2,4-DIMETHYLTHIAZOLE supplier

Name
2,4-Dimethylthiazole
EINECS 208-786-9
CAS No. 541-58-2
Article Data25
CAS DataBase
Density 1.081 g/cm³
Solubility Slightly soluble in water
Melting Point 272 °C
Formula C₅H₇NS
Boiling Point 153.4 °C at 760 mmHg
Molecular Weight 113.183
Flash Point 46 °C
Transport Information UN 1993 3/PG 3
Appearance Colorless to light yellow liquid
Safety 16-26-36-37/39
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi, F
Synonyms 2,4-Dimethyl-1,3-thiazole;2,4-Methylthiazole;NSC 7510;
PSA 41.13000
LogP 1.75990

Synthetic route

: 62-55-5
thioacetamide

: 78-95-5
chloroacetone

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
In benzene for 1h; Heating;	97%

: 62-55-5
thioacetamide

: 598-31-2
1-bromoacetone

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 1h; Hantzsch Thiazole Synthesis; Sealed tube;	75%

: 7208-05-1
2,4-dimethyloxazole

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With aluminum oxide; hydrogen sulfide at 375℃;

: 13797-62-1
α-(2-methyl-4-thiazolyl)acetic acid

A: 541-58-2
2,4-dimethylthiazole

B: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
bei der trocknen Destillation;

: 77470-53-2
4-chloromethyl-2-methylthiazole hydrochloride

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With acetic acid; zinc

: 60-35-5
acetamide

: 78-95-5
chloroacetone

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With sodium hydroxide; sodium hydrogensulfide; ethanol
With diphosphorus pentasulfide; benzene
With diphosphorus pentasulfide

: 6114-40-5
2,4-dimethyl-4,5-dihydro-1,3-thiazole

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With dihydrogen peroxide

: 693-95-8
4-Methylthiazole

: 77-78-1
dimethyl sulfate

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
(i) BuLi, Et2O, (ii) /BRN= 635994/; Multistep reaction;

: 76133-03-4
1-iminoethylthiopropanone hydrobromide

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With sodium carbonate In acetic acid at 40 - 50℃;	12.6 g

: 57516-14-0
2,4-Dimethyl-thiazole; compound with iodine

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
In tetrachloromethane at 24.9℃; Equilibrium constant; investigated by electronic absorption spectra;

2.4-dimethyl-thiazole-carboxylic acid-(5): 2.4-dimethyl-thiazole-carboxylic acid-(5)

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
With calcium oxide

<2-methyl-thiazolyl-(4)>-acetic acid: <2-methyl-thiazolyl-(4)>-acetic acid

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
bei der trocknen Destillation;

thioacetimidic acid acetonyl ester: thioacetimidic acid acetonyl ester

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
at 130 - 140℃;

: 62-55-5
thioacetamide

α-chloro-acetone: α-chloro-acetone

: 541-58-2
2,4-dimethylthiazole

: 7647-01-0
hydrogenchloride

: 75-05-8
acetonitrile

: 24653-75-6
1-mercaptopropan-2-one

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
at 135℃;

...Expand

: 854667-12-2
acetic acid-(α,β-dibromo-isopropyl ester)

: 7732-18-5
water

: 62-55-5
thioacetamide

: 541-58-2
2,4-dimethylthiazole

Conditions

Conditions	Yield
at 100℃; reagiert analog mit Thioharnstoff;

...Expand

: 132963-53-2
trichloro(2,4-dimethylthiazole)gold(III)

: lithium chloride

A: 541-58-2
2,4-dimethylthiazole

: 3145-91-3
lithium tetrachloroaurate

Conditions

Conditions	Yield
In methanol; dichloromethane; water Kinetics; addn. of Au-complex in dichloromethane to LiCl+HClO4 in methanol:water (95:5 v/v) at 25 °C; detected by UV;

...Expand

: 132963-53-2
trichloro(2,4-dimethylthiazole)gold(III)

: 16887-00-6
chloride

A: 541-58-2
2,4-dimethylthiazole

: tetrachloroaurate(III)(1-)

Conditions

Conditions	Yield
In methanol; dichloromethane; water Kinetics; addn. of Au-complex in dichloromethane to LiCl+HClO4 in methanol:water (95:5 v/v) at 25 °C; detected by UV;

...Expand

: 541-58-2
2,4-dimethylthiazole

: 3964-04-3
4-bromoquinoline

: 2,4-dimethyl-5-(quinolin-4-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	99%

: 541-58-2
2,4-dimethylthiazole

: 99-90-1
para-bromoacetophenone

: (4-(2,4-dimethylthiazol-5-yl)phenyl)ethanone

Conditions

Conditions	Yield
With [Pd(IPr*IMe)An(3-Cl-pyridinyl)Cl2]; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	98%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	81%

: 1003-09-4
2-bromothiophene

: 541-58-2
2,4-dimethylthiazole

: 2,4-dimethyl-5-(thiophen-2-yl)thiazole

Conditions

Conditions	Yield
With C68H65Cl2N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Reagent/catalyst; regioselective reaction;	98%

: 541-58-2
2,4-dimethylthiazole

: 13472-85-0
2-methoxy-5-bromopyridine

: 5-(6-methoxypyridin-3-yl)-2,4-dimethylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	98%

: 541-58-2
2,4-dimethylthiazole

: 28599-52-2
5-bromo-2,4-dimethyl-1,3-thiazole

Conditions

Conditions	Yield
With bromine; calcium carbonate In dichloromethane for 3h;	97%
Stage #1: 2,4-dimethylthiazole With bromine; acetic acid at 0℃; Stage #2: With sodium carbonate In water pH=>= 9;	83%
With carbon disulfide; bromine at 0℃;	80%

: 541-58-2
2,4-dimethylthiazole

: gold(III) tetrachloride trihydrate

: 132963-53-2
trichloro(2,4-dimethylthiazole)gold(III)

Conditions

Conditions	Yield
In methanol; water addn. of 2,4-dimethylthiazole in methanol to soln. of HAuCl4*3H2O in water, neutralised with equimolar NaHCO3;; filtration, washed (water, methanol), recrystd. (dichloromethane), elem. anal.;;	97%

: 541-58-2
2,4-dimethylthiazole

: 1122-91-4
4-bromo-benzaldehyde

: 4-(2, 4-dimethylthiazol-5-yl)benzaldehyde

Conditions

Conditions	Yield
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	97%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	96%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 541-58-2
2,4-dimethylthiazole

: 108-86-1
bromobenzene

: 19968-55-9
2,4-dimethyl-5-phenylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	85%
With [Pd(IPr*IMe)An(3-Cl-pyridinyl)Cl2]; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	55%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 541-58-2
2,4-dimethylthiazole

: 1532-97-4
4-bromoisoquinoline

: 5-(isoquinolin-4-yl)-2,4-dimethylthiazole

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	97%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	94%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	72%

: 541-58-2
2,4-dimethylthiazole

: 402-43-7
p-trifluoromethylphenyl bromide

: 2,4-dimethyl-5-(4-(trifluoromethyl)phenyl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	93%

: 541-58-2
2,4-dimethylthiazole

: 3430-13-5
5-bromo-2-methylpyridine

: 2,4-dimethyl-5-(6-methylpyridin-3-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%

: 541-58-2
2,4-dimethylthiazole

: 105-36-2
ethyl bromoacetate

: 33446-11-6
3-(carboethoxymethyl)-2,4-dimethylthiazolium bromide

Conditions

Conditions	Yield
at 50℃; for 6h;	96%
In acetonitrile Heating;

: 626-55-1
3-Bromopyridine

: 541-58-2
2,4-dimethylthiazole

: 1267180-21-1
2,4-dimethyl-5-(pyridin-3-yl)thiazole

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	96%
With C68H65Cl2N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	95%
With palladium diacetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 180℃; for 0.166667h; Reagent/catalyst; Temperature; Time; Solvent; Sealed tube; Microwave irradiation;	83%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	65%

: 541-58-2
2,4-dimethylthiazole

: 5332-24-1
3-bromoquinoline

: 1516952-56-9
2,4-dimethyl-5-(quinolin-3-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	96%
With palladium diacetate; caesium carbonate; lithium chloride In N,N-dimethyl-formamide at 150℃; for 24h; Reagent/catalyst; Temperature; Time; Solvent; Sealed tube;	82%

: 541-58-2
2,4-dimethylthiazole

: 623-00-7
4-bromobenzenecarbonitrile

: 122957-56-6
4-(2,4-dimethylthiazol-5-yl)benzonitrile

Conditions

Conditions	Yield
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	96%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	95%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 541-58-2
2,4-dimethylthiazole

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: C13H9F6NS

Conditions

Conditions	Yield
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	96%

: 541-58-2
2,4-dimethylthiazole

: 74-88-4
methyl iodide

: 5787-82-6
2,3,4-trimethylthiazol-3-ium iodide

Conditions

Conditions	Yield
In acetone for 24h; Heating;	95%

: 541-58-2
2,4-dimethylthiazole

: 619-42-1
4-methoxycarbonylphenyl bromide

: methyl 4-(2, 4-dimethylthiazol-5-yl)benzoate

Conditions

Conditions	Yield
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	95%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	93%
With [Pd(IPr*IMe)An(3-Cl-pyridinyl)Cl2]; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	88%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 541-58-2
2,4-dimethylthiazole

: 766-11-0
5-bromo-2-fluoropyridine

: 5-(6-fluoropyridin-3-yl)-2,4-dimethylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	95%

: 541-58-2
2,4-dimethylthiazole

: 619-41-0
4-(bromoacetyl)toluene

: 2,4-Dimethyl-3-(2-oxo-2-p-tolyl-ethyl)-thiazol-3-ium; perchlorate

Conditions

Conditions	Yield
With sodium perchlorate 1.) toluene, reflux, 0.5-1h, room temperature, 12h, 2.) water;	94%

: 541-58-2
2,4-dimethylthiazole

: 2586-62-1
1-bromo-2-methylnaphtalene

: 2, 4-dimethyl-5-(2-methylnaphthalen-1-yl)thiazole

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	94%
With [Pd(IPr*IMe)An(3-Cl-pyridinyl)Cl2]; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	58%

: 541-58-2
2,4-dimethylthiazole

: 62546-56-9
triphenylphosphonium bromide

: C32H30NOPS(2+)*2ClO4(1-)

Conditions

Conditions	Yield
With sodium perchlorate 1.) nitromethane, reflux, 1h, room temperature, 12h, 2.) water;	93%

: 541-58-2
2,4-dimethylthiazole

: 536-38-9
4-chlorobenzoylmethyl bromide

: 3-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-2,4-dimethyl-thiazol-3-ium; perchlorate

Conditions

Conditions	Yield
With sodium perchlorate 1.) toluene, reflux, 0.5-1h, room temperature, 12h, 2.) water;	92%

: 541-58-2
2,4-dimethylthiazole

: 96-36-6, 868-85-9
methyl phosphite

: 2,4-dimethyl-5-dimethylphosphonothiazole

Conditions

Conditions	Yield
With manganese triacetate In acetic acid at 80℃; for 3h;	92%

: 541-58-2
2,4-dimethylthiazole

: 90-11-9
1-Bromonaphthalene

: 2,4-dimethyl-5-(naphthalen-1-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	92%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	91%
With [Pd(IPr*IMe)An(3-Cl-pyridinyl)Cl2]; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	87%

: 541-58-2
2,4-dimethylthiazole

: 70-11-1
α-bromoacetophenone

: 2,4-dimethyl-3-phenacylthiazol-3-ium perchlorate

Conditions

Conditions	Yield
With sodium perchlorate 1.) toluene, reflux, 0.5h, room temperature, 12h, 2.) water;	91%

: 541-58-2
2,4-dimethylthiazole

A: 2,4-dimethylthiazole N,S,S-trioxide

B: 76133-04-5
2,4-dimethylthiazole N-oxide

Conditions

Conditions	Yield
With HOF* CH3CN In dichloromethane at 20℃; for 0.333333h;	A 5% B 91%

: 541-58-2
2,4-dimethylthiazole

: 460-00-4
1-Bromo-4-fluorobenzene

: 5-(4-fluorophenyl)-2,4-dimethylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	91%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	79%

: 541-58-2
2,4-dimethylthiazole

: 99-81-0
4-Nitrophenacyl bromide

: 2,4-Dimethyl-3-[2-(4-nitro-phenyl)-2-oxo-ethyl]-thiazol-3-ium; perchlorate

Conditions

Conditions	Yield
With sodium perchlorate 1.) toluene, reflux, 0.5-1h, room temperature, 12h, 2.) water;	90%

2,4-DIMETHYLTHIAZOLE Chemical Properties

Molecular Formula: C₅H₇NS

Formula Weight: 113.18
bp of 2,4-DIMETHYLTHIAZOLE (541-58-2): 144-146 ^°C 719 mm Hg(lit.)
density : 1.056 g/mL at 25 ^°C(lit.)
refractive index : n20/D 1.509(lit.)
Fp of 2,4-DIMETHYLTHIAZOLE (541-58-2): 109 ^°F
storage temp. : -20^°C
APPEARANCE : Clear to pale yellow liquid.
2,4-DIMETHYLTHIAZOLE (541-58-2) is dissolved in alcohol, ether and cold water.

2,4-DIMETHYLTHIAZOLE Uses

2,4-DIMETHYLTHIAZOLE (541-58-2) is used as an organic synthesis intermediate.

2,4-DIMETHYLTHIAZOLE Production

First, acetamide reacts with phosphorus pentasulfide; then condensation with acetone to form 2,4-DIMETHYLTHIAZOLE (541-58-2).

2,4-DIMETHYLTHIAZOLE Toxicity Data With Reference

ipr-mus LD50:250 mg/kg

NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 .

2,4-DIMETHYLTHIAZOLE Consensus Reports

Reported in EPA TSCA Inventory.

2,4-DIMETHYLTHIAZOLE Safety Profile

Hazard Codes : Xi,F (Irritant; Highly Flammable)
Risk Statements : 10-36/37/38 (Flammable; Irritating to eyes, respiratory system and skin)
Safety Statements : 16-26-36-37/39 (Keep away from sources of ignition - No smoking; In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable gloves and eye/face protection)
RIDADR : UN 1993 3/PG 3
WGK Germany : 3
RTECS : XJ4375000
HazardClass : 3
PackingGroup : III
Poison by intraperitoneal route. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

2,4-DIMETHYLTHIAZOLE Specification

STORAGE: Store in a cool dry place. Keep container closed. Wash thoroughly after handling.

Product Name

2,4-Dimethylthiazole

Synthetic route

2,4-DIMETHYLTHIAZOLE Chemical Properties

2,4-DIMETHYLTHIAZOLE Uses

2,4-DIMETHYLTHIAZOLE Production

2,4-DIMETHYLTHIAZOLE Toxicity Data With Reference

2,4-DIMETHYLTHIAZOLE Consensus Reports

2,4-DIMETHYLTHIAZOLE Safety Profile

2,4-DIMETHYLTHIAZOLE Specification

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