditions	Yield
With copper(l) iodide; 1-(dimethylamino-1-yl-pyridin-2-yl-methyl)naphthalen-2-ol; potassium carbonate In dimethyl sulfoxide at 120℃; for 24h; Ullmann Condensation; Green chemistry;	99%
Stage #1: 3-methyl-phenol With potassium hydroxide at 90℃; for 0.25h; Stage #2: 2-Chloronitrobenzene at 150℃; for 2h;

: 64-18-6
formic acid

: 88-73-3
2-Chloronitrobenzene

: 698-01-1
1-chloro-2-(dimethylamino)benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine)platinum; phenylsilane; C30H51Cl3Mo3N6PPtS4(1+)*BF4(1-) In tetrahydrofuran at 70℃; under 760.051 Torr; Inert atmosphere; Schlenk technique; chemoselective reaction;	99%

: 124-41-4
sodium methylate

: 88-73-3
2-Chloronitrobenzene

: 91-23-6
2-Nitroanisole

Conditions

Conditions	Yield
In methanol at 48 - 65℃; for 1h; Temperature; Large scale;	98.9%

: 1679-18-1
4-Chlorophenylboronic acid

: 88-73-3
2-Chloronitrobenzene

: 6271-80-3
4'-chloro-2-nitrobiphenyl

Conditions

Conditions	Yield
With potassium carbonate In water; isopropyl alcohol at 100℃; for 10h; Suzuki-Miyaura Coupling; Inert atmosphere;	98%
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;	98%

: 88-73-3
2-Chloronitrobenzene

: 2217-65-4
bis(2-nitrophenyl)ether

Conditions

Conditions	Yield
With sodium ethanolate In methanol at 45 - 80℃; for 1.25h; Solvent; Temperature; Large scale;	98.9%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; water; caesium carbonate; 1,2-bis-(diphenylphosphino)ethane; bis(pinacol)diborane In N,N-dimethyl-formamide at 140℃; for 24h; Schlenk technique; chemoselective reaction;	73%

1-Chloro-2-nitrobenzene Consensus Reports

Reported in EPA TSCA Inventory.

1-Chloro-2-nitrobenzene Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification: 6.1; Label: Poison

1-Chloro-2-nitrobenzene Specification

1-Chloro-2-nitrobenzene is also named as ONCB; 2-cnb; 2-Chlornitrobenzol; O-CHLORONITROBENZENE; O-NITROCHLOROBENZENE; 2-NITROCHLOROBENZENE; 2-CHLORONITROBENZENE; Chloro-o-nitrobenzene; 2-Chluoronitrobenzene; chloro-1nitro-2benzene. With the CAS NO.88-73-3, 1-Chloro-2-nitrobenzene is an important intermediate for pesticides (such as carbendazim), dye, medicine, but also can be used a raw material for rubber accelerator M.

Physical properties about 1-Chloro-2-nitrobenzene are: (1)ACD/LogP: 2.335; (2)ACD/LogD(pH 5.5): 2.34; (3)ACD/LogD (pH 7.4): 2.34; (4)ACD/BCF (pH 5.5): 35.07; (5)ACD/BCF (pH 7.4): 35.07; (6)ACD/KOC (pH 5.5): 444.06; (7)ACD/KOC (pH 7.4): 444.06; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.58; (11)Molar Refractivity: 37.693 cm³; (12)Molar Volume: 113.226 cm³; (13)Polarizability: 14.943 10-24cm³; (14)Surface Tension: 48.3880004882813 dyne/cm; (15)Density: 1.391 g/cm³; (16)Flash Point: 96.521 °C; (17)Enthalpy of Vaporization: 46.304 kJ/mol; (18)Boiling Point: 245.499 °C at 760 mmHg; (19)Vapour Pressure: 0.0450000017881393 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. Wear suitable protective clothing, gloves and eye/face protection;
2. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
3. This material and/or its container must be disposed of as hazardous waste;
4. In case of insufficient ventilation, wear suitable respiratory equipment;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H4ClNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H;
(2)InChIKey=BFCFYVKQTRLZHA-UHFFFAOYSA-N;
(3)Smilesc1(c(cccc1)Cl)[N+](=O)[O-];

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	oral	135mg/kg (135mg/kg)	National Technical Information Service. Vol. PB214-270,
rabbit	LD50	oral	280mg/kg (280mg/kg)	"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 92, 1982.
rabbit	LD50	skin	400mg/kg (400mg/kg)	Fundamental and Applied Toxicology. Vol. 7, Pg. 609, 1986.
rat	LD50	oral	268mg/kg (268mg/kg)	National Technical Information Service. Vol. PB214-270,

Product Name

2-Nitrochlorobenzene

Synthetic route

1-Chloro-2-nitrobenzene Consensus Reports

1-Chloro-2-nitrobenzene Standards and Recommendations

1-Chloro-2-nitrobenzene Specification

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