2,6-Dimethylaniline supplier

Name
2,6-Dimethylaniline
EINECS 201-758-7
CAS No. 87-62-7
Article Data192
CAS DataBase
Density 0.975 g/cm³
Solubility water: 7.5 g/L (20 °C)
Melting Point 10-12 °C(lit.)
Formula C₈H₁₁N
Boiling Point 217.9 °C at 760 mmHg
Molecular Weight 121.182
Flash Point 91.1 °C
Transport Information UN 1711 6.1/PG 2
Appearance colorless to reddish yellow liquid
Safety 23-25-36/37-61
Risk Codes 20/21/22-37/38-40-51/53
Molecular Structure
Hazard Symbols Xn,N,T
Synonyms 2,6-Xylidine(8CI);1-Amino-2,6-dimethylbenzene;2,6-Dimethylbenzenamine;2,6-Dimethylphenylamine;2,6-Xylylamine;2-Amino-1,3-dimethylbenzene;2-Amino-1,3-xylene;2-Amino-m-xylene;NSC 7098;o-Xylidine;2,6 Xylidine;
PSA 26.02000
LogP 2.46680

Synthetic route

: 81-20-9
2,6-dimethylnitrobenzene

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With potassium fluoride; polymethylhydrosiloxane; palladium diacetate In tetrahydrofuran; water at 20℃; for 3h;	100%
With potassium fluoride; polymethylhydrosiloxane; palladium diacetate In tetrahydrofuran at 20℃; for 0.5h;	100%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 10h;	100%

: 26334-20-3
2,6-dimethylphenylazide

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With sodium hydrogen telluride In diethyl ether; ethanol for 0.25h; Ambient temperature;	100%
With aluminium(III) iodide In benzene for 0.166667h; Reduction; Heating;	90%
With diphosphorus tetraiodide In benzene for 11h; Heating;	40%

: 767-71-5
N-methyl-2,6-dimethylaniline

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine In acetonitrile at -78℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere; Irradiation;	100%

: 3095-48-5
4-amino-3,5-dimethyl-benzoic acid methyl ester

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With sodium hydroxide In water at 60 - 130℃; under 4560.31 Torr; for 3.5h; Temperature;	99.1%

: 2-(2,6-dimethylphenyl)-4,5,6,7-tetrafluoroisoindoline-1,3-dione

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With ethylenediamine In ethanol at 65℃; for 14h;	99%

: 6781-98-2
2,6-dimethyl-1-chlorobenzene

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With 2-((dicyclohexylphosphino)methyl)-1,3-bis(2,6-diisopropylphenyl)-4,5-dimethyl-1H-imidazol-3-ium iodide; ammonia; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere;	98%
With C28H30Cl5N3Pd; ammonia; lithium isopropoxide; sodium t-butanolate In 1,4-dioxane at 100℃; for 2h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	91%
With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 24h; Inert atmosphere;	89%

: 3095-47-4
3,5-dimethyl-4-aminobenzoic acid ethyl ester

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With potassium hydroxide In water at 60 - 125℃; under 2280.15 Torr; for 3h;	97.5%

: 91-16-7
1,2-dimethoxybenzene

: 18109-39-2
N-(2,6-diimethylphenyl)benzamide

A: 4038-14-6
3,4-dimethoxybenzophenone

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
Stage #1: N-(2,6-diimethylphenyl)benzamide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 0℃; for 0.166667h; Inert atmosphere; Stage #2: 1,2-dimethoxybenzene In dichloromethane at 0 - 20℃; Inert atmosphere; Stage #3: With hydrogenchloride; water In ethanol for 2h; Inert atmosphere; Reflux; chemoselective reaction;	A 97% B 90%

...Expand

: 576-26-1
2.6-dimethylphenol

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With 2,6-dimethylcyclohexanone; ammonium hydroxide; 5%-palladium/activated carbon at 180℃; for 5h; Concentration; Temperature;	95.62%
With ammonia; hydrogen In 1,4-dioxane at 230℃; under 760.051 Torr;	86.56%
With ammonia

: 39604-15-4
2,6-dimethylphenyl diethyl phosphate

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With potassium; potassium amide In diethyl ether; ammonia at -78℃; 1.0-1.2 h;	95%

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 12h;	92%
With potassium carbonate; ammonium hydroxide In methanol at 60℃; for 13h;	87%
With copper(ll) sulfate pentahydrate; ammonia; sodium hydroxide In water at 20℃; under 760.051 Torr; for 4h;	58%
Multi-step reaction with 2 steps 1: potassium hydrogenfluoride / methanol; water / 0.5 h / 0 °C 2: ammonium hydroxide; copper(ll) sulfate pentahydrate; sodium hydroxide / water / 24 h / 25 °C View Scheme

: 576-22-7
2-Bromo-m-xylene

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 80℃; for 15h; Inert atmosphere;	88%
With magnesium In diethyl ether Ambient temperature;	79%
With [N,N'-bis(5-sulfonatosalicylidene)-1,2-diaminoethane]copper disodium salt; ammonia; sodium hydroxide In water at 120℃; for 12h; sealed tube;	64%
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 120℃; under 5171.62 Torr; for 48h; Inert atmosphere;	7%
With ammonium hydroxide; sodium hydroxide In water

: N'-(2,6-methyl-phenyl)-N,N-dimethyl-formamidine

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; palladium hydroxide - carbon In methanol; water at 20℃; under 3620.04 Torr; for 60h; Hydrogenolysis;	86%

: 627-37-2
N-methyl-N-allylamine

: 16239-27-3
N-(2,6-dimethylphenyl)benzimidamide

A: 1,4-dimethyl-2-phenyl-4,5-dihydro-1H-imidazole

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With bis(trimethylsilyl)amide yttrium(III) In neat (no solvent) at 100℃; for 120h; Inert atmosphere;	A 86% B n/a

...Expand

: N'-(2,6-dimethyl-phenyl)-N,N-dibenzyl-formamidine

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; palladium hydroxide - carbon In methanol; water under 3620.04 Torr; Ambient temperature;	83%
With hydrogen; palladium on activated charcoal; palladium hydroxide - carbon In methanol; water at 20℃; under 3620.04 Torr; for 64h; Hydrogenolysis;	83%

: 77470-78-1
5-chloropentano-2',6'-xylidide

: 109-89-7
diethylamine

A: 77470-82-7
5-(diethylamino)pentano-2',6'-xylidide

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With sodium iodide In ethanol for 48h; Heating;	A 82% B n/a

...Expand

: 35203-02-2
2,6-dimethyl-N-methylene benzamine

A: 767-71-5
N-methyl-2,6-dimethylaniline

B: 769-06-2
N,N,2,6-tetramethylaniline

C: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether Heating;	A 81% B 3% C 10%

...Expand

: 105887-12-5
(E)-3-Phenyl-acrylic acid 1-(2,6-dimethyl-phenylcarbamoyl)-1-methyl-2-oxo-propyl ester

A: 105915-43-3
N-(2,6-dimethylphenyl) 2-acetyl 2-hydroxypropanamide

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride In tetrahydrofuran for 24h; Heating;	A 80% B n/a

: 100379-00-8
2,6-dimethylbenzene boronic acid

A: 576-26-1
2.6-dimethylphenol

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With ammonium hydroxide; potassium nitrate In water at 20℃; for 2h; Electrochemical reaction; chemoselective reaction;	A n/a B 73%
With ammonium hydroxide; potassium nitrate In water at 20℃; for 4h; Electrochemical reaction; chemoselective reaction;	A 70% B n/a

: 2-(2,6-bismethylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With O-Methylhydroxylamin; n-butyllithium In tetrahydrofuran; hexane at -78 - 60℃; for 24h; Inert atmosphere; Cooling with acetone-dry ice; stereospecific reaction;	71%

: 2-methyl-6-(thiomethoxymethyl)-aniline

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
	66%

: 2816-57-1
2,6-dimethylcyclohexanone

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With ethene; 5%-palladium/activated carbon; ammonium acetate In acetonitrile at 90℃; under 760.051 Torr; for 15h; Schlenk technique;	63%
With urea In water; 1,3,5-trimethyl-benzene at 150℃; under 760.051 Torr; for 24h; Schlenk technique; Inert atmosphere;	37 %Chromat.

: 77470-76-9
4-chlorobutyro-2',6'-xylidide

: 109-89-7
diethylamine

A: 21236-53-3
N-(2,6-dimethylphenylcarbamoylpropyl)diethylamine

B: 77470-81-6
1-(2,6-dimethylphenyl)pyrrolidin-2-one

C: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
In toluene for 2h; Heating;	A 31% B 60% C n/a

...Expand

: 160938-51-2
3-Methoxy-pyridine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

A: 87-62-7
2,6-dimethylaniline

B: 3-Methoxy-1,4,5,6-tetrahydro-pyridine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

Conditions

Conditions	Yield
With water In methanol at 25℃; electrochemical reduction;	A 60% B 5%

: η6-2,6-dimethylaniline-η5-cyclopentadienyliron hexafluorophosphate

: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
Sample heated for 1.0 h at 200-220°C and 1 torr.;	60%

: 49673-43-0
N1,N2-bis(2,6-dimethylphenyl)ethane-1,2-diimine

: 613-73-0
1,2-phenylenediacetonitrile

A: 3029-30-9
naphthalene-1,4-dicarbonitrile

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide at 100℃; for 15h;	A 58% B n/a

...Expand

: 108-38-3
m-xylene

A: 108-69-0
3,5-dimethylaminoaniline

B: 95-68-1
2,4-Xylidine

C: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With tris-(2-chloro-ethyl)-amine; trifluorormethanesulfonic acid; trifluoroacetic acid In chloroform at 25℃; for 1h;	A 2% B 58% C 15%
With hydrogenchloride; aluminium trichloride; sodium azide In various solvent(s) at 20℃;
With sodium azide; trifluorormethanesulfonic acid at 20℃; Ultrasonic irradiation;
Stage #1: m-xylene With sulfuric acid; hydroxylamine hydrochloride In acetonitrile at 25℃; for 0.166667h; Stage #2: With hydrogenchloride; titanium(III) chloride In water; acetonitrile at 25℃; Inert atmosphere; Sealed tube; Overall yield = 60 percent; Overall yield = 72 mg;

...Expand

: 627-37-2
N-methyl-N-allylamine

: C49H53N6OY

A: 1,4-dimethyl-2-phenyl-4,5-dihydro-1H-imidazole

B: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
In neat (no solvent) at 100℃; for 120h;	A 57% B n/a

...Expand

: 105887-10-3
Acetic acid 1-(2,6-dimethyl-phenylcarbamoyl)-1-methyl-2-oxo-propyl ester

A: 25348-08-7
N,N'-di (2,6-dimethylphenyl) urea

B: 105915-43-3
N-(2,6-dimethylphenyl) 2-acetyl 2-hydroxypropanamide

C: 105915-44-4
2,3-Dimethyl-5-oxo-2,5-dihydro-furan-2-carboxylic acid (2,6-dimethyl-phenyl)-amide

D: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride In tetrahydrofuran for 4h; Heating;	A n/a B 50% C 40% D n/a

...Expand

: 64-18-6
formic acid

: 87-62-7
2,6-dimethylaniline

: 607-92-1
2,6-dimethylformanilide

Conditions

Conditions	Yield
In toluene Reflux;	100%
In toluene Reflux;	100%
In toluene Reflux;	100%

: 88-88-0
2,4,6-trinitrochlorobenzene

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃;	100%

: 26551-87-1
Carbonylbis(isocyaniddichlorid)

: 87-62-7
2,6-dimethylaniline

: 84384-14-5
4,6-Dichlor-5-(2,6-dimethylphenyl)-1,3,5-triazin-2(5H)-on

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 0.75h;	100%

: 87-62-7
2,6-dimethylaniline

: 2258-42-6
Acetic formic anhydride

: 607-92-1
2,6-dimethylformanilide

Conditions

Conditions	Yield
In tetrahydrofuran at -20℃; for 0.25h;	100%
In tetrahydrofuran at 20℃;
In dichloromethane at 20℃; for 2h;

: 87-62-7
2,6-dimethylaniline

: 75-98-9
Trimethylacetic acid

: 39627-97-9
2,2-dimethyl-N-(2,6-dimethylphenyl)propionamide

Conditions

Conditions	Yield
With diphosphorus tetraiodide In tetrachloromethane; dichloromethane Heating;	100%

: 24932-48-7
1,2-dibromo-4,5-dimethylbenzene

: 87-62-7
2,6-dimethylaniline

: N,N'-bis(2,6-dimethylphenyl)-4,5-dimethyl-o-phenylenediamine

Conditions

Conditions	Yield
With ammonium chloride; sodium t-butanolate; palladium diacetate In water; argon; toluene	100%
With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 14h;	75%

: 24424-99-5
di-tert-butyl dicarbonate

: 87-62-7
2,6-dimethylaniline

: N-tert-butoxycarbonyl-2,6-dimethylaniline

Conditions

Conditions	Yield
With indium(III) bromide at 30 - 35℃; for 0.5h;	100%
In ethanol at 30℃; for 48h;	99%
copper(II) bis(tetrafluoroborate) at 30 - 33℃; for 0.5h;	98%
With choline chloride; urea at 50℃; Green chemistry;	90%
In tetrahydrofuran; water for 0.5h;	111 mg

: 5950-87-8
2,4-dinitrophenyl 2,4,6-trinitrophenyl ether

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃;	100%
In acetonitrile at 25℃; Equilibrium constant; Kinetics; Further Variations:; title comp. concentration;

: 4461-30-7
2-chloroacetylisocyanate

: 87-62-7
2,6-dimethylaniline

: C11H13ClN2O2

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%
In dichloromethane at 20℃;

: 87-62-7
2,6-dimethylaniline

: 130403-23-5
3-(2,6-dimethyl phenyl carbamoyl)-5-acetoxymethyl isoxazole

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate In tetrahydrofuran	100%
With triethylamine; trichlorophosphate In tetrahydrofuran	100%

: 6973-40-6
2,4,6-trinitrophenyl phenyl ether

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃; Kinetics;	100%

: 10242-31-6
1-(4-nitrophenoxy)-2,4,6-trinitrobenzene

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃; Kinetics; Concentration;	100%

: 10242-30-5
2-nitrophenyl 2,4,6-trinitrophenyl ether

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃; Kinetics; Concentration;	100%

: 103612-93-7
2,6-dinitrophenyl 2,4,6-trinitrophenyl ether

: 87-62-7
2,6-dimethylaniline

: (2,6-dimethyl-phenyl)-picryl-amine

Conditions

Conditions	Yield
In acetonitrile at 25℃; Kinetics; Concentration;	100%

: 536-74-3
phenylacetylene

: 87-62-7
2,6-dimethylaniline

: 75472-72-9, 75472-77-4, 10228-84-9
2,6-dimethyl-N-(1-phenylethylidene)benzenamine

Conditions

Conditions	Yield
With C30H36FeP22Au(1+)Cl(1-)*C32H12BF24(1-) In (2)H8-toluene at 120℃; for 6h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube; Glovebox;	100%
With silver tetrafluoroborate; {(2,6-bis(1-isopropyl-2,3-dihydro-1H-imidazole-2-thione)pyridine)12Cu8}(PF6)8 In acetonitrile at 70℃; for 2h; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere; regioselective reaction;	99%
With silver tetrafluoroborate; C57H72Au4I4N12O4 In [D3]acetonitrile at 70℃; for 6h; Reagent/catalyst; Inert atmosphere;	93%

: 138735-96-3
[RuVI(5,10,15,20-tetrakis(4-methylphenyl)porphyrinato(2-))O2]

: 87-62-7
2,6-dimethylaniline

: 1237762-58-1
[Ru(IV)(ttp)(NQu)(OH)]

Conditions

Conditions	Yield
Stage #1: [RuVI(5,10,15,20-tetrakis(4-methylphenyl)porphyrinato(2-))O2]; 2,6-dimethylaniline In ethanol for 8h; Stage #2: With water In dichloromethane for 0.5h;	100%

: 138735-97-4
[Ru(VI)(O)2(5,10,15,20-tetrakis(4-methoxyphenyl)porphyrinate)]

: 87-62-7
2,6-dimethylaniline

: 1237762-71-8
[Ru(IV)(4-OMe-ttp)(NQu)(OH)]

Conditions

Conditions	Yield
Stage #1: [Ru(VI)(O)2(5,10,15,20-tetrakis(4-methoxyphenyl)porphyrinate)]; 2,6-dimethylaniline In ethanol for 8h; Stage #2: With water In dichloromethane for 0.5h;	100%

: 138735-98-5
[Ru(VI)(meso-tetrakis(p-chlorophenyl)porphyrinato)O2]

: 87-62-7
2,6-dimethylaniline

: 1237762-72-9
[Ru(IV)(4-Cl-ttp)(NQu)(OH)]

Conditions

Conditions	Yield
Stage #1: [Ru(VI)(meso-tetrakis(p-chlorophenyl)porphyrinato)O2]; 2,6-dimethylaniline In ethanol for 8h; Stage #2: With water In dichloromethane for 0.5h;	100%

: 90-02-8
salicylaldehyde

: 87-62-7
2,6-dimethylaniline

: 54220-52-9
2-(((2,6-dimethylphenyl)imino)methyl)phenol

Conditions

Conditions	Yield
In ethanol at 80℃; for 2h; Inert atmosphere;	100%
With magnesium sulfate In toluene for 4h; Inert atmosphere; Reflux;	98%
In isopropyl alcohol at 80℃; for 24h; Inert atmosphere;

: 97-51-8
5-Nitrosalicylaldehyde

: 87-62-7
2,6-dimethylaniline

: 339991-46-7
2-[(2,6-dimethylphenylimino)methyl]-4-nitrophenol

Conditions

Conditions	Yield
In ethanol at 80℃; for 2h; Inert atmosphere;	100%
In isopropyl alcohol at 80℃; for 24h; Inert atmosphere;

: (NCNdipp)3Lu3(μ2-Me)3(μ3-Me)(μ3-CH2)

: 87-62-7
2,6-dimethylaniline

: (PhC(NC6H3iPr2-2,6)2)3Lu3(μ2-Me)3(μ3-Me)(μ-η1:η3-NC6H3Me2-2,6)

Conditions

Conditions	Yield
In toluene at 20℃; for 48h;	100%

: (NCNdipp)3Y3(μ2-Me)3(μ3-Me)(μ3-CH2)

: 87-62-7
2,6-dimethylaniline

: (PhC(NC6H3iPr2-2,6)2)3Y3(μ2-Me)3(μ3-Me)(μ-η1:η3-NC6H3Me2-2,6)

Conditions

Conditions	Yield
In toluene at 20℃; for 48h;	100%

: 98-88-4
benzoyl chloride

: 87-62-7
2,6-dimethylaniline

: 18109-39-2
N-(2,6-diimethylphenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In toluene Heating;	99%
With triethylamine In acetone at 20℃; Cooling with ice;	93%
With triethylamine In dichloromethane for 48h; Reflux;	67%

: 598-21-0
2-Bromoacetyl bromide

: 87-62-7
2,6-dimethylaniline

: 32433-61-7
2-bromo-N-(2,6-dimethyl-phenyl)-acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0℃; for 1h;	99%
With sodium carbonate In water pH=9 - 10;	99%
With triethylamine In chloroform at -10℃; for 2.25h;	88%

: 87-62-7
2,6-dimethylaniline

: 74-88-4
methyl iodide

: 767-71-5
N-methyl-2,6-dimethylaniline

Conditions

Conditions	Yield
	99%
Stage #1: 2,6-dimethylaniline With n-butyllithium In hexane at -20 - 20℃; for 3h; Inert atmosphere; Stage #2: methyl iodide In diethyl ether at -20 - 20℃; Inert atmosphere;	94%
Stage #1: 2,6-dimethylaniline With n-butyllithium In hexane at -20 - 20℃; for 3h; Inert atmosphere; Stage #2: methyl iodide In diethyl ether at -20 - 20℃; Inert atmosphere;	85%

: 87-62-7
2,6-dimethylaniline

: 17420-02-9, 52867-02-4
2,6-dimethyl-N-sulfinyl-benzenamine

Conditions

Conditions	Yield
With thionyl chloride In benzene for 16h; Reflux;	99%
With thionyl chloride
With thionyl chloride In benzene Heating;
Multistep reaction;
With thionyl chloride In toluene Reflux;

2,6-Dimethylaniline Chemical Properties

IUPAC Name: 2,6-dimethylaniline
Synonyms: 2,6-dimethyl-anilin;2,6-Dimethylbenzenamine;2,6-dimethylphenylamine;2,6-dimethyl-benzenamin;2,6-dimethyl-Benzenamine;2,6-Dimethylbenzeneamine;2,6-Dimethyl-phenylamine;2,6-DMA;
The Molecular formula of 2,6-Dimethylaniline(87-62-7): C₈H₁₁N
The Molecular Weight of 2,6-Dimethylaniline(87-62-7): 121.18
Molecular Structure :

EINECS: 201-758-7
Melting point: 10-12 °C(lit.)
Boiling point: 216 °C
Flash point: 196 °F
density: 0.984 g/mL at 25 °C(lit.)
vapor pressure: <0.01 mm Hg ( 20 °C)
refractive index: n20/D 1.560(lit.)
Water Solubility: 7.5 g/L (20 ^oC)

2,6-Dimethylaniline Uses

2,6-Dimethylaniline(87-62-7) is used as a pesticide, pharmaceutical intermediate.

2,6-Dimethylaniline Toxicity Data With Reference

1、RTECS#: CAS# 87-62-7: ZE9275000
2、LD50/LC50: RTECS: CAS# 87-62-7: Oral, mouse: LD50 = 707 mg/kg;Oral, rat: LD50 = 840 mg/kg;.
3、Carcinogenicity: 2,6-Dimethylaniline - California: carcinogen, initial date 1/1/91 IARC: Group 2B carcinogen
4、Other: See actual entry in RTECS for complete information.

2,6-Dimethylaniline Safety Profile

The Hazard Codes of 2,6-Dimethylaniline(87-62-7):

Xn,

T
HazardClass: 6.1
The Risk Statements information of 2,6-Dimethylaniline(87-62-7):
40: Limited evidence of a carcinogenic effect
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
37/38: Irritating to respiratory system and skin
51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
The Safety Statements information of 2,6-Dimethylaniline(87-62-7):
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
25: Avoid contact with eyes
61: Avoid release to the environment. Refer to special instructions safety data sheet
36/37: Wear suitable protective clothing and gloves
RIDADR: UN 1711 6.1/PG 2
WGK Germany: 2
RTECS: ZE9275000
F: 8

2,6-Dimethylaniline Specification

(1):Fire Fighting Measures of 2,6-Dimethylaniline
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Containers may explode in the heat of a fire. Combustible liquid.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
(2):Accidental Release Measures of 2,6-Dimethylaniline
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Do not let this chemical enter the environment

Product Name

2,6-Dimethylaniline

Synthetic route

2,6-Dimethylaniline Chemical Properties

2,6-Dimethylaniline Uses

2,6-Dimethylaniline Toxicity Data With Reference

2,6-Dimethylaniline Safety Profile

2,6-Dimethylaniline Specification

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