Product Name

  • Name

    2-Methyl-2-phenylpropionic acid

  • EINECS 212-556-3
  • CAS No. 826-55-1
  • Article Data96
  • CAS DataBase
  • Density 1.089 g/cm3
  • Solubility Insoluble in water
  • Melting Point 80-82 °C
  • Formula C10H12O2
  • Boiling Point 270.5 °C at 760 mmHg
  • Molecular Weight 164.204
  • Flash Point 167.7 °C
  • Transport Information
  • Appearance White crystalline
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 826-55-1 (2-Methyl-2-phenylpropionic acid)
  • Hazard Symbols Xi
  • Synonyms 2,2-Dimethyl-2-phenylacetic acid;2-Phenyl-2-methylpropionic acid;2-Phenylisobutyric acid;NSC 28952;NSC 29095;TH 4161;a,a-Dimethylbenzeneacetic acid;a,a-Dimethylphenylacetic acid;Hydratropicacid, a-methyl- (6CI,7CI,8CI);
  • PSA 37.30000
  • LogP 2.04880

Synthetic route

diphenyl N-<2-methyl-2-phenyl-1-(1-pyrrolidinyl)propylidene>phosphoramidate
67174-28-1

diphenyl N-<2-methyl-2-phenyl-1-(1-pyrrolidinyl)propylidene>phosphoramidate

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide In ethylene glycol Heating;100%
methyl 2-methyl-2-phenylpropionate
57625-74-8

methyl 2-methyl-2-phenylpropionate

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane for 24h;98%
With sodium hydroxide In methanol; water for 4h; Ambient temperature; Yield given;
With sodium hydroxide; water In methanol at 80℃; for 12h; Hydrolysis;
2-bromo-2-phenylpropane
3575-19-7

2-bromo-2-phenylpropane

carbon dioxide
124-38-9

carbon dioxide

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With Ag nano wire core encapsulated by a N-doped carbon shell at 700 °C In acetonitrile at 25℃; under 750.075 Torr; Electrochemical reaction;91%
With nitrogen-doped carbon nanofibers embedded with platinum nanoparticles onto flexible carbon cloth In acetonitrile at 25℃; under 760.051 Torr; Electrochemical reaction;92 %Chromat.
2-methyl-2-phenylpropionitrile
1195-98-8

2-methyl-2-phenylpropionitrile

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With water; potassium hydroxide In ethylene glycol at 100℃; for 48h; Inert atmosphere;73%
carbon dioxide
124-38-9

carbon dioxide

2-phenyl-2-propyl phenyl sulfide
4148-93-0

2-phenyl-2-propyl phenyl sulfide

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

lithium thiophenoxide
2973-86-6

lithium thiophenoxide

Conditions
ConditionsYield
Stage #1: 2-phenyl-2-propyl phenyl sulfide With lithium In diethyl ether at 3 - 8℃; for 2h;
Stage #2: carbon dioxide In diethyl ether
A 73%
B n/a
2,2-(dimethyl)-2-phenylacetaldehyde
3805-10-5

2,2-(dimethyl)-2-phenylacetaldehyde

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With sodium hydroxide; silver nitrate for 2h; cooling;70%
With silver(l) oxide
Ethyl 2-phenylethanoate
101-97-3

Ethyl 2-phenylethanoate

methyl iodide
74-88-4

methyl iodide

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

ethyl 2-methyl-2-phenylpropionate
2901-13-5

ethyl 2-methyl-2-phenylpropionate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 10 - 20℃; for 16h; Alkylation;A 28%
B 52%
carbon monoxide
201230-82-2

carbon monoxide

isopropenylbenzene
98-83-9

isopropenylbenzene

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With water; bis-triphenylphosphine-palladium(II) chloride In butanone at 115℃; under 40504.1 Torr; for 5.5h;50%
carbon dioxide
124-38-9

carbon dioxide

N,N,N-trimethyl-2-phenylpropan-2-aminium trifluoromethanesulfonate

N,N,N-trimethyl-2-phenylpropan-2-aminium trifluoromethanesulfonate

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; potassium carbonate; caesium carbonate In N,N-dimethyl-formamide at 25 - 30℃; for 36h; Schlenk technique; Glovebox; Sealed tube; Irradiation;43%
phenylacetic acid
103-82-2

phenylacetic acid

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With ammonia; potassium amide anschliessend Behandeln mit CH3I;
Isopropylbenzene
98-82-8

Isopropylbenzene

propyl potassium
88982-51-8

propyl potassium

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

4-Isopropylbenzoic acid
536-66-3

4-Isopropylbenzoic acid

C

3-isopropylbenzoic acid
5651-47-8

3-isopropylbenzoic acid

D

2-isopropylbenzoic acid
2438-04-2

2-isopropylbenzoic acid

Conditions
ConditionsYield
at 90℃; Product distribution; anschliessend Behandeln mit festem Kohlendioxid;
Isopropylbenzene
98-82-8

Isopropylbenzene

pentyl potassium
2875-37-8

pentyl potassium

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

4-Isopropylbenzoic acid
536-66-3

4-Isopropylbenzoic acid

C

3-isopropylbenzoic acid
5651-47-8

3-isopropylbenzoic acid

D

2-isopropylbenzoic acid
2438-04-2

2-isopropylbenzoic acid

Conditions
ConditionsYield
at 20℃; Product distribution; anschliessend Behandeln mit festem Kohlendioxid;
Isopropylbenzene
98-82-8

Isopropylbenzene

ethyl potassium
4522-40-1

ethyl potassium

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

4-Isopropylbenzoic acid
536-66-3

4-Isopropylbenzoic acid

C

3-isopropylbenzoic acid
5651-47-8

3-isopropylbenzoic acid

D

2-isopropylbenzoic acid
2438-04-2

2-isopropylbenzoic acid

Conditions
ConditionsYield
at 20℃; Product distribution; anschliessend Behandeln mit festem Kohlendioxid;
at 85℃; Product distribution; anschliessend Behandeln mit festem Kohlendioxid;
Isopropylbenzene
98-82-8

Isopropylbenzene

diethylmercury
627-44-1

diethylmercury

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With sodium anschliessendes Behandeln mit festem Kohlendioxid;
Isopropylbenzene
98-82-8

Isopropylbenzene

n-pentylsodium
1822-71-5

n-pentylsodium

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

4-Isopropylbenzoic acid
536-66-3

4-Isopropylbenzoic acid

C

3-isopropylbenzoic acid
5651-47-8

3-isopropylbenzoic acid

D

2-isopropylbenzoic acid
2438-04-2

2-isopropylbenzoic acid

Conditions
ConditionsYield
at 20℃; Product distribution; anschliessend Behandeln mit festem Kohlendioxid;
diethyl ether
60-29-7

diethyl ether

cumyl potassium
3003-91-6

cumyl potassium

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-bromo-2-methylpropionic acid
2052-01-9

2-bromo-2-methylpropionic acid

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With aluminum tri-bromide; benzene
2-methyl-2-phenylbutan-3-one
770-85-4

2-methyl-2-phenylbutan-3-one

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With sodium hypochlorite
2-bromo-2-methyl-1-phenyl-propan-1-one
10409-54-8

2-bromo-2-methyl-1-phenyl-propan-1-one

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With ethanol; silver nitrate
2-methyl-2-phenyl-propanamide
826-54-0

2-methyl-2-phenyl-propanamide

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With alkaline solution
With sulfuric acid
With hydrogenchloride; sodium nitrite
2-methyl-1-nitro-2-phenylpropane
76173-50-7

2-methyl-1-nitro-2-phenylpropane

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With alkaline KMNO4
cumyl potassium
3003-91-6

cumyl potassium

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With carbon dioxide
α-chloroisobutyrophenone
7473-99-6

α-chloroisobutyrophenone

A

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

B

2-hydroxy-2-methylpropiophenone
7473-98-5

2-hydroxy-2-methylpropiophenone

Conditions
ConditionsYield
With 1,4-dioxane; silver-salt
With 1,4-dioxane; mercury-salt
poly(methacrylic acid)
79-41-4

poly(methacrylic acid)

benzene
71-43-2

benzene

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With hydrogenchloride; aluminium trichloride
With aluminium trichloride
With aluminum (III) chloride Industry scale;
With aluminum (III) chloride Industry scale;
ethyl 2-bromoisovalerate
609-12-1

ethyl 2-bromoisovalerate

benzene
71-43-2

benzene

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With aluminium trichloride
2-bromo-2-methylpropionic acid
2052-01-9

2-bromo-2-methylpropionic acid

benzene
71-43-2

benzene

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With aluminum tri-bromide at 150℃;
With aluminium trichloride
formic acid
64-18-6

formic acid

1-methyl-1-phenylethyl alcohol
617-94-7

1-methyl-1-phenylethyl alcohol

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
With sulfuric acid at 20 - 25℃; for 2h;
Isopropylbenzene
98-82-8

Isopropylbenzene

carbon dioxide
124-38-9

carbon dioxide

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
(i) nBuLi, heptane, (ii) /BRN= 1900390/; Multistep reaction;
4-methyl-2,4-diphenylpent-2-ene
22768-22-5, 22768-23-6, 6258-73-7

4-methyl-2,4-diphenylpent-2-ene

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

Conditions
ConditionsYield
(i) O3, (ii) CrO3; Multistep reaction;
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

methoxymethyl 2-methyl-2-phenylpropanoate

methoxymethyl 2-methyl-2-phenylpropanoate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 3h; Inert atmosphere;100%
methanol
67-56-1

methanol

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

methyl 2-methyl-2-phenylpropionate
57625-74-8

methyl 2-methyl-2-phenylpropionate

Conditions
ConditionsYield
With sulfuric acid at 20 - 70℃; for 21.5h; Inert atmosphere;99.5%
With sulfuric acid at 70℃; for 12h;94%
With sulfuric acid Heating;
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-propan-1-ol
2173-69-5

2-methyl-2-phenyl-propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether Reduction;99%
Stage #1: 2-methyl-2-phenylpropionic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.5h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water
90%
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 2h; Inert atmosphere;81%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

triphenylbismuthane
603-33-8

triphenylbismuthane

bismuth(III) 2-phenylisobutyrate

bismuth(III) 2-phenylisobutyrate

Conditions
ConditionsYield
In toluene at 110℃; for 16h; Schlenk technique; Inert atmosphere;99%
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

lithium 2-phenylisobutyrate

lithium 2-phenylisobutyrate

Conditions
ConditionsYield
Stage #1: n-butyllithium; 2-methyl-2-phenylpropionic acid In hexane at -80℃; Schlenk technique; Inert atmosphere;
Stage #2: In hexane at 20℃; for 2h; Schlenk technique; Inert atmosphere;
99%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-methyl-2-phenylpropanamide
889798-61-2

N-benzyl-2-methyl-2-phenylpropanamide

Conditions
ConditionsYield
With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine In tetrahydrofuran at 60℃; for 15h; Inert atmosphere;98%
With 4-(2-(1,3-dioxa-3a1,8,10-triaza-2,3a,14b-triboradibenzo[fg,op]tetracen-2-yl)phenyl)benzo[c]pyrimido[4,5-e][1,2]azaborinin-6(5H)-ol In fluorobenzene at 85℃; for 8h; Molecular sieve;92%
ethanol
64-17-5

ethanol

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

ethyl 2-methyl-2-phenylpropionate
2901-13-5

ethyl 2-methyl-2-phenylpropionate

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With thionyl chloride In dichloromethane for 15h; Reflux;
Stage #2: ethanol In dichloromethane
96%
With thionyl chloride Reflux;88%
With potassium carbonate; dibromotriphenylphosphorane In acetonitrile at 60℃; for 72h;66%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

ethyl acrylate
140-88-5

ethyl acrylate

C15H18O4

C15H18O4

Conditions
ConditionsYield
With oxygen; palladium diacetate; potassium hydrogencarbonate; p-benzoquinone In tert-Amyl alcohol at 85℃; under 760.051 Torr; for 48h; regioselective reaction;96%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

4,4-dimethyl-2-phenyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid hydrazide

4,4-dimethyl-2-phenyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid hydrazide

4,4-dimethyl-2-phenyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid N-(2-methyl-2-phenyl-propionyl)hydrazide

4,4-dimethyl-2-phenyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid N-(2-methyl-2-phenyl-propionyl)hydrazide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 2h;96%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-cyclohexyl-2-methylpropanoic acid
16386-97-3

2-cyclohexyl-2-methylpropanoic acid

Conditions
ConditionsYield
With Rh/Al2O3; hydrogen In acetic acid under 5688.78 Torr;95%
With hydrogen; platinum(IV) oxide
tert-butylmethyl ether
28509-24-2

tert-butylmethyl ether

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide
169280-16-4

2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide

Conditions
ConditionsYield
With hydrogenchloride; thionyl chloride; potassium carbonate In water; toluene95%
With hydrogenchloride; thionyl chloride; potassium carbonate In water; toluene95%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide
169280-16-4

2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With thionyl chloride In toluene at 20℃; Heating / reflux;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With potassium carbonate In water; toluene for 2h;
95%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

para-fluorobenzylamine
140-75-0

para-fluorobenzylamine

C17H18FNO

C17H18FNO

Conditions
ConditionsYield
With C36H24B4N2O3 In toluene at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Molecular sieve;95%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

ethyl (p-methoxyphenyl)oxoacetate
40140-16-7

ethyl (p-methoxyphenyl)oxoacetate

ethyl 2-hydroxy-2-(4-methoxyphenyl)-3-methyl-3-phenylbutanoate

ethyl 2-hydroxy-2-(4-methoxyphenyl)-3-methyl-3-phenylbutanoate

Conditions
ConditionsYield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate In dimethyl sulfoxide at 40℃; for 1h; Glovebox; Inert atmosphere; Irradiation;95%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

1-chloro-3-methyl-3-phenylbutan-2-one
64922-05-0

1-chloro-3-methyl-3-phenylbutan-2-one

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;
Stage #2: diazomethane In tetrahydrofuran; diethyl ether at 0 - 20℃; for 12h;
Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether at 0℃; for 0.0833333h;
94%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

4-methoxy-aniline
104-94-9

4-methoxy-aniline

N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide
862876-03-7

N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate In acetonitrile at 23℃; for 0.166667h;94%
With C36H24B4N2O3 In toluene at 80℃; for 14h; Molecular sieve;89%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

4-chloro-aniline
106-47-8

4-chloro-aniline

N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide
862876-04-8

N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate In acetonitrile at 23℃; for 0.333333h;94%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

(phenyl)methyl 2-methyl-2-phenylpropanoate

(phenyl)methyl 2-methyl-2-phenylpropanoate

Conditions
ConditionsYield
In toluene for 18h; Inert atmosphere; Reflux;94%
tert-butyl (1S,4R,5R,7S)-7-amino-5-(3-isopropoxyphenyl)-4-methyl-2-azabicyclo[3.3.1]nonane-2-carboxylate
911422-98-5

tert-butyl (1S,4R,5R,7S)-7-amino-5-(3-isopropoxyphenyl)-4-methyl-2-azabicyclo[3.3.1]nonane-2-carboxylate

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

tert-butyl (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-7-[(2-methyl-2-phenylpropanoyl)amino]-2-azabicyclo[3.3.1]nonane-2-carboxylate
911423-23-9

tert-butyl (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-7-[(2-methyl-2-phenylpropanoyl)amino]-2-azabicyclo[3.3.1]nonane-2-carboxylate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; for 4h;93%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

4-Aminobenzonitrile
873-74-5

4-Aminobenzonitrile

N-(4-cyanophenyl)-2-methyl-2-phenylpropanamide
862876-05-9

N-(4-cyanophenyl)-2-methyl-2-phenylpropanamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate In acetonitrile at 23℃; for 21h; Reagent/catalyst; Solvent;93%
4-ethoxycarbonylpyrazole
37622-90-5

4-ethoxycarbonylpyrazole

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

ethyl 1-(2-phenylpropan-2-yl)-1H-pyrazole-4-carboxylate

ethyl 1-(2-phenylpropan-2-yl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; tert-butylammonium hexafluorophosphate(V) In dichloromethane for 2.5h; Molecular sieve; Electrochemical reaction;93%
pyrrolidine
123-75-1

pyrrolidine

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-propionic acid , pirrolidineamide

2-methyl-2-phenyl-propionic acid , pirrolidineamide

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With thionyl chloride In toluene at 20℃; Heating / reflux;
Stage #2: pyrrolidine With potassium carbonate In water; toluene for 2h;
92%
4-aminopyridine
504-24-5

4-aminopyridine

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-N-(pyridin-4-yl)propanamide

2-methyl-2-phenyl-N-(pyridin-4-yl)propanamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate In acetonitrile at 23℃; for 5h;92%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

methyl 2-methyl-2-phenylpropionate
57625-74-8

methyl 2-methyl-2-phenylpropionate

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 16h; Inert atmosphere; Green chemistry;91%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

tert-butyl 4-((2-(hydrazinecarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
1443209-30-0

tert-butyl 4-((2-(hydrazinecarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

tert-butyl 4-((2-(2-(2-methyl-2-phenylpropanoyl)hydrazinecarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
1581303-74-3

tert-butyl 4-((2-(2-(2-methyl-2-phenylpropanoyl)hydrazinecarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 18h;91%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

aniline
62-53-3

aniline

2-methyl-N,2-diphenylpropanamide
58265-36-4

2-methyl-N,2-diphenylpropanamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate In acetonitrile at 23℃; for 0.666667h;91%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;91%
Stage #1: N-hydroxyphthalimide; 2-methyl-2-phenylpropionic acid With dmap In dichloromethane for 0.0833333h; Inert atmosphere;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;
90%
With dmap; diisopropyl-carbodiimide In tetrahydrofuran at 20℃; Inert atmosphere;87%
With dmap; diisopropyl-carbodiimide In dichloromethane
With diisopropyl-carbodiimide In dichloromethane

2-Methyl-2-phenylpropionic acid Chemical Properties

Product Name: 2-Methyl-2-phenylpropionic acid (CAS NO.826-55-1)


Molecular Formula: C10H12O2
Molecular Weight: 164.2g/mol
Mol File: 826-55-1.mol
EINECS: 212-556-3
Melting Point: 80-82°C
Boiling point: 270.5 °C at 760 mmHg
Flash Point: 167.7 °C
Density: 1.089 g/cm3
Surface Tension: 39.1 dyne/cm
Enthalpy of Vaporization: 53.73 kJ/mol
Vapour Pressure: 0.00336 mmHg at 25°C
XLogP3-AA: 1.6
H-Bond Donor: 1
H-Bond Acceptor: 2
Structure Descriptors of 2-Methyl-2-phenylpropionic acid (CAS NO.826-55-1):
  IUPAC Name: 2-methyl-2-phenylpropanoic acid
  Canonical SMILES: CC(C)(C1=CC=CC=C1)C(=O)O
  InChI: InChI=1S/C10H12O2/c1-10(2,9(11)12)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,11,12) 
  InChIKey: YYEROYLAYAVZNW-UHFFFAOYSA-N
Product Categories: Acids and Derivatives

2-Methyl-2-phenylpropionic acid Safety Profile

Safety Information of 2-Methyl-2-phenylpropionic acid (CAS NO.826-55-1):
Risk Statements: 36/37/38 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 26-36/37/39
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection

2-Methyl-2-phenylpropionic acid Specification

 2-Methyl-2-phenylpropionic acid , its CAS NO. is 826-55-1, the synonym is 2-Phenylisobutyric acid .

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