2-Hydroxybenzyl alcohol supplier

Name
2-Hydroxybenzyl alcohol
EINECS 201-960-5
CAS No. 90-01-7
Article Data265
CAS DataBase
Density 1.22 g/cm³
Solubility water: 67 g/L (22 °C)
Melting Point 83-85 °C(lit.)
Formula C₇H₈O₂
Boiling Point 267.5 °C at 760 mmHg
Molecular Weight 124.139
Flash Point 133.7 °C
Transport Information
Appearance light brown crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzylalcohol, o-hydroxy- (8CI);1-(o-Hydroxyphenyl)methanol;2-Hydroxybenzenemethanol;2-Hydroxymethylphenol;2-Methylolphenol;Diathesin;NSC 3814;Salicyl alcohol;Salicylicalcohol;Saligenin;Saligenol;o-(Hydroxymethyl)phenol;o-Hydroxybenzylalcohol;o-Methylolphenol;a,2-Dihydroxytoluene;a-Hydroxy-o-cresol;
PSA 40.46000
LogP 0.88450

Synthetic route

: 5735-41-1
3H-benzo[c][1,2]oxaborol-1-ol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran; water; acetic acid for 30h; Ambient temperature;	100%

: 119-36-8
methyl salicylate

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
Stage #1: methyl salicylate With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 0℃; Inert atmosphere;	100%
With lithium aluminium tetrahydride In 2-methyltetrahydrofuran at -15 - 20℃; for 24.16h;	93%
With zinc(II) tetrahydroborate; cyclohexene In tetrahydrofuran for 4h; Heating;	70%
With lithium aluminium tetrahydride In diethyl ether
With C21H24N4Ru(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran at 50℃; under 18751.9 Torr; for 4h; Catalytic behavior;

: 89-95-2
2-methyl-benzyl alcohol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride In methanol; diethyl ether for 4h; Reduction; Heating;	100%
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran at 20℃; for 0.166667h;	100%
With Zr(BH4)2Cl2(dabco)2 In water for 0.8h; Heating;	93%

: C28H28BO8(1-)*Na(1+)

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With water	100%

: 90-02-8
salicylaldehyde

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With formic acid; C20H29ClIrN4(1+)*Cl(1-) In water at 80℃; for 0.166667h; chemoselective reaction;	99%
With hydrogen for 0.583333h;	98%
With (7,8-benzoquinolinato)hydrido(aqua)bis(triphenylphosphine)iridium(III) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; N-ethyl-N,N-diisopropylamine In toluene at 80℃; under 760.051 Torr; for 4h;	98%

: 82112-31-0
1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 18h;	99%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 0.25h;

: 69-72-7
salicylic acid

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 4.5h; Product distribution; Further Variations:; Reagents; reagent ratios;	98%
With [Zn(BH4)2(py)] In tetrahydrofuran for 1.5h; Heating;	93%
With lithium aluminium tetrahydride In diethyl ether at 23℃; for 5h; Inert atmosphere;	93%

: 18544-92-8
1-Trimethylsilanyloxy-2-trimethylsilanyloxymethyl-benzene

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	98%
With Nafion-H(R); silica gel In hexane at 20℃; for 0.5h;	95%
With montmorillonite K-10 In methanol for 0.7h; Ambient temperature;	90%
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.833333h; Green chemistry;	80%

: 1058648-87-5
2-((methoxymethoxy)methyl)phenol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
phosphotungstic acid In ethanol for 2h; Heating;	96%
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0416667h; Microwave irradiation; chemoselective reaction;	90%

: 1058648-91-1
2-[(ethoxymethoxy)methyl]phenol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0333333h; Microwave irradiation; chemoselective reaction;	94%
phosphotungstic acid In ethanol for 3.5h; Heating;	90%

: 50-00-0
formaldehyd

: 108-95-2
phenol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With sodium metaborate tetrahydrate In water at 40℃; for 12h; Green chemistry; regioselective reaction;	93%
With boric acid In benzene for 22h; Heating;	53%
With zinc diacetate
With cadmium(II) formate

: 5159-41-1
2-iodobenzyl alcohol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; cesium hydroxide; 2-(1H-pyrazol-1-yl)-N-(pyridine-2-ylmethyl)ethan-1-amine In dimethylsulfoxide-d6; water at 120℃; for 6h;	93%

: 82112-31-0
1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

A: 90-01-7
salicylic alcohol

B: 96013-79-5
{2-[(tert-butyldimethylsilyl)oxy]phenyl}methanol

Conditions

Conditions	Yield
With carbon tetrabromide In methanol at 65℃; for 2h;	A 7% B 91%

: 50-78-2
aspirin

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With zirconium(IV) borohydride In tetrahydrofuran at 25℃; for 1h; Reduction;	90%
With zinc(II) tetrahydroborate In tetrahydrofuran for 3h; Heating;	85%
With tetrabutylammonium borohydride In dichloromethane Reduction; Heating;	69%

: 133682-05-0
toluene-α(2),2(2')-diyl 4,5-dimethoxy-5',6'-methylenedioxybiphenyl,2,2'-dicarboxylate

A: 90-01-7
salicylic alcohol

B: 139058-87-0
4,5-dimethoxy-5',6'-methylenedioxybiphenyl-2,2'-dicarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water for 3h; Ambient temperature;	A 70% B 89%

: 77023-20-2
1-formylbenzene oxide

A: 90-01-7
salicylic alcohol

B: 108-95-2
phenol

Conditions

Conditions	Yield
With borate buffer; carbonate(2-) In tetrahydrofuran; water pH 10.0;	A 12% B 88%

: 90-02-8
salicylaldehyde

A: 90-01-7
salicylic alcohol

B: 64158-23-2
1R,2S-1,2-di(-hydroxyphenyl)-1,2-ethanediol

Conditions

Conditions	Yield
With titanium(IV) isopropylate; samarium; iodine In methanol at -78℃; for 1h;	A 88% B 10%

: 2-[(tetrahydro-2H-pyran-2-yloxy)methyl]phenol

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With sulfuric acid; silica gel In methanol at 20℃; for 2.08333h;	84%

: 1433-61-0
2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;	84%

: 77023-21-3
1-(hydroxymethyl)benzene oxide

A: 90-01-7
salicylic alcohol

B: 108-95-2
phenol

Conditions

Conditions	Yield
With borate buffer; carbonate(2-) In tetrahydrofuran; water for 72h; Product distribution; Mechanism; other pH;	A 83% B 17%

: 888958-33-6
6-iodo-2,2-dimethylbenzo[1,3]dioxin-4-one

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; for 2h;	83%

: 6009-10-5
4H-benzo[d][1,3]dioxin-4-one

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride at 20℃;	82%

: 50-00-0
formaldehyd

: 108-95-2
phenol

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With sodium metaborate tetrahydrate In water at 60℃; Green chemistry; regioselective reaction;	A 10% B 80%
With sodium hydroxide In water at 30℃; for 1h; Product distribution; other reagents, reagent concentrations, time and solvents;
With sodium hydroxide; HP-β-cyclodextrin In water at 4℃; for 240h; Product distribution; further additives;

...Expand

: 254-27-3
4H-1,3,2-benzodioxin

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Heating;	80%

: 118-61-6
2-hydroxy-benzoic acid ethyl ester

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With potassium borohydride; hafnium tetrachloride In tetrahydrofuran at 40℃; for 13.3h; Inert atmosphere; Cooling with ice;	70%

: 50-00-0
formaldehyd

: 108-95-2
phenol

A: 254-27-3
4H-1,3,2-benzodioxin

B: 623-05-2
(4-hydroxyphenyl)methanol

C: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 65℃; for 20h;	A 3% B 68% C 7%

...Expand

: 1127-92-0
3,4-dihydro-4-hydroxy-2H-1,3-benzoxazin-2-one

A: 1125-85-5
3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

B: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With lithium borohydride; lithium triethylborohydride In tetrahydrofuran for 48h; Ambient temperature;	A 17% B 66%

: 108-95-2
phenol

paraformaldehyde: paraformaldehyde

: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; xylene at 135℃; for 12h;	66%

: 95-48-7
ortho-cresol

A: 90-01-7
salicylic alcohol

B: 90-02-8
salicylaldehyde

C: 69-72-7
salicylic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In methanol; water at 60℃; for 2h; Reagent/catalyst; Molecular sieve;	A 9.5% B 65.5% C 15%
With dihydrogen peroxide In water; acetonitrile at 69.84℃; for 7h; Temperature;
With dihydrogen peroxide In methanol at 60℃; under 3800.26 Torr; for 2h; Reagent/catalyst; Autoclave;

...Expand

: 90-01-7
salicylic alcohol

: 90-02-8
salicylaldehyde

Conditions

Conditions	Yield
With air; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (NO+)Ru(II)-salen In diethyl ether for 11h; Irradiation;	100%
With dihydrogen peroxide In neat (no solvent) at 80℃; for 4h; Green chemistry;	100%
In neat (no solvent) at 20℃; for 0.0333333h; Microwave irradiation;	100%

: 90-01-7
salicylic alcohol

: 108-24-7
acetic anhydride

: 1575-87-7
o-acetoxybenzyl acetate

Conditions

Conditions	Yield
zeolite HSZ-360 In neat (no solvent) at 60℃; for 1.5h;	100%
With poly(N-vinylimidazole) In neat (no solvent) at 20℃; for 0.133333h; Green chemistry;	98%
With succinimide-N-sulfonic acid In neat (no solvent) at 20℃; for 0.0666667h; Mechanism;	98%

: 108-05-4
vinyl acetate

: 90-01-7
salicylic alcohol

: 6161-96-2
2-acetoxymethylphenol

Conditions

Conditions	Yield
With Candida cylindracea lipase In hexane for 6h;	100%
With porcine pancreatic lipase (PPL, Type II) In tetrahydrofuran at 42 - 45℃; for 120h; Acetylation;	95%
With Pseudomonas cepacia PS lipase In di-isopropyl ether at 25℃; for 0.25h;

: 90-01-7
salicylic alcohol

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 82112-31-0
1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

Conditions

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Ambient temperature; other silylating agent;	100%

: 90-01-7
salicylic alcohol

: 109-92-2
ethyl vinyl ether

: 10419-35-9
2-ethoxy-3,4-dihydro-2H-chromene

Conditions

Conditions	Yield
In water; acetonitrile Irradiation;	100%
With pyrrolidine In toluene at 150℃; for 20h; Diels-Alder Cycloaddition;	24%
at 201.85℃; Yield given;

: ethylzinc 2-hydroxymethylphenoxide

: 90-01-7
salicylic alcohol

: 557-20-0
diethylzinc

A: zinc bis(2-ethylzincoxyphenmethoxide)

B: 74-84-0
ethane

Conditions

Conditions	Yield
react. of the educts in a molar ration of 3:2;	A n/a B 100%

...Expand

: 90-01-7
salicylic alcohol

: 11113-50-1
boric acid

: 791-31-1
triphenylhydroxysilane

: 82172-56-3
2-triphenylsiloxy-4H-1,3,2-benzodioxaborin

Conditions

Conditions	Yield
In benzene byproducts: H2O; azeotropic removal of water; elem. anal.;	100%

...Expand

: 90-01-7
salicylic alcohol

: 29182-97-6
N-methyl-2-bromoacetanilide

: 1447608-45-8
2-[2-(hydroxymethyl)phenoxy]-N-methyl-N-phenylacetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux;	100%
With potassium carbonate In acetone for 12h; Reflux; Inert atmosphere;	100%

: 90-01-7
salicylic alcohol

: 77-76-9
2,2-dimethoxy-propane

: 78023-79-7
2,2-dimethyl-4H-benzo[d][1,3]dioxin

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; sodium sulfate In acetone at 40℃;	99%
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 6h;	89%
With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 24h; Ambient temperature;	1.4 g

: 90-01-7
salicylic alcohol

: 630-19-3
pivalaldehyde

: 201140-05-8
2-tert-Butyl-4H-benzo[1,3]dioxine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; sodium sulfate In dichloromethane at 50℃;	99%

: 75-30-9
2-iodo-propane

: 90-01-7
salicylic alcohol

: [2-(propan-2-yloxy)phenyl]methanol

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 3h; Heating / reflux;	99%
With potassium carbonate In ethanol for 3h; Heating / reflux;	99%
With potassium carbonate In ethanol for 3h; Heating / reflux;	99%
With potassium carbonate In ethanol for 3h; Heating / reflux;	99%
With caesium carbonate In N,N-dimethyl-formamide at 85℃;	78%

platinum-containing active charcoal: platinum-containing active charcoal

: 90-01-7
salicylic alcohol

: 90-02-8
salicylaldehyde

Conditions

Conditions	Yield
With silver; silver nitrate In sodium hydroxide	99%

: 90-01-7
salicylic alcohol

: 511286-63-8
(4S) 3,4-dibenzyl[1,2,3]oxathiazolidine-2,2-dioxide

: 1198161-49-7
C23H25NO2

Conditions

Conditions	Yield
Stage #1: salicylic alcohol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h; Stage #2: (4S) 3,4-dibenzyl[1,2,3]oxathiazolidine-2,2-dioxide In N,N-dimethyl-formamide; mineral oil at 20℃; for 16.5h; Further stages;	99%

: 67-56-1
methanol

: 90-01-7
salicylic alcohol

: 103-67-3
benzyl-methyl-amine

: 60460-63-1
2-(N-methyl-N-benzyl)aminomethylphenol

Conditions

Conditions	Yield
With Ru-MACHO-BH In toluene at 150℃; for 20h;	99%

...Expand

: 90-01-7
salicylic alcohol

: 84589-82-2
diphenylphosphine hydrogen iodide

: bis(2-hydroxybenzyl)diphenylphosphonium iodide

Conditions

Conditions	Yield
In acetonitrile at 90℃; for 24h;	99%

: 90-01-7
salicylic alcohol

: tri-n-butylphosphine hydrogen iodide

: (2-hydroxybenzyl)tri-n-butylphosphonium iodide

Conditions

Conditions	Yield
In acetonitrile at 90℃; for 12h;	99%

: 67-56-1
methanol

: 90-01-7
salicylic alcohol

: 5635-98-3
2-(methoxymethyl)phenol

Conditions

Conditions	Yield
at 150℃; for 1h; Pyrex pressure bottle;	98%
at 150℃; for 4h;	58%
With ytterbium(III) triflate In acetonitrile at 80℃; for 5h;	27%

: 90-01-7
salicylic alcohol

: 69-72-7
salicylic acid

Conditions

Conditions	Yield
With oxygen In acetonitrile at 20℃; for 7.5h; Catalytic behavior;	98%
With sodium hypochlorite; water at 25℃; for 0.416667h;	96%
With ferrous(II) sulfate heptahydrate; Oxone In water at 20℃; for 0.5h; Sonication; Green chemistry;	92%

: 90-01-7
salicylic alcohol

: 67-64-1
acetone

: 78023-79-7
2,2-dimethyl-4H-benzo[d][1,3]dioxin

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate at 20℃; for 2h;	98%

: 90-01-7
salicylic alcohol

: 64-19-7
acetic acid

: 1575-87-7
o-acetoxybenzyl acetate

Conditions

Conditions	Yield
With poly(4-vinylpyridine) perchlorate In neat (no solvent) at 20℃; for 0.4h;	98%

: 79-01-6
Trichloroethylene

: 90-01-7
salicylic alcohol

: 18162-48-6
tert-butyldimethylsilyl chloride

: C15H22Cl2O2Si

Conditions

Conditions	Yield
Stage #1: Trichloroethylene; salicylic alcohol With sodium hydroxide In dimethyl sulfoxide Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 20℃;	98%

...Expand

: 90-01-7
salicylic alcohol

: 106-95-6
allyl bromide

: 26906-01-4
2-allyloxybenzyl alcohol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux; Inert atmosphere;	97%
With potassium carbonate In acetone	72%
With potassium carbonate In acetone Reflux;	61%
With potassium carbonate In acetone at 20℃; for 14h;	50%
With ethanol; potassium carbonate

2-Hydroxybenzyl alcohol Chemical Properties

2-HYDROXYMETHYLPHENOL(90-01-7) is an organic compound with the formula of C₇H₈O_{2 ,}its chemical name is 2-Hydroxybenzyl alcohol and the formula weight is 124.14g/mol
CAS No.: 90-01-7
EINECS: 201-960-5
RTECS: DO6430000
RTECS Class: Reproductive Effector
IUPAC NAME: 2-(hydroxymethyl)phenol
Chemical Structure:

The chemical synonymous of 2-HYDROXYMETHYLPHENOL(90-01-7) are 2-Dihydroxytoluene;2-hydroxy-benzenemethano;2-Hydroxybenzenemethanol;2-hydroxy-Benzenemethanol;2-Hydroxymethylphenol;alpha,2-Dihydroxytoluene;alpha-Hydroxy-o-cresol;Benzenemethanol, 2-hydroxy- and so on.
The density of 2-HYDROXYMETHYLPHENOL(90-01-7) is 1,613 g/cm³and it has a melting point of 83-85 °C(lit.).The boiling point is 267.5 °C at 760 mmHg.Its flash point is 133.7 °C.The water solubility should be equal to 67 g/L (22 oC).
Appearance: light brown crystalline powder

2-Hydroxybenzyl alcohol History

Product Categories about 2-HYDROXYMETHYLPHENOL(90-01-7) is mainly Aromatics .

2-Hydroxybenzyl alcohol Uses

2-HYDROXYMETHYLPHENOL(90-01-7) is used for the pharmaceutical industry and used as a medicine, perfume, pesticide intermediates

2-Hydroxybenzyl alcohol Consensus Reports

Reported in EPA TSCA Inventory.

2-Hydroxybenzyl alcohol Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
    Xi: Irritant
Risk Statements about 2-HYDROXYMETHYLPHENOL(90-01-7):
    R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about 2-HYDROXYMETHYLPHENOL(90-01-7):
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S36 Wear suitable protective clothing.

2-Hydroxybenzyl alcohol Specification

Stability: Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents.
Storage:Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling:Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Fire Fighting:Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.Use agent most appropriate to extinguish fire.

Product Name

2-Hydroxybenzyl alcohol

Synthetic route

2-Hydroxybenzyl alcohol Chemical Properties

2-Hydroxybenzyl alcohol History

2-Hydroxybenzyl alcohol Uses

2-Hydroxybenzyl alcohol Consensus Reports

2-Hydroxybenzyl alcohol Safety Profile

2-Hydroxybenzyl alcohol Specification

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