1-PIPERIDINOCYCLOHEXANECARBONITRILE supplier

Name
1-piperidinocyclohexanecarbonitrile
EINECS
CAS No. 3867-15-0
Article Data24
CAS DataBase
Density 1.01g/cm³
Solubility
Melting Point
Formula C12H20 N2
Boiling Point 309.5°Cat760mmHg
Molecular Weight 192.304
Flash Point 126.9°C
Transport Information
Appearance
Safety Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x and CN⁻. See also NITRILES.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Cyclohexanecarbonitrile,1-piperidino- (6CI,7CI,8CI); 1-(1-Cyanocyclohexyl)piperidine;1-Cyano-1-(1-piperidinyl)cyclohexane; 1-Cyano-1-piperidinocyclohexane;1-Piperidino-1-cyanocyclohexane; 1-Piperidino-1-cyclohexanecarbonitrile;1-Piperidinocyclohexanecarbonitrile; NSC 97072; PCC
PSA 27.03000
LogP 2.63668

Synthetic route

: 7677-24-9
trimethylsilyl cyanide

: 18304-40-0
C6H10C5H10N(1+)*ClO4(1-)=(C6H10C5H10N)(ClO4)

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With Co(II) complex supported on mesoporous SBA-15 at 40℃; for 3h; Strecker-type reaction;	95%
With Co(II) complex supported on mesoporous SBA-15 at 40℃; for 3h; Strecker type reaction; Sealed tube;	95%

: 110-89-4
piperidine

: 5496-10-6
1-amino-1-cyanocyclohexane

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
In neat (no solvent) at 60 - 70℃;	88%

: 110-89-4
piperidine

: 143-33-9
sodium cyanide

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With sodium hydrogensulfite at 20℃;	82.1%

...Expand

: 110-89-4
piperidine

: 108-94-1
cyclohexanone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With magnesium sulfate In N,N-dimethyl acetamide at 45℃; for 48h;	80%

...Expand

: 110-89-4
piperidine

: 773837-37-9
sodium cyanide

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With hydrogenchloride	77%
With hydrogenchloride
With hydrogenchloride
pH=5; Strecker type reaction;
With hydrogenchloride

...Expand

: 110-89-4
piperidine

: potassium cyanide

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With sodium hydrogensulfite	77%
With sodium hydrogensulfite
With sodium hydrogen sulfite
With sodium hydrogen sulfite

...Expand

: 151-50-8
potassium cyanide

: 6091-44-7
piperidine hydrochloride

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With ethanol

...Expand

: 110-89-4
piperidine

: 64-17-5
ethanol

: 7732-18-5
water

: 151-50-8
potassium cyanide

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
beim Behandeln des Hydrochlorids;

...Expand

: 110-89-4
piperidine

: 7677-24-9
trimethylsilyl cyanide

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
With zinc(II) iodide In methanol; diethyl ether at 80℃; for 8h; Strecker reaction;

...Expand

: 108-94-1
cyclohexanone

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 20 - 25 °C 2: neat (no solvent) / 60 - 70 °C View Scheme

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 3319-01-5
1-cyclohexylpiperidine

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; Hg(II) trifluoroacetate; sodium cyanoborohydride In methanol for 24h; Ambient temperature;	93%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 591-51-5
phenyllithium

: 16283-47-9
1-(1-benzimidoylcyclohexyl)piperidine

Conditions

Conditions	Yield
In diethyl ether for 4h; Ambient temperature;	89%

: 110-00-9
furan

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 101355-99-1
N-[1-(furan-2-yl)-cyclohexan-1-yl] piperidine

Conditions

Conditions	Yield
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; magnesium bromide In diethyl ether; hexane Heating;	76%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

A: 41805-36-1
C-(1-piperidin-1-yl-cyclohexyl)methylamine

B: 41805-37-2
1-(1-aminomethyl-cyclohexyl)-piperidine; dihydrochloride

Conditions

Conditions	Yield
With LiAlH4	A n/a B 74.4%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 21473-01-8
2-naphthalenylmagnesium bromide

: 81490-58-6
1-<1-(2-Naphthyl)cyclohexyl>piperidine

Conditions

Conditions	Yield
In tetrahydrofuran for 6h; Heating;	65%

: 108-86-1
bromobenzene

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 77-10-1
Phencyclidine

Conditions

Conditions	Yield
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran; diethyl ether Stage #2: 1-piperidinocyclohexylcarbonitrile In tetrahydrofuran; diethyl ether Reflux;	58%
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran Stage #2: 1-piperidinocyclohexylcarbonitrile In tetrahydrofuran	58%
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran Stage #2: 1-piperidinocyclohexylcarbonitrile

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 100-58-3
phenylmagnesium bromide

: 77-10-1
Phencyclidine

Conditions

Conditions	Yield
	58%

: 59-50-7
4-Chloro-3-methylphenol

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 1372710-21-8
1-[1-[3-hydroxy-5-methylphenyl][cyclohexyl]]piperidine

Conditions

Conditions	Yield
Stage #1: 4-Chloro-3-methylphenol With iodine; magnesium In diethyl ether Reflux; Stage #2: 1-piperidinocyclohexylcarbonitrile In diethyl ether; toluene for 336h; Reflux;	56%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 121817-69-4
N-(1-cyanocyclohexyl)piperidone

Conditions

Conditions	Yield
With iodosylbenzene In water for 96h; Ambient temperature;	55%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 74-86-2
acetylene

: 101438-14-6
1-(2-pyridyl)-1-piperidinocyclohexane

Conditions

Conditions	Yield
With cobaltocene In tetrahydrofuran at 160℃; under 10640 Torr; for 3h;	44%

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

A: 41805-36-1
C-(1-piperidin-1-yl-cyclohexyl)methylamine

B: 119658-17-2
bis-(1-piperidino-cyclohexylmethyl)-amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 2201-13-0
1-piperidin-1-yl-cyclohexanecarboxylic acid amide

Conditions

Conditions	Yield
With sulfuric acid

: 36748-89-7
2-iodobenzothiophene

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 112726-66-6
1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine

Conditions

Conditions	Yield
With magnesium 1.) ether, 2.) reflux, 16 h; Yield given. Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 580-13-2
2-bromonaphthalene

: 81490-58-6
1-<1-(2-Naphthyl)cyclohexyl>piperidine

Conditions

Conditions	Yield
With magnesium 1.) ether, RT, 2.) ether, reflux, 12 h; Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 4165-57-5
bromobenzene-d5

: 60124-86-9
1-(1-d5-phenylcyclohexyl)piperidine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 106-37-6
1.4-dibromobenzene

A: 2201-33-4
4-Bromophencyclidine

B: 76916-13-7
1,1'-(1,4-Phenylenedicyclohexylidene)bis

Conditions

Conditions	Yield
With magnesium 1.) benzene, ether, 2.) reflux, 4 h; Yield given. Multistep reaction;
With magnesium 1.) benzene, ether, 2.) reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 106-37-6
1.4-dibromobenzene

: 76916-13-7
1,1'-(1,4-Phenylenedicyclohexylidene)bis

Conditions

Conditions	Yield
With magnesium 1.) Et2O, THF, reflux, 5 h; 2.) THF, Et2O, reflux, 1 h; Yield given. Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 624-38-4
para-diiodobenzene

A: 77415-80-6
4-iodophencyclidine

B: 77415-81-7
1-<1-(1,1'-Biphenyl-4-yl)cyclohexyl>piperidine

C: 76916-13-7
1,1'-(1,4-Phenylenedicyclohexylidene)bis

Conditions

Conditions	Yield
With magnesium 1.) ether, benzene, reflux, 2.) reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
With magnesium 1.) ether, benzene, reflux, 2.) reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 90-11-9
1-Bromonaphthalene

: 2201-37-8
1-(1-naphthalen-1-yl-cyclohexyl)-piperidine

Conditions

Conditions	Yield
With magnesium 1.) ether, RT, 2.) ether, reflux, 12 h; Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 92-66-0
4-bromo-1,1'-biphenyl

: 77415-81-7
1-<1-(1,1'-Biphenyl-4-yl)cyclohexyl>piperidine

Conditions

Conditions	Yield
With magnesium 1.) Et2O, THF, reflux, 2 h; 2.) THF, Et2O, reflux, 1 h; Yield given. Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 69626-75-1
2-iodobenzofuran

: 1-(2-benzo(b)furanyl)-1-(1-piperidino)-cyclohexane

Conditions

Conditions	Yield
With magnesium 1.) ether, RT, 2.) ether, reflux, 12 h; Multistep reaction;

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 585-71-7, 38661-81-3
(1-bromoethyl)benzne

: 77745-00-7
1-<1-(1-Phenylethyl)cyclohexyl>piperidine

Conditions

Conditions	Yield
With magnesium 1.) Et2O, reflux, 2 h; 2.) Et2O, reflux, 1 h; Yield given. Multistep reaction;

1-PIPERIDINOCYCLOHEXANECARBONITRILE Toxicity Data With Reference

1.	orl-mus LD50:133 mg/kg	JPPMAB Journal of Pharmacy and Pharmacology. 28 (1976),713.
2.	ipr-mus LD50:30 mg/kg	JATOD3 Journal of Analytical Toxicology. 4 (1980),119.
3.	ivn-mus LD50:18 mg/kg	CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03387 .

1-PIPERIDINOCYCLOHEXANECARBONITRILE Consensus Reports

Cyanide and its compounds are on the Community Right-To-Know List.

1-PIPERIDINOCYCLOHEXANECARBONITRILE Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x and CN⁻. See also NITRILES.

Product Name

1-piperidinocyclohexanecarbonitrile

Synthetic route

1-PIPERIDINOCYCLOHEXANECARBONITRILE Toxicity Data With Reference

1-PIPERIDINOCYCLOHEXANECARBONITRILE Consensus Reports

1-PIPERIDINOCYCLOHEXANECARBONITRILE Safety Profile

Related Products

Hot Products