2-methyl-2-sulphatopropionamide
2-hydroxyisobutyramide
2-methyllactic acid
Conditions | Yield |
---|---|
With methanesulfonic acid; water at 130℃; under 1875.19 Torr; for 1h; Product distribution / selectivity; | 99.3% |
With nitromethane; water at 120℃; under 1875.19 Torr; for 1h; Product distribution / selectivity; | 98% |
With water; acetic acid at 130℃; under 1875.19 Torr; for 1h; Product distribution / selectivity; | 98.8% |
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-2-methylpropanenitrile With sulfuric acid; water; 1-Nitropropane at 40 - 55℃; for 0.5h; Stage #2: With water; 1-Nitropropane at 130℃; for 1h; Product distribution / selectivity; | 99.2% |
Stage #1: 2-hydroxy-2-methylpropanenitrile With nitromethane; sulfuric acid; water at 40 - 55℃; for 0.25 - 0.5h; Stage #2: With nitromethane; water at 120 - 130℃; for 0.5 - 1h; Product distribution / selectivity; | 98% |
Stage #1: 2-hydroxy-2-methylpropanenitrile With Nitroethane; sulfuric acid; water at 40 - 55℃; for 0.333333h; Stage #2: With Nitroethane; water at 120 - 130℃; for 0.75 - 1h; Product distribution / selectivity; | 98% |
2-isopropylidene-1,3-benzodithiole
A
2-methyllactic acid
B
1,2-benzenedisulfonyl dichloride
Conditions | Yield |
---|---|
With chlorine In water; tert-butyl alcohol at 0 - 5℃; for 2h; | A 77% B 95% |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water at 20℃; | 89% |
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether | 85% |
methanol
2-methyl-2-sulphatopropionamide
2-hydroxyisobutyramide
A
2-methyllactic acid
B
methyl 2-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With water; acetic acid at 115℃; under 1875.19 Torr; for 1h; Product distribution / selectivity; | A 19.2% B 81.5% |
chloroform
acetone
1-benzyl-4-methyl-1,2-dihydro-pyrazol-3-one
A
poly(methacrylic acid)
B
2-methyllactic acid
C
2-chloro-2-methylpropanoic acid
D
2-(1-benzyl-4-methyl-1H-pyrazol-3-yloxy)-2-methyl-propionic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 49 - 54℃; Further byproducts given; | A 0.07 mol B 0.15 mol C n/a D 77.2% |
(8aS)-3,3-dimethyl-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo<2,1-c><1,4>oxazine
2-methyllactic acid
Conditions | Yield |
---|---|
With potassium hydroxide; water for 2h; Heating; | 63% |
2-methylenesuccinic acid
A
propene
B
poly(methacrylic acid)
C
2-methyllactic acid
D
carbon dioxide
E
2-oxo-propionic acid
F
acetone
Conditions | Yield |
---|---|
With barium hexa-aluminate In water at 250℃; under 15001.5 Torr; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere; | A n/a B 50% C n/a D n/a E n/a F n/a |
dimethylacetylene
A
1-oxiranyl-ethanone
B
2,2,5,5-Tetramethyl-1,3-dioxolane-4-one
C
2-methyllactic acid
Conditions | Yield |
---|---|
With 3,3-dimethyldioxirane In acetone for 20h; Ambient temperature; | A n/a B 3% C 42% |
dimethylacetylene
acetone
A
1-oxiranyl-ethanone
B
2,2,5,5-Tetramethyl-1,3-dioxolane-4-one
C
2-methyllactic acid
Conditions | Yield |
---|---|
With 3,3-dimethyldioxirane for 20h; Ambient temperature; | A n/a B 3% C 42% |
With 3,3-dimethyldioxirane for 20h; Product distribution; Mechanism; Ambient temperature; | A n/a B 3% C 42% |
poly(methacrylic acid)
A
2-methyllactic acid
B
hex-1-ene-2,5-dicarboxylic acid
C
isopropyl alcohol
D
acetone
Conditions | Yield |
---|---|
With water at 230℃; for 1h; sealed tube; Further byproducts given; | A 10.4% B n/a C n/a D n/a |
tetrachloromethane
α-(α-hydroxy-isobutyryloxy)-isobutyric acid amide
A
2-methyllactic acid
B
2-hydroxyisobutyramide
Conditions | Yield |
---|---|
beim kurzem Kochen; |
Conditions | Yield |
---|---|
With nitric acid; vanadia; dinitrogen tetraoxide | |
With sodium nitrate; nitric acid; dinitrogen tetraoxide | |
With sodium hydroxide at 250℃; | |
With potassium hydroxide; water; cadmium(II) oxide |
Conditions | Yield |
---|---|
With permanganate(VII) ion |
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With calcium chloride at 95 - 97℃; |
Conditions | Yield |
---|---|
Hydrolysis; |
A
2-methyllactic acid
B
α-(hydroxy-nitroso-amino)-isobutyric acid
Conditions | Yield |
---|---|
With sodium phosphate | |
With alkali | |
With sodium borate |
Conditions | Yield |
---|---|
With nitric acid |
Conditions | Yield |
---|---|
With nitric acid |
1-bromo-3-methyl-butane-2,3-diol
2-methyllactic acid
Conditions | Yield |
---|---|
With nitric acid |
2-methyllactic acid
Conditions | Yield |
---|---|
With nitric acid |
2-bromo-2-methylpropanal
A
2-Methyl-1,2-propanediol
B
2-methyllactic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
2-bromo-2-methylpropanal
2-methyllactic acid
Conditions | Yield |
---|---|
With chromic acid |
1-chloro-5-methyl-hexa-2,4-diene
A
Tetramethyl-[1,2,4,5]tetroxan
B
formic acid
C
2-methyllactic acid
Conditions | Yield |
---|---|
bei der Ozonolyse; |
1-chloro-5-methyl-hexa-2,4-diene
2-methyllactic acid
Conditions | Yield |
---|---|
With potassium permanganate; water | |
Ozonolyse; | |
With potassium permanganate; acetone |
Conditions | Yield |
---|---|
With water at 180℃; |
2-bromo-2-methylpropionic acid
A
poly(methacrylic acid)
B
2-methyllactic acid
Conditions | Yield |
---|---|
With water | |
With barium dihydroxide | |
With sodium hydroxide | |
With sodium carbonate |
3,4-Dibromo-2,5-dimethylhexa-2,4-diene
2-methyllactic acid
Conditions | Yield |
---|---|
With potassium permanganate; potassium carbonate |
2-methyllactic acid
Conditions | Yield |
---|---|
Stage #1: 2-methyllactic acid With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-bromodeacetyl colchicine In N,N-dimethyl-formamide at 20℃; | 100% |
Conditions | Yield |
---|---|
With boric acid In toluene for 21h; Heating; | 99% |
With boric acid In toluene for 21h; Heating; | 99% |
2-methyllactic acid
phenethylamine
N-benzyl-2-hydroxy-2-methylpropanamide
Conditions | Yield |
---|---|
With [2-[(2,2,6,6-tetramethylpiperidin-1-yl)methyl]phenyl]boronic acid In toluene for 14h; Reagent/catalyst; Time; Solvent; Reflux; Molecular sieve; | 99% |
With dihydroxy-methyl-borane; water In toluene for 17h; Molecular sieve; Reflux; | 86% |
2-methyllactic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 16h; | 99% |
Conditions | Yield |
---|---|
at 182℃; under 300.03 Torr; for 10.0667h; | 98.27% |
With methanesulfonic acid In cyclohexane for 60h; Reflux; | 67% |
With toluene-4-sulfonic acid In toluene for 60h; Heating; | 65% |
α-morpholine methyltriethoxysilane
2-methyllactic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; diethyl ether at 20℃; | 98% |
In acetone at 20℃; | 82.5% |
Conditions | Yield |
---|---|
With propane-1,3-diyl dinitrite In tetrahydrofuran at 100℃; under 12929 Torr; for 0.5h; Temperature; | 98% |
triethoxy<1-(3-piperidinopropyl)>silane
2-methyllactic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; diethyl ether at 20℃; | 97.8% |
2-methyllactic acid
N,N-dimethylaminomethyltriethoxysilane
Conditions | Yield |
---|---|
In diethyl ether at 20℃; | 96.3% |
2-methyllactic acid
Ν,Ν',Ν''-[boroxin-2,4,6-triyltris[[(1R)-3-methylbutane-1,1-diyl]imino(2-oxoethane-2,1-diyl)]]tris(2,5-dichlorobenzamide)
2,5-dichloro-N-(2-([(1R)-1-(4,4-dimethyl-5-oxo-1,3,2-dioxaborolan-2-yl)-3-methylbutyl]amino)-2-oxoethyl)benzamide
Conditions | Yield |
---|---|
In ethyl acetate at 25 - 60℃; | 96% |
2-methyllactic acid
phenyl isothiocyanate
5,5-dimethyl-3-phenyl-2,4-oxazolidinedione
Conditions | Yield |
---|---|
With silver trifluoroacetate; triethylamine In acetonitrile for 1h; Cyclization; desulfurization; Heating; | 95% |
Conditions | Yield |
---|---|
In ethanol mixt. of ZnCO3, α-hydroxycarboxylic acid, and diamine in EtOH refluxed for 4 h, allowed to cool to room temp., stirred for 1 wk; recrystd. from nethanol/isopropanol (1/1), dried under vac.; elem. anal.; | 95% |
2-methyllactic acid
2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine
2-(2-hydroxy-2-methylpropanamido)-N-phenyl-N,2-dimethylpropanamide
Conditions | Yield |
---|---|
In acetonitrile at 0 - 20℃; | 95% |
2-methyllactic acid
benzyl bromide
benzyl 2-(benzyloxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | 94% |
Stage #1: 2-methyllactic acid With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; | 47% |
Stage #1: 2-methyllactic acid With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; | 47% |
2-methyllactic acid
(S)-2-hydroxy-2-methyl-1-(4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)propan-1-one
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h; | 94% |
2-methyllactic acid
Conditions | Yield |
---|---|
In chloroform a soln. of ligand added dropwise to a soln. of Ti complex, stirred for 15 min; evapd. (vac.), suspended in hexanes, filtered, vac.-dried overnight; elem. anal.; | 94% |
2-methyllactic acid
benzylamine
2-hydroxy-2-methyl-N-benzylpropanamide
Conditions | Yield |
---|---|
With mesocellular siliceous foam-supported boronic acid catalyst In o-xylene at 155℃; for 5h; Sealed tube; | 94% |
With dihydroxy-methyl-borane; water In toluene for 12h; Molecular sieve; Reflux; | 93% |
With [m-(1,4-diazabicyclo[2.2.2]octanekN1:kN4)]hexamethyldialuminum In toluene for 1h; Inert atmosphere; Reflux; | 60% |
2-methyllactic acid
phenylmethyl 1-piperazinecarboxylate
Benzyl 4-(2-hydroxy-2-methylpropionyl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃; for 7h; | 92.1% |
Conditions | Yield |
---|---|
With 4-(dihydroxyboranyl)-1-methylpyridin-1-ium iodide for 15h; Heating; | 92% |
With zinc(II) chloride at 60℃; for 6h; sealed tube; | 83% |
With thionyl chloride | 81% |
Conditions | Yield |
---|---|
With salicylaldehyde at 100℃; for 36h; Inert atmosphere; chemoselective reaction; | 92% |
With copper(II) sulfate |
(S)-valinol
2-methyllactic acid
(S)-4,5-dihydro-α,α-dimethyl-4-isopropyloxazole-2-ethanol
Conditions | Yield |
---|---|
In xylene for 30h; Heating; | 92% |
In xylene for 30h; Condensation; Heating; | 31% |
In para-xylene for 28h; Heating; | 22% |
2-methyllactic acid
3-dimethylamino-2,2-dimethyl-2H-azirine
2-(2-hydroxy-2-methylpropionamido)-N,N,2-trimethylpropionamid
Conditions | Yield |
---|---|
In acetonitrile for 2h; Ambient temperature; | 92% |
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate In dichloromethane at 20℃; for 48h; | 92% |
With N-ethyl-N,N-diisopropylamine In acetonitrile | 91% |
Stage #1: 2-methyllactic acid With sodium hydride In tetrahydrofuran; mineral oil at 5 - 20℃; for 1h; Stage #2: benzyl bromide With potassium iodide at 100℃; for 3h; Microwave irradiation; | 83% |
With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate In dichloromethane; water at 20℃; for 60h; | 70% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile |
Conditions | Yield |
---|---|
With 4-(dihydroxyboranyl)-1-methylpyridin-1-ium iodide for 15h; Reflux; | 92% |
2-methyllactic acid
Conditions | Yield |
---|---|
With boric acid In toluene for 22h; Heating; | 91% |
2-methyllactic acid
ethylene glycol
2-methyl-2-propenoic acid 2-hydroxyethyl ester
Conditions | Yield |
---|---|
calcinated cesium carbonate and titan oxide on silica at 320℃; Gas phase; | 90.4% |
calcinated cesium nitrate on silica In water at 320℃; Gas phase; | 89.2% |
at 320℃; Gas phase; | 88% |
2-methyllactic acid
N-(2-adamantyl)amine
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dichloromethane at 20℃; for 2h; Condensation; | 90% |
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