3'-Hydroxyacetophenone supplier

Name
3'-Hydroxyacetophenone
EINECS 204-494-0
CAS No. 121-71-1
Article Data113
CAS DataBase
Density 1.10 g/cm³
Solubility Soluble in alcohol. Insoluble in water.
Melting Point 90-95 °C(lit.)
Formula C₈H₈O₂
Boiling Point 277 °C at 760 mmHg
Molecular Weight 136.15
Flash Point 115.8 °C
Transport Information
Appearance white crystal powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Ethanone, 1-(3-hydroxyphenyl)-;m-Acetylphenol;Ethanone, 1- (3-hydroxyphenyl)-;1-(3-Hydroxyphenyl)ethan-1-one;3-Hydroxy acetophenone;Acetophenone, 3-hydroxy- (8CI);1-(3-hydroxyphenyl)ethanone;m-Hydroxyacetophenone;Acetophenone, 3-hydroxy-;
PSA 37.30000
LogP 1.59480

Synthetic route

: 10401-11-3
3-hydroxy phenylacetylene

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With gold(III) tribromide; water at 200℃; for 0.333333h; microwave irradiation;	100%
With tropylium tetrafluoroborate; water; acetic acid at 130℃; for 1h; Catalytic behavior; Temperature; Microwave irradiation; Inert atmosphere;	92%
With trifluorormethanesulfonic acid; water In 2,2,2-trifluoroethanol at 25℃; for 24h; Sealed tube; regioselective reaction;	87%
With water at 60℃; for 20h; Sealed tube;	63%
With methanesulfonic acid; iron(II) chloride tetrahydrate In 1,2-dichloro-ethane at 60℃; for 2h; Inert atmosphere;	49%

: 124414-07-9
1-(3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With lithium acetate In water; N,N-dimethyl-formamide at 25℃; for 7h; Inert atmosphere;	99%
With dichloro bis(acetonitrile) palladium(II) In water; acetone at 75℃; for 16h;	88%
With KF-Al2O3 (acidic) In acetonitrile for 48h; Ambient temperature;	82%

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water In water; dimethyl sulfoxide at 80℃; for 24h; Schlenk technique; Inert atmosphere;	99%
With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In 1,4-dioxane; water at 80℃; for 14h;	96%
With bis(η3-allyl-μ-chloropalladium(II)); t-BuBrettPhos; p-methylbenzaldehyde oxime; caesium carbonate In N,N-dimethyl-formamide at 90℃; for 5h; Catalytic behavior; Solvent; Reagent/catalyst; Inert atmosphere;	90%
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere;	88%
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere;	72%

: 52600-91-6
1-(3-ethoxyphenyl)ethan-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.5h; Microwave irradiation; Inert atmosphere;	99%

: 2454-35-5
3-acetylphenyl acetate

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With water; sodium acetate In ethanol for 5h; Reflux;	98%
With potassium hydrogensulfate; silica gel In methanol at 20℃; for 1h;	94%
With sodium hydroxide

: 14452-30-3
3'-iodoacetophenone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere;	98%
With water; ethylene glycol; potassium hydroxide; copper dichloride In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere;	95%
With copper(I) oxide; water; potassium carbonate; Sucrose at 140℃; for 6h; Sealed tube; Inert atmosphere;	90%

: 138313-22-1
3-acetyl phenyltrifluoromethanesulfonate

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With tetraethylammonium hydroxide In 1,4-dioxane at 20℃; for 1h;	97%

: 3-acetylphenyl benzenesulfonate

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With potassium hydroxide In toluene; tert-butyl alcohol at 100℃; for 0.5h; Inert atmosphere;	97%

: 3-acetylphenylboronic acid

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With water; caesium carbonate; hydrazine hydrate at 80℃; for 48h;	95%
With oxygen; triethylamine In 2-methyltetrahydrofuran at 20℃; under 760.051 Torr; for 24h; Green chemistry;	68%
With recombinant phenylacetone monooxygenase from Thermobifida fusca, M446G mutant; NADPH In dimethyl sulfoxide at 25℃; pH=9; Kinetics; Tris/HCl buffer; Enzymatic reaction; chemoselective reaction;
Multi-step reaction with 2 steps 1: tetrahydrofuran / 40 °C / Reduced pressure 2: recombinant phenylacetone monooxygenase from Thermobifida fusca; NADPH / dimethyl sulfoxide / 25 °C / pH 9 / Tris/HCl buffer; Enzymatic reaction View Scheme
With oxygen; N-ethyl-N,N-diisopropylamine; [5,6]fullerene-C70 In chloroform; toluene at 20℃; for 12h; Irradiation;

: acetonitrile complex of hypofluorous acid

: 3-acetylphenylboronic acid

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
In dichloromethane at 20℃;	95%

: 917-54-4
methyllithium

: 99-06-9
3-Carboxyphenol

A: 121-71-1
3-Hydroxyacetophenone

B: 7765-97-1
meta-hydroxy-α,α-dimethylbenzyl alcohol

Conditions

Conditions	Yield
With chloro-trimethyl-silane In tetrahydrofuran; diethyl ether at 0℃; for 2h; Yields of byproduct given;	A 94% B n/a
With chloro-trimethyl-silane In tetrahydrofuran; diethyl ether at 0℃; for 2h; Yield given;	A 94% B n/a

...Expand

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 220℃; for 0.666667h; Inert atmosphere; Microwave irradiation;	92%
With calcium hydride; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 220℃; for 0.5h;	83%
With 1-N-ferrocenylmethyl benzimidazole tagged polymer In N,N-dimethyl-formamide Reflux;	76%
With sodium thioethylate In N,N-dimethyl-formamide at 80℃; for 3.5h;	18%

: 124414-06-8
1-(3-(methoxymethoxy)phenyl)ethan-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 0℃; for 0.0333333h;	92%

: 42758-84-9
acetic acid 3-aminophenyl ester

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
Stage #1: acetic acid 3-aminophenyl ester With sulfuric acid at 20℃; Cooling with ice; Stage #2: With sodium nitrite In water Reflux;	92%

: 58621-54-8
1-(3-(allyloxy)phenyl)ethanone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With bis(benzonitrile)palladium(II) dichloride In benzene for 20h; Heating;	90%

: 16162-70-2
1-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 0℃; for 0.0333333h;	90%

: 99-03-6
1-(3-aminophenyl)ethanone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
Stage #1: 1-(3-aminophenyl)ethanone With sulfuric acid In water at 45 - 50℃; for 0.5h; Stage #2: With water; urea; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #3: With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene; water at 90℃; for 2h;	88.3%
Stage #1: 1-(3-aminophenyl)ethanone With sodium nitrite In water at 20℃; Milling; Green chemistry; Stage #2: With water at 80℃; for 0.5h; Neutral conditions; Green chemistry;	80%
With uranyl nitrate hydrate; water; trifluoroacetic acid for 48h; Irradiation; Inert atmosphere;	58%
With sulfuric acid; water Diazotization;

: C14H14O7

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With water In dimethyl sulfoxide at 155℃; for 0.5h;	85%

: 99-02-5
3'-Chloroacetophenone

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water In water; dimethyl sulfoxide at 130℃; for 24h; Concentration; Schlenk technique; Inert atmosphere;	82%
With trans-di(μ-acetato)bis[o-(di-o-tolyl-phosphino)benzyl]dipalladium(II); C29H45Pt; potassium carbonate In water; N,N-dimethyl-formamide at 115℃; for 0.5h; Inert atmosphere; Microwave irradiation;	81%
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere;	54%

: 34068-01-4
1-[3-(phenylmethoxy)phenyl]ethan-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel; methoxybenzene at 115℃; for 3h;	81%

: 3-acetoxybenzoylmalonate diethyl ester

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 4h; Reagent/catalyst; Temperature;	77.6%

: 15040-96-7
3-acetyl-2-cyclohexen-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); 6,6'-dimethyl-2,2'-bipyridine; sodium anthraquinone-2-sulfonate; oxygen In water; dimethyl sulfoxide at 80℃; under 760.051 Torr; for 24h;	77%

: octakis(m-acetylphenyl)octasilsesquioxane

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With potassium fluoride; dihydrogen peroxide; sodium hydrogencarbonate In tetrahydrofuran; methanol at 40℃;	76%

: 70550-16-2
5-acetyl-2-cyclohexen-1-one

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With lithium bromide; copper(ll) bromide In acetonitrile for 1h; Heating;	75%

: 1663-39-4
tert-Butyl acrylate

: 529-28-2
4-iodoanisol

: 443777-09-1
1-(3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethanone

A: 121-71-1
3-Hydroxyacetophenone

B: 94113-07-2
1,1'-(biphenyl-3,3'-diyl)bis(ethan-1-one)

C: 474097-69-3
tert-butyl (E)-3-(2-methoxyphenyl)prop-2-enoate

D: tert-butyl (E)-3-(3-acetylphenyl)-acrylate

Conditions

Conditions	Yield
With oxygen; palladium diacetate; sodium carbonate In N,N-dimethyl-formamide at 50℃; for 6h; Further byproducts given;	A 6% B 5% C 26% D 71%

...Expand

: 10401-11-3
3-hydroxy phenylacetylene

: 64-19-7
acetic acid

A: 121-71-1
3-Hydroxyacetophenone

B: 2454-35-5
3-acetylphenyl acetate

Conditions

Conditions	Yield
With iron(III) sulfate hydrate at 95℃; for 24h; Schlenk technique;	A 71% B 6%

...Expand

: 2415-09-0
3-(1-hydroxyethyl)phenol

: 121-71-1
3-Hydroxyacetophenone

Conditions

Conditions	Yield
With iodine; hydrazine hydrate; dimethyl sulfoxide In water; acetonitrile at 80℃; for 7.5h;	64.7%
With chromium(VI) oxide

: 2415-09-0
3-(1-hydroxyethyl)phenol

A: 121-71-1
3-Hydroxyacetophenone

B: (R)‐(+)‐3‐(1‐hydroxyethyl)phenol

Conditions

Conditions	Yield
With Candida albicans CCT 0776 In water at 30℃; for 144h; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A 42% B 42%
With immobilized Candida albicans CCT 0776 cells in calcium alginate beads In water at 30℃; for 16h; Reagent/catalyst;	A n/a B n/a

: 98-86-2
acetophenone

A: 121-71-1
3-Hydroxyacetophenone

B: 118-93-4
o-hydroxyacetophenone

C: 99-93-4
4-Hydroxyacetophenone

Conditions

Conditions	Yield
With (difluoroboryl)dimethylglyoximatocobalt(II) bis(acetonitrile); water; 3-cyano-1-methylquinolinium cation In acetonitrile at 20℃; for 5h; Inert atmosphere; Irradiation; Green chemistry;	A 6% B 38% C 14%
With hydroxyl radical; potassium hexacyanoferrate(III) Rate constant; Ambient temperature; also without K3Fe(CN)6;
With air; carbon monoxide; sodium acetate; palladium on activated charcoal; phosphovanadomolybdic acid In water; acetic acid at 120℃; under 15200 Torr; for 4h; Title compound not separated from byproducts;

...Expand

: 121-71-1
3-Hydroxyacetophenone

: 107-08-4
1-iodo-propane

: 121704-77-6
3-(prop-1-yloxy)acetophenone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	100%
With NaH In N,N-dimethyl-formamide	98%
With sodium ethanolate

: 121-71-1
3-Hydroxyacetophenone

: 106-95-6
allyl bromide

: 58621-54-8
1-(3-(allyloxy)phenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; Reflux;	100%
With potassium carbonate In acetone for 8h; Heating;	95%
With potassium carbonate In ethanol for 3h; Reflux; Inert atmosphere;	93%

: 121-71-1
3-Hydroxyacetophenone

: 2415-09-0
3-(1-hydroxyethyl)phenol

Conditions

Conditions	Yield
Stage #1: 3-Hydroxyacetophenone With sodium tetrahydroborate at 60℃; for 0.5h; Ball milling; neat (no solvent); Stage #2: With water regiospecific reaction;	100%
With formic acid; C18H24ClIrN3 In water at 80℃; for 4h; Schlenk technique; Inert atmosphere; chemoselective reaction;	99%
With sodium tetrahydroborate; nickel(II) phthalocyanine In PEG-400 at 20℃; for 0.416667h; chemoselective reaction;	86%

: 121-71-1
3-Hydroxyacetophenone

: 3019-87-2
sodium 3-acetylphenoxide

Conditions

Conditions	Yield
With sodium hydride In benzene for 0.5h;	100%

: 121-71-1
3-Hydroxyacetophenone

: 100-39-0
benzyl bromide

: 34068-01-4
1-[3-(phenylmethoxy)phenyl]ethan-1-one

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux; Inert atmosphere;	100%
With potassium carbonate; potassium iodide In acetone for 24h; Heating / reflux;	98%
In N,N-dimethyl-formamide; mineral oil	97%

: 121-71-1
3-Hydroxyacetophenone

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 178445-80-2
(E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 0 - 20℃; for 16h;	100%
With potassium hydroxide In ethanol; water at 0 - 20℃;	92%
With potassium hydroxide In ethanol at 20℃; for 16h; Condensation;	91%

: 121-71-1
3-Hydroxyacetophenone

: 95-92-1
oxalic acid diethyl ester

: (Z)-ethyl 2-hydroxy-4-(3-hydroxyphenyl)-4-oxobut-2-enoate

Conditions

Conditions	Yield
With sodium ethanolate In tetrahydrofuran at 25℃; for 0.00277778h; microwave irradiation;	100%
With potassium tert-butylate In tetrahydrofuran at 20℃; Claisen Condensation;	88%

: 121-71-1
3-Hydroxyacetophenone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 124414-07-9
1-(3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanone

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;	93%
With dmap; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 2.5h;	91%

: 42252-34-6
N-ethyl-N-methylcarbamoyl chloride

: 121-71-1
3-Hydroxyacetophenone

: 855300-09-3
1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20 - 55℃; for 5h; Product distribution / selectivity; Heating / reflux;	100%
With potassium carbonate In acetone for 4h; Reflux;	100%
With potassium carbonate In acetone at 60℃; for 0.4h; Reagent/catalyst; Temperature; Solvent;	100%

: 121-71-1
3-Hydroxyacetophenone

: 563-47-3
3-Chloro-2-methylpropene

: 1017048-68-8
1-[3-(2-methylallyloxy)phenyl]ethanone

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃;	100%
With potassium carbonate In acetonitrile for 17h; Reflux;

: 121-71-1
3-Hydroxyacetophenone

: 106-96-7
propargyl bromide

: 34264-13-6
1-(3-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; toluene at 25℃; for 24h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
Stage #1: 3-Hydroxyacetophenone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 0 - 25℃; for 16h;

: 110-86-1
pyridine

: 121-71-1
3-Hydroxyacetophenone

: 1-(3-hydroxy-phenacyl)-pyridinium; iodide

Conditions

Conditions	Yield
With iodine at 140℃; for 3h;	100%
With iodine at 140℃; for 3h;	100%
With iodine at 140℃; for 3h;	100%

: 121-71-1
3-Hydroxyacetophenone

: (R)‐(+)‐3‐(1‐hydroxyethyl)phenol

Conditions

Conditions	Yield
With C38H46ClIrN2P; hydrogen; sodium t-butanolate In ethanol at 0 - 50℃; under 1500.15 - 75007.5 Torr; Reagent/catalyst; Solvent; Inert atmosphere; Autoclave;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 22502.3 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction;	99%
With formic acid; triethylamine; [Ru(η6-p-cymene)(HNC(Ph)C(Ph)NTs)] In ethanol at 60 - 70℃; for 5h; Product distribution / selectivity; Inert atmosphere;	90%

: 121-71-1
3-Hydroxyacetophenone

: 77-78-1
dimethyl sulfate

: 586-37-8
1-(3-Methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: 3-Hydroxyacetophenone With potassium carbonate In acetone for 0.166667h; Stage #2: dimethyl sulfate In acetone at 45℃; for 2h;	99.73%
With potassium carbonate In acetone at 45℃; for 2h; Large scale reaction;	95%
Stage #1: 3-Hydroxyacetophenone With sodium hydroxide In water for 0.5h; Large scale; Stage #2: dimethyl sulfate In water at 30 - 38℃; for 9.15h; pH=> 13; Temperature; pH-value; Microwave irradiation; Large scale;	91.1%

: 121-71-1
3-Hydroxyacetophenone

: 108-24-7
acetic anhydride

: 2454-35-5
3-acetylphenyl acetate

Conditions

Conditions	Yield
With magnesium(II) perchlorate at 20℃; for 1h;	99%
With sodium hydroxide In water at 0℃; for 1.5h; pH=7 - 8;	94%
copper(II) bis(tetrafluoroborate) at 20℃; for 0.5h;	92%

: 121-71-1
3-Hydroxyacetophenone

: 98-88-4
benzoyl chloride

: 139-28-6
3-acetylphenyl benzoate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 4h; Inert atmosphere;	99%

: 358-23-6
trifluoromethylsulfonic anhydride

: 121-71-1
3-Hydroxyacetophenone

: 138313-22-1
3-acetyl phenyltrifluoromethanesulfonate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; dmap In dichloromethane for 2h; Ambient temperature;	99%
With pyridine In dichloromethane at 0 - 20℃;	96%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: 121-71-1
3-Hydroxyacetophenone

: 107-21-1
ethylene glycol

: 2-(3-hydroxyphenyl)-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With Triisopropoxymethan; cerium triflate In hexane at 25℃; for 1h;	99%
With zeolite HSZ-360 In toluene for 11h; Heating;	88%
With toluene-4-sulfonic acid In benzene Heating / reflux;	36%

: 121-71-1
3-Hydroxyacetophenone

: 98-59-9
p-toluenesulfonyl chloride

: 58297-34-0
3-acetylphenyl p-toluenesulfonate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 2h; Green chemistry;	99%
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 0 - 20℃; Inert atmosphere;	91%
With dmap; triethylamine In dichloromethane

: 121-71-1
3-Hydroxyacetophenone

: 1609-47-8
diethyl dicarbonate

: ethyl 3-acetylphenyl carbonate

Conditions

Conditions	Yield
With magnesium(II) perchlorate at 40℃; for 4.5h;	99%

: 10147-36-1
n-propanesulfonyl chloride

: 121-71-1
3-Hydroxyacetophenone

: 937079-67-9
3-acetylphenyl propane-1-sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 5h;	99%

: 121-71-1
3-Hydroxyacetophenone

: 603-33-8
triphenylbismuthane

: 32852-92-9
3'-phenoxyacetophenone

Conditions

Conditions	Yield
With copper diacetate; triethylamine In dichloromethane at 50℃; for 3h; Reagent/catalyst; Time; Sealed tube;	99%

: 13154-24-0
triisopropylsilyl chloride

: 121-71-1
3-Hydroxyacetophenone

: 1569974-52-2
1-(3-((triisopropylsilyl)oxy)phenyl)ethanone

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 6h;	99%

: 121-71-1
3-Hydroxyacetophenone

: 1-O-acetyl-6-O-chloracetylbritannilactone

: 1-O-acetyl-6-O-(2-(3-acetylphenoxy)acetyl)britannilactone

Conditions

Conditions	Yield
With triethanolamine; N-benzyl-N,N,N-triethylammonium chloride; sodium iodide In acetone at 25℃;	99%

: 3137-63-1
4-chloro-2-(trichloromethyl)quinazoline

: 121-71-1
3-Hydroxyacetophenone

: 1-(3-(2-(trichloromethyl)quinazolin-4-yloxy)phenyl)ethanone

Conditions

Conditions	Yield
With dmap In toluene at 130℃; for 1h; Microwave irradiation; Sealed tube;	99%

: 121-71-1
3-Hydroxyacetophenone

: 40106-45-4
4-Hydrazino-5,6-tetramethylenethieno<2,3-d>pyrimidine

: 3-{1-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)hydrazono]ethyl}phenol

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	99%

3'-Hydroxyacetophenone Chemical Properties

Molecular Structure of 3-Hydroxy acetophenone (CAS No.121-71-1):

Molecular Formula: C₈H₈O₂
Molecular Weight: 136.15
IUPAC Name: 1-(3-Hydroxyphenyl)ethanone
CAS No: 121-71-1
EINECS: 204-494-0
Melting Point: 94-97 ºC
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.552
Molar Refractivity: 38.16 cm³
Molar Volume: 119.3 cm³
Surface Tension: 43.9 dyne/cm
Density: 1.14 g/cm³
Flash Point: 115.8 °C
Enthalpy of Vaporization: 53.62 kJ/mol
Boiling Point: 277 °C at 760 mmHg
Vapour Pressure: 0.00276 mmHg at 25°C
Canonical SMILES: CC(=O)C1=CC(=CC=C1)O
InChI: InChI=1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3
InChIKey: LUJMEECXHPYQOF-UHFFFAOYSA-N

3'-Hydroxyacetophenone Uses

3-Hydroxy acetophenone (CAS No.121-71-1) is used for organic synthesis; as intermediate of Phenylephrine; synthesis of pharmaceutical intermediate .

3'-Hydroxyacetophenone Safety Profile

Safety Information of 3-Hydroxy acetophenone (CAS No.121-71-1):
Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Harmful/Irritant

3'-Hydroxyacetophenone Standards and Recommendations

Assay of 3-Hydroxy acetophenone: 99%

3'-Hydroxyacetophenone Specification

3-Hydroxy acetophenone (CAS No.121-71-1), it also can be called m-Hydroxyacetophenone ; 3-Acetylphenol ; 1-(3-Hydroxyphenyl)ethanon ; Ethanone, 1- (3-hydroxyphenyl)- ; m-Acetylphenol ; 1-(3-Hydroxyphenyl)Ethan-1-One . It is beige-brown crystalline powder.

Product Name

3'-Hydroxyacetophenone

Synthetic route

3'-Hydroxyacetophenone Chemical Properties

3'-Hydroxyacetophenone Uses

3'-Hydroxyacetophenone Safety Profile

3'-Hydroxyacetophenone Standards and Recommendations

3'-Hydroxyacetophenone Specification

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