2-Fluoro-4-methoxyacetophenone supplier

Name
2-Fluoro-4-methoxyacetophenone
EINECS
CAS No. 74457-86-6
Article Data7
CAS DataBase
Density 1.127 g/cm³
Solubility Insoluble in water
Melting Point 52-54 °C(lit.)
Formula C₉H₉FO₂
Boiling Point 243 °C at 760 mmHg
Molecular Weight 168.168
Flash Point 97.9 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1-(2-Fluoro-4-methoxyphenyl)ethanone;1-Acetyl-2-fluoro-4-methoxybenzene;2'-Fluoro-4'-methoxyacetophenone;
PSA 26.30000
LogP 2.03690

Synthetic route

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube;	78%
Multi-step reaction with 3 steps 1: sodium acetate / ethanol; water / 2 h / Reflux 2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-fluorobis(benzenesulfon)imide; potassium nitrate / nitromethane / 24 h / 25 °C 3: hydrogenchloride; water / diethyl ether / 30 h / 20 °C View Scheme

: 456-49-5
1-fluoro-3-methoxybenzene

: 108-24-7
acetic anhydride

A: 51788-80-8
1-(4-fluoro-2-methoxy-phenyl)-ethanone

B: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With lithium perchlorate at 100℃; for 1h;	A 30% B 70%

...Expand

: 456-49-5
1-fluoro-3-methoxybenzene

: 108-24-7
acetic anhydride

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 20 - 35℃;	60.7%
With aluminium trichloride In 1,2-dichloro-ethane for 2h; Ambient temperature;

: 456-49-5
1-fluoro-3-methoxybenzene

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1313430-15-7
C10H12FNO2

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With hydrogenchloride; water In diethyl ether at 20℃; for 30h;	26.5 mg

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 676-58-4
methylmagnesium chloride

: 96826-25-4
2-(2-fluoro-4-methoxyphenyl)-2-isopropanol

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran; dichloromethane at 0℃; Inert atmosphere; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran; dichloromethane at 20℃; Product distribution / selectivity;	99%
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran at 20 - 35℃; for 0.666667h; Inert atmosphere; Stage #2: With water; acetic acid In tetrahydrofuran at 5 - 25℃;	98%
In tetrahydrofuran at -15 - 0℃; for 1h;	95%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 167683-93-4
2-fluoro-4-methoxy-phenol

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With magnesium sulfate; 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 120h; Stage #2: With ammonium hydroxide In methanol; acetonitrile at 20℃; for 3h; Further stages.;	98%
Multi-step reaction with 2 steps 1: mCPBA, MgSO4 / CHCl3 / 12 h / Ambient temperature 2: 94 percent / aq. NH3 / methanol / 1 h / Ambient temperature View Scheme

NH3 (aq): NH3 (aq)

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 167683-93-4
2-fluoro-4-methoxy-phenol

Conditions

Conditions	Yield
In methanol	94%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1434602-18-2
(E)-1-(2-fluoro-4-methoxyphenyl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water pH=5; Reflux;	93%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2,6-difluoro-4-methoxyphenyl)ethan-1-one

Conditions

Conditions	Yield
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube;	93%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 74457-87-7
1-(2-fluoro-4-methoxyphenyl)ethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether 1.) RT, 3 h, 2.) reflux, 1 h;	92%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 95-92-1
oxalic acid diethyl ester

: ethyl 4-(2-fluoro-4-methoxyphenyl)-2,4-dioxobutanoate

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; oxalic acid diethyl ester With sodium ethanolate In ethanol at 20℃; Inert atmosphere; Stage #2: With hydrogenchloride In water	91.2%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 95-92-1
oxalic acid diethyl ester

: ethyl (Z)-4-(2-fluoro-4-methoxyphenyl)-2-hydroxy-4-oxobut-2-enoate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 20℃; Claisen Condensation;	91%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 123-11-5
4-methoxy-benzaldehyde

: E-1-(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 12h; Ambient temperature;	90%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 7746-29-4
6-methoxy-3-methyl-1H-indazole

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With hydrazine hydrate In ethanol for 6h; Reflux; Stage #2: With ethylene glycol at 150℃; for 96h;	90%
With hydrazine hydrate In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; Inert atmosphere;	78%
With hydrazine hydrate In ethanol; ethylene glycol	59%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1779-49-3
Methyltriphenylphosphonium bromide

: 875446-55-2
2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In toluene at 20℃; for 0.5h; Inert atmosphere; Stage #2: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In toluene at 20℃; for 4h; Inert atmosphere;	88%
Stage #1: Methyltriphenylphosphonium bromide With sodium hexamethyldisilazane In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In tetrahydrofuran at -78 - 20℃;	63%
Stage #1: Methyltriphenylphosphonium bromide With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In tetrahydrofuran at -78 - 20℃; for 2.5h; Stage #3: With acetic acid In tetrahydrofuran for 0.5h;
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In toluene at 40 - 50℃; for 2h; Inert atmosphere; Stage #2: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In toluene at 55 - 65℃; for 2h; Wittig Olefination; Inert atmosphere;	233 g

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1-(2-fluoro-4-methoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	87.18%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1-(2-fluoro-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	85.18%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: C9H6F3NO4

: (E)-1-(2-fluoro-4-methoxyphenyl)-3-(2-nitro-5-(2,2,2-trifluoroethoxy)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water; acetonitrile at 20℃; for 1h; Aldol Condensation;	84%

: 6457-49-4
4-piperidinemethanol

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-(4-(hydroxymethyl)piperidin-1-yl)-4-methoxyphenyl)-ethanone

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 130℃; Reagent/catalyst; Solvent; Temperature;	84%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 2-(2-fluoro-4-methoxyphenyl)-2-methylethanenitrile

Conditions

Conditions	Yield
With potassium tert-butylate In 1,2-dimethoxyethane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate	83%
With potassium tert-butylate In 1,2-dimethoxyethane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate	83%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1-(2-fluoro-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	82.3%

: 830-79-5
2,4,6-trimethoxybenzaldehyde

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-fluoro-4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)-prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	82.1%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

A: 1414877-13-6
1-(2-fluoro-4-methoxy-3-nitro-phenyl)-ethanone

B: 1414877-12-5
1-(2-fluoro-4-methoxy-5-nitro-phenyl)-ethanone

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at -20 - -15℃; for 0.666667h;	A 2% B 82%

: 4460-86-0
asaraldehyde

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-fluoro-4-methoxyphenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	80.2%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 82772-93-8
2,6-dichloro-4-methoxy-benzaldehyde

: E-1-(2-fluoro-4-methoxyphenyl)-3-(2,6-dichloro-4-methoxyphenyl)-2-propen-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Ambient temperature;	80%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 88-17-5
2-(trifluoromethyl)benzenamine

: N-[2-(dimethylamino)ethyl]-2-(2-fluoro-4-methoxyphenyl)quinolin-4-amine

Conditions

Conditions	Yield
1-(2-fluoro-4-methoxyphenyl)-1-ethanone; 2-(trifluoromethyl)benzenamine With toluene-4-sulfonic acid In xylene Heating; Further stages.;	80%

: 75-16-1
methylmagnesium bromide

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 96826-25-4
2-(2-fluoro-4-methoxyphenyl)-2-isopropanol

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	80%
Stage #1: methylmagnesium bromide; 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In tetrahydrofuran at 0 - 20℃; for 4h; Stage #2: With water; ammonium chloride In tetrahydrofuran
In tetrahydrofuran at 0 - 20℃; for 4h;
In tetrahydrofuran at 0 - 20℃; for 4h;
In tetrahydrofuran at 0℃; for 4h;

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 100-53-8
phenylmethanethiol

: 1-(2-(benzylthio)-4-methoxyphenyl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: phenylmethanethiol With potassium tert-butylate In tetrahydrofuran for 1h; Inert atmosphere; Stage #2: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone In tetrahydrofuran for 3h; Reflux;	80%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-fluoro-4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 3h; Claisen-Schmidt Condensation;	79.4%

: 328-93-8
2,5-bis(trifluoromethyl)aniline

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(2-fluoro-4-methoxy)phenyl]quinolin-4-amine

Conditions

Conditions	Yield
2,5-bis(trifluoromethyl)aniline; 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With toluene-4-sulfonic acid In xylene Heating; Further stages.;	75%

: 493-05-0
isochromane

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-fluoro-4-methoxyphenyl)-2-(isochroman-1-yl)ethanone

Conditions

Conditions	Yield
With carbon tetrabromide In neat (no solvent) at 100℃; for 48h;	75%

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 20.5h; Inert atmosphere;	72%

2-Fluoro-4-methoxyacetophenone Chemical Properties

The Molecular formula of 2-Fluoro-4-methoxyacetophenone(74457-86-6): C₉H₉FO₂
The Molecular Weight of 2-Fluoro-4-methoxyacetophenone(74457-86-6): 168.16
Molecular Structure :

Melting point: 52-54 °C(lit.)
Boiling Point: 243 °C at 760 mmHg
Flash Point: 97.9 °C
Index of Refraction: 1.487
Molar Refractivity: 42.95 cm³
Molar Volume: 149.1 cm³
Polarizability: 17.02 10-24cm³
Surface Tension: 32.5 dyne/cm
Density: 1.127 g/cm³
Enthalpy of Vaporization: 48 kJ/mol
Vapour Pressure: 0.0329 mmHg at 25°C
Water Solubility: Insoluble
Appearance: white to light yellow crystal powder
IUPAC Name: 1-(2-fluoro-4-methoxyphenyl)ethanone
Synonyms: 2'-FLUORO-4'-METHOXYACETOPHENONE;2-Fluoro-4-methoxyacetophenone 99% (HP&;2-FLUORO-4-METHXOYACETOPHENONE;4-Methoxyphenacyl fluoride;2-Fluoro-4-methoxyacetophenone;1-(2-FLUORO-4-METHOXYPHENYL)ETHANONE;4-ACETYL-3-FLUOROANISOLE;2'-Fluoro-4'-methoxyacetophenone 99%;

2-Fluoro-4-methoxyacetophenone Safety Profile

The Hazard Codes of 2-Fluoro-4-methoxyacetophenone(74457-86-6):

Xi
The Risk Statements information of 2-Fluoro-4-methoxyacetophenone(74457-86-6):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-Fluoro-4-methoxyacetophenone(74457-86-6):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
Hazard Note: Irritant

Product Name

2-Fluoro-4-methoxyacetophenone

Synthetic route

2-Fluoro-4-methoxyacetophenone Chemical Properties

2-Fluoro-4-methoxyacetophenone Safety Profile

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