Conditions | Yield |
---|---|
With sulfuric acid; hydrogen In water at 90℃; under 3750.38 - 52505.3 Torr; for 8.5h; Reagent/catalyst; | 93.7% |
With phosphoric acid; hydrogen; pyrographite In water at 65℃; under 18751.9 Torr; for 6.4h; pH=2; Reagent/catalyst; Autoclave; | 79.3% |
With tetrahydrofuran; lithium aluminium tetrahydride |
(1'S)-N-(2'-ethyl-1'-hydroxyethyl)-1H-isoindole-1,3(2H)-dione
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With ethylenediamine In ethanol for 18h; deprotection; Heating; | 92% |
(-)-(3R,5S)-5-ethyl-3-phenylmorpholin-2-one
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol under 112509 Torr; for 72h; | 84% |
With hydrogen; palladium on activated charcoal In methanol under 114000 Torr; for 72h; Hydrogenolysis; ring cleavage; methanolysis; | 84% |
Conditions | Yield |
---|---|
With ammonium hydroxide; formate dehydrogenase; amine dehydrogenase-M0; H3N*CH2O2*H(1+); nicotinamide adenine dinucleotide In dimethyl sulfoxide at 30℃; for 24h; pH=8.9; Reagent/catalyst; enantioselective reaction; | 84% |
With (R)-1-phenyl-ethyl-amine; (R)-ω-transaminase from Mycobacterium vanbaalenii; NAD Enzymatic reaction; enantioselective reaction; | |
With glucose dehydrogenase; ammonium hydroxide; D-glucose; NAD; ammonium chloride; lysozyme; DNase I In water at 40℃; for 24h; pH=9; Catalytic behavior; Kinetics; Temperature; Reagent/catalyst; pH-value; Concentration; Enzymatic reaction; enantioselective reaction; | n/a |
N-(1-hydroxybutan-2-yl)-2-phenylacetamide
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With penicillin G acylase; Eupergit C In water at 30℃; for 0.583333h; pH=7.8; Hydrolysis; Enzymatic reaction; | 70% |
(S)-2-(1,2-dibenzyloxycarbonylhydrazinyl)-1-butanol
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With hydrogen; nickel; acetic acid In methanol under 9000.72 Torr; for 24h; | 70% |
(3S,6S)-3,6-diethylpiperazine-2,5-dione
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With C24H20ClN2OPRu; potassium tert-butylate; hydrogen In tetrahydrofuran at 110℃; under 2280.15 - 30402 Torr; for 48h; Inert atmosphere; Schlenk technique; Autoclave; | 68% |
(S)-2-(N-benzylamino)-1-butanol
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With hydrogen; acetic acid; palladium on activated charcoal In methanol for 24h; Ambient temperature; | 54% |
2-aminobutanol
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
Stage #1: 2-aminobutanol With O,O'-dibenzoyl-L-tartaric acid In acetone at 25℃; for 6h; Stage #2: With potassium hydroxide In dichloromethane | 32% |
With L-glutamic acid | |
With C22H30N6O2(2+)*2Br(1-); copper dichloride In ethanol; water | 148 mg |
With pyridoxal 5'-phosphate; (R)-1-phenyl-ethyl-amine In aq. phosphate buffer at 30℃; for 6h; pH=7; Enzymatic reaction; | n/a |
(S)-(-)-2--1-butanol
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With sodium hydroxide at 80℃; for 2h; |
(S)-(-)-2-butyl acetate
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With sodium hydroxide at 80℃; for 2h; |
2-aminobutanol
A
(2R)-2-aminobutan-1-ol
B
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 20℃; Purification / work up; | |
With glutaraldehyde crosslinked with chitosan In water under 775.743 - 1551.49 Torr; for 10h; Inert atmosphere; Resolution of racemate; |
Conditions | Yield |
---|---|
With potassium hydroxide Inert atmosphere; |
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With calcium hydroxide In water pH=10.6; |
Conditions | Yield |
---|---|
With penicillin G acylase from Bacillus megaterium immobilized on polymethacrylate; purchased from NovoCata (200 U/g); ammonia In water at 40℃; for 32h; pH=7.8; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C n/a D n/a |
N-(1-hydroxybutan-2-yl)-2-phenylacetamide
A
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With penicillin G acylase from Bacillus megaterium immobilized on polymethacrylate; purchased from NovoCata (200 U/g); ammonia In water at 40℃; for 6h; pH=7.8; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C n/a |
N-(1-hydroxybutan-2-yl)-2-phenylacetamide
A
(2R)-2-aminobutan-1-ol
B
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With penicillin G acylase from Bacillus megaterium immobilized on polymethacrylate; purchased from NovoCata (200 U/g); ammonia In water at 40℃; for 10h; pH=7.8; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C n/a D n/a |
Conditions | Yield |
---|---|
With penicillin G acylase from Bacillus megaterium immobilized on polymethacrylate; purchased from NovoCata (200 U/g); ammonia In water at 40℃; for 26h; pH=7.8; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
Conditions | Yield |
---|---|
With pyridoxal 5'-phosphate; (R)-1-phenyl-ethyl-amine In aq. phosphate buffer; Hexadecane at 30℃; for 5h; pH=7.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; | n/a |
Conditions | Yield |
---|---|
With (R)-1-phenyl-ethyl-amine; (R)-ω-transaminase from Mycobacterium vanbaalenii; 2,3 butanediol dehydrogenase from Bacillus subtilis; polyol dehydrogenase from from Gluconobacter oxydans; NAD at 30℃; pH=7.4; Enzymatic reaction; enantioselective reaction; |
Conditions | Yield |
---|---|
With Raney nickel In methanol at 60℃; for 0.2h; |
2-aminobutanol
A
(S)-2-aminobutan-1-ol
B
1-Hydroxy-2-butanone
Conditions | Yield |
---|---|
With recombinant cyclohexylamine oxidase from Arthrobacter sp. TYUT010-15 In aq. phosphate buffer at 30℃; for 3h; pH=7; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
(S)-2-aminobutan-1-ol
di-tert-butyl dicarbonate
(S)-tert-butyl 1-hydroxybutan-2-ylcarbamate
Conditions | Yield |
---|---|
In dichloromethane at 0℃; | 100% |
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 2h; Inert atmosphere; | 100% |
With sodium hydroxide In dichloromethane Ambient temperature; | 94% |
(S)-2-aminobutan-1-ol
(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one
(S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide
Conditions | Yield |
---|---|
In toluene at 100℃; for 17h; Inert atmosphere; | 99.5% |
(S)-2-aminobutan-1-ol
2-Nitrobenzenesulfonyl chloride
(S)-N-(1-hydroxy-butan-2-yl)-2-nitro-benzenesulfonamide
Conditions | Yield |
---|---|
Stage #1: (S)-2-aminobutan-1-ol With triethylamine In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2-Nitrobenzenesulfonyl chloride In tetrahydrofuran at 20℃; for 0.25h; | 99% |
(S)-2-aminobutan-1-ol
ethyl isocyanate
(S)-1-ethyl-3-(1-hydroxybutan-2-yl)urea
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 3h; | 99% |
Conditions | Yield |
---|---|
In ethanol at 78 - 80℃; for 9.5h; Solvent; Temperature; | 98.01% |
(heating); |
(S)-2-aminobutan-1-ol
diethyl 2-ethoxymethylenemalonate
2-[(1-hydroxymethylpropylamino)methylene]malonic acid diethyl ester
Conditions | Yield |
---|---|
In ethanol at 28℃; for 0.5h; | 98% |
(S)-2-aminobutan-1-ol
1,3,5-tris[4-(S)-(1-hydroxymethylpropylimino)benzyloxycarbonyl]benzene
Conditions | Yield |
---|---|
In chloroform at 20℃; for 24h; | 98% |
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With sodium sulfate In ethanol for 12h; Reflux; | 98% |
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Schlenk technique; | 98% |
(S)-2-aminobutan-1-ol
benzyl bromide
(2S)-N,N-dibenzyl-2-aminobutan-1-ol
Conditions | Yield |
---|---|
Stage #1: (S)-2-aminobutan-1-ol With sodium hydroxide; potassium carbonate In methanol for 0.5h; Metallation; Heating; Stage #2: benzyl bromide In methanol for 6h; Alkylation; Heating; | 97% |
With potassium carbonate In acetonitrile at 20℃; for 24h; | 97.3% |
With potassium carbonate In acetonitrile at 20℃; for 24h; | 97.3% |
(S)-2-aminobutan-1-ol
tert-butylchlorodiphenylsilane
(1S)-1-(t-butyldiphenylsilyloxymethyl)propylamine
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 20℃; for 16h; | 97% |
(S)-2-aminobutan-1-ol
di-tert-butyl dicarbonate
(S)-2-t-butoxycarbonylaminopropan-1-ol
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere; | 97% |
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 80℃; for 2h; Inert atmosphere; | 96.5% |
(S)-2-aminobutan-1-ol
benzenesulfonyl chloride
(S)-N-benzenesulfonyl-2-amino-1-butanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 3℃; for 4h; | 96% |
Conditions | Yield |
---|---|
In toluene for 24h; Reflux; water segregator; | 96% |
(S)-2-aminobutan-1-ol
Diethyl carbonate
(S)-(-)-4-ethyl-2-oxazolidinone
Conditions | Yield |
---|---|
With potassium carbonate at 120℃; for 3h; | 96% |
With 1,3-dichlorotetrabutyldistannoxane at 80℃; for 1h; | 98.5 %Chromat. |
Conditions | Yield |
---|---|
With copper(l) iodide; copper(ll) bromide In acetonitrile at 60℃; for 0.5h; Microwave irradiation; Sealed tube; | 96% |
(S)-2-aminobutan-1-ol
4-Chlorobutanoyl chloride
1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one
Conditions | Yield |
---|---|
With potassium hydroxide; sodium sulfate In toluene at 0 - 20℃; for 10h; | 95% |
With sodium sulfate; potassium hydroxide In toluene at 0℃; for 13h; | 80% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; | 95% |
(S)-2-aminobutan-1-ol
(R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane
Conditions | Yield |
---|---|
In methanol for 24h; | A 95% B n/a |
(S)-2-aminobutan-1-ol
Conditions | Yield |
---|---|
Stage #1: N-(3-fluorobenzyl)-4,6-bis(perfluorophenoxy)-1,3,5-triazin-2-amine With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.0833333h; Cooling with ice; Stage #2: (S)-2-aminobutan-1-ol In dichloromethane at 0 - 20℃; for 72.0833h; | 95% |
(S)-2-aminobutan-1-ol
p-toluenesulfonyl chloride
(S) (+)-N-tosyl-2-aminobutanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 3℃; for 4h; | 94% |
With triethylamine In dichloromethane | |
With triethylamine In dichloromethane at 20℃; for 18h; | |
Stage #1: (S)-2-aminobutan-1-ol With triethylamine In dichloromethane at 0℃; for 0.0833333h; Stage #2: p-toluenesulfonyl chloride In dichloromethane at 20℃; |
phthalic anhydride
(S)-2-aminobutan-1-ol
(1'S)-N-(2'-ethyl-1'-hydroxyethyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
at 140℃; | 93% |
at 200℃; for 3h; | 92% |
at 140℃; | |
With triethylamine In toluene at 130℃; for 3h; Inert atmosphere; Dean-Stark; |
ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid
(S)-2-aminobutan-1-ol
(-)-N,N,N',N'-tetrakis{[4-(S)-ethyloxazolin-2-yl]methyl}ethylene glycol bis(2-aminoethyl) ether
Conditions | Yield |
---|---|
Stage #1: ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid; (S)-2-aminobutan-1-ol In toluene for 20h; Reflux; Stage #2: at 135℃; for 8h; | 93% |
Conditions | Yield |
---|---|
With tetrabutylammonium triphenyldifluorosilicate In dimethylsulfoxide-d6 at 150℃; under 760.051 Torr; for 9h; chemoselective reaction; | 93% |
With caesium carbonate In dimethylsulfoxide-d6 at 25 - 150℃; under 2280.15 Torr; for 24h; Schlenk technique; Autoclave; | 51% |
(S)-2-aminobutan-1-ol
methyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate
Conditions | Yield |
---|---|
In xylene for 8h; Heating; | 92% |
(S)-2-aminobutan-1-ol
8-bromotheophylline
(S)-(-)-8-(1-hydroxy-2-butyl)-aminotheophylline
Conditions | Yield |
---|---|
In xylene for 20h; Heating; | 92% |
(S)-2-aminobutan-1-ol
(R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In xylene for 8h; Heating; | 91% |
The 2-Amino-1-butanol, with the CAS registry number 5856-62-2, is also known as (2S)-2-aminobutan-1-ol. It belongs to the product categories of Pharmaceutical Intermediates; Amino Alcohols (Chiral); Chiral Building Blocks; Synthetic Organic Chemistry; Amino Alcohols; Chiral Building Blocks; Organic Building Blocks. Its EINECS registry number is 227-475-9. This chemical's molecular formula is C4H11NO and molecular weight is 89.13624. Its IUPAC name is called 2-aminobutan-1-ol. What's more, this chemical is clear colorless to slightly yellowish viscous.
Physical properties of 2-Amino-1-butanol: (1)ACD/LogP: -0.43; (2)ACD/LogD (pH 5.5): -3.52; (3)ACD/LogD (pH 7.4): -2.98; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.445; (12)Molar Refractivity: 25.6 cm3; (13)Molar Volume: 96.1 cm3; (14)Surface Tension: 35.3 dyne/cm; (15)Density: 0.927 g/cm3; (16)Flash Point: 82.2 °C; (17)Enthalpy of Vaporization: 48.14 kJ/mol; (18)Boiling Point: 177.2 °C at 760 mmHg; (19)Vapour Pressure: 0.319 mmHg at 25°C.
This product is used in the preparation of emulsifier, surfactant, resin agent, polishing wax, vulcanization accelerator, pharmaceutical raw materials; acid gas absorber. This chemical can be used for the removal of hydrogen sulfide, dihydrogen dioxide. This product is widely used as a derivative of the reagents, reaction promoter.
When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact and may cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.
You can still convert the following datas into molecular structure:
(1)SMILES: OC[C@@H](N)CC
(2)InChI: InChI=1/C4H11NO/c1-2-4(5)3-6/h4,6H,2-3,5H2,1H3/t4-/m0/s1
(3)InChIKey: JCBPETKZIGVZRE-BYPYZUCNBQ
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