2-Aminoethylmethyl sulfone supplier

Name
2-Aminoethylmethyl sulfone
EINECS
CAS No. 49773-20-8
Article Data13
CAS DataBase
Density 1.223g/cm³
Solubility
Melting Point
Formula C₃H₉NO₂S
Boiling Point 368.5°Cat760mmHg
Molecular Weight 123.176
Flash Point 176.7°C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-(Methylsulfonyl)ethan-1-amine;2-(Methylsulfonyl)ethanamine;2-(Methylsulfonyl)ethaneamine;2-(Methylsulfonyl)ethylamine;2-Aminoethyl methyl sulfone;
PSA 68.54000
LogP 0.77080

Synthetic route

: 2274-42-2
methanesulfonyl-acetonitrile

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
Stage #1: methanesulfonyl-acetonitrile With dimethylsulfide borane complex In tetrahydrofuran at 20 - 40℃; for 14h; Stage #2: With methanol In tetrahydrofuran at 0 - 80℃; for 2h; Reflux;	90%
With dimethylsulfide borane complex In tetrahydrofuran

: 2-<2-(methylsulfonyl)ethyl>-1H-isoindole-1,3(2H)dione

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With hydrazine In ethanol; chloroform at 0 - 20℃;	80%

BH3·THF: BH3·THF

: 2274-42-2
methanesulfonyl-acetonitrile

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium methylate In tetrahydrofuran; methanol; dichloromethane	77.89%

: 191604-52-1
2-methylsulfonylethyl methanesulfonate

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With ammonia In dichloromethane at 45℃; under 1500.15 Torr; for 3h; Pressure; Temperature; Inert atmosphere;	66.9%

: 50890-51-2
2-chloroethyl methyl sulfone

A: 49773-20-8
2-Methanesulfonyl-ethylamine

B: bis-(2-methanesulfonyl-ethyl)-amine

Conditions

Conditions	Yield
With ammonia

: methyl-(2-nitro-ethyl)-sulfone

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With methanol; nickel Hydrogenation;

: 18542-42-2
(2-aminoethyl)methylsulfide

KMnO4: KMnO4

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 50890-51-2
2-chloroethyl methyl sulfone

A: 49773-20-8
2-Methanesulfonyl-ethylamine

B β.β'-bis-methanesulfonyl-diethylamine: β.β'-bis-methanesulfonyl-diethylamine

Conditions

Conditions	Yield
With ammonia

: 202197-68-0
[2-(methylsulfonyl)ethyl]trifluoroacetamide

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
Alkaline hydrolysis;

: 146698-94-4
(2-methanesulfonyl-ethyl)-carbamic acid benzyl ester

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

: C10H15NO3S

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With ammonium formate; palladium 10% on activated carbon In methanol

: 103275-86-1
2-(methylsulfonyl)ethyl 4-methylbenzenesulfonate

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With ammonia In diethyl ether at 50℃; for 1h;
With ammonia

: 824938-65-0
N,N-dibenzyl-2-(methylsulfonyl)ethylamine

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With hydrogen; Raney nickel In ethanol

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 49773-20-8
2-Methanesulfonyl-ethylamine

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 0.5h; Product distribution / selectivity;
With sodium methylate In methanol at 20℃; for 0.25h;

: 49773-20-8
2-Methanesulfonyl-ethylamine

: C32H37N5O15

: C30H38N2O16S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h;	98%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 6-(thiazol-5-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole-4-carboxylic acid

: N-(2-(methylsulfonyl)ethyl)-6-(thiazol-5-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole-4-carboxamide

Conditions

Conditions	Yield
Stage #1: 6-(thiazol-5-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 2-Methanesulfonyl-ethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	98%

Yield

Stage #1: 6-(thiazol-5-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 2-Methanesulfonyl-ethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;

98%

: 660870-46-2
1-(5-(methoxycarbonyl)-4-{[2-(trifluoromethyl)benzyl]oxy}thien-2-yl)-1H-benzimidazole-5-carboxylic acid

: 49773-20-8
2-Methanesulfonyl-ethylamine

: methyl 5-[5-({[2-(methylsulfonyl)ethyl]amino}carbonyl)-1H-benzimidazol-1-yl]-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) for 12h;	95%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 104-15-4
toluene-4-sulfonic acid

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 388082-78-8
lapatinib ditosylate

Conditions

Conditions	Yield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde In methanol; dichloromethane at 20℃; Stage #2: With hydrogen In methanol; dichloromethane Inert atmosphere; Stage #3: toluene-4-sulfonic acid In methanol; dichloromethane	93%

...Expand

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 104-15-4
toluene-4-sulfonic acid

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: ({5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-yl}methyl) [2-(methylsulfonyl)ethyl]azanium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde In methanol; dichloromethane at 20℃; Stage #2: With hydrogen In methanol; dichloromethane Inert atmosphere; Stage #3: toluene-4-sulfonic acid In methanol; dichloromethane; toluene Product distribution / selectivity;	93%

...Expand

: 449808-50-8
6-(2,4-difluorophenoxy)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 1280218-18-9
2-(2'-methylsulfonylethylamino)-6-(2,4-difluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 65℃; for 0.5h;	92%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: C23H24N4O14

: C24H30N2O16S

Conditions

Conditions	Yield
for 0.0833333h;	92%

: 871018-54-1
[(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetic acid sodium salt

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 2-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-5-yloxy}-N-(2-methanesulfonyl-ethyl)-acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 65℃; for 18h;	89%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate

: 104-15-4
toluene-4-sulfonic acid

: 388082-78-8
lapatinib ditosylate

Conditions

Conditions	Yield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; isopropyl alcohol for 1h; Industrial scale; Stage #2: With sodium tris(acetoxy)borohydride; isopropyl alcohol In tetrahydrofuran at 20℃; for 1.66667h; Industrial scale; Stage #3: toluene-4-sulfonic acid Industrial scale; Further stages;	88%

Yield

Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; isopropyl alcohol for 1h; Industrial scale;
Stage #2: With sodium tris(acetoxy)borohydride; isopropyl alcohol In tetrahydrofuran at 20℃; for 1.66667h; Industrial scale;
Stage #3: toluene-4-sulfonic acid Industrial scale; Further stages;

88%

...Expand

: 49773-20-8
2-Methanesulfonyl-ethylamine

: (S)-phenyl-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)carbamate

: (S)-1-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-3-(2-(methylsulfonyl)ethyl)urea

Conditions

Conditions	Yield
In tetrahydrofuran at 70℃; for 4h;	86%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 1198279-82-1
2-(3,4,5-trimethoxyphenyl)-5-methyloxazole-4-carboxylic acid

: 2-(3,4,5-dimethoxyphenyl)-5-methyl-N-(2-(methylsulfonyl)ethyl)oxazole-4-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	86%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 31716-03-7
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-iodoacetate

: 14-O-(hexadecyl)aminoacetylmutilin

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 4h;	85.31%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 231277-92-2
lapatanib

Conditions

Conditions	Yield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde In methanol; dichloromethane at 20℃; Stage #2: With hydrogen In methanol; dichloromethane Inert atmosphere;	85%
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine Stage #2: With toluene-4-sulfonic acid	80%
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With triethylamine In tetrahydrofuran; methanol for 3h; Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran at 20℃; Cooling with ice;	70%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 2-(3,4-dimethoxyphenyl)-5-methyloxazole-4-carboxylic acid

: 2-(3,4-dimethoxyphenyl)-5-methyl-N-(2-(methylsulfonyl)ethyl)oxazole-4-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	84%

2-Aminoethylmethyl sulfone Specification

The 2-Aminoethylmethyl sulfone with the cas number 49773-20-8 is also called 3-Aminopropane-1-sulfinate. The IUPAC name is 2-methylsulfonylethanamine and the systematic name is Ethanamine, 2-(methylsulfonyl)-. The molecular formula of this chemical is C₃H₉NO₂S. Its product category is API intermediates. It is potent stimulator of ATP-dependent calcium uptake.

Properties Computed from Structure: (1)XLogP3-AA: -1.3; (2)H-Bond Donor: 1; (3)H-Bond Acceptor: 3; (4)Rotatable Bond Count: 2; (5)Exact Mass: 123.035399; (6)MonoIsotopic Mass: 123.035399; (7)Topological Polar Surface Area: 68.5; (8)Heavy Atom Count: 7; (9)Formal Charge: 0; (10)Complexity: 120; (11)Isotope Atom Count: 0; (12)Defined Atom StereoCenter Count: 0; (13)Undefined Atom StereoCenter Count: 0; (14)Defined Bond StereoCenter Count: 0; (15)Undefined Bond StereoCenter Count: 0; (16)Covalently-Bonded Unit Count: 1.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CS(=O)(=O)CCN
(2)InChI: InChI=1S/C3H9NO2S/c1-7(5,6)3-2-4/h2-4H2,1H3
(3)InChIKey: SDNXQWUJWNTDCC-UHFFFAOYSA-N

Product Name

2-Aminoethylmethyl sulfone

Synthetic route

2-Aminoethylmethyl sulfone Specification

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