2-Cyanoacetamide supplier | CasNO.107-91-5

Name
2-Cyanoacetamide
EINECS 203-531-8
CAS No. 107-91-5
Article Data56
CAS DataBase
Density 1.163 g/cm³
Solubility soluble in water
Melting Point 119-121 °C(lit.)
Formula C₃H₄N₂O
Boiling Point 351.2 °C at 760 mmHg
Molecular Weight 84.0776
Flash Point 215 °C
Transport Information UN 3439 6.1/PG 3
Appearance white to light cream crystalline powder
Safety 22-26-28A
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Acetamide,cyano- (7CI);Malonamide nitrile;Propionamide, 3-nitrilo-;Malonic acid, monoamide mononitrile;Kyanacetamid;cyanoiminoaceticacid;Cyanacetamide;amidkyselinykyanoctove;3-Nitrilo-propionamide;2-cyano-acetamid;
PSA 66.88000
LogP 0.08568

Synthetic route

: 105-56-6
ethyl 2-cyanoacetate

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonia	100%
With ammonia In tetrahydrofuran; water at 20℃; for 2h;	93%
With ammonium hydroxide In tetrahydrofuran at 20℃; for 24h;	91%

: 105-34-0
methyl 2-cyanoacetate

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonia at -25 - -5℃; for 1h; Temperature;	98.4%
Stage #1: methyl 2-cyanoacetate With ammonia In methanol at 20℃; Stage #2: With pyrographite In methanol at 50℃; for 2h;

: 109-77-3
malononitrile

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With water at 110℃; for 6h;	95%
With nitrile hydratase from Rhodococcus rhodochrous J1 Y68T/W72Y mutant In aq. phosphate buffer at 35℃; for 4h; pH=7.4; Enzymatic reaction; regioselective reaction;

: 5459-58-5
cyanoacetic acid butyl ester

: 71-36-3
butan-1-ol

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With sodium methylate In methanol	91%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 105-34-0
methyl 2-cyanoacetate

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With potassium tert-butylate for 0.0333333h; microwave irradiation;	72%

: 64-17-5
ethanol

: 92188-14-2
2,4-dicyano-3-isopropyl-glutaric acid diamide

: 107-91-5
cyanoacetic acid amide

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With tetrachloromethane; ethanol at 100℃;

: 372-09-8
cyanoacetic acid

: 108-95-2
phenol

A: 6131-48-2
phenyl 2-cyanoacetate

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
at 160℃;

...Expand

: 105-56-6
ethyl 2-cyanoacetate

: 96-22-0
pentan-3-one

A: 80721-13-7
4,4-diethyl-2,6-dioxo-piperidine-3,5-dicarbonitrile

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonia

...Expand

: 105-56-6
ethyl 2-cyanoacetate

: 502-42-1
cycloheptanone

A: 96732-08-0
2,4-dioxo-3-aza-spiro[5.6]dodecane-1,5-dicarbonitrile

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonia

...Expand

: 3130-87-8
ASPARAGINE

: 127-65-1
chloroamine-T

A: 70-55-3
toluene-4-sulfonamide

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With sodium hydroxide; copper(II) In water at 45℃; Rate constant; Kinetics; Mechanism; variation of temperature, variation of concentrations;

...Expand

: 109-77-3
malononitrile

A: ammonium cyanoacetate

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
at 27℃; microbial hydrolysis by Acidovorax facilis 72W, ATCC 55746; pH 7.0 (potassium phosphate buffer);	A 83 % Chromat. B n/a

: 6825-65-6
α-carbetoxy cyanoacetamide

: 7732-18-5
water

: 107-91-5
cyanoacetic acid amide

: 105-56-6
ethyl 2-cyanoacetate

ammoniacal solution: ammoniacal solution

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
beim Eindampfen;

cyanoacetic acid ester: cyanoacetic acid ester

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonia; water

: 7664-41-7
ammonia

: 105-56-6
ethyl 2-cyanoacetate

: 502-42-1
cycloheptanone

A: 107-91-5
cyanoacetic acid amide

B cycloheptane--imide: cycloheptane--imide

...Expand

: 7664-41-7
ammonia

: 105-56-6
ethyl 2-cyanoacetate

styrylcyanoacetic acid ethyl ester: styrylcyanoacetic acid ethyl ester

A: 107-91-5
cyanoacetic acid amide

B monoammonium salt of 2.6-dioxy-4-benzyl-3.5-dicyano-pyridine: monoammonium salt of 2.6-dioxy-4-benzyl-3.5-dicyano-pyridine

C γ-phenyl-α-cyano-butyric acid amide: γ-phenyl-α-cyano-butyric acid amide

Conditions

Conditions	Yield
at 0℃;

...Expand

: 56-23-5
tetrachloromethane

: 64-17-5
ethanol

: 18852-51-2
sodium cyanoacetic acid ethyl ester

A: 28447-79-2
diethyl 2-amino-1-cyanopropene-1,3-dicarboxylate

B: 107-91-5
cyanoacetic acid amide

C α.γ-dicyano-glutaconic acid diethyl ester: α.γ-dicyano-glutaconic acid diethyl ester

Conditions

Conditions	Yield
at 100℃;

...Expand

: 92188-14-2
2,4-dicyano-3-isopropyl-glutaric acid diamide

: 7732-18-5
water

: 107-91-5
cyanoacetic acid amide

: ethyl (3-methylhex-5-en-2-ylidene)cyanoacetate

: ammonium hydroxide

A: 2550-22-3
3-methyl-5-hexen-2-one

B: 107-91-5
cyanoacetic acid amide

...Expand

<1.2-dimethyl-penten-(4)-ylidene>-cyanoacetic acid ethyl ester: <1.2-dimethyl-penten-(4)-ylidene>-cyanoacetic acid ethyl ester

A: 2550-22-3
3-methyl-5-hexen-2-one

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With ammonium hydroxide

: 70-47-3
L-asparagine

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With N-Bromosuccinimide In phosphate buffer; N,N-dimethyl-formamide at 20℃; for 0.5h; pH=5;
With hydrogenchloride; sode de l'acide trichloroisocyanurique In water for 3h;
With N-Bromosuccinimide In aq. phosphate buffer; N,N-dimethyl-formamide at 20℃; pH=5;

: 372-09-8
cyanoacetic acid

: 71-36-3
butan-1-ol

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With potassium hydroxide; sodium methylate In water

: 7664-41-7
ammonia

: 105-56-6
ethyl 2-cyanoacetate

: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
for 0.5h; Reflux;

: 109-77-3
malononitrile

A: 108-13-4
malonodiamide

B: 107-91-5
cyanoacetic acid amide

Conditions

Conditions	Yield
With nitrile hydratase from Rhodococcus rhodochrous J1 Y68T mutant In aq. phosphate buffer at 35℃; for 4h; pH=7.4; Reagent/catalyst; Enzymatic reaction; regioselective reaction;

: 100-10-7
4-dimethylamino-benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 97006-42-3
(E)-2-cyano-3-[4-(dimethylamino)phenyl]-2-propenamide

Conditions

Conditions	Yield
With triethylamine at 20℃; for 24h; Knoevenagel condensation;	100%
With tetra(n-butyl)ammonium hydroxide In ethanol; water at 20℃; for 0.166667h; Knoevenagel condensation;	94%
With Tonsil Actisil FF at 80℃; for 0.333333h; Irradiation;	55%
With potassium-exchanged zirconium hydrogen phosphate at 100℃; for 4h; Knoevenagel condensation;	49%
With diethylamine

: 104-88-1
4-chlorobenzaldehyde

: 107-91-5
cyanoacetic acid amide

: 19310-60-2, 49678-55-9
(E)-2-cyano-3-(4-chlorophenyl)-2-propenamide

Conditions

Conditions	Yield
With triethylamine at 20℃; for 24h; Knoevenagel condensation;	100%
With sodium chloride for 0.0222222h; Knoevenagel condensation; Irradiation;	98%
for 0.00833333h; Knoevenagel Condensation; Microwave irradiation; stereoselective reaction;	98%

: 123-08-0
4-hydroxy-benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 122520-81-4, 3695-89-4
ST 494

Conditions

Conditions	Yield
With triethylamine at 20℃; for 24h; Knoevenagel condensation;	100%
With USY zeolite In benzene for 5h; Heating;	90%
With 1-methyl-piperazine In methanol at 20℃; for 20h; Aldol condensation;	90%

: 43226-37-5
2,4-dibenzoyl-3-phenyl-1,4-pentadiene

: 107-91-5
cyanoacetic acid amide

: 76453-13-9
3,5-Dibenzoyl-1-cyano-4-phenyl-cyclohexanecarboxylic acid amide

Conditions

Conditions	Yield
With potassium hydroxide In pyridine Ambient temperature;	100%

: 181699-48-9
(E)-(S)-2-Ethyl-2-methoxymethoxy-5-(3-methoxymethyl-quinolin-2-yl)-5-oxo-pent-3-enoic acid diethylamide

: 107-91-5
cyanoacetic acid amide

: 195963-83-8
(S)-4-Cyano-2-ethyl-2-methoxymethoxy-3-[2-(3-methoxymethyl-quinolin-2-yl)-2-oxo-ethyl]-pentanedioic acid 5-amide 1-diethylamide

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide for 0.5h; Ambient temperature;	100%
With potassium tert-butylate In N,N-dimethyl-formamide at 25℃; Yield given;

: (E)-4-Ethyl-4-methoxymethoxy-1-(3-methoxymethyl-quinolin-2-yl)-hexa-2,5-dien-1-one

: 107-91-5
cyanoacetic acid amide

: 2-Cyano-4-ethyl-4-methoxymethoxy-3-[2-(3-methoxymethyl-quinolin-2-yl)-2-oxo-ethyl]-hex-5-enoic acid amide

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide Ambient temperature;	100%

: (E)-2-Ethyl-2-methoxymethoxy-5-(3-methoxymethyl-quinolin-2-yl)-5-oxo-pent-3-enoic acid ethyl ester

: 107-91-5
cyanoacetic acid amide

: 4-Carbamoyl-4-cyano-2-ethyl-2-methoxymethoxy-3-[2-(3-methoxymethyl-quinolin-2-yl)-2-oxo-ethyl]-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide Ambient temperature;	100%

: (E)-2-Ethyl-2-methoxymethoxy-5-(3-methoxymethyl-quinolin-2-yl)-5-oxo-pent-3-enoic acid diethylamide

: 107-91-5
cyanoacetic acid amide

: 4-Cyano-2-ethyl-2-methoxymethoxy-3-[2-(3-methoxymethyl-quinolin-2-yl)-2-oxo-ethyl]-pentanedioic acid 5-amide 1-diethylamide

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide Ambient temperature;	100%

: 234762-41-5
(Z)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

: 107-91-5
cyanoacetic acid amide

: C34H28N4O

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; methylene exchange;	100%

: 7521-41-7
2-Aminonicotinaldehyde

: 107-91-5
cyanoacetic acid amide

: 15935-96-3
2-Amino-1,8-naphthyridine-3-carboxamide

Conditions

Conditions	Yield
With piperidine at 20℃; for 0.166667h; Friedlander condensation;	100%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 107-91-5
cyanoacetic acid amide

: 1001020-08-1
tert-butyl 2-amino-3-carbamoyl-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate

Conditions

Conditions	Yield
With morpholine; sulfur In ethanol at 20℃;	100%
With morpholine; sulfur In ethanol for 4h; Gewald Aminoheterocycles Synthesis; Reflux; Inert atmosphere;	95%
With sulfur; diethylamine In ethanol at 20℃;	93%

: 40018-26-6
1,4-dithiane-2,5-diol

: 107-91-5
cyanoacetic acid amide

: 14080-51-4
2-aminothiophene-3-carboxamide

Conditions

Conditions	Yield
With triethylamine In ethanol at 68℃; for 12h; Gewald Aminoheterocycles Synthesis; Inert atmosphere;	100%
With triethylamine In ethanol at 20℃; for 2.08333h; Heating / reflux;	88%
Stage #1: 1,4-dithiane-2,5-diol; cyanoacetic acid amide In ethanol at 20℃; for 0.166667h; Stage #2: With N-methylpiperazine-functionalized Polyacrylonitrile Fiber In ethanol for 4h; Gewald Aminoheterocycles Synthesis; Reflux;	87%

: 5682-75-7
3-chloro-2-cyclohexenone

: 107-91-5
cyanoacetic acid amide

: 56053-55-5
2-cyano-2-(3-oxocyclohexa-1-en-1-yl)acetamide

Conditions

Conditions	Yield
Stage #1: cyanoacetic acid amide With sodium hydride In diethylene glycol dimethyl ether; mineral oil for 0.0833333h; Stage #2: 3-chloro-2-cyclohexenone In diethylene glycol dimethyl ether; mineral oil for 4.5h;	100%
Stage #1: cyanoacetic acid amide With sodium hydride In diethylene glycol dimethyl ether at 20℃; for 0.0833333h; Stage #2: 3-chloro-2-cyclohexenone In diethylene glycol dimethyl ether at 20℃; for 4h; Stage #3: With hydrogenchloride In diethylene glycol dimethyl ether; water	76%
In methanol; 1,2-dimethoxyethane; water
In methanol; 1,2-dimethoxyethane; water
Stage #1: cyanoacetic acid amide With sodium hydride In diethylene glycol dimethyl ether for 0.333333h; Stage #2: 3-chloro-2-cyclohexenone In diethylene glycol dimethyl ether for 8h;	900 mg

: 181294-57-5
β-formyl-β-nitroenamine

: 107-91-5
cyanoacetic acid amide

: 1118542-03-2
3-carbamoyl-5-nitro-2-propylaminopyridine

Conditions

Conditions	Yield
With piperidine In tetrahydrofuran at 60℃; for 24h;	100%

: 1284216-07-4
C13H16N2O2

: 107-91-5
cyanoacetic acid amide

: 1224437-78-8
5-((2,6-dimethylphenyl)diazenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 130℃; for 0.0833333h; Microwave irradiation;	100%

: 1284216-22-3
C11H11IN2O2

: 107-91-5
cyanoacetic acid amide

: 1224437-79-9
5-((2-iodophenyl)diazenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 130℃; for 0.0833333h; Microwave irradiation;	100%

: 1284216-62-1
C13H15BrN2O2

: 107-91-5
cyanoacetic acid amide

: 1224437-80-2
5-((4-bromo-2,6-dimethylphenyl)diazenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 130℃; for 0.0833333h; Microwave irradiation;	100%

: 75201-60-4
pentane-2,3,4-trione 3-[(2-nitro-phenyl)-hydrazone]

: 107-91-5
cyanoacetic acid amide

: 1224437-81-3
4,6-dimethyl-5-((2-nitrophenyl)diazenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 130℃; for 0.0833333h; Microwave irradiation;	100%

: C41H43NO3S3

: 107-91-5
cyanoacetic acid amide

: C49H47N3O4S3

Conditions

Conditions	Yield
With piperidine Knoevenagel Condensation;	100%

: 7089-34-1
((E)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate

: 107-91-5
cyanoacetic acid amide

: 35982-93-5
1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarbonitrile

Conditions

Conditions	Yield
Stage #1: cyanoacetic acid amide With sodium ethanolate In ethanol at 20℃; for 0.5h; Stage #2: ((E)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate In ethanol at 25℃; for 0.333333h; Mechanism; Time;	100%

: 5,5-difluoroheptane-2,4-dione

: 107-91-5
cyanoacetic acid amide

: 4-(1,1-difluoropropyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Conditions

Conditions	Yield
With triethylamine Reflux;	100%

: 107-91-5
cyanoacetic acid amide

: 7307-04-2
acetylpinacolin

: 146881-62-1
4-tert-butyl-3-cyano-6-methyl-2(1H)-pyridinone

Conditions

Conditions	Yield
With lipase from Candida cylindracea In water at 40℃; Rate constant; Kinetics;	99.8%
With lipase from Candida cylindracea In water at 40℃;	99.8%
In water at 40℃; for 96h; lipase from Candida cylindracea;	14.5%

: 100-52-7
benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 709-79-5, 148238-27-1, 15795-18-3
(E)-2-cyano-3-phenylacrylamide

Conditions

Conditions	Yield
for 0.00555556h; Knoevenagel Condensation; Microwave irradiation; stereoselective reaction;	99%
With ethanol; sodium Ambient temperature;	98%
With tellurium tetrachloride at 80℃; for 0.583333h;	94%

: 70194-64-8
5,7-diphenyl-1,2,3,4,4a,5-hexahydro-13H-benzo[4,5]imidazo[2,1-j]quinoline

: 107-91-5
cyanoacetic acid amide

: 131527-33-8, 131527-34-9
C30H26N4O

Conditions

Conditions	Yield
With manganese(IV) oxide In acetone for 1h; Ambient temperature;	99%

: 93795-24-5
5-(4-ethoxylphenyl)-2,3-dihydro-2,3-furandione

: 107-91-5
cyanoacetic acid amide

: 113308-11-5
2-Cyano-N-[3-(4-ethoxy-phenyl)-3-oxo-propionyl]-acetamide

Conditions

Conditions	Yield
In 1,4-dioxane Heating;	99%

: 104-87-0
4-methyl-benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 52287-59-9
(E)-2-cyano-3-(4-methylphenyl)acrylamide

Conditions

Conditions	Yield
for 0.00694444h; Knoevenagel Condensation; Microwave irradiation; stereoselective reaction;	99%
With ammonium acetate; acetic acid for 0.00833333h; Knoevenagel condensation; Irradiation;	94%
With sodium azide In N,N-dimethyl-formamide at 70℃; for 5h; Knoevenagel condensation;	91%
With 1-methyl-piperazine In methanol at 20℃; for 20h; Aldol condensation;	59%

: 614-47-1
1,3-diphenyl-propen-3-one

: 107-91-5
cyanoacetic acid amide

: 29261-44-7
4,6-diphenyl-2-pyridone

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide at 90℃; for 4h;	99%

: 104-88-1
4-chlorobenzaldehyde

: 126-81-8
dimedone

: 107-91-5
cyanoacetic acid amide

: 2-amino-4-(4-chloro-phenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylic acid amide

Conditions

Conditions	Yield
In water for 4h; Heating;	99%
With sodium bromide at 85℃; for 0.25h; microwave irradiation;	60%

...Expand

: 100-52-7
benzaldehyde

: 126-81-8
dimedone

: 107-91-5
cyanoacetic acid amide

: 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylic acid amide

Conditions

Conditions	Yield
In water for 4h; Heating;	99%
With sodium bromide at 85℃; for 0.25h; microwave irradiation;	63%

...Expand

2-Cyanoacetamide Consensus Reports

Cyanide and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

2-Cyanoacetamide Specification

1.Introduction of 2-Cyanoacetamide

2-Cyanoacetamide , with its CAS number of 107-91-5, is a kind of White or light yellow crystal. It has synonyms of Acetamide,cyano- (7CI);Malonamide nitrile;Propionamide, 3-nitrilo-;Malonic acid, monoamide mononitrile;Kyanacetamid;cyanoiminoaceticacid;Cyanacetamide;amidkyselinykyanoctove;3-Nitrilo-propionamide and 2-cyano-acetamid. 2-Cyanoacetamide should be stored in shady and cool warehouse and commonly used as the intermediates for medicine, dyes and electroplating solution.

2.Properties of 2-Cyanoacetamide

(1) Molecular Weight: 84.08 (2) H bond acceptors: 3 (3) H bond donors: 2
(4) Freely Rotating Bonds: 1 (5) Polar Surface Area: 44.1 Å2 (6) Index of Refraction: 1.45
(7) Molar Refractivity: 19.42 cm3 (8) Molar Volume: 72.2 cm3 (9) Surface Tension: 51.9 dyne/cm
(10) Density: 1.163 g/cm3 (11) Flash Point: 215 °C (12) Enthalpy of Vaporization: 59.59 kJ/mol
(13) Boiling Point: 351.2 °C at 760 mmHg (14) Vapour Pressure: 4.17E-05 mmHg at 25°C
(15) EINECS: 203-531-8 (16) Melting Point: 119-121 °C(lit.)

3.Structure descriptors of 2-Cyanoacetamide

IUPAC Name: 2-cyanoacetamide

InChI: InChI=1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)

InChIKey: DGJMPUGMZIKDRO-UHFFFAOYSA-N

Canonical SMILES : C(C#N)C(=O)N

4.Safety information of 2-Cyanoacetamide

Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-26-28A
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR: UN 3439 6.1/PG 3
WGK Germany: 2
PackingGroup: III

5.Uses of 2-Cyanoacetamide

The 2-Cyanoacetamide can used for process for producing 2,6-dihydroxy-3,4-dimethlpridine. The process includes reacting 2-cyanoacetamide with sodium methoxide followed by condensation with ethyl 2-methylacetoacetate in methanol to give the sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile. The sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile is hydrolyzed with hydrobromic acid and decarboxylated to the hydrobromide salt of 2,6-dihydroxy-3,4-dimethylpyridine. The desired 2,6-dihydroxy-3,4-dimethylpyridine is produced from the hydrobromide salt by neutralizing the same with sodium hydroxide.

6.Toxity data of 2-Cyanoacetamide

1.	orl-mus LD₅₀:1680 mg/kg	KHZDAN Khigiena i Zdraveopazvane. 9 (1966),50.
2.	ipr-mus LD₅₀:200 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-689 .
3.	scu-gpg LD₅₀:1155 mg/kg	MELAAD Medicina del Lavoro. Industrial Medicine. 47 (1956),192.

Product Name

2-Cyanoacetamide

Synthetic route

2-Cyanoacetamide Consensus Reports

2-Cyanoacetamide Specification

Related Products

Hot Products