2-Methylthiazole supplier | CasNO.3581-87-1

Name
2-Methylthiazole
EINECS 222-702-8
CAS No. 3581-87-1
Article Data22
CAS DataBase
Density 1.121 g/cm³
Solubility Completely miscible in water
Melting Point -24 °C
Formula C₄H₅NS
Boiling Point 128.5 °C at 760 mmHg
Molecular Weight 99.1564
Flash Point 28.9 °C
Transport Information
Appearance
Safety 23-26-36/37/39
Risk Codes 10-22
Molecular Structure
Hazard Symbols
Synonyms 2-methyl-1,3-thiazole;2-Methoxy thiazole;2-Methyl thiazole;
PSA 41.13000
LogP 1.45150

Synthetic route

: 3034-53-5
2-bromo-1,3-thiazole

[3-(dimethylamino)propyl]dimethylindium: [3-(dimethylamino)propyl]dimethylindium

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In benzene at 80℃; for 19h;	94%

: 69749-91-3
2-(methanesulfonyl)thiazole

: 74-88-4
methyl iodide

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
Stage #1: methyl iodide With magnesium In tetrahydrofuran at 10 - 30℃; for 2h; Inert atmosphere; Stage #2: 2-(methanesulfonyl)thiazole In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;	86%

: 3034-53-5
2-bromo-1,3-thiazole

bis(μ-[2-(dimethylamino)ethanolato-N,O:O]tetramethyldiindium: bis(μ-[2-(dimethylamino)ethanolato-N,O:O]tetramethyldiindium

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In benzene at 80℃; for 24h;	84%

: 2346-00-1
2-methyl-4,5-dihydro-thiazole

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
With sulfur at 100 - 110℃;

: 66867-06-9
2-methyl-2,5-dihydro-thiazole

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
With ethanol; iron(III) chloride

: 107-20-0
2-chloroethanal

: 62-55-5
thioacetamide

: 3581-87-1
2-methylthiazole

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 62-55-5
thioacetamide

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
With ethanol

: 15873-56-0
monochloroacetaldehyde hydrate

: 62-55-5
thioacetamide

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
With acetic anhydride; benzene

: 3034-53-5
2-bromo-1,3-thiazole

: 77-78-1
dimethyl sulfate

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
(i) nBuLi, Et2O, (ii) /BRN= 635994/; Multistep reaction;

: N-thiazol-2-ylmethyl-aniline; hydrochloride

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
With hydrogenchloride (electrolysis);

: 693-92-5
3-methylisothiazole

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
In ethanol Ambient temperature; Irradiation;
In ethanol Mechanism; Ambient temperature; Irradiation; other substrates, other solvents;

: 3-((7-(diethylamino)-3-iodo-2-oxo-2H-chromen-4-yl)methyl)-2-methylthiazol-3-ium bromide

: 3581-87-1
2-methylthiazole

Conditions

Conditions	Yield
In dimethyl sulfoxide pH=7.4; Quantum yield; Solvent; Irradiation;

: 3581-87-1
2-methylthiazole

: 1122-91-4
4-bromo-benzaldehyde

: 4-(2-methyl-1,3-thiazol-5-yl)benzaldehyde

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	100%

: 3581-87-1
2-methylthiazole

: 1461-22-9
tributyltin chloride

: C13H25NSSn

Conditions

Conditions	Yield
Stage #1: 2-methylthiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: tributyltin chloride In tetrahydrofuran; hexane at -78℃; for 1h;	99.2%

: 3581-87-1
2-methylthiazole

: 90-11-9
1-Bromonaphthalene

: 107559-03-5
2-methyl-5-(naphthalen-1-yl)thiazole

Conditions

Conditions	Yield
With C68H65Cl2N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	98%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	90%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	62%

: 3581-87-1
2-methylthiazole

: 3964-04-3
4-bromoquinoline

: 2-methyl-5-(quinolin-4-yl)thiazole

Conditions

Conditions	Yield
With C68H64Cl3N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Reagent/catalyst; regioselective reaction;	94%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	80%

: 3581-87-1
2-methylthiazole

: 140-88-5
ethyl acrylate

: 1392148-94-5
(E)-ethyl 3-(2-methylthiazol-5-yl)acrylate

Conditions

Conditions	Yield
Stage #1: 2-methylthiazole With C37H24F2N6O2Pd In dichloromethane at 20℃; for 0.333333h; Stage #2: ethyl acrylate With 1,1,1,3',3',3'-hexafluoro-propanol; silver(I) acetate; palladium diacetate; N-acetylglycine In dichloromethane at 80℃; for 30h; Sealed tube;	92%

: 3581-87-1
2-methylthiazole

: 98-88-4
benzoyl chloride

: 1256960-61-8
benzoic acid 1-phenyl-2-thiazol-2-ylvinyl ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 7h; Inert atmosphere; Reflux;	89%
With triethylamine In acetonitrile at 20℃; for 7h; Inert atmosphere; Reflux;	88.8%
With triethylamine In acetonitrile at 20℃; Inert atmosphere; Reflux;	76%

: 3581-87-1
2-methylthiazole

: 619-42-1
4-methoxycarbonylphenyl bromide

: methyl 4-(2-methyl-1,3-thiazol-5-yl)benzoate

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	88%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	70%

: 18448-47-0
methyl cyclohex-1-ene-1-carboxylate

: 3581-87-1
2-methylthiazole

: methyl 6-(2-methylthiazol-5-yl)cyclohex-1-enecarboxylate

Conditions

Conditions	Yield
Stage #1: 2-methylthiazole With C37H24F2N6O2Pd In dichloromethane at 20℃; for 0.333333h; Stage #2: methyl cyclohex-1-ene-1-carboxylate With 1,1,1,3',3',3'-hexafluoro-propanol; silver(I) acetate; palladium diacetate; N-acetylglycine In dichloromethane at 80℃; for 30h; Sealed tube;	88%

: 13472-85-0
2-methoxy-5-bromopyridine

: 3581-87-1
2-methylthiazole

: 5-(6-methoxypyridin-3-yl)-2-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	88%

: 3581-87-1
2-methylthiazole

: 1461-22-9
tributyltin chloride

: 223418-75-5
2-methyl-5-(tributylstannyl)thiazole

Conditions

Conditions	Yield
Stage #1: 2-methylthiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: tributyltin chloride In tetrahydrofuran; hexane at -78 - 20℃; for 2h;	85%
Stage #1: 2-methylthiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: tributyltin chloride In tetrahydrofuran; hexane at -78 - 20℃; for 2h;	85%
Stage #1: 2-methylthiazole With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: tributyltin chloride In tetrahydrofuran at -78 - 20℃; Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	72%

: 5332-24-1
3-bromoquinoline

: 3581-87-1
2-methylthiazole

: 2-methyl-5-(quinolin-3-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	83%

: 3581-87-1
2-methylthiazole

: 36016-40-7
mesitylenesulfonylhydroxylamine

: 52197-75-8
3-amino-2-methyl-thiazolium; 2,4,6-trimethyl-benzenesulfonate

Conditions

Conditions	Yield
In ethyl acetate; toluene for 2h; Cooling with ice;	81%
In dichloromethane for 0.166667h; Ambient temperature;	62%

: 3581-87-1
2-methylthiazole

: 141-32-2
acrylic acid n-butyl ester

: 1236376-59-2
(E)-butyl 3-(2-methylthiazol-5-yl)acrylate

Conditions

Conditions	Yield
With silver(I) acetate; palladium diacetate; propionic acid at 120℃; for 8h; Inert atmosphere;	80%
With 5-Nitro-1,10-phenanthroline; copper diacetate; palladium diacetate; caesium carbonate; dimethyl sulfoxide In tert-Amyl alcohol at 100℃; for 12h; Inert atmosphere; regioselective reaction;	46%

: 3581-87-1
2-methylthiazole

: 849934-94-7
methyl 2-(4-bromo-2-chlorophenyl)acetate

: 1428761-21-0
methyl 2-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)acetate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium acetate at 100℃; for 15h; Inert atmosphere;	80%
With tetrakis(triphenylphosphine) palladium(0); potassium acetate In 1,2-dimethoxyethane at 100℃; for 15h; Inert atmosphere;	80%

: 3581-87-1
2-methylthiazole

: 134271-22-0
2-Dibromomethylthiazole

Conditions

Conditions	Yield
With N-Bromosuccinimide In tetrachloromethane for 1.75h; Heating; Irradiation;	79%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 80℃; for 16h;

: 106-39-8
bromochlorobenzene

: 3581-87-1
2-methylthiazole

: 25594-97-2
5-(4-chlorophenyl)-2-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	79%

: 3581-87-1
2-methylthiazole

: 402-43-7
p-trifluoromethylphenyl bromide

: 945860-92-4
2-methyl-5-(4-(trifluoromethyl)phenyl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	78%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	69%

: 3581-87-1
2-methylthiazole

: 100-52-7
benzaldehyde

: 1-Phenyl-2-thiazol-2-yl-ethanol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; B-(trifluoromethanesulfonyloxy)-9-borabicyclo[3.3.1]nonane In dichloromethane for 17h; Ambient temperature;	77%
With diisopropylamine; 9-BBN triflate 1.) -78 deg C, 2.) RT, 17 h; Yield given. Multistep reaction;

: 64-67-5
diethyl sulfate

: 3581-87-1
2-methylthiazole

: 3-ethyl-2-methylthiazolium ethosulfate

Conditions

Conditions	Yield
In xylene at 90℃; for 0.5h;	76%

: 3581-87-1
2-methylthiazole

: 327-51-5
1,4-dibromo-2,5-difluorobenzene

: 1,4-bis(2-methylthiazol-5-yl)-2,5-difluorobenzene

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; tricyclohexylphosphine; Trimethylacetic acid In N,N-dimethyl acetamide; toluene at 100℃; for 24h; Inert atmosphere;	75%

: 766-11-0
5-bromo-2-fluoropyridine

: 3581-87-1
2-methylthiazole

: 5-(6-fluoropyridin-3-yl)-2-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	75%

: 108-86-1
bromobenzene

: 3581-87-1
2-methylthiazole

: 19968-60-6
2-methyl-5-phenylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	74%

: 3581-87-1
2-methylthiazole

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: C12H7F6NS

Conditions

Conditions	Yield
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	73%

: 617-86-7
triethylsilane

: 3581-87-1
2-methylthiazole

: 2-[(triethylsilyl)methyl]thiazole

Conditions

Conditions	Yield
With 3,5-Lutidine; chlorohydrido(2,6-bis(di-tert-butylphosphinito)phen-1-yl)iridium(III); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; cyclopentene at 130℃; for 20h; Schlenk technique; Inert atmosphere; regioselective reaction;	73%
With 3,5-Lutidine; norborn-2-ene; dodecacarbonyltetrairidium In neat (no solvent) at 160℃; for 40h; Schlenk technique; Inert atmosphere; regioselective reaction;	53%

: 3430-13-5
5-bromo-2-methylpyridine

: 3581-87-1
2-methylthiazole

: 2-methyl-5-(6-methylpyridin-3-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	73%

: 3581-87-1
2-methylthiazole

: 627-31-6
1,3-Diiodopropane

: 3-(3-iodopropyl)-2-methylthiazol-3-ium

Conditions

Conditions	Yield
In acetonitrile for 5h; Reflux;	71%

: 3581-87-1
2-methylthiazole

: 105-36-2
ethyl bromoacetate

: 3-(2-ethoxy-2-oxoethyl)-2-methylthiazol-3-ium bromide

Conditions

Conditions	Yield
for 16h; Reflux;	70%

2-Methylthiazole Chemical Properties

Molecular Structure of 2-Methylthiazole (CAS NO.3581-87-1):

IUPAC Name: 2-Methyl-1,3-thiazole
Molecular Formula:C₄H₅NS
Molecular Weight:99.154200 g/mol
XLogP3-AA: 1.4
H-Bond Donor: 0
H-Bond Acceptor: 1
Index of Refraction: 1.535
Molar Refractivity: 27.55 cm³
Molar Volume: 88.4 cm³
Surface Tension: 39.9 dyne/cm
Melting Point:-24 °C
Density:1.121 g/cm³
Flash Point:28.9 °C
Enthalpy of Vaporization:35.11 kJ/mol
Boiling Point:128.5 °C at 760 mmHg
Vapour Pressure:12.9 mmHg at 25 °C
Water Solubility:5689 mg/L at 25 °C
SMILES: n1ccsc1C
InChI: InChI=1/C4H5NS/c1-4-5-2-3-6-4/h2-3H,1H3
InChIKey: VZWOXDYRBDIHMA-UHFFFAOYAX
EINECS: 222-702-8
Product Categories: Heterocyclic Compounds; Thiazoles

2-Methylthiazole Uses

2-Methylthiazole (CAS NO.3581-87-1) is used as a food flavor.

2-Methylthiazole Safety Profile

Safety Information of 2-Methylthiazole (CAS NO.3581-87-1):
Risk Statements:10-22
10:Flammable
22:Harmful if swallowed
Safety Statements:23-26-36/37/39
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
RIDADR:1993

2-Methylthiazole Specification

2-Methylthiazole (CAS NO.3581-87-1), its Synonyms are : Thiazole, 2-methyl- ; 2-Methoxy thiazole .

Product Name

2-Methylthiazole

Synthetic route

2-Methylthiazole Chemical Properties

2-Methylthiazole Uses

2-Methylthiazole Safety Profile

2-Methylthiazole Specification

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