1-Methyl-1H-pyrazole-5-boronic acid pinacol ester supplier

Name
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
EINECS
CAS No. 847818-74-0
Article Data16
CAS DataBase
Density 1.06 g/cm³
Solubility Slightly soluble in water.
Melting Point 58-61 °C
Formula C₁₀H₁₇BN₂O₂
Boiling Point 355 °C at 760 mmHg
Molecular Weight 208.068
Flash Point 168.5 °C
Transport Information
Appearance
Safety 26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-pyrazole;
PSA 36.28000
LogP 0.71930

Synthetic route

: 930-36-9
1-methyl-1H-pyrazole

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With C26H50CoN4O2 at 20℃; for 0.0833333h; Inert atmosphere; Glovebox; Stage #2: 1-methyl-1H-pyrazole at 80℃; for 48h; Inert atmosphere; Sealed tube;	90%

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 720702-41-0
(1-methyl-1H-pyrazol-5-yl)boronic acid

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
With 4 A molecular sieve In tetrahydrofuran at 20℃; for 2h;	84%
In tetrahydrofuran at 20℃; for 48h; Molecular sieve;	67%

: 930-36-9
1-methyl-1H-pyrazole

: 61676-62-8
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1-methyl-1H-pyrazole With n-butyllithium In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran at -78 - 0℃; for 1.25h; Stage #3: With ammonium chloride In tetrahydrofuran	77%
Stage #1: 1-methyl-1H-pyrazole With n-butyllithium In tetrahydrofuran at 0 - 20℃; Stage #2: 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran at -78℃;	77%
Stage #1: 1-methyl-1H-pyrazole With n-butyllithium In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran at -78 - 0℃; for 1.25h;	77%

: 5419-55-6
Triisopropyl borate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1-methyl-1H-pyrazole With n-butyllithium In tetrahydrofuran; hexanes at -78 - 20℃; for 1h; Stage #2: Triisopropyl borate In tetrahydrofuran; hexanes for 1h; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexanes	51%

: 844501-71-9, 1086111-17-2
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 74-88-4
methyl iodide

A: 1020174-04-2
1-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

B: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; for 70h;

...Expand

: 930-36-9
1-methyl-1H-pyrazole

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

A: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

B: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer In hexane at 20℃; Glovebox; Inert atmosphere; Stage #2: With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 20℃; Glovebox; Inert atmosphere; Stage #3: 1-methyl-1H-pyrazole In hexane at 20℃; for 5h; Reagent/catalyst; Solvent; Glovebox; Inert atmosphere; Overall yield = 67 percent; regioselective reaction;

Yield

Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer In hexane at 20℃; Glovebox; Inert atmosphere;
Stage #2: With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 20℃; Glovebox; Inert atmosphere;
Stage #3: 1-methyl-1H-pyrazole In hexane at 20℃; for 5h; Reagent/catalyst; Solvent; Glovebox; Inert atmosphere; Overall yield = 67 percent; regioselective reaction;

...Expand

: 1047645-89-5
methyl 4-bromo-5-ethyl-2-thiophenecarboxylate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1047645-90-8
methyl 5-ethyl-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate

Conditions

Conditions	Yield
With potassium carbonate; bis(tri-t-butylphosphine)palladium(0) at 80℃; for 1h;	100%

: 1044851-72-0
1,1-dimethylethyl (2-{[(5-bromo-3-thienyl)carbonyl]amino}-2-phenylethyl)carbamate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1044851-74-2
1,1-dimethylethyl [2-({[5-(1-methyl-1H-pyrazol-5-yl)-3-thienyl]carbonyl}amino)-2-phenylethyl]carbamate

Conditions

Conditions	Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 80℃; for 17h; Suzuki Coupling;	100%

: 100523-84-0
2-bromothiophene-4-carboxylic acid

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1044851-90-2
5-(2-methyl-2H-pyrazol-3-yl)-thiophene-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 80℃; for 12 - 17h; Suzuki Coupling;	100%

: 175135-49-6
N-(2-bromo-4-(trifluoromethyl)phenyl)acetamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: N-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)acetamide

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water for 1h; Suzuki Coupling; Reflux;	100%
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water for 1h; Reflux;	100%

: 2-[(3R)-3-methylmorpholin-4-yl]-8-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]-1,7-naphthyridin-4-yl trifluoromethanesulfonate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: (3R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water at 110℃; for 3h; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,2-dimethoxyethane; water at 130℃; for 0.333333h; Suzuki Coupling; Microwave irradiation;

: 1047628-66-9
methyl 4-bromo-5-propyl-2-thiophenecarboxylate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1047628-67-0
methyl 4-(1-methyl-1H-pyrazol-5-yl)-5-propyl-2-thiophenecarboxylate

Conditions

Conditions	Yield
With potassium carbonate; bis(tri-t-butylphosphine)palladium(0) at 80℃; for 1h;	99%

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1430057-83-2
4-chloro-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
With N-chloro-succinimide; 2,4,6-trimethylaniline In dichloromethane at 20℃; for 24h; Inert atmosphere;	99%
With 2-chloro-1,3-bis(methoxycarbonyl)guanidine In acetonitrile at 20℃; for 12h; Reagent/catalyst; regioselective reaction;	98%
With N-chloro-succinimide; 2,2,6,6-tetramethylpiperidin-1-oxoammonium trifluoromethanesulfonate In chloroform at 25℃; for 12h; Reagent/catalyst; Schlenk technique;	96%

: tert-butyl (2-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)ethyl)carbamate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: tert-butyl (2-(4-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)ethyl)carbamate

Conditions

Conditions	Yield
With methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In tetrahydrofuran; ethanol; water at 50℃; for 12h; Inert atmosphere;	99%

: 1301612-83-8
tert-butyl 1-(4-(2-chloro-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1301612-87-2
tert-butyl 1-(4-(2-(1-methyl-1H-pyrazol-5-yl)-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 120℃; for 0.333333h; Microwave irradiation; Inert atmosphere; Sealed tube;	98%

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 2-chloro-5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)pyrimidine

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In tetrahydrofuran; water Reflux;	98%

: PU-DZ13

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1289544-05-3
2-fluoro-9-(2-(isobutylamino)ethyl)-8-((6-(1-methyl-1H-pyrazol-5-yl)benzo[d][1,3]dioxol-5-yl)methyl)-9H-purin-6-amine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride In water; N,N-dimethyl-formamide at 90℃; for 2h; Suzuki Coupling; Inert atmosphere;	97%

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: methyl 3-methyl-4-(1-methyl-1H-pyrazol-5-yl)benzoate

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 100℃; for 10h; Inert atmosphere;	97%

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 942070-88-4
4-bromo-1-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
With N-Bromosuccinimide; 2,4,6-trimethylaniline In dichloromethane at -40 - 0℃; for 24h; Inert atmosphere; regioselective reaction;	96%

: 3934-20-1
2,6-Dichloropyrimidine

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 2-chloro-4-(1-methyl-1H-pyrazol-5-yl)pyrimidine

Conditions

Conditions	Yield
With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate In 1,4-dioxane; water at 120℃; for 2h;	96%

: 1415089-66-5
5-bromo-1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-1H-indole

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1415089-44-9
C24H25FN4

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 100℃; Suzuki-Miyaura Coupling; Inert atmosphere;	95%

: 619-42-1
4-methoxycarbonylphenyl bromide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 179057-12-6
methyl 4-(1-methyl-1H-pyrazol-5-yl)benzoate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium phosphate tribasic trihydrate In N,N-dimethyl-formamide at 0 - 120℃; Suzuki Coupling; Inert atmosphere;	95%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 100℃; for 10h; Inert atmosphere;	89%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 0 - 100℃; for 10h; Inert atmosphere;	89%
With tetrakis(triphenylphosphine) palladium(0); potassium phosphate tribasic trihydrate In N,N-dimethyl-formamide at 90℃; Suzuki Coupling; Inert atmosphere;	85%

: 4-fluoro-3-iodo-naphthalene-1-carbonitrile

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 4-fluoro-3-(2-methylpyrazol-3-yl)naphthalene-1-carbonitrile

Conditions

Conditions	Yield
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In 1,4-dioxane; water at 80℃; for 18h; Inert atmosphere;	95%

: 648904-84-1
4-bromo-2-fluoro-1-(methylsulfonyl)benzene

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 5-(3-fluoro-4-methanesulfonylphenyl)-1-methyl-1H-pyrazole

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 100℃; Inert atmosphere;	94%

: 213771-32-5
5-bromo-3-methylpyridine-2-carboxylic acid methyl ester

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: methyl 3-methyl-5-(1-methyl-1H-pyrazol-5-yl)picolinate

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 100℃; for 10h; Inert atmosphere;	94%

: methyl 2-bromo-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: methyl 2-(1-methyl-1H-pyrazol-5-yl)[1,2,4]triazolo[1,5-a]pyridine-6-carboxylate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 60℃; for 2h;	94%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; dichloromethane; water at 60℃; for 2h; Suzuki Coupling;	94%

: N-[1-(4-chloro-phthalazin-1-yl)-piperidin-4-yl]-4-fluoro-N-methyl-2-trifluoromethyl-benzamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1258861-20-9
4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazole-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 74℃; for 12h; Suzuki Coupling; Inert atmosphere;	92%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 74℃; for 12h; Suzuki Coupling; Inert atmosphere;	92%

: C6H4BrFO3S

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: C10H9FN2O3S

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium phosphate tribasic trihydrate In N,N-dimethyl-formamide at 90℃; Inert atmosphere;	92%

: (6-cyano-7-quinolyl)trifluoromethanesulfonate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 7-(2-methylpyrazol-3-yl)quinoline-6-carbonitrile

Conditions

Conditions	Yield
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium hydrogencarbonate In 1,4-dioxane; water at 80℃; for 1h; Inert atmosphere;	92%

: 5-bromo-N-cyclopentyl-N-(2,4-dimethoxybenzyl)-2-methoxybenzenesulfonamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: N-cyclopentyl-N-(2,4-dimethoxybenzyl)-2-methoxy-5-(1-methyl-1H-pyrazol-5-yl)benzenesulfonamide

Conditions

Conditions	Yield
With dichloro-[1,3-bis(2,6-diisopropylpenyl)-2-imidazolidinyliden]-(3-chloropyridyl)palladium(II); caesium carbonate In 1,4-dioxane; water; N,N-dimethyl-formamide at 90℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere; Microwave irradiation;	91%

: 2-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-[3,3‘-bipyridine]-5-carboxamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: N-(4-(chlorodifluoromethoxy)phenyl)-2-(1-methyl-1H-pyrazol-5-yl)-[3,3‘-bipyridine]-5-carboxamide

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane; water at 100℃; Concentration; Inert atmosphere;	91%

: tert-butyl 4-((7-(3-bromophenyl)-6-chloro-4-oxo-4, 7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)-4-hydroxypiperidine-1-carboxylate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: tert-butyl 4-((6-chloro-7-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)-4-hydroxypiperidine-1-carboxylate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 140℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Microwave irradiation; Sealed tube;	91%

: N-(1-(6-chloro-4,5-dimethyl-3-pyridazinyl)-4-piperidinyl)-4-fluoro-N-methyl-2-(trifluoromethyl)benzamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: N-(1-(4,5-dimethyl-6-(1-methyl-1H-pyrazol-5-yl)pyridazin-3-yl)piperidin-4-yl)-4-fluoro-N-methyl-2-(trifluoromethyl)benzamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In methanol; water; toluene at 74℃; for 12h; Inert atmosphere;	89%

: tert-butyl (R)-4-((S)-10-((4-chloro-2-oxopyridin-1(2H)-yl)methyl)-10-hydroxy-7-azaspiro[4.5]decane-7-carbonyl)-3-phenylpiperazine-1-carboxylate

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: tert-butyl (R)-4-((S)-10-hydroxy-10-((4-(1-methyl-1H-pyrazol-5-yl)-2-oxopyridin-1(2H)-yl)methyl)-7-azaspiro[4.5]decane-7-carbonyl)-3-phenylpiperazine-1-carboxylate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 120℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Sealed tube; Microwave irradiation;	89%

: 6-bromo-3-cyclopropoxypicolinonitrile

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 3-cyclopropoxy-6-(1-methyl-1H-pyrazol-5-yl)picolinonitrile

Conditions

Conditions	Yield
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate In 1,4-dioxane; water at 25 - 80℃; for 2h;	89%

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Chemical Properties

Molecule structure of 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester (CAS NO.847818-74-0):

Molecular Weight: 226.08 g/mol
Molecular Formula: C₁₀H₁₉BN₂O₃
Density: 1.06 g/cm³
Melting Point: 58-61 °C
Boiling Point: 355 °C at 760 mmHg
Flash Point: 168.5 °C
Index of Refraction: 1.485
Molar Refractivity: 61.15 cm³
Molar Volume: 213 cm³
Polarizability: 24.24×10^-24 cm³
Surface Tension: 34 dyne/cm
Enthalpy of Vaporization: 63.32 kJ/mol
Vapour Pressure: 1.18E-05 mmHg at 25 °C
InChI: InChI=1/C10H19BN2O3/c1-9(2,14)10(3,4)16-11(15)8-6-7-12-13(8)5/h6-7,14-15H,1-5H3 Copy
InChIKey: KOSJKDRDKBVCGA-UHFFFAOYAV
Product Categories of 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester (CAS NO.847818-74-0): Boronic ester; Organoborons; Pyrazole

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
HazardClass: IRRITANT

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Specification

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester (CAS NO.847818-74-0) is also named as Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ; 1H-Pyrazole,1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- ; 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester, 97% ; 1H-pyrazole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxabo .

Product Name

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester

Synthetic route

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Chemical Properties

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Safety Profile

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Specification

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