2,3,4-Trifluorobenzaldehyde supplier

Name
2,3,4-Trifluorobenzaldehyde
EINECS -0
CAS No. 161793-17-5
Article Data2
CAS DataBase
Density 1.407 g/cm³
Solubility
Melting Point
Formula C₇H₃F₃O
Boiling Point 182.1 °C at 760 mmHg
Molecular Weight 160.095
Flash Point 52.7 °C
Transport Information UN 1989 3/PG 3
Appearance clear colorless liquid
Safety 26-36/37/39
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzaldehyde, 2,3,4-trifluoro-;
PSA 17.07000
LogP 1.91640

Synthetic route

: 79-19-6
thiosemicarbazide

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 2,3,4-trifluorobenzaldehyde thiosemicarbazone

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 40℃; for 4h;	96%

: (E)-N-(5-hydroxypent-2-en-1-yl)-4-nitro-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: (7-((4-nitrophenyl)sulfonyl)-1-(2,3,4-trifluorophenyl)octahydro-1H-pyrano[3,4-c]pyridin-5-yl)(phenyl)methanone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	94%

: 109-55-7
1-amino-3-(dimethylamino)propane

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1535185-04-6
C12H15F3N2

Conditions

Conditions	Yield
In toluene at 20℃; for 2h;	92%

: C14H19NO4

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 4,6-dimethoxy-1-methyl-2'-(2,3,4-trifluorophenyl)-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; diastereoselective reaction;	91%

: 1262197-67-0
3,5-dibromo-1-(2-tetrahydropyran-2-yloxyethyl)-1,2,4-triazole

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: [5-bromo-2-(2-tetrahydropyran-2-yloxyethyl)-1,2,4-triazol-3-yl]-(2,3,4-trifluorophenyl)methanol

Conditions

Conditions	Yield
Stage #1: 3,5-dibromo-1-(2-tetrahydropyran-2-yloxyethyl)-1,2,4-triazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #2: 2,3,4-trifluorobenzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 2h;	91%

: 141-84-4
2-thioxo-4-thiazolidinone

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1222801-74-2
(Z)-2-thioxo-5-(2,3,4-trifluorobenzylidene)thiazolidin-4-one

Conditions

Conditions	Yield
With piperidine; acetic acid In ethanol at 140℃; under 13501.4 Torr; for 0.5h; Knoevenagel condensation; Microwave irradiation;	87.8%

: 2295-31-0
2,4-thiazolidinedion

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1222801-77-5
(Z)-5-(2,3,4-trifluorobenzylidene)thiazolidine-2,4-dione

Conditions

Conditions	Yield
With piperidine; acetic acid In ethanol at 140℃; under 13501.4 Torr; for 0.5h; Knoevenagel condensation; Microwave irradiation;	85.8%

: 606-23-5
1H-indene-1,3(2H)-dione

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1172612-98-4
5-(2,3,4-trifluorophenyl)-1,3-dimethyl-5,11-dihydro-1H-indeno-[2',1':5,6]pyrido[2,3-d]pyrimidine-2,3,6-trione

Conditions

Conditions	Yield
With acetic acid at 110℃; for 8h; Hantzsch dihydropyridine synthesis; Inert atmosphere;	83%

...Expand

: 141-97-9
ethyl acetoacetate

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: diethyl 2,6-dimethyl-4-(2,3,4-trifluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With ammonium acetate In ethanol at 60℃; for 8h; Hantzsch Dihydropyridine Synthesis;	80%

: 67-52-7
BARBITURIC ACID

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1222801-84-4
5-(2,3,4-trifluorobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Conditions

Conditions	Yield
In water at 100℃; for 1h; Knoevenagel condensation;	78.3%

: 118672-20-1
2-(((4-chlorobenzyl)sulfonyl))acetic acid

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 334969-36-7
(E)-2,3,4-trifluorostyryl 4-chlorobenzyl sulfone

Conditions

Conditions	Yield
	78%

: 107-21-1
ethylene glycol

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 2-(2,3,4-trifluorophenyl)-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 24h; Reflux; Dean-Stark;	78%
With toluene-4-sulfonic acid In toluene for 24h; Reflux; Dean-Stark;	78%

: 1003-03-8
Cyclopentamine

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: N-(2,3,4-trifluorobenzyl)cyclopentanamine

Conditions

Conditions	Yield
Stage #1: Cyclopentamine; 2,3,4-trifluorobenzaldehyde In dichloromethane at 25℃; Molecular sieve; Stage #2: With sodium triacetoxy borohydride In dichloromethane at 25℃;	77%

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: C7H4F3NO

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;	73%

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: F3C6H2COCHOHC6H2F3

Conditions

Conditions	Yield
With sodium hydroxide; Thiamine hydrochloride In ethanol at 50℃; for 48h;	72%

: 222639-41-0
2-[(4-fluorobenzyl)sulfonyl]acetic acid

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 334969-35-6
(E)-2,3,4-trifluorostyryl 4-fluorobenzyl sulfone

Conditions

Conditions	Yield
	72%

: 637-81-0
ethyl-2-azidoacetate

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1240983-02-1
C11H8F3N3O2

Conditions

Conditions	Yield
With sodium methylate In methanol at -10 - 5℃; for 3h;	72%
With sodium methylate In methanol at -10 - 5℃; for 3h;	72%
With sodium methylate In methanol at -10 - 5℃; for 3h;	72%

: 77-76-9
2,2-dimethoxy-propane

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1223444-83-4
1-(dimethoxymethyl)-2,3,4-trifluorobenzene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 18 - 25℃;	71.7%

: 457897-92-6
(S)-1-(4-methanesulfonamidophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 457898-04-3
(S)-1-(4-methanesulfonamidophenoxy)-3-(N-(2,3,4-trifluorobenzyl)-3,4-dichlorophenylethylamino)-2-propanol

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;	65%

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 1774-11-4
5-(furan-2-yl)cyclohexane-1,3-dione

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1172613-13-6
5-(2,3,4-trifluorophenyl)-8-(furan-2-yl)-1,3-dimethyl-5,7,8,9,10-pentahydropyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H)-trione

Conditions

Conditions	Yield
With acetic acid at 110℃; for 8h; Hantzsch dihydropyridine synthesis; Inert atmosphere;	65%

...Expand

: 17414-18-5
3-amino-5-isopropyl-2-methylcyclohexa-2,5-diene-1,4-dione

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1431881-09-2
((E)-5-isopropyl-2-methyl-3-((2,3,4-trifluorobenzylidene)amino)cyclohexa-2,5-diene-1,4-dione)

Conditions

Conditions	Yield
With hydrogenchloride In water at 75℃; for 4h;	62%

: 75-89-8
2,2,2-trifluoroethanol

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 2,3,4-trifluoro-6-(2,2,2-trifluoroethoxy)benzaldehyde

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; L-valine; palladium diacetate; trifluoroacetic acid at 80℃; for 12h; Sealed tube;	62%

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 163457-23-6
3,3-difluoropyrrolidine hydrochloride

: C11H9F4NO

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; Temperature;	61%

: 15390-25-7
(acetylacetonato)borondifluoride

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: C19H9BF8O2

Conditions

Conditions	Yield
With N-butylamine In ethyl acetate at 20℃; for 12h; Inert atmosphere;	57%
With N-butylamine In ethyl acetate at 20℃; Inert atmosphere;

: 247037-82-7
1,3-thiazole-2-carboximidamide hydrochloride

: 141-97-9
ethyl acetoacetate

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: (R)-6-methyl-2-(thiazol-2-yl)-4-(2,3,4-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ethyl acetoacetate; 2,3,4-trifluorobenzaldehyde With piperidine; acetic acid In isopropyl alcohol for 4h; Stage #2: 1,3-thiazole-2-carboximidamide hydrochloride With triethylamine In isopropyl alcohol at 85℃;	52.3444%

...Expand

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1260384-41-5
6,7-difluoro-1H-indazole

Conditions

Conditions	Yield
With hydrazine In 1,4-dioxane at 150℃; for 0.5h; Microwave irradiation; Sealed tube;	46%

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: tert-butyl 4-(2,3-difluoro-4-formylphenyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h;	46%

: 5718-83-2
rhodanine 3-acetic acid

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 1222801-80-0
(Z)-2-(4-oxo-2-thioxo-5-(2,3,4-trifluorobenzylidene)thiazolidin-3-yl)acetic acid

Conditions

Conditions	Yield
With piperidine; acetic acid In ethanol at 110℃; under 13501.4 Torr; for 0.666667h; Knoevenagel condensation; Microwave irradiation;	40.5%

: (E)-2-(5-hydroxy-1-phenylpent-1-en-3-yl)phenol

: 161793-17-5
2,3,4-trifluorobenzaldehyde

A: 1394313-14-4
(E)-4-styrylchromane

: 5-phenyl-4-(2,3,4-trifluorophenyl)-1,2,4,4a,5,10b-hexahydropyrano[3,4-c]chromene

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -40℃; Inert atmosphere; stereoselective reaction;	A 40% B 35%

...Expand

: 161793-17-5
2,3,4-trifluorobenzaldehyde

: 301343-38-4
3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine

: N-{4-Oxo-2-thioxo-5-[1-(2,3,4-trifluoro-phenyl)-meth-(Z)-ylidene]-thiazolidin-3-yl}-benzenesulfonamide

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 5h;	34%

2,3,4-Trifluorobenzaldehyde Specification

The 2,3,4-Trifluorobenzaldehyde, with the CAS registry number 161793-17-5, is also known as Benzaldehyde, 2,3,4-trifluoro-. It belongs to the product categories of Halide; Aldehyde; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Fluorobenzaldehyde Series; Aldehydes; C7; Carbonyl Compounds. This chemical's molecular formula is C₇H₃F₃O and molecular weight is 160.09333. Its IUPAC name is called 2,3,4-trifluorobenzaldehyde. What's more, the product should be sealed and stored in cool, dry and well-ventilated place. This chemical can be used as chemical reagents, organic intermediates, fine chemicals.

Physical properties of 2,3,4-Trifluorobenzaldehyde: (1)ACD/LogP: 1.77; (2)ACD/LogD (pH 5.5): 1.77; (3)ACD/LogD (pH 7.4): 1.77; (4)ACD/BCF (pH 5.5): 12.95; (5)ACD/BCF (pH 7.4): 12.95; (6)ACD/KOC (pH 5.5): 217.62; (7)ACD/KOC (pH 7.4): 217.62; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.491; (11)Molar Refractivity: 32.98 cm³; (12)Molar Volume: 113.7 cm³; (13)Surface Tension: 33.5 dyne/cm; (14)Density: 1.407 g/cm³; (15)Flash Point: 52.7 °C; (16)Enthalpy of Vaporization: 41.84 kJ/mol; (17)Boiling Point: 182.1 °C at 760 mmHg; (18)Vapour Pressure: 0.822 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=C(C(=C1C=O)F)F)F
(2)InChI: InChI=1S/C7H3F3O/c8-5-2-1-4(3-11)6(9)7(5)10/h1-3H
(3)InChIKey: UQEDGFZRPSAHLC-UHFFFAOYSA-N

Product Name

2,3,4-Trifluorobenzaldehyde

Synthetic route

2,3,4-Trifluorobenzaldehyde Specification

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