2-Thiopheneacetyl Chloride supplier

Name
2-Thiopheneacetyl chloride
EINECS 254-290-0
CAS No. 39098-97-0
Article Data43
CAS DataBase
Density 1.335 g/cm³
Solubility Reacts with water.
Melting Point
Formula C₆H₅ClOS
Boiling Point 202.4 °C at 760 mmHg
Molecular Weight 160.624
Flash Point 88.7 °C
Transport Information UN 3265 8/PG 2
Appearance clear brown liquid
Safety 26-28-36/37/39-45-8-30-23
Risk Codes 14-34-37-29
Molecular Structure
Hazard Symbols C
Synonyms 2-Thienylacetyl chloride;2-thiophen-2-ylacetyl chloride;Thiophene-2-acetyl chloride;2-Thiopheneacetyl chloride (TAC);2-Thiopheneacetylchloride;2-Thiophene acetyl chloride;
PSA 45.31000
LogP 2.05600

Synthetic route

: 1918-77-0
Thiophene-2-acetic acid

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 5h; Temperature; Reagent/catalyst;	94.7%
With phosgene; 4-cyclopentylaminopyridine hydrobromide In toluene	92%
With 1-butyl-3-methylimidazolium hydroxide; thionyl chloride In chloroform at 10℃; for 8h; Reagent/catalyst; Temperature;	89.8%

: 1918-77-0
Thiophene-2-acetic acid

7-amino-3-(2-ethoxylalylhydrazono)methyl-3-cephem-4-carboxylic acid: 7-amino-3-(2-ethoxylalylhydrazono)methyl-3-cephem-4-carboxylic acid

A: 39098-97-0
2-thienylacetic acid chloride

B 7-(2-thienylacetamido)-3-(2-ethoxyalylhydrazono)methyl-3-cephem-4-carboxylic acid monohydrate: 7-(2-thienylacetamido)-3-(2-ethoxyalylhydrazono)methyl-3-cephem-4-carboxylic acid monohydrate

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In chloroform; water; ethyl acetate	A n/a B 84%

...Expand

: 5271-67-0
2-Thiophenecarbonyl chloride

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane 3: (COCl)2; DMF / CH2Cl2 View Scheme

: 527-72-0
2-thiophenylcarboxylic acid

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane 4: (COCl)2; DMF / CH2Cl2 View Scheme

: 72676-21-2
2-diazo-1-(thiophen-2-yl)ethanone

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. Ag2O / dioxane 2: (COCl)2; DMF / CH2Cl2 View Scheme

: 765-50-4
2-Chloromethylthiophene

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetone; water 2: aq.-ethanolic KOH-solution 3: thionyl chloride View Scheme
Multi-step reaction with 3 steps 1: acetone; water 2: aq.-ethanolic KOH-solution 3: thionyl chloride View Scheme

: 20893-30-5
2-cyanomethylthiophene

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq.-ethanolic KOH-solution 2: thionyl chloride View Scheme

: 1918-77-0
Thiophene-2-acetic acid

cis-4-hydroxymethyl-3-(2,2,2-trichloroethoxycarboxamido)-2-oxoazetidine: cis-4-hydroxymethyl-3-(2,2,2-trichloroethoxycarboxamido)-2-oxoazetidine

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In dichloromethane
With thionyl chloride; triethylamine In dichloromethane

: 68100-13-0
isopropyl 2-(thiophen-2-yl)acetate

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water; acetonitrile / 10 h / Reflux 2: pyridine; thionyl chloride / dichloromethane / 1 h / Reflux View Scheme

: 57382-97-5
ethyl thiophen-2-ylacetate

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / ethanol; water / 8 h / Reflux 2: pyridine; thionyl chloride / dichloromethane / 1 h / Reflux View Scheme

: 19432-68-9
methyl 2-thiopheneacetate

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water; acetonitrile / 8 h / Reflux 2: pyridine; thionyl chloride / dichloromethane / 1 h / Reflux View Scheme

: 67-56-1
methanol

: 39098-97-0
2-thienylacetic acid chloride

: 19432-68-9
methyl 2-thiopheneacetate

Conditions

Conditions	Yield
at 20℃; for 4h;	100%
for 0.5h;	82%
at 20℃; for 3h;

: 39098-97-0
2-thienylacetic acid chloride

: 121-45-9
phosphorous acid trimethyl ester

: 87600-60-0
(2-Thiophen-2-yl-acetyl)-phosphonic acid dimethyl ester

Conditions

Conditions	Yield
In diethyl ether Ambient temperature;	100%
at 0 - 20℃; for 3h;	88%
In tetrahydrofuran Heating;
at 0℃; for 1h; Reflux;

: 39098-97-0
2-thienylacetic acid chloride

: 88-17-5
2-(trifluoromethyl)benzenamine

: 2-(thiophen-2-yl)-N-(2-(trifluoromethyl)phenyl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%

: 39098-97-0
2-thienylacetic acid chloride

: 99-09-2
3-nitro-aniline

: N-(3-nitrophenyl)-2-(thiophen-2-yl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%

: 39098-97-0
2-thienylacetic acid chloride

: 90-04-0
2-methoxy-phenylamine

: C13H13NO2S

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%

: 39098-97-0
2-thienylacetic acid chloride

: 88-74-4
2-nitro-aniline

: C12H10N2O3S

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%

: 39098-97-0
2-thienylacetic acid chloride

: 660831-35-6
2-{[(2-biphenyl-4-yl-(1S)-methoxycarbonyl-ethyl)-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-methyl}-(2R)-pyrrolidinium chloride

: 3-biphenyl-4-yl-(2S)-[[1-(2-thiophen-2-yl-acetyl)-pyrrolidin-(2R)-ylmethyl]-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%

: 5,6-dihydro-4H-benzo[f][1,2,3]triazolo[1,5-a][1,4]diazepine

: 39098-97-0
2-thienylacetic acid chloride

: 1358786-71-6
C16H14N4OS

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 39098-97-0
2-thienylacetic acid chloride

: (S)-di-(ethylnipecotate)-L-(dibenzoyl)tartrate salt

: 310454-69-4
ethyl (S)-1-(2-thiopheneacetyl)-3-piperidinecarboxylate

Conditions

Conditions	Yield
With sodium carbonate In water; ethyl acetate at 20℃; for 0.5h; Schotten-Baumann Reaction; Green chemistry;	100%

: 39098-97-0
2-thienylacetic acid chloride

: 18854-66-5
tris(allyl)aluminum

: C12H16OS

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 0.5h;	98%

: 39098-97-0
2-thienylacetic acid chloride

: 371-40-4
4-fluoroaniline

: C12H10FNOS

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	98%

: 39098-97-0
2-thienylacetic acid chloride

: 57946-56-2
2-fluoro-4-chloroaniline

: C12H9ClFNOS

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	98%

: 39098-97-0
2-thienylacetic acid chloride

: 895635-70-8
{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}amine

: 941318-38-3
N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Conditions

Conditions	Yield
Stage #1: 2-thienylacetic acid chloride; {3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}amine With triethylamine In tetrahydrofuran Stage #2: With PS-Trisamine In tetrahydrofuran for 16h;	98%

: 39098-97-0
2-thienylacetic acid chloride

: 107-15-3
ethylenediamine

: 1160003-21-3
N,N'-di(2-thiopheneacetyl)ethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; Inert atmosphere;	98%

: 39098-97-0
2-thienylacetic acid chloride

: 2106-02-7
2-chloro-4-fluoroaniline

: C12H9ClFNOS

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	97%

: 39098-97-0
2-thienylacetic acid chloride

: 941319-32-0
5-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]-2-methylaniline

: 941319-33-1
N-{5-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]-2-methylphenyl}-2-(2-thienyl)acetamide

Conditions

Conditions	Yield
Stage #1: 2-thienylacetic acid chloride; 5-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]-2-methylaniline With PS-Trisamine In tetrahydrofuran for 16h; Stage #2: With triethylamine In tetrahydrofuran	97%

: 39098-97-0
2-thienylacetic acid chloride

: 2-Azidopentansaeure-methylester

: (Z)-2-(2-Thiophen-2-yl-acetylamino)-pent-2-enoic acid methyl ester

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; hydroquinone; ammonium perrhenate In ethyl acetate for 0.5h; Ambient temperature;	96%

: 39098-97-0
2-thienylacetic acid chloride

: 106-40-1
4-bromo-aniline

: C12H10BrNOS

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	96%

: 39098-97-0
2-thienylacetic acid chloride

: 62-53-3
aniline

: 69047-40-1
N-phenyl-2-(thiophen-2-yl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	96%

: 39098-97-0
2-thienylacetic acid chloride

: 5-bromo-6-methoxy-2-(trifluoromethoxy)pyridin-3-amine

: N-(5-bromo-6-methoxy-2-(trifluoromethoxy)pyridin-3-yl)-2-(thiophen-2-yl)acetamide

Conditions

Conditions	Yield
In acetonitrile at 23℃; for 2h; Inert atmosphere;	96%

: 39098-97-0
2-thienylacetic acid chloride

: 19369-53-0
methyl 2-amino-5-methylthiophene-3-carboxylate

: 5-methyl-2-[(2-thienylacetyl)amino]-thiophene-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
In 1,4-dioxane at 98℃;	95.5%

: 39098-97-0
2-thienylacetic acid chloride

: 117362-43-3
9-Methyl-5-thia-6,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalene

: 132087-68-4
C23H16N2OS2

Conditions

Conditions	Yield
With triethylamine In benzene for 1h; Heating;	95%

: 39098-97-0
2-thienylacetic acid chloride

: 895637-18-0
3-[3-(2-chloro-4-pyrimidinyl)-4-fluoropyrazolo[1,5-a]pyridin-2-yl]aniline

: 941318-80-5
N-{3-[3-(2-chloro-4-pyrimidinyl)-4-fluoropyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h;	95%

: 39098-97-0
2-thienylacetic acid chloride

: 3399-73-3
2-(1-cyclohexenyl)ethylamine

: 89413-09-2
N-<2-(cyclohexen-1-yl)ethyl>thiophene-2-acetamide

Conditions

Conditions	Yield
With potassium carbonate In benzene for 1h; Ambient temperature;	94%

: 39098-97-0
2-thienylacetic acid chloride

: 706791-83-5
3-amino-5-bromobenzoic acid methyl ester

: 1188322-86-2
methyl 3-bromo-5-[2-(thiophen-2-yl)acetamido]benzoate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 20℃; Inert atmosphere; Cooling with ice;	94%

: 39098-97-0
2-thienylacetic acid chloride

: 15401-69-1
berberrubine chloride

: 1297302-78-3
C25H20NO5S(1+)*Cl(1-)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h;	94%

: 39098-97-0
2-thienylacetic acid chloride

: 93601-86-6
(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

: (2S)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-propyl-2-thiophen-2-ylacetamide

Conditions

Conditions	Yield
Stage #1: (S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride With sodium carbonate In dichloromethane; water at 27℃; for 1h; Stage #2: 2-thienylacetic acid chloride In dichloromethane; water at 27℃; for 1h;	94%

: 39098-97-0
2-thienylacetic acid chloride

: 112697-91-3
quino<2,3-b><1,5>benzoxazepine

: 132087-58-2
C22H14N2O2S

Conditions

Conditions	Yield
With triethylamine In benzene for 1h; Heating;	93%

: 39098-97-0
2-thienylacetic acid chloride

: 117362-42-2
quino<2,3-b><1,5>benzothiazepine

: 132087-65-1
C22H14N2OS2

Conditions

Conditions	Yield
With triethylamine In benzene for 1h; Heating;	93%

2-Thiopheneacetyl Chloride Chemical Properties

Molecular Formula:C₆H₅ClOS
Molecular Weight:160.62
EINECS:254-290-0
Density:1.303 g/mL at 25 °C(lit.)
Boiling Point:130-135 °C (90 mmHg)
Flash Point:101 °C
Appearance:Clear brown liquid
2-Thiopheneacetyl chloride's(39098-97-0) Synonyms: TIMTEC-BB SBB006705;THIOPHENE-2-ACETYL CHLORIDE;2-Thiopheneacethylchloride;2-(2-THIENYL)ACETYL CHLORIDE;2-THIOPHENEACETYL CHLORIDE;2-THIENYLACETYL CHLORIDE;AKOS BBS-00003919;2-Thienylacetic acid chloride
2-Thiopheneacetyl chloride's(39098-97-0) Molecular Structure:

2-Thiopheneacetyl Chloride Uses

2-Thiopheneacetyl chloride(39098-97-0) can be used for pharmaceutical intermediates.

2-Thiopheneacetyl Chloride Safety Profile

Safety Information of 2-Thiopheneacetyl chloride(39098-97-0)
Hazard Codes C
Risk Statements 14-34-37-29
Safety Statements 26-28-36/37/39-45-8-30-23
RIDADR UN 3265 8/PG 2
WGK Germany 3
F 8-10-21
TSCA T
HazardClass 8
PackingGroup III
HS Code 29349990

2-Thiopheneacetyl Chloride Specification

Accidental Release Measures of 2-Thiopheneacetyl chloride(39098-97-0)
【Small spills/leaks】Clean up spills immediately, using the appropriate protective equipment. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Provide ventilation. Do not get water inside containers.

Stability and Reactivity of 2-Thiopheneacetyl chloride(39098-97-0)
【Stability】Stable under normal temperatures and pressures. May decompose on exposure to moist air or water. Moisture sensitive.
【Incompatibilities】Strong oxidizing agents, strong bases, moisture.
【Decomposition】Hydrogen chloride, carbon monoxide, oxides of sulfur, carbon dioxide.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.

Product Name

2-Thiopheneacetyl chloride

Synthetic route

2-Thiopheneacetyl Chloride Chemical Properties

2-Thiopheneacetyl Chloride Uses

2-Thiopheneacetyl Chloride Safety Profile

2-Thiopheneacetyl Chloride Specification

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