18-Crown-6 supplier | CasNO.17455-13-9

Name
18-Crown-6
EINECS 241-473-5
CAS No. 17455-13-9
Article Data59
CAS DataBase
Density 0.995 g/cm³
Solubility soluble in water
Melting Point 42-45 ºC(lit.)
Formula C₁₂H₂₄O₆
Boiling Point 395.8 ºC at 760 mmHg
Molecular Weight 264.319
Flash Point 163.8 ºC
Transport Information
Appearance slightly yellow solid
Safety 26-36-39
Risk Codes 22-36/37/38-36-20/22-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 18-Crownether-6;18-Crown-6 ether;Ethylene oxide cyclic hexamer;NSC159836;1,4,7,10,13,16-Hexaoxacyclooctadecane;
PSA 55.38000
LogP 0.09960

Synthetic route

: 1,4,7,10,13,16-Hexaoxa-cyclooctadecane-2,9-dione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1.5h;	92%

: 62796-84-3
1,4,7,10,13,16-hexaoxacyclooctadecane-2,6-dione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1.5h;	89%

: 1,4,7,10,13,16-Hexaoxa-cyclooctadecane-2,12-dione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1.5h;	83%

: C12H24O6*C3H7N*ClH

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With calcium oxide In water	80%

: C12H24O6*C7H9N*BrH

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With calcium oxide In water	80%

: 75-77-4
chloro-trimethyl-silane

: 1,4-dipotassio tetrasilane

A: 17455-13-9
18-crown-6 ether

B: 79848-13-8
octakis(i-propyl)cycloterasilane

C: linear hexasilane

Conditions

Conditions	Yield
In benzene Ring cleavage;	A n/a B 9% C 79%

...Expand

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In acetonitrile for 72h; Ambient temperature;	78%
With potassium hydroxide In water at 25℃; for 0.5h; Solvent; Temperature;	54%

: 1,4,7,10,13,16-Hexaoxa-cyclooctadecane-2,15-dione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1.5h;	77%

: 2615-15-8
pentaethylene glycol

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 60℃;	75%

: 2615-15-8
pentaethylene glycol

A: 17455-13-9
18-crown-6 ether

B: 71092-59-6
<36>crown-12

C: 71092-62-1
54-Crown-18

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 65℃;	A 69% B 1.1% C 0.1%

...Expand

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With p-toluenesulfonyl chloride; potassium hydroxide In tetrahydrofuran at 55 - 60℃; for 3h;	65.2%
With sodium hydroxide; benzenesulfonyl chloride In various solvent(s) Ambient temperature;
Multi-step reaction with 2 steps 1: 34 percent / toluene 2: 92 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 °C View Scheme
Multi-step reaction with 2 steps 1: thionyl chloride View Scheme

: 112-60-7
Tetraethylene glycol

: 7460-82-4
diethylene glycol ditosylate

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 27℃; for 0.5h;	58%
With aluminum oxide; potassium fluoride In acetonitrile for 24h; Ambient temperature;	70 % Chromat.

: 4792-15-8
Pentaethylene glycol

: 6315-52-2
1,2-bis-tosyloxyethane

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With potassium hydroxide In water at 20℃; for 0.333333h;	55%

: 112-26-5
1,2-bis(2-chloroethoxy)ethane

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With potassium hydroxide for 0.133333h; microwave irradiation;	54%
With potassium hydroxide In tetrahydrofuran at 70℃; for 13h; Inert atmosphere;	35%

: 86309-77-5
1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3-dithione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With nickel In diethyl ether; dichloromethane at 0℃; for 1h;	45%

: 37860-51-8
tetraethylene glycol di(p-toluenesulfonate)

: 111-46-6
diethylene glycol

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 20℃; for 1h;	45%

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 122861-55-6
C42H84O21

C: 52902-52-0
<27>crown-9

D: 71092-59-6
<36>crown-12

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 65℃; Further byproducts given;	A 42% B 1.3% C 10% D 4.1%

...Expand

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 52902-52-0
<27>crown-9

C: 71092-59-6
<36>crown-12

D: 109635-67-8
45-Crown-15

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 65℃; Further byproducts given;	A 42% B 10% C 4.1% D 2.2%

...Expand

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 52902-52-0
<27>crown-9

C: 71092-59-6
<36>crown-12

D: 109635-67-8
45-Crown-15

E: 71092-62-1
54-Crown-18

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 65℃; Product distribution; var. glycols; template effect of K(+).;	A 42% B 10% C 4.1% D 2.2% E 2%

...Expand

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 52902-52-0
<27>crown-9

C: 71092-59-6
<36>crown-12

D: 71092-62-1
54-Crown-18

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 65℃; Further byproducts given;	A 42% B 10% C 4.1% D 2%

...Expand

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 71092-59-6
<36>crown-12

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 25℃;	A 40% B 13%

...Expand

: 112-60-7
Tetraethylene glycol

: 7460-82-4
diethylene glycol ditosylate

A: 17455-13-9
18-crown-6 ether

B: 71092-59-6
<36>crown-12

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 25℃;	A 37% B 18%

...Expand

: 112-60-7
Tetraethylene glycol

: 111-44-4
3-oxa-1,5-dichloropentane

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran	34%
With potassium hydroxide In tetrahydrofuran Heating;	30%
With potassium hydroxide In tetrahydrofuran Heating; other metal hydroxides as 'template' agents;	30%
With potassium hydroxide In tetrahydrofuran for 18h; Heating;
In tetrahydrofuran for 24h; Heating;

: 112-60-7
Tetraethylene glycol

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

A: 17455-13-9
18-crown-6 ether

B: 33089-36-0
1,4,7,10,13,16,10-heptaoxacyclohenicosane

C: 33089-37-1
24-crown-8

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 60℃;	A 19% B 33% C 14%

...Expand

: (18-phenylsulfonyl-2,5,8,11,14,17-hexaoxaoctadecylsulfonyl)benzene

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With sodium amalgam In benzene Heating;	25%

: 112-60-7
Tetraethylene glycol

: 111-46-6
diethylene glycol

A: 294-93-9
(1,4,7,10-tetraoxacyclododecane)

B: 17455-13-9
18-crown-6 ether

C: 33089-37-1
24-crown-8

Conditions

Conditions	Yield
With potassium hydroxide; p-toluenesulfonyl chloride In 1,4-dioxane at 60℃;	A n/a B 23% C 3%

...Expand

: 86309-78-6
1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3,11,12-tetrathione

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With nickel In diethyl ether; dichloromethane at 0℃; for 1h;	21%

: (9-phenylsulfonyl-2,5,8-trioxanonylsulfonyl)benzene

: 17455-13-9
18-crown-6 ether

Conditions

Conditions	Yield
With sodium amalgam In benzene Heating;	16%

: 33100-27-5
15-crown-5

: C14H14Mg*C12H24O6

A: 17455-13-9
18-crown-6 ether

B C14H14Mg*C10H20O5: C14H14Mg*C10H20O5

Conditions

Conditions	Yield
In benzene at 25℃; Equilibrium constant;

...Expand

: 33089-36-0
1,4,7,10,13,16,10-heptaoxacyclohenicosane

: 31270-13-0
(18-crown-6)potassium

A: 17455-13-9
18-crown-6 ether

B: C14H28O7*K(1+)

Conditions

Conditions	Yield
In gas at 76.9℃; Equilibrium constant; Thermodynamic data; ΔG;

...Expand

: 17455-13-9
18-crown-6 ether

: [NO+*crown*H(NO3)2-]

Conditions

Conditions	Yield
With dinitrogen tetroxide; Nitrogen dioxide In dichloromethane at -10℃; for 0.5h;	100%
With dinitrogen tetraoxide; Nitrogen dioxide In dichloromethane at -10℃; for 0.5h;	100%
With dinitrogen tetraoxide In chloroform at -10℃; for 1h; complexation;	90%

: 17455-13-9
18-crown-6 ether

: 536-80-1
iodosylbenzene

: phenyl(hydroxy)(tetrafluoroborato)-λ3-iodane 18-crown-6 complex (1:1)

Conditions

Conditions	Yield
With tetrafluoroboric acid dimethyl ether complex In dichloromethane at -78 - 0℃; for 3.5h;	100%

: 17455-13-9
18-crown-6 ether

: potassium (5-trifluoroborate-3-tert-butyl-2-trimethylsilanyloxybenzylidene)-(2,6-diisopropylphenyl)amine

: C23H30BF3NO(1-)*C12H24O6*K(1+)

Conditions

Conditions	Yield
In toluene for 24h;	100%

: 17455-13-9
18-crown-6 ether

: 7647-18-9
antimonypentachloride

: lead(II) chloride

: {Pb(O6(CH2)12)(CH3CN)3}(2+)*2(SbCl6)(1-)={Pb(O6(CH2)12)(CH3CN)3}{SbCl6}2

Conditions

Conditions	Yield
In acetonitrile PbCl2 is dissolved by injection of SbCl5 in MeCN, addn. of 18-crown-6; concn. the volume under vac., standing for some time at 20°C, filtn., elem. anal.;	100%

...Expand

: 17455-13-9
18-crown-6 ether

: hexafluorotitanic acid

: H2TiF6*6H2O*2(C12H24O6)

Conditions

Conditions	Yield
In tetrahydrofuran; water slow addn. of concd. acid to THF soln of 18-crown-6, pptn.; filtered, washed (diethyl ether), dried in air, elem. anal.;	100%

: 17455-13-9
18-crown-6 ether

: nido-NB10H13

: potassium triethylborohydride

A: bis[(18-crown-6)potassium][undecahydro-7-aza-nido-undecaborate]

B: 1333-74-0
hydrogen

Conditions

Conditions	Yield
In tetrahydrofuran byproducts: BEt3; molar ratio NB10H13:KBHEt3 1:2, cooling (-78°C), stirring (2 h, room temp.); evapn. (vac.), dissoln. (THF), crystn. (-40°C), recrystn. (CH3CN); elem. anal.;	A 23% B 100%

...Expand

: 17455-13-9
18-crown-6 ether

: 851576-85-7
[W(carbonyl)5([bis(trimethylsilyl)methyl]cyanophosphane)]

: 865-47-4
potassium tert-butylate

: 947333-63-3
[(OC)5WP(CH(SiMe3)2)CNK(18-crown-6)]

Conditions

Conditions	Yield
In tetrahydrofuran under Ar; cooled (-80°C) soln. of KO-t-Bu in THF added dropwise to stirred soln. of W complex in THF and 18-crown-6; warmed slowly to room temp. for 3.5 h; solvent removed under vac.; washed with Et2O and n-pentane; dried under reduced pressure; elem. anal.;	100%

...Expand

: 67-56-1
methanol

: 17455-13-9
18-crown-6 ether

: 1033846-72-8
1,3,5-tris(2,6-dimethyl-4-hydroxyphenyl)benzene

: 1253939-59-1
CH4O*C12H24O6*C30H30O3*H2O

Conditions

Conditions	Yield
With water In ethanol	100%

...Expand

: 17455-13-9
18-crown-6 ether

: 64-17-5
ethanol

: 1253939-64-8
1,3,5-tris(4-hydroxyphenyl)mesitylene

: 71-43-2
benzene

: 1253939-66-0
C2H6O*C6H6*C12H24O6*C27H24O3*H2O

Conditions

Conditions	Yield
With water	100%

...Expand

: 105139-33-1
(hydrido)(5,10,15,20-tetrakis(p-tolyl)porphyrinato)iridium(III)

: 17455-13-9
18-crown-6 ether

: 1215770-26-5
potassium (18-crown-6)(5,10,15,20-tetrakis(p-tolyl)porphyrinato)iridate(I)

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 150℃; for 0.75h;	100%

: 17455-13-9
18-crown-6 ether

: 3C12H24KO6*O4P(3-)

Conditions

Conditions	Yield
With potassium phosphate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: 2C12H24KO6*HO4P(2-)

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: C12H24KO6*H2O4P(1-)

Conditions

Conditions	Yield
With potassium dihydrogenphosphate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: Br(1-)*C12H24KO6

Conditions

Conditions	Yield
With potassium bromide In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: C12H24KO6*NO3(1-)

Conditions

Conditions	Yield
With potassium nitrate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: C12H24KO6*HO(1-)

Conditions

Conditions	Yield
With potassium hydroxide In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: C12H24KO6*ClO3(1-)

Conditions

Conditions	Yield
With potassium chlorate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: BrO3(1-)*C12H24KO6

Conditions

Conditions	Yield
With potassium bromate In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: 127-08-2
potassium acetate

: C2H3O2(1-)*C12H24KO6

Conditions

Conditions	Yield
In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: 584-08-7
potassium carbonate

: CO3(2-)*2C12H24KO6

Conditions

Conditions	Yield
In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: 298-14-6
potassium hydrogencarbonate

: CHO3(1-)*C12H24KO6

Conditions

Conditions	Yield
In water at 20℃; for 12h;	100%

: 17455-13-9
18-crown-6 ether

: 105139-33-1
Ir(ttp)H

: C12H30KO6(1+)*C48H36IrN4(1-)

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 150℃; for 0.75h; Inert atmosphere;	100%

: 12116-66-4
bis(cyclopentadienyl)hafnium dichloride

: 17455-13-9
18-crown-6 ether

: 7440-09-7
potassium

: (18-crown-6)*K[Cp2HfCl2]

Conditions

Conditions	Yield
In toluene (N2) Hf complex, K and 18-crown-6 in toluene were stirred for 24 h; pentane was added, ppt. was filtered off; elem. anal.;	100%

...Expand

: 462-06-6
fluorobenzene

: 17455-13-9
18-crown-6 ether

: 1402068-67-0
C16AlF36O4(1-)*Ga(1+)

: C16AlF36O4(1-)*Ga(1+)*2.25C6H5F*C12H24O6

Conditions

Conditions	Yield
Inert atmosphere; Schlenk technique;	100%

...Expand

: 462-06-6
fluorobenzene

: 17455-13-9
18-crown-6 ether

: 1262800-74-7
C16AlF36O4(1-)*In(1+)

: C16AlF36O4(1-)*In(1+)*2.25C6H5F*C12H24O6

Conditions

Conditions	Yield
Inert atmosphere; Schlenk technique;	100%

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: 17455-13-9
18-crown-6 ether

: 536-80-1
iodosylbenzene

: C6H6BF4IO*C12H24O6

Conditions

Conditions	Yield
In dichloromethane at -78 - 0℃; for 3.5h; Inert atmosphere;	100%

...Expand

: 17455-13-9
18-crown-6 ether

: 536-80-1
iodosylbenzene

: 109-63-7
boron trifluoride diethyl etherate

: C6H6BF4IO*C12H24O6

Conditions

Conditions	Yield
In dichloromethane at -78 - 0℃; for 4h; Inert atmosphere;	100%

...Expand

: 17455-13-9
18-crown-6 ether

: C55H10F25S5

: C55H10F25S5(1+)*C12H24KO6(1+)

Conditions

Conditions	Yield
With potassium superoxide In dimethyl sulfoxide at 25℃; for 0.25h;	100%

: 7446-70-0, 7784-13-6
aluminum (III) chloride

: 17455-13-9
18-crown-6 ether

: potassium chloride

: C12H24KO6(1+)*AlCl4(1-)

Conditions

Conditions	Yield
Stage #1: 18-crown-6 ether; potassium chloride In water at 20℃; for 12h; Stage #2: aluminum (III) chloride In ethanol for 12h; Reflux;	100%

...Expand

: 17455-13-9
18-crown-6 ether

: potassium chloride

: 7646-85-7
zinc(II) chloride

: C12H24KO6(1+)*Cl3Zn(1-)

Conditions

Conditions	Yield
Stage #1: 18-crown-6 ether; potassium chloride In water at 20℃; for 12h; Stage #2: zinc(II) chloride In ethanol for 12h; Reflux;	100%

...Expand

18-Crown-6 Chemical Properties

IUPAC Name: 3,6,9,12,15,18-Hexaoxacyclooctadecane
Molecular Formula: C₁₂H₂₄O₆
Molecular Weight: 264.32 g/mol
SMILES: C1COCCOCCOCCOCCOCCO1
InChI: InChI=1/C12H24O6/c1-2-14-5-6-16-9-10-18-12-11-17-8-7-15-4-3-13-1/h1-12H2
EINECS: 241-473-5
Classification Code: Drug / Therapeutic Agent; Skin / Eye Irritant
Product Categories: API intermediates; Crown Ethers; Functional Materials; Macrocycles for Host-Guest Chemistry
storage temperature: Store at 0-5 °C
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
Melting Point: 42-45 °C(lit.)
Index of Refraction: 1.404
Molar Refractivity: 64.97 cm³
Molar Volume: 265.5 cm³
Polarizability: 25.75×10^-24 cm³
Surface Tension: 31.2 dyne/cm
Density: 0.995 g/cm³
Flash Point: 163.8 °C
Enthalpy of Vaporization: 62.08 kJ/mol
Boiling Point: 395.8 °C at 760 mmHg
Vapour Pressure of 18-Crown-6 (CAS NO.17455-13-9): 4.09E-06 mmHg at 25 °C

18-Crown-6 Uses

18-Crown-6 (CAS NO.17455-13-9) is used as a metal ion complexing agent.

18-Crown-6 Production

18-Crown-6 (CAS NO.17455-13-9) is commonly producted by the method of Wei Lianlin synthesis.

18-Crown-6 Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	59mg/kg (59mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 92, 1988.
mouse	LD50	intraperitoneal	464mg/kg (464mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.
mouse	LD50	intravenous	> 1gm/kg (1000mg/kg)		Russian Pharmacology and Toxicology Vol. 47, Pg. 167, 1984.
mouse	LD50	oral	540mg/kg (540mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 92, 1988.
rabbit	LD50	skin	3888mg/kg (3888mg/kg)	BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	National Technical Information Service. Vol. OTS0571014,
rat	LD50	intraperitoneal	830mg/kg (830mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.
rat	LD50	intratracheal	56mg/kg (56mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI	National Technical Information Service. Vol. OTS0536187,
rat	LD50	oral	525mg/kg (525mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 92, 1988.
rat	LDLo	skin	7gm/kg (7000mg/kg)		National Technical Information Service. Vol. OTS0540542,

18-Crown-6 Consensus Reports

Reported in EPA TSCA Inventory.

18-Crown-6 Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38-36-20/22-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
R20/22:Harmful by inhalation and if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S39:Wear eye / face protection.
RIDADR: 2811
WGK Germany: 3
RTECS: MP4500000
F: 10
HazardClass: 6.1(b)
PackingGroup of 18-Crown-6 (CAS NO.17455-13-9): III

18-Crown-6 Specification

18-Crown-6 (CAS NO.17455-13-9), its Synonyms are 1,4,7,10,13,16-Hexanoxacyclooctadecane ; 1,4,7,10,13,16-Hexaoxacyclooctadecane ; Ethylene oxide cyclic hexamer . It is slightly yellow solid.

Product Name

18-Crown-6

Synthetic route

18-Crown-6 Chemical Properties

18-Crown-6 Uses

18-Crown-6 Production

18-Crown-6 Toxicity Data With Reference

18-Crown-6 Consensus Reports

18-Crown-6 Safety Profile

18-Crown-6 Specification

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