2-Methoxynaphthalene supplier

Name
2-Methoxynaphthalene
EINECS 202-213-6
CAS No. 93-04-9
Article Data226
CAS DataBase
Density 1.072 g/cm³
Solubility insoluble in water
Melting Point 70-73 °C(lit.)
Formula C₁₁H₁₀O
Boiling Point 272 °C at 760 mmHg
Molecular Weight 158.2
Flash Point 102.3 °C
Transport Information
Appearance white powder
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ether,methyl 2-naphthyl (3CI);2-Naphthol methyl ether;2-Naphthyl methyl ether;6-Methoxy-2-naphthalene;Methyl 2-naphthyl ether;Methyl b-naphthyl ether;NSC 4171;Nerolin;Nerolin (old);Yara yara;b-Methoxynaphthalene;b-Naphthol methyl ether;b-Naphthyl methyl ether;
PSA 9.23000
LogP 2.84840

Synthetic route

: 135-19-3
β-naphthol

: 18107-18-1
diazomethyl-trimethyl-silane

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol; hexane; acetonitrile for 15h; Ambient temperature;	100%

: 3401-47-6
1-bromo-2-methoxynaphthalene

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate In methanol; benzene at 40℃; for 18h;	100%
Stage #1: 1-bromo-2-methoxynaphthalene With palladium dichloride In water at 20℃; for 0.0333333h; Stage #2: With 1,1,3,3-Tetramethyldisiloxane for 0.966667h;	90%
With boron nitride In methanol at 20℃; for 23h;	84%

: 135-19-3
β-naphthol

: 74-88-4
methyl iodide

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	99%
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 2h;	95%
With potassium hydroxide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 25℃; for 2h; Williamson synthesis;	92%

: 616-38-6
carbonic acid dimethyl ester

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
at 180℃; for 1h;	99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In sulfolane at 220℃; for 0.166667h;	97%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 220℃; for 0.166667h; Inert atmosphere;	95%

: 77-78-1
dimethyl sulfate

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With poly(ethylene glycol) 400; sodium carbonate at 110℃; for 8h;	99%
Stage #1: β-naphthol With potassium carbonate In acetone for 0.25h; Stage #2: dimethyl sulfate In acetone for 7h; Reflux;	97%
With potassium carbonate In acetone for 1h; Heating;	93%

: 104116-17-8
2-methoxynaphthalene-1-boronic acid

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With CpPd(SIPr)Cl; potassium tert-butylate In isopropyl alcohol at 25℃; for 24h; Inert atmosphere;	99%
With C38H52Cl2N8O4Pd; 1-bromo-2-methoxynaphthalene; potassium carbonate In tetrahydrofuran at 75℃;

: 67-56-1
methanol

: 580-13-2
2-bromonaphthalene

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
Stage #1: methanol; 2-bromonaphthalene With nickel(II) chloride hexahydrate; cadmium(II) sulphide; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide for 0.00277778h; Schlenk technique; Sonication; Stage #2: In N,N-dimethyl acetamide at 20℃; Schlenk technique; Irradiation;	99%
Stage #1: methanol With lithium methanolate at 20℃; for 0.0833333h; Stage #2: 2-bromonaphthalene With copper(l) iodide at 20 - 80℃; Ullmann etherification; Sealed tube;	95%
With palladium diacetate; caesium carbonate; tert-butyl XPhos In toluene at 80℃; for 9h;	90%
With 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; palladium diacetate; caesium carbonate In toluene at 80℃; for 12h;	67%
With potassium tert-butylate; C11H21ClN2NiO; bis(pinacol)diborane In toluene at 25℃; for 24h;	21%

: phenyl 6-methoxy-2-naphthoate

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	99%

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 3h;	98%
With hydrogen; triethylamine In methanol; water at 120℃; under 22502.3 Torr; for 96h; Autoclave;	95%
With sodium hydride; lithium iodide In tetrahydrofuran; mineral oil at 50℃; for 7h; Reagent/catalyst; Solvent; Temperature; Sealed tube;	81%

: 67886-70-8
2-cyano-6-methoxynaphthalene

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; tri-n-butyl phosphite; chlorotriisopropylsilane In ethylcyclohexane at 130℃; for 15h; Inert atmosphere;	98%
With bis(1,5-cyclooctadiene)nickel (0); hydrogen; trimethylaluminum; tricyclohexylphosphine In toluene at 130℃; under 750.075 Torr; for 24h; Schlenk technique;	73%
With bis(acetylacetonate)nickel(II); 1,1,3,3-Tetramethyldisiloxane; trimethylaluminum; tricyclohexylphosphine In toluene at 130℃; for 24h; Inert atmosphere;	70%
With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; ethanol; potassium hexamethylsilazane In toluene at 150℃; for 8h; Inert atmosphere;	64%

: 6-methoxynaphthalen-2-yl pivalate

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); sodium formate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 120℃; for 24h; Inert atmosphere; Schlenk technique;	96%

: 77-78-1
dimethyl sulfate

Amberlite IRA-400 2-naphthoxide anion: Amberlite IRA-400 2-naphthoxide anion

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
In methanol for 0.33h; Methylation;	95%

: 75-57-0
tetramethlyammonium chloride

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With diethylene glycol dimethyl ether; potassium carbonate at 155℃; for 6h;	95%
With potassium carbonate In 1,2-dimethoxyethane at 145℃; for 0.416667h; Microwave irradiation; Inert atmosphere; Sealed vessel;	87%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With rhodium(II) acetate; 1,3-bis-(diphenylphosphino)propane In toluene at 200℃; under 7500.75 Torr; Inert atmosphere;	95%

: 5392-12-1
2-methoxy-1-naphthaldehyde

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With palladium nanoparticles supported on fibrous silica In cyclohexane at 130℃; Molecular sieve;	95%

: 373-68-2
tetramethylammonium fluoride

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
In toluene at 100℃; for 6h;	95%

: 32721-21-4
1-iodo-2-methoxynapthalene

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With 9-N-methylamino-1-oxophenalene; potassium tert-butylate; potassium In 1,4-dioxane; dimethyl sulfoxide at 20℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox;	94%
With caesium carbonate; hydroquinone; palladium diacetate In N,N-dimethyl acetamide at 125℃; for 48h;	91%
Stage #1: 1-iodo-2-methoxynapthalene With palladium dichloride In water at 20℃; for 0.0333333h; Stage #2: With 1,1,3,3-Tetramethyldisiloxane for 0.966667h;	85%

: 1523-11-1
naphthalen-2-yl acetate

: 74-88-4
methyl iodide

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With sodium methylate In N,N-dimethyl-formamide for 0.5h; Ambient temperature;	92%
With 18-crown-6 ether; potassium carbonate In acetone for 10h; Heating;	69%

: 2471-70-7
2-methoxy-6-naphthoic acid

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With triethylsilane; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane In toluene at 160℃; for 15h; chemoselective reaction;	92%

: 62790-91-4
2-(dimethyl-1,1’-dimethylethylsilyloxy)naphthalene

: 74-88-4
methyl iodide

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide for 12h; Ambient temperature;	91%

: 762-42-5
dimethyl acetylenedicarboxylate

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole In neat (no solvent) at 100℃; for 0.116667h; Microwave irradiation; Green chemistry;	90%

: 67-56-1
methanol

: 616-38-6
carbonic acid dimethyl ester

: 135-19-3
β-naphthol

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride at 120 - 160℃;	90%

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 135-19-3
β-naphthol

A: 93-04-9
2-Methoxynaphthalene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 2h; Heating;	A 89% B n/a

...Expand

: 90-15-3
α-naphthol

: 616-38-6
carbonic acid dimethyl ester

A: 93-04-9
2-Methoxynaphthalene

B: 2216-69-5
1-Methoxynaphthalene

Conditions

Conditions	Yield
With dimanganese decacarbonyl at 180℃; for 1h;	A 11% B 89%

...Expand

: 947-62-6
2-methoxy-1-naphthoic acid

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; trifluoroacetic acid In dimethyl sulfoxide; N,N-dimethyl-formamide at 70℃; for 24h;	88%
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;	63%

: 5672-94-6
1-acetyl-2-methoxynaphthalene

A: 93-04-9
2-Methoxynaphthalene

B: 3900-45-6
6-methoxy-2-acetylnaphthalene

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In nitromethane at 50℃; for 18h; Product distribution;	A 86% B 9%

: 3401-47-6
1-bromo-2-methoxynaphthalene

: 98-80-6
phenylboronic acid

A: 93-04-9
2-Methoxynaphthalene

B: 75907-52-7
1-phenyl-2-methoxynaphthalene

Conditions

Conditions	Yield
With potassium fluoride; o-(dicyclohexylphosphino)diisopropylbenzamide; tris(dibenzylideneacetone)dipalladium (0) In N,N-dimethyl-formamide at 80℃; for 24h; Suzuki cross-coupling;	A n/a B 86%

...Expand

: 83710-62-7
1-bromo-6-methoxynaphthalene

: 677-22-5
tert-butylmagnesium chloride

A: 93-04-9
2-Methoxynaphthalene

B: 1263428-86-9
1-(tert-butyl)-6-methoxynaphthalene

Conditions

Conditions	Yield
With 1.54H2O*Cl2Ni; 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate In tetrahydrofuran at -10℃; for 1.5h; Kumada coupling reaction; Inert atmosphere;	A 13 mg B 86%

...Expand

: 1469537-96-9
N,N,N-trimethyl-2-naphthalenaminium trifluoromethanesulfonate

: 865-33-8
potassium methanolate

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique;	85%

: 93-04-9
2-Methoxynaphthalene

: 13101-92-3
1-chloro-2-methoxynaphthalene

Conditions

Conditions	Yield
With hydrogenchloride; 2-nitropropane; pyridine hydrochloride for 1h; Heating;	100%
With Nitroethane; pyridine hydrochloride for 2h; Heating;	100%
With Nitroethane; pyridine hydrochloride for 2h; Heating;	100%

: 93-04-9
2-Methoxynaphthalene

: 696-62-8
para-iodoanisole

: 59115-45-6
2-(4-methoxyphenyl)naphthalene

Conditions

Conditions	Yield
Stage #1: para-iodoanisole With methyllithium; zinc(II) chloride In tetrahydrofuran; diethyl ether at -78℃; for 2h; Stage #2: 2-Methoxynaphthalene With bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine In toluene at 20℃; for 12h; Negishi coupling reaction; Inert atmosphere;	100%

: 93-04-9
2-Methoxynaphthalene

: 33974-41-3
neopentylmagnesium bromide

: 61760-11-0
2-neopentyl-naphthalene

Conditions

Conditions	Yield
With nickel diacetate; 1,3-dicyclohexyl-1H-imidazol-3-ium chloride In tetrahydrofuran; toluene at 20℃; for 18h; Inert atmosphere; Sealed tube;	100%

: 93-04-9
2-Methoxynaphthalene

: 515-42-4
sodium phenylsulfonate

: 108979-03-9
(2-methoxynaphthalen-1-yl)(phenyl)sulfane

Conditions

Conditions	Yield
With hydrogenchloride In water at 80℃; for 6h;	100%

: 93-04-9
2-Methoxynaphthalene

: 32721-21-4
1-iodo-2-methoxynapthalene

Conditions

Conditions	Yield
With N-iodo-succinimide; trifluoroacetic acid In acetonitrile at 20℃; for 0.5h;	99%
With dicloroiodoisocyanuric acid In acetonitrile at 20℃; for 0.0166667h; Darkness; regioselective reaction;	99%
With methyltriphenylphosphonium peroxydisulfate; iodine In acetonitrile for 0.4h; Heating;	98%

: 93-04-9
2-Methoxynaphthalene

: 3401-47-6
1-bromo-2-methoxynaphthalene

Conditions

Conditions	Yield
With dimethylbromosulphonium bromide In tetrahydrofuran; water for 24h; Product distribution; Mechanism; Heating; other aromatic compounds, other reagents: bromodimethylsulfonium bromide/acetic acid, bromine, bromine/acetic acid, other solvents: acetonitrile, CCl4, other reaction temperature and time;	99%
With N-Bromosuccinimide In tetrachloromethane at 25℃; for 3h; Irradiation;	99%
With dimethylbromosulphonium bromide In tetrahydrofuran; water for 24h; Heating; other reagents: bromodimethylsulfonium bromide/acetic acid, bromine, bromine/acetic acid;	99%

: 93-04-9
2-Methoxynaphthalene

: 335642-28-9
1-(2,3,4,5,6-pentafluorophenylthio)-2,3,5,6-tetramethyl-4-oxocyclohexa-2,5-dienyl 2-chloroacetate

A: 4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

B: 1-(2,3,4,5,6-pentafluorophenylthio)-2-methoxynaphthalene

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 0℃; for 0.166667h;	A n/a B 99%

...Expand

: 93-04-9
2-Methoxynaphthalene

: 335642-28-9
1-(2,3,4,5,6-pentafluorophenylthio)-2,3,5,6-tetramethyl-4-oxocyclohexa-2,5-dienyl 2-chloroacetate

: 1-(2,3,4,5,6-pentafluorophenylthio)-2-methoxynaphthalene

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 0℃; for 0.166667h;	99%

: 93-04-9
2-Methoxynaphthalene

: 5123-13-7
5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane

: 612-94-2
2-phenylnaphthalene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel(0); cesium fluoride; tricyclohexylphosphine In toluene at 120℃; for 12h;	99%
With potassium phosphate; [(N,N,N',N'-tetramethylethylendiamine)NiCl(o-tolyl)]; cesium fluoride; tricyclohexylphosphine In toluene at 120℃; for 12h; Reagent/catalyst; Glovebox; Inert atmosphere; Sealed tube;	98%
With bis(1,5-cyclooctadiene)nickel (0); cesium fluoride; tricyclohexylphosphine In toluene at 120℃; for 12h; Suzuki-Miyaura coupling;	93%

: 91-01-0
1,1-Diphenylmethanol

: 93-04-9
2-Methoxynaphthalene

: 1224199-06-7
1-benzhydryl-2-methoxynaphthalene

Conditions

Conditions	Yield
With silica gel supported sodium hydrogen sulfate In 1,2-dichloro-ethane at 30℃; for 0.5h; Friedel-Crafts type alkylation;	99%
With phosphomolybdic acid In acetonitrile at 20℃; for 0.5h;	91%
With pentafluorophenylboronic acid In 1,2-dichloro-ethane for 16h; Friedel-Crafts arylation; Reflux; Molecular sieve;	87%

: 93-04-9
2-Methoxynaphthalene

: 91-20-3
naphthalene

Conditions

Conditions	Yield
With triethylsilane; bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine In toluene at 110℃; for 14h; Reagent/catalyst; Concentration; Solvent;	99%
With isopropylmagnesium bromide; nickel diacetate; 1,3-dicyclohexyl-1H-imidazol-3-ium chloride In tetrahydrofuran at 100℃; for 18h; Inert atmosphere; Sealed tube;	70%
With bis(1,5-cyclooctadiene)nickel (0); sodium formate; 1,3-dicyclohexyl-1H-imidazol-3-ium chloride; sodium t-butanolate In toluene at 140℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	63%

: 93-04-9
2-Methoxynaphthalene

: 4294-57-9
para-methylphenylmagnesium bromide

: 59115-49-0
2-(p-tolyl)naphthalene

Conditions

Conditions	Yield
Stage #1: 2-Methoxynaphthalene With Ni(PCy3)(1,3-di-tert-butylimidazol-2-ylidene)Br2 In tetrahydrofuran at 0℃; for 0.0333333h; Inert atmosphere; Schlenk technique; Stage #2: para-methylphenylmagnesium bromide In tetrahydrofuran at 25℃; for 10h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	99%
With bis(1,5-cyclooctadiene)nickel (0); magnesium; 1,3-di-tert-butylimidazol-2-ylidene In tetrahydrofuran at 60℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Green chemistry;	99%
With C68H72Cl2N6NiP2 In tetrahydrofuran at 25℃; for 24h; Inert atmosphere;	95%

: 93-04-9
2-Methoxynaphthalene

: 1822-00-0
trimethylsilylmethyllithium

: 27016-35-9
trimethyl(naphthalen-2-ylmethyl)silane

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0) In toluene; pentane at 50℃; for 2h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;	99%
With bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate; tricyclohexylphosphine In toluene at 80℃; for 12h; Inert atmosphere; Schlenk technique; Glovebox;	76%

: 93-04-9
2-Methoxynaphthalene

: C8H15IMg

: 2-(2-cyclohexylethyl)naphthalene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel(0); 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 80℃; for 14h; Inert atmosphere; Glovebox; Sealed tube;	99%

: 93-04-9
2-Methoxynaphthalene

: 21473-01-8
2-naphthalenylmagnesium bromide

: 612-78-2
2,2'-binaphthalene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); C23H28N4 In tetrahydrofuran; m-xylene at 60℃; for 4h; Kumada Cross-Coupling; Inert atmosphere; Sealed tube;	99%

: 93-04-9
2-Methoxynaphthalene

: C26H11Co2F13O8

: 2-methoxy-1-(pro-2-yn-1-yl)naphthalene dicobalt hexacarbonyl

Conditions

Conditions	Yield
With C2F6NO4S2(1-)C18H12F3PAu(1+) In 1,2-dichloro-ethane at 20℃; for 0.25h; Molecular sieve; Heating; Inert atmosphere;	99%
With C20H12AuF9NO4PS2 In 1,2-dichloro-ethane at 20℃; for 0.25h; Catalytic behavior; Reagent/catalyst; Solvent; Nicholas Reaction; Inert atmosphere; Molecular sieve;	23.8 mg

: 93-04-9
2-Methoxynaphthalene

: 75-66-1
2-methylpropan-2-thiol

: 32689-97-7
isobutyl β-naphthyl sulfide

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 0℃; for 1.2h;	98.6%

: 93-04-9
2-Methoxynaphthalene

: 108-24-7
acetic anhydride

: 5672-94-6
1-acetyl-2-methoxynaphthalene

Conditions

Conditions	Yield
With Zr6(μ3-O)4(μ3-OH)4(trimesic acid )2[triflate]6 at 25℃; for 2h; Catalytic behavior; Reagent/catalyst; Friedel-Crafts Acylation;	98%
With ZrOTfBTCSiO2 In dichloromethane at 25℃; for 2h; Reagent/catalyst; Temperature; Solvent; Friedel-Crafts Acylation;	98%
With aluminium dodecatungsten phosphate at 60 - 70℃; for 1.6h;	91%

: 93-04-9
2-Methoxynaphthalene

: 5111-65-9
2-Bromo-6-methoxynaphthalene

Conditions

Conditions	Yield
With hydrogen bromide; sodium bromide In chloroform; water at 0℃; Electrochemical reaction;	98%
With bromine; acetic acid at 55 - 85℃; under 760.051 Torr; for 0.275h; Temperature;	90.2%
With tin; bromine; acetic acid 2.) reflux; Multistep reaction;

: 93-04-9
2-Methoxynaphthalene

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran at 67℃; for 48h;	98%
With dimethylboron bromide In 1,2-dichloro-ethane at 70℃; for 36h;	96%
With boron trichloride; tetra-(n-butyl)ammonium iodide In dichloromethane at -78 - 0℃; for 1h; dealkylation;	96%

: 93-04-9
2-Methoxynaphthalene

: 108-98-5
thiophenol

: 7570-96-9
2-naphthyl phenyl sulfide

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In neat (no solvent) at 120℃; for 24h; Inert atmosphere; Sealed tube;	98%
With bismuth(lll) trifluoromethanesulfonate In water; 1,2-dichloro-ethane at 110℃; for 24h; Schlenk technique; Inert atmosphere;	95%
With aluminium trichloride In dichloromethane for 27.5h; Ambient temperature;	81.3%

: 93-04-9
2-Methoxynaphthalene

: 64-19-7
acetic acid

: 5672-94-6
1-acetyl-2-methoxynaphthalene

Conditions

Conditions	Yield
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 2.5h; Friedel-Crafts acylation;	98%
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 0.25h;	98%
With silica gel supported aluminium trichloride In 1,2-dichloro-ethane at 80℃; for 2.2h; Friedel Crafts acylation; regioselective reaction;	91%
With cross-linked polystyrene-supported aluminum triflate In 1,2-dichloro-ethane at 80℃; for 3.1h; Friedel-Crafts acylation; regioselective reaction;	90%
With trifluoromethylsulfonic anhydride In nitromethane at 20℃; for 0.0333333h; Friedel-Crafts acylation;	87%

2-Methoxynaphthalene Specification

The 2-Methoxynaphthalene is an organic compound with the formula C₁₁H₁₀O. The IUPAC name of this chemical is 2-methoxynaphthalene. With the CAS registry number 93-04-9, it is also named as Methyl 2-naphthyl ether. The product's categories are Food & Feed Additives; Naphthalene Derivatives. Besides, it is a white powder, which should be stored in a closed and cool place. It is used as a soap fragrance.

Physical properties about 2-Methoxynaphthalene are: (1)ACD/LogP: 3.36; (2)ACD/LogD (pH 5.5): 3.36; (3)ACD/LogD (pH 7.4): 3.36; (4)ACD/BCF (pH 5.5): 212.28; (5)ACD/BCF (pH 7.4): 212.28; (6)ACD/KOC (pH 5.5): 1611.41; (7)ACD/KOC (pH 7.4): 1611.41; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 9.23 Å²; (11)Index of Refraction: 1.604; (12)Molar Refractivity: 50.77 cm³; (13)Molar Volume: 147.5 cm³; (14)Polarizability: 20.12×10^-24cm³; (15)Surface Tension: 38.5 dyne/cm; (16)Density: 1.072 g/cm³; (17)Flash Point: 102.3 °C; (18)Enthalpy of Vaporization: 48.97 kJ/mol; (19)Boiling Point: 272 °C at 760 mmHg; (20)Vapour Pressure: 0.0104 mmHg at 25°C.

Preparation: this chemical can be prepared by naphthalen-2-ol and iodomethane. This reaction will need reagent KOH and methanol.

Uses of 2-Methoxynaphthalene: it can be used to produce (1-iodo-[2]naphthyl)-methyl ether by heating. It will need reagent N-iodosuccinimide and solvent acetonitrile with reaction time of 30 hours. The yield is about 89%.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c2ccc1c(cccc1)c2)C
(2)InChI: InChI=1/C11H10O/c1-12-11-7-6-9-4-2-3-5-10(9)8-11/h2-8H,1H3
(3)InChIKey: LUZDYPLAQQGJEA-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C11H10O/c1-12-11-7-6-9-4-2-3-5-10(9)8-11/h2-8H,1H3
(5)Std. InChIKey: LUZDYPLAQQGJEA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Food and Cosmetics Toxicology. Vol. 13, Pg. 885, 1975.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Food and Cosmetics Toxicology. Vol. 13, Pg. 885, 1975.

Product Name

2-Methoxynaphthalene

Synthetic route

2-Methoxynaphthalene Specification

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