Conditions | Yield |
---|---|
With [Pd(N-(naphthyl)-salicylaldimine(-2H))(triphenylphosphine)]; sodium hydroxide at 120℃; for 24h; Reagent/catalyst; Suzuki Coupling; | 100% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 18h; Inert atmosphere; Reflux; | 100% |
With potassium phosphate; (PdCl2)(2-pyridyl)-6-isopropyl cis piperidine complex In water; N,N-dimethyl-formamide at 110℃; for 2h; | 99% |
N-(phenyl(2-phenylpyridin-1(2H)-yl)methylene)methanamine
2-phenylpyridine
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran at 25℃; | 100% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride | 100% |
Conditions | Yield |
---|---|
Stage #1: phenylmagnesium bromide With indium(III) chloride In tetrahydrofuran at 25℃; Stage #2: 2-iodopyridine; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane In tetrahydrofuran; water for 5h; Heating; Further stages.; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-fluoropyridine; phenylmagnesium bromide; bis(acetylacetonate)nickel(II); ((2-hydroxymethyl)phenyl)diphenylphosphine In diethyl ether for 0.5h; Stage #2: With methanol In diethyl ether Product distribution / selectivity; | 100% |
Stage #1: 2-fluoropyridine; phenylmagnesium bromide; 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether for 2h; Stage #2: With methanol In diethyl ether Product distribution / selectivity; | 96% |
Conditions | Yield |
---|---|
With 4-di-tert-butylphosphanyl-1,5-diphenyl-1H-[1,2,3]triazole; potassium phosphate; bis(dibenzylideneacetone)-palladium(0) In toluene at 100℃; for 12h; Suzuki-Miyaura coupling; | 99% |
With 4-di-tert-butylphosphanyl-1,5-diphenyl-1H-[1,2,3]triazole; potassium phosphate; bis(dibenzylideneacetone)-palladium(0) In toluene at 100℃; for 12h; Suzuki-Miyaura coupling; | 99% |
With potassium phosphate; palladium diacetate In tetrahydrofuran at 100℃; for 24h; Suzuki-Miyaura coupling; | 99% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride | 99% |
Conditions | Yield |
---|---|
With chromium dichloride; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 40℃; for 12h; Mechanism; Catalytic behavior; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 99% |
With bis(1,5-cyclooctadiene)nickel(0); (dimethoxy)methylsilane; tricyclohexylphosphine In toluene at 80℃; for 12h; Inert atmosphere; | 96% |
With bis(1,5-cyclooctadiene)nickel(0); 1,1,3,3-Tetramethyldisiloxane; tricyclohexylphosphine In toluene at 110℃; for 10h; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
With (2-hydroxyethyl)(methyl)amine; copper(l) iodide; dichloro(1,3-bis(dicyclohexylphosphino)propane)palladium In N,N-dimethyl-formamide at 100℃; for 16h; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere; | 99% |
1,3-dimethoxy-2-(2-pyridyl)benzene
2-phenylpyridine
Conditions | Yield |
---|---|
With chromium dichloride; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 40℃; for 12h; Schlenk technique; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 25℃; for 5h; | 98% |
Pd(dppf)Cl2 In tetrahydrofuran; tert-butyl methyl ether; water | 98.1% |
With isoquinoline; ferric(III) bromide In tetrahydrofuran; tert-butyl methyl ether at 25℃; for 0.25h; Reagent/catalyst; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride | 98% |
With (dcpp)Ni(η2–toluene) In tetrahydrofuran at 60℃; for 2h; Negishi Coupling; Glovebox; Schlenk technique; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With [1,3-bis(2,6-diisopropylphenyl)-imidazolium][Ni(PPh3)Cl3] In tetrahydrofuran at 30℃; for 5h; Kumada Cross-Coupling; Schlenk technique; Inert atmosphere; | 98% |
With CpPd(SIMes)Cl; lithium chloride In tetrahydrofuran; 1,2-dimethoxyethane at 20℃; for 36h; Kumada-Tamao-Corriu cross-coupling reaction; Inert atmosphere; | 87% |
With (IPr)Ni(π-allyl)Cl In tetrahydrofuran at 20℃; for 1h; Kumada Cross-Coupling; Inert atmosphere; | 86% |
2-bromo-pyridine
trimethyl((5-methyl-2-phenyl-1,3,2-dioxaborinan-5-yl)methoxy)silane
2-phenylpyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol at 100℃; for 18h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With hydrogenchloride; iodine; oxygen In dimethyl sulfoxide at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Time; Temperature; | 98% |
With oxygen; palladium diacetate; toluene-4-sulfonic acid In tetrahydrofuran for 10h; Catalytic behavior; Reagent/catalyst; Reflux; | 89% |
With oxygen In ethanol at 100℃; under 760.051 Torr; for 24h; Solvent; | 75% |
Conditions | Yield |
---|---|
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; hydrazine hydrate In dimethyl sulfoxide at 20℃; for 11h; Reagent/catalyst; Inert atmosphere; Irradiation; chemoselective reaction; | 97% |
With palladium on activated charcoal; tetrabutylammomium bromide; water; sodium hydroxide; silicon at 100℃; for 6h; | 95% |
With titanium In tetrahydrofuran for 0.25h; Ambient temperature; | 89% |
Conditions | Yield |
---|---|
1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 25℃; for 5h; | 97% |
With reduced graphene oxide supported Ni nanoparticles (~40 wtpercent) In tetrahydrofuran at 25℃; for 10h; Kumada Cross-Coupling; Inert atmosphere; | 91% |
With ferric(III) bromide In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 1.16667h; Inert atmosphere; Schlenk technique; | 83% |
With C25H16CuN4O6 In diethyl ether; N,N-dimethyl-formamide at 20℃; for 0.5h; Catalytic behavior; Kumada Cross-Coupling; | 78% |
With [Ni(9,10-phenanthrenequinone-N''-methylthiosemicarbazone)2] In diethyl ether at 20℃; for 4h; Reagent/catalyst; Kumada Cross-Coupling; | 70% |
Conditions | Yield |
---|---|
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate In ethanol; water at 35℃; for 3h; Suzuki Coupling; chemoselective reaction; | 97% |
Conditions | Yield |
---|---|
bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; 1,2-dimethoxyethane at 0 - 20℃; for 0.5h; | 96% |
Conditions | Yield |
---|---|
With [Pd(N-(3-chloro-2-quinoxalinyl)-N'-(2,6-diisopropylphenyl)imidazolium)(PPh3)Cl2]; potassium carbonate In water at 70℃; for 3h; Catalytic behavior; Suzuki-Miyaura Coupling; | 96% |
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 2h; Suzuki-Miyaura Coupling; | 91% |
With palladium diacetate; sodium carbonate In ethanol; water at 80℃; for 4h; Suzuki-Miyaura Coupling; | 89% |
[2-(hydroxymethyl)phenyl](dimethyl)phenylsilane
2-iodopyridine
2-phenylpyridine
Conditions | Yield |
---|---|
With N-cyclohexyl-1-[2-(diphenylphosphanyl)phenyl]methanimine; potassium carbonate; palladium dichloride In water; dimethyl sulfoxide at 50℃; for 13h; | 96% |
With potassium carbonate; N-cyclohexyl-1-[2-(diphenylphosphanyl)phenyl]methanimine; palladium dichloride In water; dimethyl sulfoxide at 50℃; for 13h; | 92% |
Conditions | Yield |
---|---|
With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether at 20℃; for 2h; | 96% |
Conditions | Yield |
---|---|
With potassium acetate In ethanol; dimethyl sulfoxide at 100℃; for 10h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; | 96% |
With potassium carbonate In water at 90℃; for 0.333333h; Suzuki Coupling; | 96% |
With potassium phosphate In 1,4-dioxane at 80℃; for 1.5h; Suzuki-Miyaura Coupling; | 95% |
Conditions | Yield |
---|---|
With potassium phosphate; tetrabutylammomium bromide In water at 90℃; for 6h; Suzuki-Miyaura Coupling; Green chemistry; | 96% |
Stage #1: 3-Chloropyridine; phenylboronic acid With palladium diacetate; (R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl In dodecane; butan-1-ol at 25℃; for 0.166667h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; Stage #2: With cesiumhydroxide monohydrate In dodecane; water; butan-1-ol at 25℃; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; | 96% |
Conditions | Yield |
---|---|
Stage #1: iodobenzene With TurboGrignard In tetrahydrofuran at -40℃; for 1h; Inert atmosphere; Stage #2: With tbepc In tetrahydrofuran at -40 - 0℃; for 2h; Inert atmosphere; Stage #3: pyridine-2-yl magnesium chloride Further stages; | 96% |
Conditions | Yield |
---|---|
With potassium tert-butylate; vasicine at 20 - 110℃; for 72h; Schlenk technique; Inert atmosphere; | 95% |
With bathophenanthroline; potassium tert-butylate; iron(II) acetate at 20 - 80℃; Inert atmosphere; | 85% |
With potassium tert-butylate at 110℃; for 3h; | 85% |
5-bromo-2-phenylpyridine
2-phenylpyridine
Conditions | Yield |
---|---|
With hydrogen; triethylamine; palladium on activated charcoal In ethanol | 95% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride | 95% |
2-bromo-pyridine
[2-(hydroxymethyl)phenyl](diisopropyl)phenylsilane
A
2-phenylpyridine
B
1,1-diisopropyl-1,3-dihydrobenzo[c][1,2]oxasilole
Conditions | Yield |
---|---|
With potassium carbonate; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); ruphos In tetrahydrofuran; N,N-dimethyl-formamide at 75℃; for 23h; Product distribution / selectivity; | A 95% B 95% |
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; cesium fluoride; 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole In toluene at 60℃; for 10h; Stille coupling; Inert atmosphere; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 6h; Catalytic behavior; Stille Cross Coupling; | 86% |
With 2C13H19N2(1+)*Cl6Pd2(2+); cesium fluoride In N,N-dimethyl-formamide at 120℃; for 0.166667h; Stille Cross Coupling; Microwave irradiation; | 82% |
With cesium fluoride In water; N,N-dimethyl-formamide at 40℃; for 8h; Stille coupling; | 78% |
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; Inert atmosphere; | 100% |
With 3,3-dimethyldioxirane In acetone at 23℃; Kinetics; | 98% |
With phosphomolybdic acid; dihydrogen peroxide In water; acetonitrile at 50℃; for 12h; Mechanism; | 78% |
Conditions | Yield |
---|---|
In hexane at -78℃; | 100% |
2-phenylpyridine
Conditions | Yield |
---|---|
With potassium tert-butylate; deuterium In tetrahydrofuran at 55℃; under 1500.15 Torr; for 24h; Reagent/catalyst; regioselective reaction; | 100% |
With copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; potassium deuterohydroxide; water-d2; zinc In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 99% |
With deuterium In tetrahydrofuran at 55℃; under 750.075 Torr; for 36h; Glovebox; Inert atmosphere; regioselective reaction; | 84% |
With Crabtree's catalyst; water-d2; deuterium In dichloromethane at 20℃; | |
With [(2)H6]acetone; C54H50NOP2Rh(1+)*F6P(1-) at 100℃; for 8h; regioselective reaction; |
2-phenylpyridine
2-chloro-6-phenyl-pyridine
Conditions | Yield |
---|---|
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In hexane at 0℃; for 1h; Stage #2: With hexachloroethane In hexane at -78 - 20℃; | 100% |
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In hexane at 0℃; for 1h; Stage #2: With hexachloroethane In hexane at -78 - 20℃; Further stages.; | 81% |
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In tetrahydrofuran at -78℃; Stage #2: With hexachloroethane In tetrahydrofuran at -78 - 20℃; | 72% |
2-phenylpyridine
2-bromo-6-phenylpyridine
Conditions | Yield |
---|---|
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In hexane at 0℃; for 1h; Stage #2: With carbon tetrabromide In hexane at -78 - 20℃; | 100% |
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In hexane at 0℃; for 1h; Stage #2: With carbon tetrabromide In hexane at -78 - 20℃; Further stages.; | 89% |
Stage #1: 2-phenylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In hexane at -10℃; for 1h; Stage #2: With ethylene dibromide In tetrahydrofuran; hexane at -40 - 20℃; | 69% |
2-phenylpyridine
potassium tetrachloroplatinate(II)
phenylpyridinebridgedichloro platinum
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water at 80℃; for 23h; Inert atmosphere; | 100% |
In 2-ethoxy-ethanol; water aq. degassed soln. of K2PtCl4 (1.2 mmol) added under N2 to soln. of 2-phenylpyridine (1.2 mmol) in 2-ethoxyethanol (stirring); heated (80°C, 48 h); cooled in ice bath; H2O added; ppt. filtered; washed with EtOH; dried (vac.); | 95% |
In 2-ethoxy-ethanol; water at 70℃; for 2h; | 77.2% |
Conditions | Yield |
---|---|
With dichloro[1-(3-methylbenzyl)-3-(n-butyl)benzimidazol-2-ylidene]ruthenium(II); potassium acetate In water at 100℃; for 1h; Reagent/catalyst; | 100% |
With rhodium(III) chloride hydrate; sodium carbonate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 140℃; for 22h; Inert atmosphere; | 99% |
With C36H35Cl2PRu; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; regioselective reaction; | 87% |
Conditions | Yield |
---|---|
With dichloro[1-(3-methylbenzyl)-3-(n-butyl)benzimidazol-2-ylidene]ruthenium(II); potassium acetate In water at 100℃; for 5h; Reagent/catalyst; | 100% |
With C36H35Cl2PRu; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; regioselective reaction; | 86% |
2-phenylpyridine
((2,6-iPr2C6H3)NCH2CH2N(2,6-iPr2C6H3))Y(CH2SiMe3)(THF)2
Conditions | Yield |
---|---|
In benzene at 20℃; | 100% |
Conditions | Yield |
---|---|
In neat (no solvent) at 25℃; for 0.05h; Sonication; | 100% |
Conditions | Yield |
---|---|
In neat (no solvent) at 25℃; for 0.05h; Sonication; | 100% |
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate at 60℃; for 17h; Catalytic behavior; Concentration; Schlenk technique; Sealed tube; | 100% |
2-thienyl chloride
2-phenylpyridine
2-(2-(thiophene-2-yl)phenyl)pyridine
Conditions | Yield |
---|---|
With dichloro[1-(3-methylbenzyl)-3-(n-butyl)benzimidazol-2-ylidene]ruthenium(II); potassium acetate In water at 100℃; for 20h; Reagent/catalyst; | 100% |
2-phenylpyridine
Conditions | Yield |
---|---|
With potassium carbonate for 0.1h; Time; Inert atmosphere; Microwave irradiation; Reflux; | 99.1% |
2-phenylpyridine
fac-tris[2-phenylpyridinato-C2,N]iridium(III)
Conditions | Yield |
---|---|
In water at 205℃; for 48h; Temperature; Inert atmosphere; | 99.1% |
2-phenylpyridine
2-(2,6-dideuterophenyl)pyridine
Conditions | Yield |
---|---|
With η4-cycloocta-1,5-diene(1,3-dimesitylimidazoline-2-ylidene)(triphenylphosphine)iridium(I) hexafluorophosphate; deuterium In dichloromethane at 20℃; for 72h; Sealed tube; | 99% |
With copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; water-d2; zinc In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 99% |
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; tetradeuterioacetic acid at 60℃; for 24h; Inert atmosphere; Darkness; | 98% |
Conditions | Yield |
---|---|
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,3-bis-(2,6-(i-Pr)2-C6H4)-[1,3,2]diazaphospholidine 2-oxide; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 8h; | 99% |
With [RhCl2(p-cymene)]2; potassium pivalate; potassium carbonate In Diethyl carbonate at 120℃; for 2h; Inert atmosphere; | 96% |
With potassium carbonate; bis(1-adamantyl)phosphine oxide; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; | 95% |
2-phenylpyridine
Conditions | Yield |
---|---|
With oxygen; copper diacetate; lithium carbonate; benzoyl chloride In toluene at 145℃; for 60h; chemoselective reaction; | 99% |
With N-chloro-succinimide; benzoic acid; copper(l) chloride at 100℃; for 24h; Inert atmosphere; Schlenk technique; | 96% |
With hydrogenchloride; platinum; palladium dichloride In water; N,N-dimethyl-formamide at 90℃; Electrochemical reaction; regioselective reaction; | 94% |
2-phenylpyridine
Conditions | Yield |
---|---|
With N-iodo-succinimide; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 80℃; for 16h; Solvent; Reagent/catalyst; Sealed tube; | 99% |
With N-iodo-succinimide; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; Trimethylacetic acid In 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; regioselective reaction; | 88% |
With N-iodo-succinimide; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer for 3h; Time; Milling; | 84% |
With N-iodo-succinimide; acetic acid; palladium diacetate at 100℃; for 12h; | 41% |
With N-iodo-succinimide; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In 1,2-dichloro-ethane at 85℃; for 0.5h; |
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water Reflux; Inert atmosphere; | 99% |
In 2-ethoxy-ethanol for 24h; Reflux; | 90% |
In 2-ethoxy-ethanol; water for 24h; Reflux; | 90% |
2-phenylpyridine
potassium tetrachloroplatinate(II)
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water other Radiation; 2-phenylpyridine (2.2 mmol) treated with K2PtCl4 (1 mmol) in degassed soln. (N2) of 2-ethoxyethanol/H2O (3:1, v/v); irradiated with microwave radiation (250 W, 1 min, max. temp. 110°C); cooled; filtered off; recrystd. from CH2Cl2/EtOH; elem. anal.; | 99% |
In 2-ethoxy-ethanol; water aq. degassed soln. of K2PtCl4 (1.2 mmol) (3 ml) added to degassed soln. of 2-phenylpyridine (2.4 mmol) in 2-ethoxyethanol (9 ml) under N2 (stirring); heated (80°C) overnight; cooled in ice bath; distd. H2O added; ppt. filtered off; washed with cold EtOH; dried (vac.); crystd. from CH2Cl2/EtOH; | 95% |
In acetic acid suspn. ligand and K2(PtCl4) in AcOH was heated at 75°C for 15 h; soln. was cooled to room temp., evapd., residue was dissolved in CH2Cl2,washed with 2.5 M HCl, water, dried over MgSO4, soln. was concd., Et2O was added, ppt. was collected by filtration; elem. anal.; | 82% |
2-phenylpyridine
Conditions | Yield |
---|---|
In dichloromethane under inert atm. or in vac.; stirred (23°C, 15 min, then 3.0 h, room temp.); pptd. by adding hexane; filtered, washed (hexane); dried in vacuo; recrystd. (CH2Cl2/hexane); | 99% |
In dichloromethane byproducts: CH4; inert atmosphere; stirring (23°C, 2.5 h); pptn. with hexane, collection (filtration), washing (hexane), drying (vac.), recrystn. (CH2Cl2/hexane); elem. anal.; | 92% |
3-Bromothiophene
2-phenylpyridine
2-di[2-(3-thiophenyl)]phenylpyridine
Conditions | Yield |
---|---|
With potassium carbonate; triphenylphosphine; RuCl2(η6-C6H6) In 1-methyl-pyrrolidin-2-one at 120℃; for 20h; | 99% |
The 2-Phenylpyridine, with the CAS registry number 1008-89-5, is also known as Pyridine, 2-phenyl-. It belongs to the product categories of Pyridines, Pyrimidines, Purines and Pteredines; Heterocyclic Compounds; C9 to C46; Heterocyclic Building Blocks; Pyridines. Its EINECS registry number is 213-763-1. This chemical's molecular formula is C11H9N and molecular weight is 155.19586. Its IUPAC name is called 2-phenylpyridine. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides.
Physical properties of 2-Phenylpyridine: (1)ACD/LogP: 2.63; (2)ACD/LogD (pH 5.5): 2.59; (3)ACD/LogD (pH 7.4): 2.63; (4)ACD/BCF (pH 5.5): 54.07; (5)ACD/BCF (pH 7.4): 58.66; (6)ACD/KOC (pH 5.5): 591.41; (7)ACD/KOC (pH 7.4): 641.58; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.575; (11)Molar Refractivity: 48.93 cm3; (12)Molar Volume: 147.9 cm3; (13)Surface Tension: 41.1 dyne/cm; (14)Density: 1.049 g/cm3; (15)Flash Point: 113.3 °C; (16)Enthalpy of Vaporization: 48.85 kJ/mol; (17)Boiling Point: 270.8 °C at 760 mmHg; (18)Vapour Pressure: 0.0111 mmHg at 25°C.
Preparation of 2-Phenylpyridine: this chemical can be prepared by 2-bromo-pyridine and benzene. This reaction will need reagent tris(trimethylsilyl)silane and AIBN. The reaction time is 24 hours with reaction temperature of 80 °C. The yield is about 41%.
Uses of 2-Phenylpyridine: it can be used to produce 2-phenyl-pyridine-1-oxide. This reaction will need reagents acetic acid and aqueous hydrogen peroxide.
When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=N2
(2)InChI: InChI=1S/C11H9N/c1-2-6-10(7-3-1)11-8-4-5-9-12-11/h1-9H
(3)InChIKey: VQGHOUODWALEFC-UHFFFAOYSA-N
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