2-Amino-5-bromopyridine supplier

Name
2-Amino-5-bromopyridine
EINECS 214-019-9
CAS No. 1072-97-5
Article Data92
CAS DataBase
Density 1.71 g/cm³
Solubility Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.
Melting Point 135-138 °C
Formula C₅H₅BrN₂
Boiling Point 230.9 °C at 760 mmHg
Molecular Weight 173.012
Flash Point 93.4 °C
Transport Information UN 2811 6.1/PG 3
Appearance Light yellow crystal
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 5-Bromo-2-pyridylamine;5-bromopyridin-2-amine;5-bromo-1H-pyridin-2-amine;2-amino-5-bromothiazolo[5,4-b]pyridine;2-Amino-5-Bromo Pyridine;2-amino-5-bromopyridin;sell: 2-amino-5-bromopyridine;
PSA 38.91000
LogP 2.00750

Synthetic route

: 504-29-0
2-aminopyridine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetone at 0 - 20℃;	98%
With N-Bromosuccinimide In acetonitrile at 20℃; for 2h;	98%
With N-Bromosuccinimide In acetonitrile at 20℃; for 2h;	98%

: 504-29-0
2-aminopyridine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 35486-42-1
2-amino-3,5-dibromopyridine

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In chloroform at 20℃; for 0.0333333h; other reagent: tetraphenylphosphonium tribromide;	A 98% B 2%
With N-Bromosuccinimide; lithium perchlorate; silica gel In dichloromethane at 20℃; for 0.0833333h;	A 90% B 10%
With bromine In ethanol at 20℃;	A 76% B 12%

: 504-29-0
2-aminopyridine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 408352-48-7
2-amino-4,6-dibromopyridine

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In chloroform for 0.0333333h; Ambient temperature;	A 98% B 2%

: 39856-50-3
5-bromo2-nitropyridine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With tetrahydroxydiboron; 5%-palladium/activated carbon; water In acetonitrile at 50℃; for 24h;	96%
With potassium borohydride; TPGS-750-M In tetrahydrofuran; water at 20℃; for 20h; Inert atmosphere;	91%
With potassium tert-butylate; isopropyl alcohol; bis(pinacol)diborane at 110℃; for 2h;	90%

: 444811-18-1
5-bromo-N,N-bis[(4-methoxyphenyl)methyl]pyridin-2-amine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 5h;	90%

: 19596-07-7
pent-4-ynenitrile

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With hydrogen bromide; bromine; sodium hydroxide In dichloromethane; water at 30 - 45℃;	89.9%

: 33245-29-3
5-bromo-2-nitraminopyridine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With 50percent aq. HPO2 for 5h; Heating;	88%

: 664988-25-4
2-[(N,N-dibenzyl)amino]-5-bromopyridine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In acetonitrile at 20℃; for 0.5h;	87%

: 766-11-0
5-bromo-2-fluoropyridine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;	86%
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h;	86%
With ammonia; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 180℃; for 2h;

: 148292-03-9
pyridinium N-<2'-(3',5'-dibromopyridyl)>aminide

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With zinc In acetic acid for 29h; Ambient temperature;	75%

: 157020-26-3
pyridinium N-<2'-(5'-bromopyridyl)>aminide

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With triethylammonium formate; platinum on activated charcoal In acetonitrile for 4h; Heating;	63%
With acetic acid; zinc

: 899452-28-9
5-bromo-1-(difluoromethyl)pyridin-2(1H)-imine

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With potassium hydroxide at 100℃; for 2h;	63%

: 504-29-0
2-aminopyridine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 13534-99-1
2-Amino-3-bromopyridine

Conditions

Conditions	Yield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In N,N-dimethyl-formamide at 30℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube; regioselective reaction;	A 50% B 25%

: 1616981-13-5
(E)-5-bromo-2-((4-chlorophenyl)diazenyl)pyridine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 1616981-14-6
N1-(5-bromopyridin-2-yl)-5-chlorobenzene-1,2-diamine

Conditions

Conditions	Yield
Stage #1: (E)-5-bromo-2-((4-chlorophenyl)diazenyl)pyridine With trimethylsilyl iodide In hexane at 0 - 20℃; for 8h; Benzidine Rearrangement; Stage #2: With hydrogenchloride; tin(ll) chloride In ethanol; water at 110℃; for 2h; Benzidine Rearrangement;	A 40% B 37%

: 39856-50-3
5-bromo2-nitropyridine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 14916-65-5
6-nitropyridin-3-ylamine

Conditions

Conditions	Yield
With ammonium hydroxide at 150℃;

: 89284-11-7
5,6-dibromopyridin-2-ylamine

palladium/charcoal: palladium/charcoal

methanol. NaOH: methanol. NaOH

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

picolinic acid amide: picolinic acid amide

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
With potassium hydroxide; bromine

: 1452-77-3
pyridine-2-carboxylic acid amide

: 7726-95-6
bromine

diluted KOH-solution: diluted KOH-solution

A: 504-29-0
2-aminopyridine

B: 1072-97-5
5-bromo-2-pyridylamine

C: 35486-42-1
2-amino-3,5-dibromopyridine

...Expand

: 39856-50-3
5-bromo2-nitropyridine

: 64-17-5
ethanol

: 7664-41-7
ammonia

A: 1072-97-5
5-bromo-2-pyridylamine

B: 14916-65-5
6-nitropyridin-3-ylamine

Conditions

Conditions	Yield
at 150℃;

...Expand

: 39856-50-3
5-bromo2-nitropyridine

: ammonium hydroxide

A: 1072-97-5
5-bromo-2-pyridylamine

B: 14916-65-5
6-nitropyridin-3-ylamine

Conditions

Conditions	Yield
at 150℃;

...Expand

: 64500-14-7
N-(5-bromopyridin-2-yl)-3-oxobutanamide

: 7664-93-9
sulfuric acid

A: 1072-97-5
5-bromo-2-pyridylamine

B: 64500-11-4
7- bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

...Expand

: 624-28-2
2,5-dibromopyridine

: 107-21-1
ethylene glycol

A: 1072-97-5
5-bromo-2-pyridylamine

B: 2-((5 bromopyridin-2-yl)oxy)ethanol

Conditions

Conditions	Yield
With copper(I) oxide; ammonia at 60℃; for 40h;

...Expand

: 46224-49-1
(pyridin-1-iumyl)[(pyridin-2-yl)aminide]

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Br2 / CH2Cl2 / 0 °C 2: Zn, acetic acid View Scheme

: 138888-98-9
N’-(5-bromopyridin-2-yl)-N,N-dimethylformimidamide

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water / 1 h / 140 °C / Microwave irradiation; Inert atmosphere; Sealed tube 2: ammonium acetate View Scheme

: 5-bromo-N-formyl-N-(3-oxobutyl)-2-pyridylamine

A: 1072-97-5
5-bromo-2-pyridylamine

B: 78-94-4
methyl vinyl ketone

Conditions

Conditions	Yield
With ammonium acetate

: 5231-96-9
N-(2-pyridyl)acetamide

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
Stage #1: N-(2-pyridyl)acetamide With bromine at 20 - 50℃; for 2.5h; Stage #2: With sodium hydroxide In water for 0.5h; Temperature;	14.1 g

: pyridine-2-ylcarbamic acid

: 1072-97-5
5-bromo-2-pyridylamine

Conditions

Conditions	Yield
Stage #1: pyridine-2-ylcarbamic acid With bromine at 20 - 50℃; for 2.5h; Stage #2: With sodium hydroxide In water for 0.5h; Temperature;	14.1 g

: 1072-97-5
5-bromo-2-pyridylamine

: 98-59-9
p-toluenesulfonyl chloride

: 207801-52-3
N-(5-bromopyridin-2-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With pyridine at 0 - 90℃;	100%
With pyridine at 0 - 90℃;	100%
With pyridine at 20 - 90℃; for 24h;	98%

: 107-20-0
2-chloroethanal

: 1072-97-5
5-bromo-2-pyridylamine

: 6188-23-4
6-bromoimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Stage #1: 2-chloroethanal; 5-bromo-2-pyridylamine In ethanol; water for 3h; Reflux; Stage #2: With sodium hydrogencarbonate In water	100%
In ethanol; water at 80℃; for 15h;	100%
In ethanol for 6h; Reflux;	98%

: 1072-97-5
5-bromo-2-pyridylamine

: 638-07-3
ethyl (2-chloroaceto)acetate

: 59128-04-0
ethyl 2-(6-bromoimidazo[1,2-a]pyridin-2-yl)acetate

Conditions

Conditions	Yield
In ethanol for 4h; Reflux; Inert atmosphere;	100%
In toluene Reflux;	24%
In toluene at 115℃; for 18h;
In ethanol Heating / reflux;

: 1072-97-5
5-bromo-2-pyridylamine

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 1010120-60-1
ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

Conditions

Conditions	Yield
In dichloromethane at 5 - 20℃; for 16.25h;	100%
In dichloromethane at 5 - 20℃; for 16.25h;	100%
In 1,4-dioxane at 25℃; for 18h; Inert atmosphere;	100%

: 1072-97-5
5-bromo-2-pyridylamine

: 1663-39-4
tert-Butyl acrylate

: 227938-85-4
(E)-tert-butyl 3-(6-aminopyridin-3-yl)acrylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate In N,N-dimethyl-formamide; propiononitrile at 100℃; for 20h; Inert atmosphere;	100%

: 1072-97-5
5-bromo-2-pyridylamine

: 111-25-1
1-bromo-hexane

: 5-bromo-N,N-dihexylpyridin-2-amine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 50℃;	100%
With sodium hydride In tetrahydrofuran at 50℃; Reflux;

: 1072-97-5
5-bromo-2-pyridylamine

: 1663-67-8
malonoyl dichloride

: 7-bromo-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
In dichloromethane at 0 - 15℃; for 48h;	100%
In dichloromethane at 0 - 15℃; for 48h; Inert atmosphere;	84%

: 1072-97-5
5-bromo-2-pyridylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: N-(5-bromopyridin-2-yl)cyclopropylcarboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Cooling with ice;	100%

: 1072-97-5
5-bromo-2-pyridylamine

: 84249-02-5
2-nitroamino-4-bromopyridine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at -8℃; for 0.333333h;	99.2%

: 1072-97-5
5-bromo-2-pyridylamine

: 108-24-7
acetic anhydride

: 7169-97-3
N-(5-bromopyridin-2-yl)acetamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; Industrial scale;	99.04%
at 80℃; for 24h;	97%
With pyridine In tetrahydrofuran at 20℃;	92%

: 1072-97-5
5-bromo-2-pyridylamine

: 28539-02-8
1-Hydroxymethyl-1H-benzotriazole

: 111184-64-6
Benzotriazol-1-ylmethyl-(5-bromo-pyridin-2-yl)-amine

Conditions

Conditions	Yield
In ethanol for 5h; Ambient temperature;	99%

: 1072-97-5
5-bromo-2-pyridylamine

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 100-52-7
benzaldehyde

: 6-bromo-N-(tert-butyl)-2-phenylimidazo[1,2-a]pyridin-3-amine

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 20℃; for 3h;	99%
With cellulose sulfuric acid In methanol at 20℃; for 2h;	98%
With sulfuric acid; silica gel In methanol at 20℃; for 3h;	97%

...Expand

: 1072-97-5
5-bromo-2-pyridylamine

: 73183-34-3
bis(pinacol)diborane

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

Conditions

Conditions	Yield
With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate In 1,4-dioxane at 80℃; for 16h; Temperature; Solvent; Inert atmosphere;	99%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 12h;	75%
With 10H-phenothiazine; caesium carbonate In acetonitrile for 48h; Irradiation; Sealed tube; Inert atmosphere;	62%

: 1072-97-5
5-bromo-2-pyridylamine

: 110-13-4
2,5-hexanedione

: 228710-82-5
5-bromo-2-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Conditions

Conditions	Yield
In toluene for 14h; Reflux; Dean-Stark; Inert atmosphere;	99%
With toluene-4-sulfonic acid In toluene for 14h; Heating / reflux;	92%
toluene-4-sulfonic acid In toluene for 14h; Heating / reflux; Dean Stark conditions;	92%

: 1072-97-5
5-bromo-2-pyridylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 138888-98-9
N’-(5-bromopyridin-2-yl)-N,N-dimethylformimidamide

Conditions

Conditions	Yield
In methanol at 70℃; for 16h;	99%
In methanol at 70℃; for 6h;	82%
In N,N-dimethyl-formamide at 130℃; for 12h; Inert atmosphere;	76%

: 1072-97-5
5-bromo-2-pyridylamine

: 557-20-0
diethylzinc

: 19842-07-0
5-ethylpyridin-2-yl amine

Conditions

Conditions	Yield
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; hexane at 20℃; for 75h; Heating / reflux;	99%
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; hexane at 20℃; for 75h; Heating / reflux;	99%

: 1072-97-5
5-bromo-2-pyridylamine

: 1885-14-9
phenyl chloroformate

: 95676-73-6
phenyl (5-bromopyridin-2-yl)carbamate

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; for 1h; Concentration;	99%
With pyridine In dichloromethane at 0℃;	91.5%
With pyridine In dichloromethane at 5℃;	90%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 2h;	59%

: 1072-97-5
5-bromo-2-pyridylamine

: 70-23-5
ethyl Bromopyruvate

: 67625-37-0
ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 12h;	98%
With magnesium sulfate In 1,4-dioxane at 80℃; for 18h;	93%
Stage #1: 5-bromo-2-pyridylamine; ethyl Bromopyruvate In 1,2-dimethoxyethane for 5h; Stage #2: In ethanol Reflux;	87%

: 1072-97-5
5-bromo-2-pyridylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 138240-34-3
(E)-N’-(5-bromopyridin-2-yl)-N,N-dimethylformamidine

Conditions

Conditions	Yield
In methanol at 70℃; for 6h; Inert atmosphere;	98%
In isopropyl alcohol at 80℃;	75%
In methanol Heating;	73%

: 1072-97-5
5-bromo-2-pyridylamine

: 98-80-6
phenylboronic acid

: 33421-40-8
5-phenyl-pyridin-2-ylamine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile at 90℃; for 16h;	98%
With [(t-Bu)3PH]BF4; palladium diacetate; sodium hydroxide In water; butan-1-ol at 25℃; for 0.25h; Suzuki Coupling; Inert atmosphere; Glovebox;	94%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In methanol; toluene for 12h; Suzuki reaction; Heating;	92%

: 1072-97-5
5-bromo-2-pyridylamine

: 931-53-3
Cyclohexyl isocyanide

: 100-52-7
benzaldehyde

: 6-bromo-N-cyclohexyl-2-phenylimidazo[1,2-a]pyridin-3-amine

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 20℃; for 3h;	98%
With sulfuric acid; silica gel In methanol at 20℃; for 3h;	98%
With cellulose sulfuric acid In methanol at 20℃; for 2h;	98%

...Expand

: 1072-97-5
5-bromo-2-pyridylamine

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: N'-(5-bromopyridin-2-yl)-N,N-dimethylethenimidamide

Conditions

Conditions	Yield
In methanol at 80℃; for 16h;	98%
In methanol at 80℃; for 16h;	98%
With N,N-dimethyl-formamide at 130℃; for 12h;
In N,N-dimethyl-formamide at 130℃; for 12h;

: 1072-97-5
5-bromo-2-pyridylamine

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 6-bromo-2-trifluoromethylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-pyridylamine; 3-bromo-1,1,1-trifluoroacetone With potassium carbonate In ethanol for 24h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In dichloromethane; water	98%
With potassium carbonate In ethanol for 2h; Reflux;	91%

: 1072-97-5
5-bromo-2-pyridylamine

: 3900-89-8
2-Chlorobenzeneboronic acid

: 5-(2-chloro-phenyl)-pyridin-2-ylamine

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; benzene at 20℃; for 24h; Suzuki Coupling; Heating / reflux;	98%

: 1072-97-5
5-bromo-2-pyridylamine

: 79-37-8
oxalyl dichloride

: 66907-52-6
3,4,5-trimethoxy-2-nitrobenzoic acid

: N-(5-bromo(2-pyridyl))(3,4,5-trimethoxy-2-nitrophenyl)carboxamide

Conditions

Conditions	Yield
With pyridine In hexane; dichloromethane; ethyl acetate	98%
With pyridine In hexane; dichloromethane; ethyl acetate	98%

...Expand

: 1072-97-5
5-bromo-2-pyridylamine

: 66907-52-6
3,4,5-trimethoxy-2-nitrobenzoic acid

: N-(5-bromo(2-pyridyl))(3,4,5-trimethoxy-2-nitrophenyl)carboxamide

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxy-2-nitrobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: 5-bromo-2-pyridylamine With pyridine In dichloromethane at 20℃;	98%

: 1072-97-5
5-bromo-2-pyridylamine

: 19514-02-4
alpha-(3-methylphenoxy)acetophenone

: 6-bromo-2-phenyl-3-(m-tolyloxy)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	98%

2-Amino-5-bromopyridine Specification

The IUPAC name of 2-Amino-5-bromopyridine is 5-bromopyridin-2-amine. With the CAS registry number 1072-97-5 and EINECS 214-019-9, it is also named as 2-Pyridinamine, 5-bromo-. The product's categories are Compounds of Pyridine; Fine Chemical & Intermediates;Amines; Blocks; Bromides; Pyridines; Pyridine; Pyridine Derivative; Pyridines, Pyrimidines, Purines and Pteredines; Organic Acids; Bromopyridines; Halopyridines; Heterocyclic Building Blocks; Amino-pyridine Series; Organohalides. It is light yellow crystal which is stable under normal temperature and pressure. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.98; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.93; (4)ACD/LogD (pH 7.4): 1.98; (5)ACD/BCF (pH 5.5): 16.6; (6)ACD/BCF (pH 7.4): 18.92; (7)ACD/KOC (pH 5.5): 250.42; (8)ACD/KOC (pH 7.4): 285.41; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 36.27 cm³; (14)Molar Volume: 101.1 cm³; (15)Polarizability: 14.37×10^-24 cm³; (16)Surface Tension: 56.9 dyne/cm; (17)Enthalpy of Vaporization: 46.75 kJ/mol; (18)Vapour Pressure: 0.0643 mmHg at 25°C; (19)Tautomer Count: 2; (20)Exact Mass: 171.963611; (21)MonoIsotopic Mass: 171.963611; (22)Topological Polar Surface Area: 38.9; (23)Heavy Atom Count: 8; (24)Complexity: 76.8.

Preparation of 2-Amino-5-bromopyridine: It can be obtained by pyridin-2-ylamine. This reaction needs reagent NBS and solvent acetonitrile at temperature of 20 °C. The reaction time is 17 hours. The yield is 93%.

Uses of 2-Amino-5-bromopyridine: It is used to produce drugs and other fine chemicals. It also can react with benzotriazol-1-yl-methanol to get benzotriazol-1-ylmethyl-(5-bromo-pyridin-2-yl)-amine. This reaction needs solvent ethanol at ambient temperature. The reaction time is 5 hours. The yield is 99%.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:Brc1cnc(N)cc1
2. InChI:InChI=1/C5H5BrN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
3. InChIKey:WGOLHUGPTDEKCF-UHFFFAOYAB

Product Name

2-Amino-5-bromopyridine

Synthetic route

2-Amino-5-bromopyridine Specification

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