2'-Bromoacetophenone supplier

Name
2'-Bromoacetophenone
EINECS 218-398-1
CAS No. 2142-69-0
Article Data114
CAS DataBase
Density 1.451 g/cm³
Solubility practically insoluble in water
Melting Point °C
Formula C₈H₇BrO
Boiling Point 249 °C at 760 mmHg
Molecular Weight 199.047
Flash Point 86.6 °C
Transport Information
Appearance Clear pale yellow to orange liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetophenone,2'-bromo- (7CI,8CI);1-(2-Bromophenyl)ethanone;1-Acetyl-2-bromobenzene;2-Acetylbromobenzene;2-Bromophenyl methyl ketone;NSC155380;o-Bromoacetophenone;o-Bromophenyl methyl ketone;
PSA 17.07000
LogP 2.65170

Synthetic route

: 1025869-90-2
(1-(2-bromophenyl)ethoxy)trimethylsilane

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With nitrogen dioxide at 20℃; for 1h;	100%

: 1973-22-4
1-bromo-2-ethylbenzene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With Iron(III) nitrate nonahydrate; 1-hydroxy-pyrrolidine-2,5-dione; oxygen In benzonitrile at 90℃; for 21h;	99%
With Iron(III) nitrate nonahydrate; N-hydroxyphthalimide In benzonitrile at 100℃; for 20h;	95%
With oxygen; silica gel; 4-aminoperbenzoic acid In dichloromethane at 20℃; for 12h;	73%

: 2042-37-7
o-cyanobromobenzene

: 75-16-1
methylmagnesium bromide

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water; toluene at 20 - 25℃; for 2h; Friedel-Crafts Acylation;	96.5%

: 5411-56-3
1-(2-bromophenyl)ethanol

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With silica gel; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; Inert atmosphere;	96%
With silica gel; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; Inert atmosphere;	95%
With C53H46ClN3P2Ru; potassium tert-butylate; acetone at 56℃; under 750.075 Torr; for 3h; Oppenauer Oxidation;	94%

: 766-46-1
2-bromo-1-ethynylbenzene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With water at 80℃; for 2h; Temperature; Green chemistry;	86%
With iron(III) chloride; water; silver(I) triflimide In 1,4-dioxane at 80℃; for 60h; regioselective reaction;	84%
With water at 80℃; for 15h;	84%

: 75-16-1
methylmagnesium bromide

: 7154-66-7
2-bromobenzoic acid chloride

A: 2142-69-0
2-bromophenyl methyl ketone

B: 577-16-2, 122382-54-1
2-Methylacetophenone

Conditions

Conditions	Yield
With iron(III)-acetylacetonate In tetrahydrofuran at -78℃;	A 85% B 7 % Chromat.

...Expand

: 60199-33-9
ortho-bromobenzenesulfonyl hydrazide

: 75-05-8
acetonitrile

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With 1,10-Phenanthroline; water; palladium diacetate at 100℃; under 760.051 Torr; for 6h;	82%

: 98-86-2
acetophenone

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With trifluoromethanesulfonic acid anhydride; magnesium bromide In diethyl ether at 0℃; for 0.166667h;	79%
With N-Bromosuccinimide; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate In 1,2-dichloro-ethane at 120℃; for 21h; Inert atmosphere; regioselective reaction;	50%
With tetra-n-butylammonium tribromide In methanol; diethyl ether; dichloromethane
With N-Bromosuccinimide; C18H24I2N5Pd(1+) In acetonitrile at 95℃; for 24h; Reagent/catalyst; Sealed tube;	22 %Chromat.
With N-Bromosuccinimide; 2Ru(2+)4F6P(1-)C47H34N8Pd(2+)C2H6OS*2I(1-) In 1,2-dichloro-ethane at 95℃; for 16h; Sealed tube;	57 %Chromat.

: 294881-08-6
3-(2-bromophenyl)-3-oxopropionic acid methyl ester

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 70℃; for 6h;	76%

: 108-86-1
bromobenzene

: 75-36-5
acetyl chloride

A: 2142-69-0
2-bromophenyl methyl ketone

B: 99-90-1
para-bromoacetophenone

Conditions

Conditions	Yield
With iron(III) sulfate In hexane at 20℃; for 0.75h; Friedel-Crafts acylation; Sonication;	A 5.2% B 74%
With poly(4-vinylpyridine) supported trifluoromethanesulfonic acid at 0 - 20℃; for 6h; Friedel-Crafts Acylation; Overall yield = 20 %;

...Expand

: 1429632-21-2
C10H11BrOS

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere;	74%

: 6213-94-1
trimethylsiloxyethene

: 583-55-1
1-Bromo-2-iodobenzene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; triphenylphosphine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20 - 100℃; for 2h; Heck Reaction; Microwave irradiation; regioselective reaction;	72%

: 899425-05-9
2-bromo-N-methoxy-N-methylbenzamide

: 75-16-1
methylmagnesium bromide

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether at 0℃; for 15h; Inert atmosphere;	72%
In tetrahydrofuran; diethyl ether at 0 - 20℃;

: 2039-88-5
2-bromostyrene

A: 2142-69-0
2-bromophenyl methyl ketone

B: 5411-56-3
1-(2-bromophenyl)ethanol

Conditions

Conditions	Yield
With tris(dibenzoylmethano)iron(III); phenylsilane In ethanol at 20℃; for 27h; Reagent/catalyst; Wacker Oxidation;	A 72% B 23%
With triethylsilane; (1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-Hexadecafluorophthalocyaninato)iron(II); oxygen In ethanol at 20℃; under 760.051 Torr; for 13h; Wacker Oxidation; Sealed tube; Green chemistry; chemoselective reaction;	A 65% B 5%

: 105-56-6
ethyl 2-cyanoacetate

: 244205-40-1
(2-bromophenyl)boronic acid

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 60℃; for 5h; regioselective reaction;	66%

: 551-93-9
2-aminoacetophenone

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
Stage #1: 2-aminoacetophenone With hydrogen bromide; sodium nitrite In water at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With copper(I) bromide In water Inert atmosphere;	60%
With hydrogen bromide; copper(I) bromide
With sulfuric acid; copper(I) bromide Diazotization;

: 7073-69-0
2-(2-bromophenyl)propanol

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate; dipotassium peroxodisulfate; silver nitrate In water at 30℃; for 24h; Inert atmosphere; Green chemistry;	60%

: 5411-56-3
1-(2-bromophenyl)ethanol

A: 2142-69-0
2-bromophenyl methyl ketone

B: 5411-56-3, 76116-20-6, 118375-26-1, 114446-55-8
(1S)-1-(2-bromophenyl)ethanol

C: 5411-56-3, 114446-55-8, 118375-26-1, 76116-20-6
(1R)-1-(2-bromophenyl)ethan-1-ol

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium bromide; chiral 4,1'-dinaphthyl-3,2'-cyclo[C(Me)2-N(oxyl)-C(Me)2] In dichloromethane; water at -15℃; for 1.5h; resolution of racemate; Electrolysis; Title compound not separated from byproducts;	A 54% B n/a C n/a
Stage #1: 1-(2-bromophenyl)ethanol With N,N'-bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; potassium acetate In dichloromethane; water for 0.0833333h; Stage #2: With N-Bromosuccinimide In dichloromethane; water at 20℃; for 4h; Kinetics; enantioselective reaction;	A n/a B n/a C n/a

...Expand

: 2039-88-5
2-bromostyrene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With manganese(IV) oxide; palladium dichloride In water; acetonitrile at 60℃; for 25h;	53%
With methanol; oxygen; potassium carbonate at 150℃; under 3000.3 Torr; for 12h; regioselective reaction;	47.3 %Chromat.

: 5411-56-3
1-(2-bromophenyl)ethanol

A: 2142-69-0
2-bromophenyl methyl ketone

B: 5411-56-3, 114446-55-8, 118375-26-1, 76116-20-6
(1R)-1-(2-bromophenyl)ethan-1-ol

Conditions

Conditions	Yield
With C50H42ClN2O3Ru In chloroform at 25℃; Kinetics; Molecular sieve; Resolution of racemate; enantioselective reaction;	A n/a B 48.8%
Stage #1: 1-(2-bromophenyl)ethanol With C28H36ClMnN2O2; potassium acetate In dichloromethane; water for 0.0833333h; Stage #2: With N-Bromosuccinimide In dichloromethane; water at 20℃; for 4h; Kinetics; enantioselective reaction;	A n/a B n/a

: 7073-94-1
1-bromo-2-isopropylbenzene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With oxygen at 190℃; under 760.051 Torr; for 24h; Autoclave;	34%

: 135774-34-4
o-bromo-α-fluoroacetophenone

A: 450-95-3
2-fluoroacetophenone

B: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; azobisisobutyronitrile In acetonitrile at 90℃; for 1.5h; Rate constant; other temp., other concentration, and time;	A 8.5% B 21.7%

: 135774-35-5
α-(benzoyloxy)-o-bromoacetophenone

A: 33868-50-7
phenacyl benzoate

B: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With tris(2,2'-bipyridine)ruthenium(II) perchlorate; 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole In acetonitrile at 20℃; for 13h; Rate constant; Irradiation; other reagents, reaction without irradiation, var. time;	A 15.7% B 12.5%

: 186581-53-3, 908094-01-9
diazomethane

: 7154-66-7
2-bromobenzoic acid chloride

: 2142-69-0
2-bromophenyl methyl ketone

: 917-64-6
methyl magnesium iodide

: 2042-37-7
o-cyanobromobenzene

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With diethyl ether anschliessendes Behandeln mit wss. HCl;

: 50671-05-1
3-(2-bromophenyl)-3-oxopropionic acid ethyl ester

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With sulfuric acid

: 7154-66-7
2-bromobenzoic acid chloride

: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With diethyl (ethoxymagnesio)malonate
With dimethylcadmium
Multi-step reaction with 3 steps 1: aqueous ammonia 2: thionyl chloride 3: diethyl ether / anschliessendes Behandeln mit wss. HCl View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: tetrahydrofuran; diethyl ether / 0 - 20 °C View Scheme

: 143798-76-9
3-methyl-4-(o-bromophenyl)-1,2-dioxetane

A: 50-00-0
formaldehyd

B: 2142-69-0
2-bromophenyl methyl ketone

Conditions

Conditions	Yield
With 9,10-Dibromoanthracene; 9,10-diphenylanthracene In tetrachloromethane at 60℃; Rate constant; Thermodynamic data; Ea; ΔH(excit.); ΔS(excit.); ΔG(excit.);

: 98-86-2
acetophenone

A: 2142-69-0
2-bromophenyl methyl ketone

B: 2142-63-4
1-(3-Bromophenyl)ethanone

Conditions

Conditions	Yield
With potassium bromate; sulfuric acid In water Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 2142-69-0
2-bromophenyl methyl ketone

: 5411-56-3
1-(2-bromophenyl)ethanol

Conditions

Conditions	Yield
With [{(CH3)2C3HN2-C5H3N-C3H3N2}RuCl2(PPh3)]; potassium isopropoxide; isopropyl alcohol at 82℃; for 0.00277778h; Inert atmosphere;	100%
Stage #1: 2-bromophenyl methyl ketone With C107H90Cl2N10P4Ru2(2+)*2Cl(1-) In isopropyl alcohol at 82℃; for 0.166667h; Inert atmosphere; Stage #2: With potassium isopropoxide In isopropyl alcohol for 2h; Catalytic behavior; Inert atmosphere;	100%
Stage #1: 2-bromophenyl methyl ketone With sodium tetrahydroborate In methanol at 20℃; for 24h; Stage #2: With water In methanol	100%

: 2142-69-0
2-bromophenyl methyl ketone

: 100-63-0
phenylhydrazine

: 1011736-72-3
N-[1-(2-Bromo-phenyl)-eth-(Z)-ylidene]-N'-phenyl-hydrazine

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 160℃; for 0.166667h; microwave irradiation;	100%
In diethyl ether Heating;
With acetic acid In ethanol for 0.166667h; Heating; Yield given;

: 2142-69-0
2-bromophenyl methyl ketone

: 16419-60-6
2-Methylphenylboronic acid

: 217468-51-4
1-(2′-methyl-[1,1′-biphenyl]-2-yl)ethanone

Conditions

Conditions	Yield
With potassium phosphate; CyJohnPhos; polymer-incarcerated palladium In water; toluene for 2h; Suzuki-Miyaura coupling; Heating;	100%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; ethanol Product distribution; Heating; Suzuki coupling of bromo-acylbenzenes resp. bromo-indole carbaldehydes with boronic acids;	98%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; ethanol rt, 15 min; reflux, 48 h;	98%

: 2142-69-0
2-bromophenyl methyl ketone

: 4-(2-bromophenyl)-1,2,3-thiadiazole

Conditions

Conditions	Yield
Stage #1: 2-bromophenyl methyl ketone With polystyrene-sulfonylhydrazide resin; acetic acid In tetrahydrofuran at 50℃; for 4h; Solid phase reaction; Stage #2: With thionyl chloride In 1,2-dichloro-ethane at 60℃; for 5h; Solid phase reaction; Hurd-Mori cyclization;	100%
Multi-step reaction with 2 steps 1: sulfuric acid / ethanol / 2 h / Reflux 2: thionyl chloride / 2 h / 5 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / ethanol / 20 °C / Reflux 2: thionyl chloride / 2 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: ethanol / 3 h / 80 °C 2: thionyl chloride / 2 h / 80 °C View Scheme

: 2142-69-0
2-bromophenyl methyl ketone

: 544-97-8
dimethyl zinc(II)

: 577-16-2, 122382-54-1
2-Methylacetophenone

Conditions

Conditions	Yield
(1,2-bis(diphenylphosphino)ethane)palladium(II) chloride In 1,4-dioxane for 1.5h; Heating;	100%

: 2142-69-0
2-bromophenyl methyl ketone

: 5188-07-8
sodium thiomethoxide

: 1441-97-0
2'-(methylthio)acetophenone

Conditions

Conditions	Yield
In tetrahydrofuran at 75℃; for 10h;	100%
In tetrahydrofuran at 75℃; for 12h;	88%
In tetrahydrofuran

: 2142-69-0
2-bromophenyl methyl ketone

: 26767-16-8
2-(2-bromophenyl)-2-oxoacetic acid

Conditions

Conditions	Yield
With pyridine; selenium(IV) oxide at 100℃; for 2h;	100%
With hydrogenchloride; sodium dichromate In water at 95℃; for 6h;	90%
With pyridine; selenium(IV) oxide at 120℃; for 18h; Inert atmosphere;	87%

: 2142-69-0
2-bromophenyl methyl ketone

: (E)-1-(2-bromophenyl)ethan-1-one oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;	100%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 20℃; for 24h; pH=9; Cooling with ice;	92%
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water pH=5; Reflux;	89%

: 2142-69-0
2-bromophenyl methyl ketone

: 444581-46-8
1-bromo-2-(1,1-difluoroethyl)benzene

Conditions

Conditions	Yield
With 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride; pyridine hydrofluoride In dichloromethane at 23℃; for 18h;	100%
With (bis-(2-methoxyethyl)amino)sulfur trufluoride; methanol at 70℃; for 18h;	63%
With morpholinosulfur trifluoride In dichloromethane; water at 20℃; for 672h;	12%

: 2142-69-0
2-bromophenyl methyl ketone

: 189321-65-1
1-(tert-butoxycarbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid

: 1035389-11-7
4-tert-butoxycarbonylamino-4-(5-phenyl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 1-(tert-butoxycarbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid With caesium carbonate In methanol for 2h; Stage #2: 2-bromophenyl methyl ketone In N,N-dimethyl-formamide for 2h; Stage #3: With ammonium acetate In xylenes at 20 - 135℃; for 52h;	100%

: 2142-69-0
2-bromophenyl methyl ketone

: 54655-41-3
B-allyl-1,3,2-dioxaborinane

: 1201827-38-4
(S)-(−)-2-(2-bromophenyl)-pent-4-en-2-ol

Conditions

Conditions	Yield
Stage #1: B-allyl-1,3,2-dioxaborinane With (S)-3,3'-dibromo-1,1'-bi-2-naphthol In toluene at 135℃; for 1h; Inert atmosphere; Stage #2: 2-bromophenyl methyl ketone In toluene at 35℃; for 120h; Inert atmosphere;	100%
With (S)-3,3'-dibromo-1,1'-bi-2-naphthol; tert-butyl alcohol In toluene at 20℃; for 24h; Inert atmosphere; enantioselective reaction;	95%

: 2142-69-0
2-bromophenyl methyl ketone

: 5411-56-3, 114446-55-8, 118375-26-1, 76116-20-6
(1R)-1-(2-bromophenyl)ethan-1-ol

Conditions

Conditions	Yield
With lithium hydroxide; (S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine; hydrogen; triphenylphosphine; iridium In methanol at 30℃; under 45004.5 Torr; for 3h; optical yield given as %ee; enantioselective reaction;	99%
With dimethylsulfide borane complex; 3-hydroxy-N-[(1R,2S)-cis-2-hydroxy-2,3-dihydro-1H-inden-1-yl]naphthalene-2-carboxamide In tetrahydrofuran at 65℃; Inert atmosphere; enantioselective reaction;	99%
With formic acid; triethylamine In water at 50℃; for 6h; enantioselective reaction;	98%

: 2142-69-0
2-bromophenyl methyl ketone

: 5411-56-3, 76116-20-6, 118375-26-1, 114446-55-8
(1S)-1-(2-bromophenyl)ethanol

Conditions

Conditions	Yield
With hydrogen; potassium hydroxide; 9-amino-9-deoxyepicinchonine In isopropyl alcohol at 40℃; under 45004.5 Torr; for 5h; Autoclave; optical yield given as %ee; enantioselective reaction;	99%
With dimethylsulfide borane complex; 3-hydroxy-N-[(2S)-1-hydroxy-1,1,3-triphenylpropan-2-yl]naphthalene-2-carboxamide In tetrahydrofuran at 65℃; Inert atmosphere; enantioselective reaction;	99%
With D-glucose In aq. phosphate buffer at 25℃; for 24h; pH=7.0; stereoselective reaction;	99%

: 136918-14-4
phthalimide

: 2142-69-0
2-bromophenyl methyl ketone

: 83665-31-0
2-(2-acetylphenyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With copper(I) oxide at 100℃; for 48h;	99%

: 2142-69-0
2-bromophenyl methyl ketone

: 98-80-6
phenylboronic acid

: 2142-66-7
1-([1,1'-biphenyl]-2-yl)ethanone

Conditions

Conditions	Yield
With palladium diacetate; N,N-diisopropyl-1,1-diphenylphosphanamine; potassium carbonate In tetrahydrofuran for 48h; Suzuki-Miyamura cross-coupling reaction; Heating;	99%
With potassium phosphate monohydrate; 1‐ethyl‐2‐(1‐ethylindol-2-yl)benzoimidazole; palladium diacetate In 1,4-dioxane at 60℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	99%
With Ph2P(CH2CH2O)22CH3; triethylamine; palladium dichloride In water at 100℃; for 1h; Suzuki coupling; Inert atmosphere;	98%

: 2142-69-0
2-bromophenyl methyl ketone

: 5720-07-0
4-methoxyphenylboronic acid

: 2'-p-methoxyphenylacetophenone

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 18h; Suzuki coupling; Inert atmosphere; Reflux;	99%
With triethylamine In methanol for 8h; Suzuki Coupling;	91%
With C42H48Cl4N4Pd2S2; potassium carbonate In water at 60℃; for 24h; Time; Suzuki-Miyaura Coupling; Inert atmosphere;	88%

: 2142-69-0
2-bromophenyl methyl ketone

: 380626-56-2
1,3,5-tris(2’-bromophenyl)benzene

Conditions

Conditions	Yield
With tetrachlorosilane In ethanol at 20℃;	99%
With tetrachlorosilane In ethanol at 0 - 20℃; for 16h; Inert atmosphere;	97%
With tetrachlorosilane In ethanol at 0 - 20℃; for 25.5h; Inert atmosphere;	90%

: 2142-69-0
2-bromophenyl methyl ketone

: 1530-32-1
ethyltriphenylphosphonium bromide

: 96308-15-5
(E)-1-bromo-2-(but-2-en-2-yl)benzene

Conditions

Conditions	Yield
Stage #1: ethyltriphenylphosphonium bromide With potassium tert-butylate In toluene at 0 - 23℃; Stage #2: 2-bromophenyl methyl ketone In toluene for 8h; Heating;	99%

: 7677-24-9
trimethylsilyl cyanide

: 2142-69-0
2-bromophenyl methyl ketone

: 2-(trimethylsilyloxy)-2-(2'-bromophenyl)propanenitrile

Conditions

Conditions	Yield
With KNdF4 for 0.0666667h; Irradiation;	99%
With C29H38AlN4O2(1+)*CF3O3S(1-) In neat (no solvent) at 20℃; for 0.5h; Catalytic behavior; Inert atmosphere; Schlenk technique;	97%
Fe(Cp)2PF6 at 20℃; for 0.166667h;	93%
With R-(+)-α-methylbenzylamine-(2R,3R)-(-)-2,3-dihydroxybutanedioic acid In dichloromethane at 10 - 20℃; for 84h; optical yield given as %ee;

: 2142-69-0
2-bromophenyl methyl ketone

: 40138-16-7
2-formylbenzene boronic acid

: 100914-80-5
2’acetyl-[1,1'-biphenyl]-2-carbaldehyde

Conditions

Conditions	Yield
With potassium fluoride; palladium diacetate; 2-[bis(1,1-dimethylethyl)phosphino]-1-phenyl-1H-indole In tetrahydrofuran at 20℃; for 2h; Suzuki-Miyaura coupling; Inert atmosphere;	99%
With tris-(dibenzylideneacetone)dipalladium(0); potassium fluoride dihydrate; tri tert-butylphosphoniumtetrafluoroborate In tetrahydrofuran at 40℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	99%
With tris-(dibenzylideneacetone)dipalladium(0); potassium fluoride dihydrate; tri tert-butylphosphoniumtetrafluoroborate In tetrahydrofuran Suzuki-Miyaura coupling; Inert atmosphere;	95%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,3-dioxane at 80℃; for 14h; Inert atmosphere;	71%

: 2142-69-0
2-bromophenyl methyl ketone

: 94838-88-7
2-formyl-4,5-(methylenedioxy)benzeneboronic acid

: 1149344-88-6
6-(2-acetylphenyl)benzo[d][1,3]dioxole-5-carbaldehyde

Conditions

Conditions	Yield
With potassium fluoride; palladium diacetate; 2-[bis(1,1-dimethylethyl)phosphino]-1-phenyl-1H-indole In tetrahydrofuran at 20℃; for 2h; Suzuki-Miyaura coupling; Inert atmosphere;	99%

: 23743-82-0
2,6-bis(hydrazino)pyridine

: 2142-69-0
2-bromophenyl methyl ketone

: 1337906-88-3
C21H19Br2N5

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Reflux; Inert atmosphere;	99%

: 13331-23-2
fur-2-ylboronic acid

: 2142-69-0
2-bromophenyl methyl ketone

: 19275-14-0
1-(2-(furan-2-yl)phenyl)ethan-1-one

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 18h; Inert atmosphere; Reflux;	99%

: 5390-04-5
pent-1-yn-5-ol

: 2142-69-0
2-bromophenyl methyl ketone

: 1-(2-(5-hydroxypent-1-yn-1-yl)phenyl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: 2-bromophenyl methyl ketone With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 20℃; for 0.5h; Sealed tube; Inert atmosphere; Stage #2: pent-1-yn-5-ol at 85℃; for 48h; Sealed tube; Inert atmosphere;	99%

: 2142-69-0
2-bromophenyl methyl ketone

: 100-52-7
benzaldehyde

: 108237-92-9
1-(2-bromophenyl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 25℃; Claisen-Schmidt Condensation;	98.3%
With sodium hydroxide In ethanol at 20℃; for 3h;	91%

: 2142-69-0
2-bromophenyl methyl ketone

: 107-21-1
ethylene glycol

: 50777-64-5
2-(2-bromophenyl)-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Dean-Stark; Reflux; Inert atmosphere;	98%
With toluene-4-sulfonic acid In toluene for 18h; Dean-Stark; Reflux;	94%
With toluene-4-sulfonic acid In benzene for 2h; Heating;	93%

: 2142-69-0
2-bromophenyl methyl ketone

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 116384-68-0, 1221721-25-0
2-(2-bromophenyl)-pent-4-en-2-ol

Conditions

Conditions	Yield
With indium In water at 30℃; for 24h; Inert atmosphere;	98%
With indium iodide In tetrahydrofuran at 40℃; for 24h;	97%

: 98-01-1
furfural

: 2142-69-0
2-bromophenyl methyl ketone

: (E)-1-(2-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; Inert atmosphere;	98%
With ethanol; sodium hydroxide at 20℃; for 3h; Claisen Schmidt condensation;	70%

2'-Bromoacetophenone Specification

The Ethanone,1-(2-bromophenyl)-, with CAS registry number 2142-69-0, belongs to the following product categories: (1)Carbonyl Compounds; (2)Aromatic Acetophenones & Derivatives (substituted); (3)Benzene series; (4)Adehydes, Acetals & Ketones; (5)Bromine Compounds; (6)Acetophenone series. It has the systematic name of 1-(2-bromophenyl)ethanone. This chemical is a kind of clear pale yellow to orange liquid. What's more, its EINECS is 218-398-1.

Physical properties of Ethanone,1-(2-bromophenyl)-: (1)ACD/LogP: 2.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.28; (4)ACD/LogD (pH 7.4): 2.28; (5)ACD/BCF (pH 5.5): 31.64; (6)ACD/BCF (pH 7.4): 31.64; (7)ACD/KOC (pH 5.5): 412.57; (8)ACD/KOC (pH 7.4): 412.57; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 43.97 cm³; (15)Molar Volume: 137.1 cm³; (16)Polarizability: 17.43×10^-24cm³; (17)Surface Tension: 39 dyne/cm; (18)Enthalpy of Vaporization: 48.62 kJ/mol; (19)Vapour Pressure: 0.0235 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(2-bromo-phenyl)-ethanol. This reaction will need reagent PCC.

Uses of Ethanone,1-(2-bromophenyl)-: it can be used to produce 1-methyl-3H-2-benzazepine. This reaction will need reagent Pd(PPh₃)₄ and solvent toluene. The reaction time is 24 hour(s). The yield is about 86%.

When you are using this chemical, please be cautious about it as the following:
The Ethanone,1-(2-bromophenyl)- irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccccc1Br)C
(2)InChI: InChI=1/C8H7BrO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,1H3
(3)InChIKey: PIMNFNXBTGPCIL-UHFFFAOYAO
(4)Std. InChI: InChI=1S/C8H7BrO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,1H3
(5)Std. InChIKey: PIMNFNXBTGPCIL-UHFFFAOYSA-N

Product Name

2'-Bromoacetophenone

Synthetic route

2'-Bromoacetophenone Specification

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