2-Phenylethylamine hydrochloride supplier

Name
2-Phenylethylamine hydrochloride
EINECS 205-849-2
CAS No. 156-28-5
Article Data56
CAS DataBase
Density
Solubility
Melting Point 220-222 °C(lit.)
Formula C₈H₁₂ClN
Boiling Point 196.5 °C at 760 mmHg
Molecular Weight 157.643
Flash Point 90.6 °C
Transport Information UN 2811
Appearance
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Benzeneethanamine,hydrochloride (9CI);Phenethylamine, hydrochloride (8CI);2-Phenethylaminehydrochloride;2-Phenethylammonium chloride;Benzeneethanamine,hydrochloride (1:1);2-Phenylethylammonium chloride;Phenethylammonium chloride;b-Phenethylamine hydrochloride;b-Phenylethylamine hydrochloride;
PSA 26.02000
LogP 2.69010

Synthetic route

: 140-29-4
phenylacetonitrile

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen In propan-1-ol; water at 60℃; under 375.038 Torr; for 18h; Flow reactor;	100%
Stage #1: phenylacetonitrile With water; palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In dichloromethane at 25℃; for 12h; Sealed tube; Inert atmosphere; Stage #2: With hydrogenchloride In water chemoselective reaction;	99%
Stage #1: phenylacetonitrile With ammonium hydroxide; hydrogen; cobalt(II) diacetate tetrahydrate; zinc trifluoromethanesulfonate; zinc In methanol at 120℃; under 30003 Torr; for 15h; Sealed tube; Autoclave; Stage #2: With hydrogenchloride In diethyl ether	96%

: 6926-44-9
phenethyl azide

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: phenethyl azide With triphenylphosphine at 110℃; for 20h; Staudinger Azide Reduction; Green chemistry; Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether Green chemistry;	97%
Stage #1: phenethyl azide With 1,3-diphenyl-disiloxane; triphenylphosphine at 20℃; for 24h; Staudinger Azide Reduction; Stage #2: With water Stage #3: With hydrogenchloride In 1,4-dioxane chemoselective reaction;	90%
Multi-step reaction with 2 steps 1: benzene / Ambient temperature 2: HCl / benzene / 2 h / Ambient temperature View Scheme

: 64-04-0
phenethylamine

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol	90%
With hydrogenchloride In water
With hydrogenchloride In methanol; diethyl ether at 20℃; Inert atmosphere;
With hydrogenchloride In water at 20℃;	68.6 mg

: 6125-24-2
2-Phenylnitroethane

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-Phenylnitroethane With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Schlenk technique; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 20℃;	83%

: 102-93-2
3-phenylpropionamide

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 3-phenylpropionamide With tetrafluoroboric acid; iodobenzene; 3-chloro-benzenecarboperoxoic acid In dichloromethane; water at 25℃; for 48h; Hofmann rearrangement; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water Inert atmosphere;	82%
With hydrogenchloride; formic acid; iodosylbenzene 1.) CH3CN, H2O, 15 h, room temp.; Yield given. Multistep reaction;

: 1-phenethyl-3,4-diphenyl-1H-pyrrole-2,5-dione

A: 4808-48-4
2,3-diphenylmaleic anhydride

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-phenethyl-3,4-diphenyl-1H-pyrrole-2,5-dione With potassium hydroxide In ethanol; water at 102℃; for 0.133333h; Microwave irradiation; Green chemistry; Stage #2: With hydrogenchloride In ethanol; water pH=4; Temperature; Green chemistry;	A n/a B 82%

: 63-91-2
L-phenylalanine

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: L-phenylalanine With (R)-Carvone In propan-1-ol at 190℃; under 11251.1 Torr; for 0.0833333h; Sealed tube; Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h;	78%
Multi-step reaction with 2 steps 1: propan-1-ol / 20 - 190 °C / Green chemistry 2: hydrogenchloride / propan-1-ol / 0.08 h / 190 °C / Green chemistry View Scheme

: C18H23N

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Temperature; Green chemistry;	78%

: 3278-14-6
N-phenethylbenzamide

: 925-90-6
ethylmagnesium bromide

A: 156-28-5
2-phenylethylamine hydrochloride

B: 93-55-0
1-phenyl-propan-1-one

Conditions

Conditions	Yield
Stage #1: N-phenethylbenzamide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0℃; for 0.5h; Stage #2: ethylmagnesium bromide With cerium(III) chloride In tetrahydrofuran; dichloromethane at -78℃; for 2h; Stage #3: With hydrogenchloride In ethyl acetate	A 76% B n/a

...Expand

: 103-81-1
Benzeneacetamide

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: Benzeneacetamide With [(aNHC)KN(SiMe3)2]2; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 40℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: With water; sodium hydroxide In diethyl ether; toluene at 40℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique; Stage #3: With hydrogenchloride In diethyl ether; water Inert atmosphere; Glovebox; Schlenk technique;	75%
Stage #1: Benzeneacetamide With triethyl borane; phenylsilane; potassium acetate In tetrahydrofuran; tert-butyl methyl ether at 120℃; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: With hydrogenchloride In ethyl acetate at 20℃; for 8h; Inert atmosphere; chemoselective reaction;	54%
Stage #1: Benzeneacetamide With triethyl borane; phenylsilane; potassium acetate In tert-butyl methyl ether at 120℃; Inert atmosphere; Glovebox; Schlenk technique; Sealed tube; Stage #2: With hydrogenchloride In ethyl acetate at 20℃; for 8h; Inert atmosphere; Schlenk technique; Glovebox; Sealed tube;	54%
Multi-step reaction with 2 steps 1: lithium 2,6-di-tert-butylphenolate / neat (no solvent) / 18 h / 60 °C / Inert atmosphere; Glovebox; Schlenk technique 2: sodium hydroxide / water; diethyl ether / 1 h View Scheme

: 130820-32-5
ethyl 3-(4-oxo-1-(2-phenylethyl)-3-piperidinyl)propionate hydrochloride

: 62-53-3
aniline

A: 1208-52-2
2,4'-diaminodiphenylmethane

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
In toluene for 4h;	A n/a B 69%

...Expand

: 124316-00-3
1-<<(Triphenylphosphoranylidene)amino>methyl>benzotriazole

: 6921-34-2
benzylmagnesium chloride

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride 1.) THF/diethyl ether, 20 min, rt.; 2.) diethyl ether, 1h;	67%

: 102-96-5
(2-nitroethenyl)benzene

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In ethanol at 0℃; for 6h; Inert atmosphere;	51%

: 5153-67-3
nitrostyrene

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In ethanol at 0℃; for 3.5h;	51%

: 877-95-2
methyl-N-(benzyl-methyl)-formamide

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: methyl-N-(benzyl-methyl)-formamide With pyridine; oxalyl dichloride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: With propylene glycol In tetrahydrofuran at 0 - 25℃; Inert atmosphere;	49%

: 2-oxo-2-phenylethyl phenethylcarbamate

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-oxo-2-phenylethyl phenethylcarbamate With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 3h; Sealed tube; Irradiation; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether Inert atmosphere;	49%

: 67-56-1
methanol

: 62056-94-4
Nα-diphenylphosphinyl-2-phenylethylamine

A: 156-28-5
2-phenylethylamine hydrochloride

B: 1706-90-7
methyl diphenylphosphinate

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 67-56-1
methanol

: 80918-98-5
N-(2-phenylethyl)-P,P-dimethylphosphinamide

A: 14337-77-0
dimethyl-phosphinic acid methyl ester

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 67-56-1
methanol

: 80918-96-3
N-(2-phenylethyl)-P,P-diethylphosphinamide

A: 5689-41-8
methyl diethylphosphinate

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 67-56-1
methanol

: 80918-97-4
N-(2-phenylethyl)-P,P-di-n-butylphosphinamide

A: 7163-67-9
methyl dibutylphosphinate

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 67-56-1
methanol

: 80918-99-6
5-dibenzophosphole-5-oxide

A: 40932-00-1
5-methoxydibenzophosphole 5-oxide

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 67-56-1
methanol

: 80918-95-2
N-(2-phenylethyl)-P,P-dibenzylphosphinamide

A: 21713-63-3
methyl dibenzylphosphinate

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

...Expand

: 58367-45-6
1--2-phenyl-ethan

A: 107-46-0
Hexamethyldisiloxane

B: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; water In diethyl ether Yield given;

: 62056-94-4
Nα-diphenylphosphinyl-2-phenylethylamine

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.166667h;

: 5636-54-4
N,N-dibenzyl-2-phenylethan-1-amine

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol at 65℃; for 2h; Yield given;

: 146039-09-0
Phenethyl-phosphorimidic acid triethyl ester

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In benzene for 2h; Ambient temperature; Yield given;

: 148715-47-3
3-<(E)-(2-phenylethenyl)>-4,5-diphenyl-2(3H)oxazolone

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal 1) EtOH, H2O, HOAc, 50 deg C, 50 psi, 4h, 2) EtOH; Yield given. Multistep reaction;

: 3-<(E)-<2-(4-chlorophenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal 1) EtOH, H2O, HOAc, 50 deg C, 50 psi, 4h, 2) EtOH; Yield given. Multistep reaction;

: 501-52-0
3-Phenylpropionic acid

: 156-28-5
2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium azide 2) ether; Multistep reaction;

: 156-28-5
2-phenylethylamine hydrochloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 15795-36-5
N,N-dimethyl-N'-phenethyl-formamidine

Conditions

Conditions	Yield
for 2h; Reflux;	100%

: 156-28-5
2-phenylethylamine hydrochloride

: 2,2-dideuterio-2-phenylethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogen; water-d2; palladium on activated charcoal at 20℃; for 72h;	99%
With hydrogen; water-d2; palladium on activated charcoal at 110℃; under 760.051 Torr; for 24h;	94%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 100-19-6
(4-nitrophenyl)ethanone

: C17H18N2O3*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 8h; Mannich reaction; Heating;	98%

...Expand

: 156-28-5
2-phenylethylamine hydrochloride

: 536-74-3
phenylacetylene

: 5460-60-6
N-phenethyl-2-phenylacetamide

Conditions

Conditions	Yield
With potassium hexafluorophosphate; 4-methylpyridine-1-oxide; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); potassium carbonate In 1,2-dichloro-ethane at 100℃; for 24h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Sealed tube;	98%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 122-00-9
para-methylacetophenone

: C18H21NO*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 8h; Mannich reaction; Heating;	97%
With hydrogenchloride In ethanol; water Mannich reaction; Reflux;	24%

...Expand

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 99-90-1
para-bromoacetophenone

: C17H18NOBr*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 14h; Mannich reaction; Heating;	97%

...Expand

: (1RS,5RS)-8-benzyl-6-ethyl-2-oxa-8-azabicyclo[3.4.0]nonan-3-one

: 156-28-5
2-phenylethylamine hydrochloride

: (3'SR,4'RS,5'RS)-2-(1-benzyl-3-ethyl-5-hydroxypiperidin-4-yl)-N-phenethylacetamide

Conditions

Conditions	Yield
With sodium 2-ethylhexanoic acid In tetrahydrofuran at 20℃; for 144h;	96%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 99-91-2
para-chloroacetophenone

: C17H18NOCl*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 16h; Mannich reaction; Heating;	96%
In isopropyl alcohol Mannich reaction; Heating; Acidic conditions;	35%

...Expand

: 156-28-5
2-phenylethylamine hydrochloride

: 65-85-0
benzoic acid

: 3278-14-6
N-phenethylbenzamide

Conditions

Conditions	Yield
Stage #1: benzoic acid With 1,1'-carbonyldiimidazole In neat (no solvent) for 0.0833333h; Milling; Stage #2: 2-phenylethylamine hydrochloride In neat (no solvent) for 0.166667h; Milling;	96%
Stage #1: benzoic acid With 1,1'-carbonyldiimidazole for 0.0833333h; Milling; Green chemistry; Stage #2: 2-phenylethylamine hydrochloride for 0.166667h; Milling; Green chemistry;	96%

: 109-09-1
2-chloropyridine

: 358-23-6
trifluoromethylsulfonic anhydride

: 455-24-3
4-trifluoromethylbenzoic acid

: 156-28-5
2-phenylethylamine hydrochloride

: 757880-98-1
1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylbenzoic acid; 2-phenylethylamine hydrochloride With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 17h; Stage #2: 2-chloropyridine; trifluoromethylsulfonic anhydride at -78 - 20℃; for 37h; Stage #3: With sodium tetrahydroborate In methanol at 20℃; for 13h;	96%

...Expand

: 710-11-2
2-oxo-4-phenylbutyric acid

: 156-28-5
2-phenylethylamine hydrochloride

: 10264-31-0
N-phenethyl-3-phenylpropanamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In water; acetonitrile at 20℃; for 1h; Reagent/catalyst; Sealed tube; Darkness; chemoselective reaction;	96%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 98-86-2
acetophenone

: 3-(benzylmethylamino)-1-phenylpropane-1-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 7h; Mannich reaction; Heating;	95%
With hydrogenchloride In ethanol; water Mannich reaction; Reflux;	18%

...Expand

: sodium 3,5-bis(ethoxycarbonyl)pyrazolate

: 156-28-5
2-phenylethylamine hydrochloride

: 2C8H11N*2C9H12N2O4

Conditions

Conditions	Yield
In chloroform at 25℃; for 24h;	95%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 100-06-1
1-(4-methoxyphenyl)ethanone

: C18H21NO2*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 13h; Mannich reaction; Heating;	94%
Stage #1: 2-phenylethylamine hydrochloride; 1-(4-methoxyphenyl)ethanone In ethanol Mannich reaction; Heating; Stage #2: formaldehyd In ethanol; water for 9h; Mannich reaction; Heating; Stage #3: With hydrogenchloride In diethyl ether

...Expand

: 151-50-8
potassium cyanide

: 156-28-5
2-phenylethylamine hydrochloride

: 14789-54-9
3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one

: 144054-89-7
3,7-dimethyl-9-phenethylamino-3,7-diazabicyclo<3.3.1>nonane-9-carbonitrile

Conditions

Conditions	Yield
In methanol; water for 72h; Ambient temperature;	93%

...Expand

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 99-93-4
4-Hydroxyacetophenone

: C17H19NO2*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 19h; Mannich reaction; Heating;	93%

...Expand

: 88-15-3
2-Acetylthiophene

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: C15H17NOS*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 7h; Mannich reaction; Heating;	93%

...Expand

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 2234-16-4
1-(2,4-dichlorophenyl)ethan-1-one

: C17H17NOCl2*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 26h; Mannich reaction; Heating;	91%

...Expand

: 156-28-5
2-phenylethylamine hydrochloride

: 75-36-5
acetyl chloride

: 877-95-2
methyl-N-(benzyl-methyl)-formamide

Conditions

Conditions	Yield
Stage #1: 2-phenylethylamine hydrochloride With triethylamine In dichloromethane for 0.5h; Stage #2: acetyl chloride In dichloromethane at 0 - 20℃; for 18.5h;	90%
With sodium hydroxide In dichloromethane for 3h;	65%

: 156-28-5
2-phenylethylamine hydrochloride

: 889126-06-1
2,5-di-O-acetyl-3-azido-1-(6-chloropurin-9-yl)-β-D-1,3-dideoxyribofuranose

: C5H6(OCOCH3)2ON3C5H2N4NHCH2CH2C6H5

Conditions

Conditions	Yield
With triethylamine In ethanol at 50℃;	90%

: 156-28-5
2-phenylethylamine hydrochloride

: 1304-76-3
bismuth(III) oxide

: 3C6H5CH2CH2NH3(1+)*[BiCl6](3-)=[C6H5CH2CH2NH3]3BiCl6

Conditions

Conditions	Yield
In hydrogenchloride; water 80°C; cooling (room temp.), pptn., filtn., washing (aq. HCl), recrystn. (aq. HCl); elem. anal.;	89%

: 156-28-5
2-phenylethylamine hydrochloride

: 100-52-7
benzaldehyde

: 3278-14-6
N-phenethylbenzamide

Conditions

Conditions	Yield
With copper(l) iodide; calcium carbonate In water; acetonitrile at 40℃; for 6h;	88%
Stage #1: benzaldehyde With 1-hydroxy-pyrrolidine-2,5-dione; oxygen; cobalt(II) diacetate tetrahydrate; sodium hydrogencarbonate In acetonitrile at 20℃; under 760.051 Torr; for 1h; Molecular sieve; Stage #2: 2-phenylethylamine hydrochloride In acetonitrile at 20℃; Molecular sieve;	80%

: 50-00-0
formaldehyd

: 156-28-5
2-phenylethylamine hydrochloride

: 403-42-9
1-(4-fluorophenyl)ethanone

: C17H18NOF*HCl

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 12h; Mannich reaction; Heating;	87%

...Expand

: 1169605-26-8
6-chloro-9-((3aR,3bR,4aS,5R,5aS)-hexahydro-2,2dimethylbicyclo[3.1.0]hex-1(5)-eno[3,2-d] [1,3]dioxol-5-yl)-2-iodo-9H-purine

: 156-28-5
2-phenylethylamine hydrochloride

: 1383554-58-2
(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2-phenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; Inert atmosphere;	84%

: 1161-13-3
N-Cbz-L-Phe

: 156-28-5
2-phenylethylamine hydrochloride

: 187678-28-0
Cbz-L-Phe-NHCH2CH2Ph

Conditions

Conditions	Yield
Stage #1: N-Cbz-L-Phe With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 2-phenylethylamine hydrochloride In tetrahydrofuran; water at 0℃; for 0.5h;	84%

2-Phenylethylamine hydrochloride Chemical Properties

The molecular structure of 2-Phenylethylamine hydrochloride (CAS NO.156-28-5):

IUPAC Name: 2-Phenylethanamine hydrochloride
Molecular Weight: 157.64058 g/mol
Molecular Formula: C₈H₁₂ClN
Melting Point: 220-222 °C(lit.)
Flash Point: 90.6 °C
Enthalpy of Vaporization: 43.27 kJ/mol
Boiling Point: 196.5 °C at 760 mmHg
Vapour Pressure: 0.398 mmHg at 25 °C
H-Bond Donor: 2
H-Bond Acceptor: 1
Rotatable Bond Count: 2
Exact Mass: 157.065827
MonoIsotopic Mass: 157.065827
Topological Polar Surface Area: 26
Heavy Atom Count: 10
Canonical SMILES: C1=CC=C(C=C1)CCN.Cl
InChI: InChI=1S/C8H11N.ClH/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H
InChIKey: SKHIBNDAFWIOPB-UHFFFAOYSA-N
EINECS: 205-849-2
Classification Code: Drug / Therapeutic Agent; Human Data; Skin / Eye Irritant

2-Phenylethylamine hydrochloride Toxicity Data With Reference

1.	eye-man 50 mg SEV	AIMDAP Archives of Internal Medicine. 39 (1927),404.
2.	orl-hmn TDLo:714 mg/kg:CVS	AIMDAP Archives of Internal Medicine. 39 (1927),404.
3.	orl-hmn TDLo:45 mg/kg:CNS	KLWOAZ Klinische Wochenscrift. 17 (1938),1580.
4.	scu-rat LDLo:160 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 71 (1941),62.
5.	scu-mus LD50:470 mg/kg	JPPMAB Journal of Pharmacy and Pharmacology. 15 (1963),472.
6.	ivn-rbt LDLo:50 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 36 (1929),363.
7.	skn-gpg LDLo:200 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 32 (1927),121.

2-Phenylethylamine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

2-Phenylethylamine hydrochloride Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 2811
WGK Germany: 3
RTECS: SH7175000
HazardClass: 6.1(b)
PackingGroup: III
Poison by skin contact, subcutaneous, and intravenous routes. A human eye irritant. A skin irritant and possible sensitizer. Human systemic effects by ingestion: blood pressure lowering, anorexia. When heated to decomposition it emits very toxic fumes of NO_x and HCl.

2-Phenylethylamine hydrochloride Specification

2-Phenylethylamine hydrochloride (CAS NO.156-28-5) is also named as 1-Phenyl-2-aminoethane hydrochloride ; Benzeneethanamine hydrochloride ; NSC 138569 ; Phenethylammonium chloride ; UNII-VOF61XW69D ; USAF EL-76 ; beta-Phenethylamine hydrochloride ; beta-Phenylathylaminhydrochlorid ; beta-Phenylathylaminhydrochlorid [German] ; beta-Phenylethylamine hydrochloride .

Product Name

2-Phenylethylamine hydrochloride

Synthetic route

2-Phenylethylamine hydrochloride Chemical Properties

2-Phenylethylamine hydrochloride Toxicity Data With Reference

2-Phenylethylamine hydrochloride Consensus Reports

2-Phenylethylamine hydrochloride Safety Profile

2-Phenylethylamine hydrochloride Specification

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