2-AMINOBENZIMIDAZOLE supplier

Name
2-Aminobenzimidazole
EINECS 213-280-6
CAS No. 934-32-7
Article Data94
CAS DataBase
Density 1.367 g/cm³
Solubility Soluble in water (Slightly).
Melting Point 226-230 °C(lit.)
Formula C₇H₇N₃
Boiling Point 368.9 °C at 760 mmHg
Molecular Weight 133.153
Flash Point 204.6 °C
Transport Information
Appearance light yellow to cream or beige powder or flakes
Safety 26-36/37/39-22
Risk Codes 22-36/37/38-43
Molecular Structure
Hazard Symbols Xn
Synonyms Benzimidazole,2-amino- (6CI,7CI,8CI);1H-Benzimidazol-2-ylamine;2-Amino-1H-benzimidazole;2-Benzimidazolamine;2-Benzimidazolylamine;2-Iminobenzimidazoline;NSC 27793;NSC 7628;
PSA 54.70000
LogP 1.72630

Synthetic route

: 1516-74-1
2-azido-1H-benzo[d]imidazole

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With sodium tetrahydroborate; tin bis(1,2-benzenethiolate) In tetrahydrofuran; phosphate buffer at 10℃; for 0.5h; pH=10; Reduction;	100%
With dibutyltin In benzene at 40℃; for 2h; other reagents;	98%
With acetic acid In dichloromethane at 20℃; for 2h; Irradiation;

: 506-68-3
bromocyane

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
In methanol; water at 20 - 60℃; Inert atmosphere;	97%
In ethanol; water at 70℃; for 1h;	90%
In methanol; water at 50℃; for 1h;	89%

: 1184-90-3
aminoiminomethanesulfonic acid

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
In isopropyl alcohol at 60℃;	95%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With N-sulfonated biguanidine modified silica coated on cobalt ferrite nanoparticle core In ethanol at 20℃; for 0.3h; Green chemistry;	92%

: cyanogen bromide

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
In methanol; water at 20℃; for 24h;	88%
In water at 20℃;	75%

: N-(1H-benzimidazol-2-yl)-N'-(p-methylbenzylidene)hydrazine

A: 934-32-7
1H-benzimidazol-2-amine

B: 104-85-8
para-methylbenzonitrile

Conditions

Conditions	Yield
at 700℃; under 0.02 Torr; Gas phase;	A 85% B 86%

: N-(1H-benzimidazol-2-yl)-N'-(p-methoxybenzylidene)hydrazine

A: 934-32-7
1H-benzimidazol-2-amine

B: 874-90-8
4-methoxybenzonitrile

Conditions

Conditions	Yield
at 700℃; under 0.02 Torr; Gas phase;	A 78% B 85%

: 506-68-3
bromocyane

: 615-28-1
o-phenylenediamine dihydrochloride

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
Stage #1: bromocyane; o-phenylenediamine dihydrochloride With sodium hydrogencarbonate In water; acetonitrile at 0 - 20℃; Stage #2: With sodium carbonate In water; acetonitrile	85%

: 6306-71-4
lobendazole

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 4h; Heating;	82%

: 1438395-75-5
N-tert-butyl-1H-benzo[d]imidazol-2-amine

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With hydrogenchloride In water for 12h; Reflux;	82%

: 162976-69-4
1H-benzimidazol-2-ylcarbamic acid methyl ester

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With sodium hydroxide In water for 2h; Reflux;	80%
Stage #1: 1H-benzimidazol-2-ylcarbamic acid methyl ester With sodium hydroxide In water for 2h; Reflux; Stage #2: With hydrogenchloride In water	65%
With oxygen In various solvent(s) at 20℃; for 5h; pH=11; Quantum yield; Kinetics; Further Variations:; pH-values; Reagents; conc. of dissolved O2; Decomposition; Photolysis;
Alkaline conditions;
With water Alkaline conditions;

: 60059-51-0
N-(1H-benzimidazol-2-yl)-N'-benzylidenehydrazine

A: 934-32-7
1H-benzimidazol-2-amine

B: 100-47-0
benzonitrile

Conditions

Conditions	Yield
at 700℃; under 0.02 Torr; Gas phase;	A 73% B 78%

: 113-00-8
guanidine nitrate

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
Irradiation; microwave;	75%

: N-(1H-benzimidazol-2-yl)-N'-(p-chlorobenzylidene)hydrazine

A: 623-03-0
4-Cyanochlorobenzene

B: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
at 700℃; under 0.02 Torr; Gas phase;	A 65% B 67%

: N-(1H-benzimidazol-2-yl)-N'-(p-nitrobenzylidene)hydrazine

A: 934-32-7
1H-benzimidazol-2-amine

B: 100-47-0
benzonitrile

C: 619-72-7
4-nitrobenzonitrile

Conditions

Conditions	Yield
at 700℃; under 0.02 Torr; Gas phase;	A 65% B 10% C 58%

...Expand

: 34840-26-1
1,3-dicarbethoxy-S-methylisothiourea

: 95-54-5
1,2-diamino-benzene

A: 934-32-7
1H-benzimidazol-2-amine

B: 615-16-7
1H-benzimidazol-2-ol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 5h; Heating;	A 60% B 22%

...Expand

: 95-54-5
1,2-diamino-benzene

: 104619-51-4
di(1H-imidazol-1-yl)methanimine

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
In tetrahydrofuran for 12h; Heating;	59%

: 55305-43-6
N-cyano-N-phenyl-p-toluenesulfonamide

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran; hexane at 5 - 20℃; for 1h; Green chemistry;	56%

: 122128-68-1
2-Amino-1-benzylideneaminobenzimidazole

A: 934-32-7
1H-benzimidazol-2-amine

B: 100-47-0
benzonitrile

Conditions

Conditions	Yield
In nitrobenzene for 12h; Heating;	A 47% B n/a

: 60059-51-0
N-(1H-benzimidazol-2-yl)-N'-benzylidenehydrazine

A: 934-32-7
1H-benzimidazol-2-amine

B: 1,3-diphenyl-8H-2,3a,8-triazacyclopenta[a]indene

C: 1233945-59-9
5,11-diphenyl-6H,12H-dibenzimidazo[1,2-a;1',2'-d]pyrazine

D: 484-47-9
lophine

E: 100-47-0
benzonitrile

Conditions

Conditions	Yield
at 280℃; under 0.045 Torr; for 0.25h; Gas phase;	A 20% B 15% C 18% D 21% E 15%

...Expand

: 40828-54-4
1H-benzimidazole-2-sulfonic acid

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With ammonium hydroxide at 145 - 150℃; for 5h;
With ammonium hydroxide
With ammonia

: Ammonium salt of Benzimidazole-2-sulfonic Acid

A: 934-32-7
1H-benzimidazol-2-amine

B: 583-39-1
2,3-dihydrobenzimidazol-2-thione

Conditions

Conditions	Yield
With formamide Heating; Yield given. Yields of byproduct given;
With formamide Heating; Yield given. Yields of byproduct given;
With formamide Product distribution; Heating; also 1-alkyl-substituted benzimidazole-2-sulfonic acids investigated;

: 143-33-9
sodium cyanide

: 95-54-5
1,2-diamino-benzene

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With bromine 1) water, 5 deg C; 2) water, room temperature, 5 h.; Yield given. Multistep reaction;

: 245111-10-8
2-(1-ethylbenzimidazol-2-yl)methyleneaminobenzimidazole

A: 934-32-7
1H-benzimidazol-2-amine

B: 34734-20-8
1-ethyl-1H-benzo[d]imidazole-2-carbaldehyde

Conditions

Conditions	Yield
With water Hydrolysis;

: 2-(1-vinylbenzimidazol-2-yl)methyleneaminobenzimidazole

A: 934-32-7
1H-benzimidazol-2-amine

B: 118482-08-9
1-vinylbenzimidazole-2-carboxaldehyde

Conditions

Conditions	Yield
With water In dimethylsulfoxide-d6 for 120h; Hydrolysis;

-urea: -urea

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With hydrogenchloride

N.N'-o-phenylene-N''-benzoyl-guanidine: N.N'-o-phenylene-N''-benzoyl-guanidine

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With potassium hydroxide

N.N'-o-phenylene-N''-cinnamoyl-guanidine: N.N'-o-phenylene-N''-cinnamoyl-guanidine

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With potassium hydroxide

N.N'-o-phenylene-N.N''-dicyano-guanidine: N.N'-o-phenylene-N.N''-dicyano-guanidine

: 934-32-7
1H-benzimidazol-2-amine

Conditions

Conditions	Yield
With hydrogenchloride

: 934-32-7
1H-benzimidazol-2-amine

: 22945-27-3
cyclohexanone-2-carboxamide

: 83785-99-3
1,2,3,4,6,12-Hexahydrobenzimidazo<2,1-b>chinazolin-12-on

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 3h; Heating;	100%

: 934-32-7
1H-benzimidazol-2-amine

: (4S,4'S)-4-(benzyl(methyl)amino)-4-(2',2'-dimethyl-1,3-dioxolan-4'-yl)-3-methoxybut-2-enal

: (1R,4'S)-{benzo[4,5]imidazo[1,2-a]pyrimidin-4-yl-(2',2'dimethyl-1',3-dioxolan-4'-yl)-methyl}benzylmethylamine

Conditions

Conditions	Yield
In ethanol Reflux; Inert atmosphere;	100%

: 934-32-7
1H-benzimidazol-2-amine

: 75-36-5
acetyl chloride

: 21202-05-1
2-acetamidobenzimidazole

Conditions

Conditions	Yield
Heating;	99%
With triethylamine for 16h; Cooling with ice;	72%
With triethylamine at 50 - 55℃;

: 289499-65-6
3-(2-furyl)-2-(2-methoxycarbonylphenylhydrazono)-3-oxo-propanal

: 934-32-7
1H-benzimidazol-2-amine

: methyl 2-(2-{1-[(1H-benzimidazol-2-ylimino)-methyl]-2-(furan-2-yl)-2-oxo-ethylidene}hydrazino)benzoate

Conditions

Conditions	Yield
In ethanol for 0.166667h; microwave irradiation;	99%

: 289499-66-7
2-(2-methoxycarbonylphenylhydrazono)-3-oxo-3-(2-pyrrolyl)propanal

: 934-32-7
1H-benzimidazol-2-amine

: methyl 2-(2-{1-[(1H-benzimidazol-2-ylimino)-methyl]-2-oxo-2-(1H-pyrrol-2-yl)-ethylidene}hydrazino)benzoate

Conditions

Conditions	Yield
In ethanol for 0.166667h; microwave irradiation;	99%

: 934-32-7
1H-benzimidazol-2-amine

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 555-16-8
4-nitrobenzaldehdye

: 1259091-97-8
2-(((1H-benzo[d]imidazol-2-yl)amino)(4-nitrophenyl)methyl)-3-hydroxynaphthalene-1,4-dione

Conditions

Conditions	Yield
With MCM-41 In ethanol at 20℃; for 1.16667h; Green chemistry;	99%
With montmorillonite K-10 In ethanol at 20℃; for 8h;	93%
With indium(III) chloride In water for 6h; Reflux;	80%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 61066-33-9, 61066-34-0, 61066-35-1, 61127-23-9
pyrimidine-2,4,5,6(1H,3H)-tetraone

: 615-94-1
2,5-dihydroxy-1,4-benzoquinone

: 1367748-62-6
2-amino-1H-benzo[d]imidazol-3-ium 3-hydroxy-1-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)-2,5,6-trioxocyclohex-3-en-1-ide

Conditions

Conditions	Yield
In chloroform for 4h; Reflux;	99%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 459-57-4
4-fluorobenzaldehyde

: 107-91-5
cyanoacetic acid amide

: 1392308-35-8
2,5-bis(4-fluorophenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one

Conditions

Conditions	Yield
With silica sulfuric acid In ethylene glycol at 120℃; for 0.0166667h; Catalytic behavior; Reagent/catalyst; Solvent; Green chemistry;	99%
With poly(ethylene glycol)-400 at 20℃; for 1h; Green chemistry;	90%
In water for 2h; Reflux;	89%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 126-81-8
dimedone

: 6630-33-7
ortho-bromobenzaldehyde

: 3,3-dimethyl-12-(2-bromophenyl)-1,2,3,4,5,12-hexahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1-one

Conditions

Conditions	Yield
With acetic acid at 60℃; for 0.333333h; Green chemistry;	99%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 591-31-1
3-methoxy-benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 2,5-bis(3-methoxyphenyl)-2,3,5,12-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one

Conditions

Conditions	Yield
With silica sulfuric acid In ethylene glycol at 120℃; for 0.0166667h; Green chemistry;	99%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 69954-01-4
2,3,5-trichloro-6-methoxybenzoic acid chloride

: 1-(3,5,6-trichloro-2-methoxybenzoyl)-2-aminobenzimidazole

Conditions

Conditions	Yield
With triethylamine In acetone at 55℃;	98.7%
	98%

: 934-32-7
1H-benzimidazol-2-amine

: 99-61-6
3-nitro-benzaldehyde

: 124066-54-2
(1H-benzimidazol-2-yl)-(3-nitro-benzyliden)-amine

Conditions

Conditions	Yield
In toluene for 20h; Heating;	98%

: 934-32-7
1H-benzimidazol-2-amine

: 555-16-8
4-nitrobenzaldehdye

: 126-81-8
dimedone

: 3,3-dimethyl-12-(4-nitrophenyl)-3,4,5,12-tetrahydrobenzo[4,5]imidazo-[2,1-b]quinazolin-1(2H)-one

Conditions

Conditions	Yield
With silica In acetonitrile at 25 - 30℃; for 0.5h; Green chemistry;	98%
With toluene-4-sulfonic acid In acetonitrile at 40 - 50℃; for 0.333333h; Green chemistry;	98%
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.116667h; Irradiation; Green chemistry; chemoselective reaction;	98%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 123-11-5
4-methoxy-benzaldehyde

: 126-81-8
dimedone

: 3,3-dimethyl-12-(4-methoxyphenyl)-3,4,5,12-tetrahydrobenzo [4,5]imidazo-[2,1-b]quinazolin-1(2H)-one

Conditions

Conditions	Yield
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.15h; Irradiation; Green chemistry; chemoselective reaction;	98%
With acetic acid at 60℃; for 0.333333h; Green chemistry;	96%
With 4-methyl-4-sulfonic acid morpholinium chloride at 90℃; for 0.0833333h; Reagent/catalyst;	96%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 50-00-0
formaldehyd

: 459-05-2
(4-fluoro-phenyl)-thiourea

: 5-(1H-benzoimidazol-2-yl)-1-(4-fluoro-phenyl)-[1,3,5]triazinane-2-thione

Conditions

Conditions	Yield
In water for 0.025h; microwave irradiation;	98%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 104-88-1
4-chlorobenzaldehyde

: 126-81-8
dimedone

: 12-(4-chlorophenyl)-3,3-dimethyl-3,4,5,12-tetrahydrobenzo[4,5]imidazo[2,1-b]quinazoline-1(2H)-one

Conditions

Conditions	Yield
With butane-1-sulfonic acid modified starch coated γ-Fe2O3 magnetic nanoparticles In neat (no solvent) at 100℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	98%
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.116667h; Irradiation; Green chemistry; chemoselective reaction;	98%
With 4-methyl-4-sulfonic acid morpholinium chloride at 90℃; for 0.0666667h; Catalytic behavior; Reagent/catalyst; Temperature;	97%

...Expand

: 824953-65-3
3-(4-chlorophenyl)-2-(2-methoxycarbonylphenylhydrazono)-3-oxo-propanal

: 934-32-7
1H-benzimidazol-2-amine

: methyl 2-(2-{1-[(1H-benzimidazol-2-ylimino)-methyl]-2-(4-chlorophenyl)-2-oxo-ethylidene}hydrazino)benzoate

Conditions

Conditions	Yield
In ethanol for 0.166667h; microwave irradiation;	98%

: 934-32-7
1H-benzimidazol-2-amine

: 360574-95-4
2-[hydroxy-(3-nitro-phenyl)-methyl]-acrylic acid methyl ester

: 1227670-24-7
6-[(3-nitrophenyl)hydroxymethyl]-5,6-dihydro-8H-benzo[4,5]imidazo[1,2-a]pyrimidin-7-one

Conditions

Conditions	Yield
In 1,4-dioxane at 100℃; for 2h;	98%
In tetrahydrofuran; water at 50℃; for 24h; Michael addition-cyclization tandem reaction;	77%

: 872-85-5
pyridine-4-carbaldehyde

: 934-32-7
1H-benzimidazol-2-amine

: 141-97-9
ethyl acetoacetate

: 727405-62-1
ethyl 2-methyl-4-(pyridin-4-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With Thiamine hydrochloride In water for 3h; Reflux;	98%
With zinc perchlorate In methanol for 6h; Reflux;	70%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 141-97-9
ethyl acetoacetate

: 587-04-2
3-Chlorobenzaldehyde

: 727405-73-4
4-(3-chlorophenyl)-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.333333h;	98%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide In neat (no solvent) at 100℃; for 0.666667h; Reagent/catalyst; Green chemistry;	96%
With 4,4'-(butane-1,4-diyl)bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride In neat (no solvent) at 90℃; for 0.25h; Green chemistry;	92%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 541540-90-3
2,5-bis(chloromethyl)-1,3,4-oxadiazole

: 1489236-38-5
C18H16N8O

Conditions

Conditions	Yield
With potassium hydroxide In acetone Reflux;	98%

: 934-32-7
1H-benzimidazol-2-amine

: 83124-74-7
4-ethoxy-1,1,1-trichloro-3-buten-2-one

: 1320212-46-1
2-(trichloromethyl)benzo[4,5]imidazol[1,2-a]pyrimidine

Conditions

Conditions	Yield
With triethylamine In toluene for 2h; Reflux;	98%

: 934-32-7
1H-benzimidazol-2-amine

: 104-88-1
4-chlorobenzaldehyde

: 109-77-3
malononitrile

: 378760-56-6
2-amino-4-(4-chlorophenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With Ag-TiO2 nanocomposite In neat (no solvent) at 60℃; for 0.133333h; Catalytic behavior; Solvent; Temperature;	98%
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.05h; Irradiation; Green chemistry; chemoselective reaction;	97%
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.25h;	96%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 459-57-4
4-fluorobenzaldehyde

: 109-77-3
malononitrile

: 380891-82-7
2-amino-4-(4-fluorophenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.05h; Irradiation; Green chemistry;	98%
With Ag-TiO2 nanocomposite In neat (no solvent) at 60℃; for 0.133333h;	97%
With zinc ferrite In methanol at 70℃; for 1.48333h; Sonication; Green chemistry;	92%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 3132-99-8
m-bromobenzoic aldehyde

: 109-77-3
malononitrile

: 933194-36-6
2-amino-4-(3-bromophenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.0666667h;	98%
With 1-methyl-3-(trimethoxysilylpropyl)imidazolium hydrogen sulfate supported on rice husk ash In neat (no solvent) at 100℃; for 0.05h; Green chemistry;	90%
With zinc ferrite In methanol at 70℃; for 1.36667h; Sonication; Green chemistry;	90%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 122-03-2
(4-isopropylbenzaldehyde)

: 109-77-3
malononitrile

: 932995-93-2
2-amino-4-(4-isopropylphenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.0666667h;	98%
With toluene-4-sulfonic acid In neat (no solvent) at 80℃; for 0.55h; Green chemistry;	92%
With 1-methyl-3-(trimethoxysilylpropyl)imidazolium hydrogen sulfate supported on rice husk ash In neat (no solvent) at 100℃; for 0.0833333h; Green chemistry;	88%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 1122-91-4
4-bromo-benzaldehyde

: 109-77-3
malononitrile

: 1608468-74-1
2-amino-4-(4-bromophenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With Ag-TiO2 nanocomposite In neat (no solvent) at 60℃; for 0.166667h;	98%
With starch functionalized Fe3O4 nanoparticles In water at 20℃; for 0.0666667h; Irradiation; Green chemistry;	97%
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.333333h;	95%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 3132-99-8
m-bromobenzoic aldehyde

: 141-97-9
ethyl acetoacetate

: 932210-11-2
ethyl 4-(3-bromophenyl)-1,4-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylate

Conditions

Conditions	Yield
With poly(vinylpyrrolidonium) perchlorate ([PVPH]ClO4) at 100℃; for 0.666667h;	98%
With Copper-polysulfonamide complex immobilized on graphene oxide In ethanol for 0.333333h; Reflux;	95%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide In neat (no solvent) at 100℃; for 0.583333h; Reagent/catalyst; Green chemistry;	90%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 1622068-87-4
3-[3-(2-oxiranyl-ethoxy)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester

: 1622069-40-2
potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water at 100℃; for 1h; Microwave irradiation;	98%

2-AMINOBENZIMIDAZOLE Chemical Properties

The Molecular formula of 2-AMINOBENZIMIDAZOLE(934-32-7): C₇H₇N₃
The Molecular Weight of 2-AMINOBENZIMIDAZOLE(934-32-7): 133.15
Molecular Structure:

EINECS: 213-280-6
Melting point: 226-230 °C(lit.)
Boiling Point: 368.9 °C at 760 mmHg
Flash Point: 204.6 °C
Index of Refraction: 1.78
Molar Refractivity: 40.85 cm³
Molar Volume: 97.3 cm³
Polarizability: 16.19 10^-24 cm³
Surface Tension: 79.4 dyne/cm
Density: 1.367 g/cm³
Enthalpy of Vaporization: 61.56 kJ/mol
Vapour Pressure: 1.23E-05 mmHg at 25°C
IUPAC Name: 1H-benzimidazol-2-amine
Synonyms: 2-Iminobenzimidazoline;Benzimidazole, 2-amino-;2-amino-benzimidazol;USAF ek-4037;usafek-4037;2-BENZIMIDAZOLAMINE;2-BENZIMIDAZOLYLAMINE;2-AMINOBENZIMIDAZOLE;

2-AMINOBENZIMIDAZOLE Toxicity Data With Reference

1.	mma-sat 710 µmol/L	ENMUDM Environmental Mutagenesis. 3 (1981),11.
2.	mmo-sat 100 µg/plate	MUREAV Mutation Research. 15 (1972),273.
3.	orl-rat TDLo:426 mg/kg (8-15D preg):TER	THERAP Therapie. 31 (1976),505.
4.	orl-rat LDLo:500 mg/kg	NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),22.
5.	orl-mus LD40:600 mg/kg	JACSAT Journal of the American Chemical Society. 67 (1945),905.
6.	ipr-mus LD50:100 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
7.	ivn-mus LD50:126 mg/kg	29QHAQ Principles of Medicinal Chemistry Foye, W.O., eds.,Philadelphia, PA.: Lea and Febiger,1974,246.

2-AMINOBENZIMIDAZOLE Consensus Reports

Reported in EPA TSCA Inventory.

2-AMINOBENZIMIDAZOLE Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic NO_x. See also AROMATIC AMINES.
The Hazard Codes of 2-AMINOBENZIMIDAZOLE(934-32-7):

Xn
The Risk Statements information of 2-AMINOBENZIMIDAZOLE(934-32-7):
22: Harmful if swallowed
43: May cause sensitization by skin contact
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-AMINOBENZIMIDAZOLE(934-32-7):
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
WGK Germany: 3
RTECS: DD5775000
HS Code: 29339990

Product Name

2-Aminobenzimidazole

Synthetic route

2-AMINOBENZIMIDAZOLE Chemical Properties

2-AMINOBENZIMIDAZOLE Toxicity Data With Reference

2-AMINOBENZIMIDAZOLE Consensus Reports

2-AMINOBENZIMIDAZOLE Safety Profile

Related Products

Hot Products