2,3-diaminopyridine supplier

Name
2,3-Diaminopyridine
EINECS 207-200-9
CAS No. 452-58-4
Article Data27
CAS DataBase
Density 1.251 g/cm³
Solubility 100 g/L (20 °C) in water
Melting Point 110-115 °C(lit.)
Formula C₅H₇N₃
Boiling Point 311.3 °C at 760 mmHg
Molecular Weight 109.131
Flash Point 167.7 °C
Transport Information UN 2811
Appearance brown power
Safety 26-36/37-45-37/39-28A-36
Risk Codes 22-36/37/38-25
Molecular Structure
Hazard Symbols Xn, Xi, T
Synonyms 2,3-Pyridinediamine (9CI);Pyridine-2,3-diyldiamine;pyridine-2,3-diamine;Pyridine, 2,3-diamino-;5-22-11-00241 (Beilstein Handbook Reference);1H-pyridine-5,6-diamine;2, 3-Pyridinediamine;
PSA 64.93000
LogP 1.40840

Synthetic route

: 101458-28-0
3,3'-dinitro-2,2'-hydrazobipyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol under 3102.9 Torr; for 3h; Ambient temperature;	92%

: 4214-75-9
2-amino-3-nitropyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sulfur; sodium hydroxide In methanol; water at 80℃; for 16h; Green chemistry;	89%
With hydrogen; palladium on activated charcoal In ethyl acetate at 20 - 35℃; under 3102.9 Torr; other solvent;	80%
With hydrogenchloride; ethanol; iron

: 15367-16-5
2-Hydrazino-3-nitropyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With hydrogen; nickel In tetrahydrofuran; ethanol at 65℃; under 3102.9 Torr; for 16h;	70%
Multi-step reaction with 2 steps 1: 31 percent / (C2H5)3N / ethanol / 96 h / Heating 2: 92 percent / H2 / Raney Ni / ethanol / 3 h / 3102.9 Torr / Ambient temperature View Scheme

: 385377-29-7
2-amino-3-nitropyridine 1-oxide

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sulfur; sodium hydroxide In methanol; water at 80℃; for 16h; Green chemistry;	68%

: 6298-19-7
2-chloro-3-aminopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With zinc ammonium chloride at 220℃; for 5h; Autoclave;	60%
With ammonium hydroxide; copper(II) sulfate at 130℃; under 13239.1 Torr;

: 28664-54-2
2-nitro-3-azidopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 0.5h;	50%
With hydrazine hydrate In ethanol for 0.5h; Mechanism;	50%

: benzyl N-(2-amino-6-chloropyridin-3-yl)carbamate

A: 452-58-4
2,3-Diaminopyridine

B: 40851-95-4
6-chloropyridine-2,3-diamine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate In methanol at 20℃; under 760.051 Torr; for 2h; Sealed tube; Overall yield = 87 %Spectr.; chemoselective reaction;	A 45% B 42%

: 3723-70-4
benzyl-(3-nitro-pyridin-2-yl)-amine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol at 80℃; under 3102.9 Torr; for 18h;	41%

: 928163-52-4
2-amino-3-azidopyridine

: 78-84-2
isobutyraldehyde

A: 452-58-4
2,3-Diaminopyridine

B: 21714-53-4
2-(1-methylethyl)imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
In ethanol for 24h; Heating;	A 33% B 8%

...Expand

: 6945-68-2
5-bromo-3-nitro-pyridin-2-ylamine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sulfuric acid; zinc In methanol; water at 90℃; for 48h;	20%
With sodium hydroxide; aluminum nickel

: 462-08-8
pyridin-3-ylamine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With 4-methylisopropylbenzene; sodium amide at 210℃;
Multi-step reaction with 2 steps 1: concentrated aqueous HCl 2: CuSO4; aqueous NH3 / 130 °C / 13239.1 Torr View Scheme

: 38875-53-5
5-bromo-pyridine-2,3-diamine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sodium hydroxide; Pd/SrCO3 Hydrogenation;

: 13269-19-7
3-amino-2-nitropyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With methanol; nickel Hydrogenation;
With sodium hydroxide; aluminum nickel

: 4214-75-9
2-amino-3-nitropyridine

A: 452-58-4
2,3-Diaminopyridine

B: 40851-95-4
6-chloropyridine-2,3-diamine

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 5409-39-2
2-amino-5-chloro-3-nitropyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sodium hydroxide; aluminum nickel

: 462-08-8
pyridin-3-ylamine

: 99-87-6
4-methylisopropylbenzene

: sodium amide

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
at 210℃;

...Expand

: 7647-01-0
hydrogenchloride

: 4214-75-9
2-amino-3-nitropyridine

tin: tin

A: 452-58-4
2,3-Diaminopyridine

B: 40851-95-4
6-chloropyridine-2,3-diamine

...Expand

: 928163-50-2
3-amino-2-phthalimidopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: HCl; sodium nitrite / H2O / 3.5 h / cooling 1.2: 60 percent / sodium azide / H2O; diethyl ether / 2 h / 0 °C 2.1: 96 percent / hydrazine hydrate / ethanol; tetrahydrofuran; H2O / 26 h / 20 °C 3.1: 33 percent / ethanol / 24 h / Heating View Scheme

: 928163-51-3
3-azido-2-phthalimidopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / hydrazine hydrate / ethanol; tetrahydrofuran; H2O / 26 h / 20 °C 2: 33 percent / ethanol / 24 h / Heating View Scheme

: 928163-49-9
3-nitro-2-phthalimidopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: 50 percent / hydrogen / Pd/C / ethanol / 15 h / 60 °C / 3040 Torr 2.1: HCl; sodium nitrite / H2O / 3.5 h / cooling 2.2: 60 percent / sodium azide / H2O; diethyl ether / 2 h / 0 °C 3.1: 96 percent / hydrazine hydrate / ethanol; tetrahydrofuran; H2O / 26 h / 20 °C 4.1: 33 percent / ethanol / 24 h / Heating View Scheme

: 5470-18-8
2-Chloro-3-nitropyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / ethanol / 3 h / Heating 2: 41 percent / H2 / 5percent Pd/C / ethanol / 18 h / 80 °C / 3102.9 Torr View Scheme
Multi-step reaction with 2 steps 1: 65 percent / CH3COONH4 / bis-(2-methoxy-ethyl) ether / 12 h / Heating 2: 80 percent / H2 / 5percent Pd/C / ethyl acetate / 20 - 35 °C / 3102.9 Torr / other solvent View Scheme
Multi-step reaction with 3 steps 1: 78 percent / N2H4 / acetonitrile / 1 h / Heating 2: 31 percent / (C2H5)3N / ethanol / 96 h / Heating 3: 92 percent / H2 / Raney Ni / ethanol / 3 h / 3102.9 Torr / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 78 percent / N2H4 / acetonitrile / 1 h / Heating 2: 70 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 16 h / 65 °C / 3102.9 Torr View Scheme
Multi-step reaction with 2 steps 1: iron; acetic acid 2: CuSO4; aqueous NH3 / 130 °C / 13239.1 Torr View Scheme

: 6276-11-5
3-ethoxycarbonylaminopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: concentrated H2SO4; HNO3 2: aqueous NaOH 3: nickel-aluminium-alloy; aq.-ethanolic NaOH View Scheme

: 55304-91-1
ethyl N-(2-nitro-3-pyridyl)carbamate

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: nickel-aluminium-alloy; aq.-ethanolic NaOH View Scheme

: 504-29-0
2-aminopyridine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 0.25 h 2: nitric acid; sulfuric acid / 4 h / 0 - 50 °C 3: sulfuric acid; zinc / water; methanol / 48 h / 90 °C View Scheme

: 1072-97-5
5-bromo-2-pyridylamine

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 4 h / 0 - 50 °C 2: sulfuric acid; zinc / water; methanol / 48 h / 90 °C View Scheme

: 4663-94-9
pyridine-2,3-dicarboxamide

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With sodium hypochlorite; potassium hydroxide In water at 5 - 100℃; for 5h; Reagent/catalyst;

: 88-74-4
2-nitro-aniline

: 452-58-4
2,3-Diaminopyridine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 25℃; for 2h;

: 452-58-4
2,3-Diaminopyridine

: 431-03-8
dimethylglyoxal

: 7154-32-7
dimethyl-2,3 pyrido<2,3-b>pyrazine

Conditions

Conditions	Yield
With zirconium(IV) chloride In methanol at 20℃; for 0.0833333h;	100%
With silica-supported stannous chloride In methanol at 20℃; for 0.166667h;	95%
With acetic acid In ethanol at 70℃; for 16h;	95%

: 452-58-4
2,3-Diaminopyridine

: 7478-57-1
4-benzoyl-3-hydroxy-2,5-dihydrofuran-2-one

: 138196-75-5
2-aminopyrido-3-ammonium 4-benzoyl-2(5H)-furanone-3-oxide

Conditions

Conditions	Yield
In chloroform Ambient temperature;	100%

: 452-58-4
2,3-Diaminopyridine

: (7aSR,9RS,11aRS)-11a-ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid

: (7aSR,9RS,11aRS)-11a-ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-pyridin-3-yl)-amide

Conditions

Conditions	Yield
Stage #1: (7aSR,9RS,11aRS)-11a-ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 2,3-Diaminopyridine In N,N-dimethyl-formamide at 20℃; for 18h;	100%

: 452-58-4
2,3-Diaminopyridine

: 498-95-3
nipecotic acid

: C11H14N4

Conditions

Conditions	Yield
With polyphosphoric acid at 180℃; for 16h;	100%

: 452-58-4
2,3-Diaminopyridine

: 122-51-0
orthoformic acid triethyl ester

: 273-21-2
3H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
Stage #1: 2,3-Diaminopyridine; orthoformic acid triethyl ester at 145℃; for 3h; Stage #2: With formic acid at 110℃; for 2h;	99%
Stage #1: 2,3-Diaminopyridine; orthoformic acid triethyl ester for 3.5h; Reflux; Stage #2: With hydrogenchloride In water for 1h; Reflux;	83%
With H-Y-zeolite In ethanol for 10h; Heating;	81%

: 452-58-4
2,3-Diaminopyridine

: 82-86-0
acenaphthene quinone

: 821773-03-9
acenaphtho[1,2-b]pyrido[2,3-e]pyrazine

Conditions

Conditions	Yield
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 2h; Reflux;	99%
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	98%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	98%

: 452-58-4
2,3-Diaminopyridine

: 64-18-6
formic acid

: 273-21-2
3H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
Stage #1: 2,3-Diaminopyridine With orthoformic acid triethyl ester at 145℃; for 3h; Stage #2: formic acid at 110℃; for 2h; Stage #3: In methanol at 20℃;	99%
at 170℃; for 48h;	30%

: 452-58-4
2,3-Diaminopyridine

: 134-81-6
benzil

: 1232-99-1
2,3-diphenylpyrido[3,2-b]pyrazine

Conditions

Conditions	Yield
With silica-supported bismuth(III) chloride In methanol at 20℃; for 0.5h; Catalytic behavior;	98%
In methanol; acetic acid at 160℃; for 0.0833333h; Irradiation;	97%
With zirconium(IV) chloride In methanol at 20℃; for 1h;	96%

: 452-58-4
2,3-Diaminopyridine

: 57-13-6
urea

: 16328-62-4
1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Conditions

Conditions	Yield
at 140℃; for 5h;	98%
at 130 - 140℃;

: 75-15-0
carbon disulfide

: 452-58-4
2,3-Diaminopyridine

: 29448-81-5
1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione

Conditions

Conditions	Yield
In pyridine for 5h; Heating;	98%
With sodium hydroxide	76%
With potassium hydroxide In ethanol; water at 80℃;	69%

: 452-58-4
2,3-Diaminopyridine

: 3222-47-7
6-methylnicotinic acid

: 120623-51-0
2-(6-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With PPA at 210℃; for 2h;	98%

: 452-58-4
2,3-Diaminopyridine

: 3222-50-2
4-methylnicotinic acid

: 120623-49-6
2-(4-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With PPA at 210℃; for 2h;	98%

: 452-58-4
2,3-Diaminopyridine

: 201230-82-2
carbon monoxide

: 16328-62-4
1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Conditions

Conditions	Yield
With selenium In tetrahydrofuran at 100℃; under 22800.7 Torr; for 20h;	98%

: 452-58-4
2,3-Diaminopyridine

: 83431-64-5
C11H12N2OS3

: 103588-24-5
(3H-Imidazo[4,5-b]pyridin-2-yl)-(6-methoxy-benzothiazol-2-yl)-amine

Conditions

Conditions	Yield
In various solvent(s) Heating;	98%

: 452-58-4
2,3-Diaminopyridine

: 109-52-4
valeric acid

: 68175-10-0
2-n-butyl-imidazo<4,5-b>pyridine

Conditions

Conditions	Yield
With PPA for 3h; Heating;	98%
With polyphosphoric acid at 100℃; for 5h;	80%
With PPA at 100℃; for 5h;	62%

: 452-58-4
2,3-Diaminopyridine

: 63604-59-1
2-methyl-1H-imidazo[4,5-c]pyridine

: 63572-60-1
2-(1H-Imidazo[4,5-c]pyridin-2-yl)-3H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With sulfur at 200 - 210℃; for 4h;	98%

: 452-58-4
2,3-Diaminopyridine

: 1074-12-0
phenylglyoxal hydrate

: 2-phenylpyrido[2,3-b]pyrazine

Conditions

Conditions	Yield
With silica-supported bismuth(III) chloride In methanol at 20℃; for 0.166667h; Catalytic behavior; regioselective reaction;	98%
With bismuth(lll) trifluoromethanesulfonate In water at 20℃; for 0.0833333h;	92%
With (2,3,4,5,6-pentafluorophenyl)ammonium triflate In water at 20℃; for 1h; Green chemistry;	92%
In ethanol Heating;	77%

: 452-58-4
2,3-Diaminopyridine

: 89-95-2
2-methyl-benzyl alcohol

: 189822-35-3
N,N′-bis(salicyliden)-2,3-diaminopyridine

Conditions

Conditions	Yield
for 0.0333333h; microwave irradiation;	98%

: 452-58-4
2,3-Diaminopyridine

: 5970-45-6
zinc(II) acetate dihydrate

: 90-02-8
salicylaldehyde

: 727375-59-9
[N,N′-bis(salicylidene)-2,3-diiminopyridine]zinc(II)

Conditions

Conditions	Yield
In methanol at 70℃; for 4h;	98%
In methanol under N2; salicylaldehyde in MeOH treated with Zn salt, mixt. stirred atroom temp., 2,3-diaminopyridine added, mixt. stirred; ppt. filtered off, washed with MeOH; elem. anal.;	77%

...Expand

: 452-58-4
2,3-Diaminopyridine

: 4-hexadecyloxy-2-hydroxybenzaldehyde

: 5970-45-6
zinc(II) acetate dihydrate

: 1352312-67-4
[N,N-bis(4-hexadecyloxy-2-hydroxybenzylidene)-2,3-pyridinediaminato]zinc(II)

Conditions

Conditions	Yield
In ethanol under N2; to a soln. of 4-alcoxy-2-hydroxybenzaldehyde (1.00 mmol) in ethanol, diamine (0.500 mmol) was added under stirring; mixt. was heated at reflux with stirring for 1 h; Zn-contg. compd. (0.500 mmol) addn.; heating at reflux with stirring for 1 h; after cooling, the ppt was collected by filtration, washed with ethanol and dried; elem. anal.;	98%

...Expand

: 452-58-4
2,3-Diaminopyridine

: 95-92-1
oxalic acid diethyl ester

: 2067-84-7
NSC 91561

Conditions

Conditions	Yield
at 100℃;	98%
In water at 60℃; for 2h;	81%
for 4h; Reflux;	75%

: 452-58-4
2,3-Diaminopyridine

: 83431-63-4
Dimethyl N-(4-chloro-2-benzothiazolyl)-dithiocarbonimidate

: 103588-25-6
(4-Chloro-benzothiazol-2-yl)-(3H-imidazo[4,5-b]pyridin-2-yl)-amine

Conditions

Conditions	Yield
In various solvent(s) Heating;	97%

: 452-58-4
2,3-Diaminopyridine

: 105-56-6
ethyl 2-cyanoacetate

: 107932-97-8
2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; Microwave irradiation;	97%
at 180℃; for 2h;	75%
at 110 - 115℃; for 14h; Neat (no solvent);	70%

: 452-58-4
2,3-Diaminopyridine

: 76-05-1
trifluoroacetic acid

: 13797-63-2
2-Trifluoromethyl-3H-imidazo<4,5-b>pyridine

Conditions

Conditions	Yield
for 48h; Heating;	97%

: 452-58-4
2,3-Diaminopyridine

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 2,3-bis(p-methoxyphenyl)pyrido<2,3-b>pyrazine

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	97%
With zirconium(IV) chloride In methanol at 20℃; for 4h;	95%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	95%

: 452-58-4
2,3-Diaminopyridine

: 3973-08-8
Thiazole-4-carboxylic acid

: 1848-82-4
4-(1H-imidazo[4,5-b]pyridin-2-yl)thiazole

Conditions

Conditions	Yield
With PPA at 180℃; for 2h;	97%

: 452-58-4
2,3-Diaminopyridine

: 476692-34-9
di(2-azulenyl)ethanedione

: 1145777-27-0
2,3-di(2-azulenyl)-5.azaquinoxaline

Conditions

Conditions	Yield
In ethanol for 20h; Reflux;	97%

: 452-58-4
2,3-Diaminopyridine

: 579-39-5
1,2-bis(4-fluorophenyl)ethane-1,2-dione

: 149159-43-3
2,3-bis(4-fluorophenyl)pyrido[2,3-b]pyrazine

Conditions

Conditions	Yield
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	97%
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	96%
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 2h; Reflux;	96%

: 452-58-4
2,3-Diaminopyridine

: 17630-76-1
5-chloroindole 2,3-dione

: 1621885-01-5
C13H7ClN4

Conditions

Conditions	Yield
In ethylene glycol at 80℃; for 0.2h; Microwave irradiation; Green chemistry; chemoselective reaction;	97%

: 452-58-4
2,3-Diaminopyridine

: 105-56-6
ethyl 2-cyanoacetate

: 2-(1H-imidazo[4,5-b]pyridin-2-yl)acetonitrile

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; Microwave irradiation;	97%

2,3-diaminopyridine Specification

The 2,3-diaminopyridine, with the cas registry number 452-58-4, has the IUPAC name of pyridine-2,3-diamine. This is a kind of brown power and is sensitive to air. Besides, its product categories are various, including pyridines, pyrimidines, purines and pteredines; amines; pyridines derivates; highly purified reagents; other categories; refined products by sublimation; boronic acid; c5; heterocyclic building blocks.

The characteristics of this kind of chemical are as follows: (1)ACD/LogP: 0.27; (2)ACD/LogD (pH 5.5): -0.55; (3) ACD/LogD (pH 7.4): 0.24; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 5.06; (7)ACD/KOC (pH 7.4): 31.19; (8)#H bond acceptors: 3; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 19.37; (12)Index of Refraction: 1.676; (13)Molar Refractivity: 32.81 cm³; (14)Molar Volume: 87.2 cm³; (15)Polarizability: 13 ×10^-24cm³; (16)Surface Tension: 70.9 dyne/cm; (17)Density: 1.251 g/cm³; (18)Flash Point: 167.7 °C; (19)Enthalpy of Vaporization: 55.22 kJ/mol; (20)Boiling Point: 311.3 °C at 760 mmHg; (21)Vapour Pressure: 0.00057 mmHg at 25°C; (22)Exact Mass: 109.063997; (23)MonoIsotopic Mass:109.063997; (24)Topological Polar Surface Area: 64.9; (25)Heavy Atom Count: 8; (26)Formal Charge: 0; (27)Complexity: 74.1.

The production method of this chemical is as below: 3-nitro-pyridin-2-ylamine could react to produce 2,3-diaminopyridine, with the following condition: reagent: iron; concentrated aqueous HCl; ethanol.

The use of this chemical is as below: 2,3-diaminopyridine could react with 2-oxo-propionic acid ethyl ester to produce 2-methyl-4H-pyrido[2,3-b]pyrazin-3-one, with the following condition: reagent: benzene.

When you are dealing with this chemical, you should be very careful and then take some measures to protect yourself. For being a kind of irritant chemical, it is irritating to eyes, respiratory system and skin and may cause inflammation to the skin or other mucous membranes. Then it is a kind of toxic chemical which may cause damage to health. Therefore, you should take the following instructions. Wear suitable gloves and eye/face protection and protective clothing. If in case of contacting with eyes, rinse immediately with plenty of WATER and seek medical advice, and if in case of accident or if you feel unwell, seek medical advice immediately (show label where possible). Besides, after contacting with skin, wash immediately with plenty of ... (to be specified by the manufacturer).

Additionally, the following datas could be converted into the molecular structure:
(1)Canonical SMILES: C1=CC(=C(N=C1)N)N
(2)InChI: InChI=1S/C5H7N3/c6-4-2-1-3-8-5(4)7/h1-3H,6H2,(H2,7,8)
(3)InChIKey: ZZYXNRREDYWPLN-UHFFFAOYSA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	25mg/kg (25mg/kg)		Journal of Medicinal Chemistry. Vol. 8, Pg. 296, 1965.

Product Name

2,3-Diaminopyridine

Synthetic route

2,3-diaminopyridine Specification

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