2-Acetyl-6-methoxynaphthalene supplier

Name
2-Acetyl-6-methoxynaphthalene
EINECS 223-453-8
CAS No. 3900-45-6
Article Data105
CAS DataBase
Density 1.118 g/cm³
Solubility 760mg/L at 27℃
Melting Point 107-109 °C(lit.)
Formula C₁₃H₁₂O₂
Boiling Point 343.4 °C at 760 mmHg
Molecular Weight 200.237
Flash Point 158.9 °C
Transport Information
Appearance Light yellow-beige powder.
Safety 37/39-26-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 6-Methoxy-2-naphthyl methyl ketone;6-Methoxy-2-acetylnaphthalene;6-Acetyl-2-methoxynaphthalene;1-(6-methoxy-2-naphthalenyl)ethanone;1-(6-Methoxy-2-naphthyl)ethanone;1-(2-Methoxynaphthalen-6-yl)ethanone;NSC 105564;6'-Methoxy-2'-acetonaphthone;2'-Acetonaphthone,6'-methoxy- (6CI,7CI,8CI);
PSA 26.30000
LogP 3.05100

Synthetic route

: 129113-00-4
2-ethynyl-6-methoxynaphthalene

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With water In neat (no solvent) at 100℃; for 4h; Green chemistry;	98%
With water; silver trifluoromethanesulfonate for 5.5h; Heating;	94%
With silver(I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; water In ethyl acetate at 80℃; for 12h; Green chemistry; chemoselective reaction;	92%

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; copper(I) triflate; 5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole In N,N-dimethyl-formamide at 25℃; for 0.5h; Catalytic behavior;	97%
With 1-hydroxy-1H-1,2,3-benziodoxathiole 1,3,3-trioxide; Oxone; cetyltrimethylammonim bromide In water at 20℃; for 2h; Green chemistry; chemoselective reaction;	93%
With chromium (VI) oxide In acetonitrile at 135℃; Fixed-bed flow reactor; Inductive heating; High pressure;	92%

: 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃;	91%
With (2,2'-dipyridyl)bis(5-methyl-2-(4-fluoro)phenylpyridine-N,C)iridium(III) hexafluorophosphate; oxygen; sodium carbonate; 1,1'-diethyl-4,4'-bipyridinium diperchlorate In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 16h; Irradiation;	80%
With mercury(II) fluoride; oxygen In acetonitrile at 25℃; for 24h; Irradiation;	78%
With potassium permanganate In dichloromethane for 24h;	26%

: 95-93-2
1,2,4,5-tetramethylbenzene

: 84167-74-8
5-bromo-6-methoxy-2-acetylnaphthalene

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
aluminium trichloride	90.6%
aluminium trichloride	90.6%

: 84167-74-8
5-bromo-6-methoxy-2-acetylnaphthalene

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; aluminium trichloride In water; toluene	88.7%
aluminium trichloride	88.2%
aluminium trichloride	88.2%

: 93-04-9
2-Methoxynaphthalene

: 75-36-5
acetyl chloride

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 25℃; for 12h;	88%
With hydrogenchloride; aluminium trichloride In chloroform; nitrobenzene	63%
With aluminium trichloride In nitrobenzene for 24h;	49%

: 5672-94-6
1-acetyl-2-methoxynaphthalene

A: 93-04-9
2-Methoxynaphthalene

B: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In nitromethane at 50℃; for 18h; Product distribution;	A 86% B 9%

: 54828-56-7
2-(6-methoxynaphthalen-2-yl)acetaldehyde

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With acetic anhydride	86%
With acetic anhydride	86%

: 93-04-9
2-Methoxynaphthalene

: 108-24-7
acetic anhydride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 5672-94-6
1-acetyl-2-methoxynaphthalene

Conditions

Conditions	Yield
With antimony(III) trifluoromethanesulfonate; lithium perchlorate In nitromethane at 50℃; for 5h; Acetylation; Friedel-Crafts acylation;	A 75% B n/a
With H-beta In 1,2-dichloro-ethane at 120℃; for 3h; Kinetics; Reagent/catalyst; Friedel-Crafts Acylation; Sealed tube;	A 18.3% B 18.4%
With scandium tris(trifluoromethanesulfonate) In nitromethane at 50℃; for 18h; Friedel-Crafts reaction;	A 15% B 85 % Chromat.

...Expand

: 34352-92-6
2-methoxy-6-(prop-1-en-2-yl)-naphthalene

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; oxygen; 2,5-Dimercapto-1,3,4-thiadiazole In acetonitrile at 20 - 80℃; under 760.051 Torr; for 15h; Schlenk technique;	75%
Multi-step reaction with 3 steps 1: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 2: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 3: 35 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme

: 23981-80-8
naproxen

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; N,N,N',N'-tetramethylguanidine In acetonitrile at 20℃; for 6h; Irradiation;	72%
With sodium anthraquinone-2-sulfonate In water; acetonitrile at 20℃; for 18h; Irradiation; Green chemistry;	95 %Chromat.

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 129113-01-5
2-(1-Iodo-vinyl)-6-methoxy-naphthalene

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 129113-02-6
methyl 2-(6-methoxynaphthalen-2-yl)acrylate

Conditions

Conditions	Yield
With triethylamine; palladium In tetrahydrofuran at 65℃; under 15200 Torr; for 17h;	A 9% B 70%

...Expand

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 78191-00-1
N-Methoxy-N-methylacetamide

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - -70℃; for 1.5h;	68%

: 90708-65-9
1-(6-methoxy-2-naphthyl)-prop-1-ene

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
Stage #1: 1-(6-methoxy-2-naphthyl)-prop-1-ene With N-iodo-succinimide; cetyltrimethylammonim bromide In 1,4-dioxane; water at 115℃; for 0.25h; Microwave irradiation; Stage #2: With dipyridinium dichromate; acetic acid In 1,4-dioxane; water at 115℃; for 0.25h; Microwave irradiation;	67%

: 93-04-9
2-Methoxynaphthalene

: 108-24-7
acetic anhydride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 58149-89-6
1-(6-methoxynaphthalen-1-yl)ethanone

Conditions

Conditions	Yield
With phosphotungstic acid In tetrachloromethane at 140℃; for 3h; Solvent; Reflux; regioselective reaction;	A 22% B 56%
With phosphotungstic acid In nitrobenzene at 140℃; for 3h; Reflux; regioselective reaction;	A 38% B 8%

...Expand

: 93-04-9
2-Methoxynaphthalene

: 108-24-7
acetic anhydride

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With Amberlyst 16 WET at 90℃; for 66h;	53.8%
With zeolitic material In chlorobenzene at 100℃; for 24h; Reagent/catalyst;

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

: 143-33-9
sodium cyanide

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

C: 23979-41-1
(R)-2-(6-methoxy-2-naphthyl)propionic acid

Conditions

Conditions	Yield
Multistep reaction. Title compound not separated from byproducts;	A 51% B n/a C n/a

...Expand

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

: 143-33-9
sodium cyanide

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 133097-35-5
(S)-(-)-2-(6-methoxy-2-naphthalene)propionitrile

C: 108865-01-6
(R)-(+)-2-(6-methoxy-2-naphthalene)propionitrile

Conditions

Conditions	Yield
Stage #1: 1-(6-methoxy-2-naphthyl)ethanol With oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; Stage #2: With pyridine; phosphorus tribromide In diethyl ether at -20 - 0℃; Stage #3: sodium cyanide In N,N-dimethyl-formamide at 80℃; Title compound not separated from byproducts;	A 51% B n/a C n/a

...Expand

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 77301-42-9, 108781-65-3, 125712-80-3, 119341-64-9
(S)-1-[2-(6-methoxynaphthyl)]ethanol

C: 77301-42-9, 119341-64-9, 125712-80-3, 108781-65-3
(R)-1-(6-methoxynaphthalen-2-yl)ethanol

Conditions

Conditions	Yield
With oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr;	A 51% B n/a C n/a
With ammonium sulfate cross-linked glutaraldehyde compound-modified protein complex In water; dimethyl sulfoxide; isopropyl alcohol at 40℃; for 48h; Solvent;	A n/a B n/a C n/a

...Expand

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: (S)-1-(6-methoxy-2-naphthyl)-1-bromoethane

C: (R)-(+)-1-(6-methoxy-2-naphthyl)-1-bromoethane

Conditions

Conditions	Yield
Stage #1: 1-(6-methoxy-2-naphthyl)ethanol With oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; Stage #2: With pyridine; phosphorus tribromide In diethyl ether at -20 - 0℃; Title compound not separated from byproducts;	A 51% B n/a C n/a

...Expand

: 93-04-9
2-Methoxynaphthalene

: 75-36-5
acetyl chloride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 5672-94-6
1-acetyl-2-methoxynaphthalene

Conditions

Conditions	Yield
Stage #1: acetyl chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 0.75h; Friedel-Crafts Acylation; Inert atmosphere; Stage #2: 2-Methoxynaphthalene In 1,2-dichloro-ethane at 0℃; for 4h; Friedel-Crafts Acylation; Inert atmosphere;	A 51% B 46%

...Expand

: 27602-75-1
2-(6-methoxy-2-naphthyl)propanal

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 23981-80-8
naproxen

Conditions

Conditions	Yield
With potassium permanganate; magnesium sulfate In acetone for 2h;	A 35% B 50%

: 58601-32-4
6-methoxy-2-naphthoyl chloride

: 18815-73-1
methylzinc iodide

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With toluene

: 93-04-9
2-Methoxynaphthalene

: 75-36-5
acetyl chloride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 5672-98-0
1,6-diacetyl-2-methoxy-naphthalene

Conditions

Conditions	Yield
With aluminium trichloride; nitrobenzene

...Expand

: 93-04-9
2-Methoxynaphthalene

: 75-36-5
acetyl chloride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 102876-54-0
1,3-bis-(6-methoxy-[2]naphthyl)-but-2-en-1-one

Conditions

Conditions	Yield
With aluminium trichloride; nitrobenzene

...Expand

: 5672-94-6
1-acetyl-2-methoxynaphthalene

A: 93-04-9
2-Methoxynaphthalene

B: 3900-45-6
6-methoxy-2-acetylnaphthalene

C: 3453-55-2
1-(7-methoxy-1-naphthalenyl)ethanone

Conditions

Conditions	Yield
With indium(III) chloride In nitrobenzene at 50℃; for 3h;	A 52 % Chromat. B 32 % Chromat. C 6 % Chromat.
With indium(III) chloride In nitrobenzene at 50℃; for 12h;	A 38 % Chromat. B 23 % Chromat. C 8 % Chromat.

...Expand

: 23981-80-8
naproxen

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 30012-51-2
methyl 2-(6-methoxy-2-naphthyl)propionate

C: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

D: 132367-16-9
2-methoxy-6-(1-methoxyethyl)naphthalene

E: 1,1'-bis(6-methoxy-2-naphtyl)ethoxyethane

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In methanol for 0.5h; Product distribution; var. molar ratio of the oxidant; other oxidant; also anodic oxidation; sodium salt of naproxen;

...Expand

: 123207-06-7
4,4-Dimethoxy-3-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-pentan-2-one

: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
at 475 - 500℃; vapor-phase pyrolysis; Yield given;
at 470 - 510℃; drip type pyrrolysis unit filled with fine Vycor chips was used; Yield given;

: 93-04-9
2-Methoxynaphthalene

: 108-24-7
acetic anhydride

A: 3900-45-6
6-methoxy-2-acetylnaphthalene

B: 5672-94-6
1-acetyl-2-methoxynaphthalene

C: 3453-55-2
1-(7-methoxy-1-naphthalenyl)ethanone

Conditions

Conditions	Yield
With indium(III) chloride In 1,2-dichloro-ethane at 50℃; for 3h; Yield given. Yields of byproduct given;
With HBEA-15 In nitrobenzene for 50h; Product distribution; Kinetics; Further Variations:; Reagents; Solvents; Temperatures; reaction time;	A 68.4 % Chromat. B 23.4 % Chromat. C 8.2 % Chromat.
With H-BEA-15 zeolite In nitrobenzene at 99.85℃; under 750.06 Torr; for 1h; Product distribution; Further Variations:; reaction time;
Stage #1: acetic anhydride With Zr4+-zeolite beta(ie) In neat (no solvent) for 0.0333333h; Inert atmosphere; Stage #2: 2-Methoxynaphthalene In neat (no solvent) at 140℃; for 36h; Inert atmosphere;

...Expand

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 108781-65-3, 119341-64-9, 125712-80-3, 77301-42-9
1-(6-methoxy-2-naphthyl)ethanol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; 5% Pd on active carbon In tetrahydrofuran	100%
With methanol; sodium tetrahydroborate at 20℃; for 3h;	99%
Stage #1: 6-methoxy-2-acetylnaphthalene With bis-{[N,N′-bis(2,6-(di-isopropyl)phenyl)imidazol-2-ylidene]-(1H-1,2,4-triazol-1-yl)}copper(I) In tetrahydrofuran at 55℃; for 6h; Stage #2: With sodium hydroxide In methanol; water at 25℃; for 1.5h;	98%

: 75-77-4
chloro-trimethyl-silane

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 151-50-8
potassium cyanide

: 107727-73-1
2-(6-methoxy-2-naphthyl)-2-(trimethylsilyloxy)propiononitrile

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 13.5h;	100%

...Expand

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: trimethyl sulfonium hydrogen sulfate

: 27602-74-0
2-(6-methoxynaphth-2-yl)-1,2-propylene oxide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane at 30℃; for 3h;	99.4%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 77301-42-9, 119341-64-9, 125712-80-3, 108781-65-3
(R)-1-(6-methoxynaphthalen-2-yl)ethanol

Conditions

Conditions	Yield
Stage #1: 6-methoxy-2-acetylnaphthalene With cobalt(II) acetate; bis-[2-((4S)-4-phenyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine In tetrahydrofuran at 65℃; Inert atmosphere; Stage #2: With diethoxymethylane In tetrahydrofuran at 65℃; optical yield given as %ee; enantioselective reaction;	99%
Stage #1: 6-methoxy-2-acetylnaphthalene With (R)-(3,4,5-trimethoxyphenyl)-MeOBIPHEP; TPGS-750-M; copper(II) acetate monohydrate In water; toluene at 22℃; for 1.5h; Sealed tube; Inert atmosphere; Schlenk technique; Green chemistry; Stage #2: In water; toluene at 0 - 22℃; Catalytic behavior; Temperature; Reagent/catalyst; Sealed tube; Inert atmosphere; Schlenk technique; Green chemistry; enantioselective reaction;	91%
With borane-THF; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; enantioselective reaction;	89%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 77086-38-5
ketene t-butyldimethylsilyl methyl acetal

: C22H32O4Si

Conditions

Conditions	Yield
With C90H89F6N3O8P2S2 In diethyl ether at 20℃; for 12h; Temperature; Mukaiyama Aldol Addition; enantioselective reaction;	99%

: 110-91-8
morpholine

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 53077-21-7
2-(6-methoxynaphthalen-2-yl)-1-morpholinoethanethione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; sulfur at 130℃; for 45h; Willgerodt-Kindler reaction;	98%
With sulfur at 140℃;

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 1000375-33-6
2-iodo-1-(6-methoxy-2-naphthyl)ethanone

Conditions

Conditions	Yield
With iodine; copper(II) oxide In methanol for 2h; Heating;	98%
Stage #1: 6-methoxy-2-acetylnaphthalene With iodine In methanol Stage #2: With sodium sulfite

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 84167-74-8
5-bromo-6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With Oxone; ammonium bromide In methanol at 20℃; for 0.666667h; regioselective reaction;	97%
With dihydrogen peroxide; ammonium bromide; acetic acid at 20℃; for 5h;	81%
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 4h; Inert atmosphere;	80%
With phenyltrimethylammonium tribromide In tetrahydrofuran; water at 25℃; for 25h;	90 % Chromat.

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 10441-41-5
1-(6-hydroxy-2-naphthyl)ethan-1-one

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane; water at 85℃; for 4h;	96%
With hydrogenchloride In water for 2h; Reflux;	95.7%
With hydrogenchloride In water at 90℃; for 2h;	91%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 124-41-4
sodium methylate

: 901766-67-4
methyl (E)-3-(6-methoxynaphthalen-2-yl)but-2-enoate

Conditions

Conditions	Yield
In methanol; N,N-dimethyl-formamide at 0 - 25℃; for 20h; Horner-Wadsworth-Emmons reaction;	96%

...Expand

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 10262-65-4
2-bromo-1-(6-methoxy-2-naphthyl)ethanone

Conditions

Conditions	Yield
With copper(I) bromide In ethanol at 60℃; Inert atmosphere;	95%
With 1-butyl-3-methylimidazolium tribromide In neat (no solvent) for 0.166667h;	93.6%
With potassium bromate; water; potassium bromide In ethanol for 0.75h;	77%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 100-52-7
benzaldehyde

: (E)-1-(6-methoxynaphthalen-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
With fly-ash:H2SO4 Aldol condensation; Microwave irradiation; Neat (no solvent);	95%
With SiO2-H3PO4 Aldol Condensation; Microwave irradiation;	85%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 13101-88-7
6-methoxy-2-naphthylamine

Conditions

Conditions	Yield
With methanol; O-benzenesulfonyl-acetohydroxamic acid ethyl ester; toluene-4-sulfonic acid at 23℃; for 9h; Reagent/catalyst; Inert atmosphere;	95%
With O-benzenesulfonyl-acetohydroxamic acid ethyl ester; toluene-4-sulfonic acid In methanol at 20℃; for 24h; Inert atmosphere;	90%
Multi-step reaction with 2 steps 1: HN3, H2SO4 / CHCl3 2: aq. H2SO4 / ethanol View Scheme
With sulfuric acid; trifluoroacetic acid In ethanol; water

: 589-18-4
4-Methylbenzyl alcohol

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 1-(6-methoxy naphthalen-2-yl)-3-p-tolylpropan-1-ol

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; rhodium(III) acetylacetonate; potassium hydroxide In toluene at 110℃; for 4h; Sealed tube;	95%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: (E)-3-(dimethylamino)-1-(6-methoxynaphthalen-2-yl)prop-2-en-1-one

Conditions

Conditions	Yield
at 120℃; for 48h; Inert atmosphere;	95%

: 2942-58-7
diethyl cyanophosphonate

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 2408-36-8
lithium cyanide

: 3-cyano-1,5-diphenylpentan-3-yl diethylphosphate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h;	95%

...Expand

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 91-56-5
indole-2,3-dione

: 2-(6-methoxynaphthalen-2-yl)quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In water Pfitzinger Quinoline Synthesis; Reflux;	94%
With potassium hydroxide

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 6-bromo-2-(6-methoxynaphthalen-2-yl)quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In water Reflux;	94%
With potassium hydroxide

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 133097-30-0
<1-(6-Methoxy-2-naphthyl)ethyl>amin

Conditions

Conditions	Yield
With 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate In methanol at 80℃; for 12h; Inert atmosphere; chemoselective reaction;	94%
With ammonium acetate; ammonia; hydrogen; nickel In 1,4-dioxane at 100℃; under 76000.1 Torr; for 3h;	82%
With ammonium acetate; sodium cyanoborohydride
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride / methanol / 4 h / 50 °C / Inert atmosphere 2: raney nickel / methanol / 16 h / 80 °C / Inert atmosphere View Scheme

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 3893-38-7
1-(6-methoxynaphthalen-2-yl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol at 50℃; for 4h; Inert atmosphere;	93%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 5123-13-7
5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane

: 1188303-98-1
1-(6-methoxynaphthalen-2-yl)-1-phenylethanol

Conditions

Conditions	Yield
Stage #1: 6-methoxy-2-acetylnaphthalene; 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane With bis(1,5-cyclooctadiene)nickel (0); N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; cesium fluoride In toluene at 30 - 80℃; Inert atmosphere; Stage #2: With 2,2'-iminobis[ethanol] In tetrahydrofuran; toluene at 20℃; Inert atmosphere;	93%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: C13H14N2O

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; for 12h;	93%

: 5927-18-4
trimethyl phosphonoacetate

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 136691-28-6
3-(6-methoxynaphthalen-2-yl)but-2-enoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: trimethyl phosphonoacetate; 6-methoxy-2-acetylnaphthalene With lithium hexamethyldisilazane at 10 - 20℃; for 0.0833333h; Stage #2: 6-methoxy-2-acetylnaphthalene In tetrahydrofuran at 50℃; for 14h;	92%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 21388-17-0
2-methoxy-6-ethylnaphthalene

Conditions

Conditions	Yield
With palladium 10% on activated carbon In methanol; chlorobenzene at 25℃; for 2h; Sealed tube;	91%
With sodium tetrahydroborate; trifluoroacetic acid at 0 - 20℃;	60%
With hydrazine hydrate; diethylene glycol at 120℃; Versetzen mit KOH und Kochen des Reaktionsgemisches unter Abdestillieren des entstehenden Wassers;

: 917-64-6
methyl magnesium iodide

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 34352-83-5
2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene

Conditions

Conditions	Yield
In diethyl ether 1.) 20 deg C, 10 h, 2.) reflux, 30 min;	90%

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 77301-42-9, 108781-65-3, 125712-80-3, 119341-64-9
(S)-1-[2-(6-methoxynaphthyl)]ethanol

Conditions

Conditions	Yield
Stage #1: 6-methoxy-2-acetylnaphthalene With C32H41CrN3O2Si; C7H14O4Si In toluene at -40 - 20℃; for 2h; Stage #2: With potassium carbonate In methanol for 1h; enantioselective reaction;	90%
With Daucus carota root In water at 20℃; for 42h;	78%
Daucas carota root; extract of In water at 37 - 40℃; for 42h; pH=7.0; Conversion of starting material; Enzymatic reaction; Aqueous phosphate buffer;	78%

2-Acetyl-6-methoxynaphthalene Chemical Properties

IUPAC Name: 1-(6-Methoxynaphthalen-2-yl)ethanone
Empirical Formula: C₁₃H₁₂O₂
Molecular Weight: 200.2332
Freely Rotating Bonds: 2
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.594
Molar Refractivity: 60.8 cm³
Molar Volume: 179 cm³
Polarizability: 24.1 ×10^-24cm³
Surface Tension: 40.9 dyne/cm
Density: 1.118 g/cm³
Flash Point: 158.9 °C
Enthalpy of Vaporization: 58.73 kJ/mol
Boiling Point: 343.4 °C at 760 mmHg
Vapour Pressure: 7.04E-05 mmHg at 25°C
The Cas Register Number of 2-Acetyl-6-methoxynaphthalene is 3900-45-6.The chemical synonyms of 2-Acetyl-6-methoxynaphthalene (CAS NO.3900-45-6) are 1-(6-Methoxy-2-naphthyl)ethan-1-one.The molecular structure of 2-Acetyl-6-methoxynaphthalene (CAS NO.3900-45-6) is
.

2-Acetyl-6-methoxynaphthalene Uses

2-Acetyl-6-methoxynaphthalene (CAS NO.3900-45-6) is used as pharmaceutical intermediate.

2-Acetyl-6-methoxynaphthalene Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 37/38-36/37/38
R37/38: Irritating to respiratory system and skin.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26-36/37
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
Hazard Note: Irritant

Product Name

2-Acetyl-6-methoxynaphthalene

Synthetic route

2-Acetyl-6-methoxynaphthalene Chemical Properties

2-Acetyl-6-methoxynaphthalene Uses

2-Acetyl-6-methoxynaphthalene Safety Profile

Related Products

Hot Products