Product Name

  • Name

    3,4-Diaminotoluene

  • EINECS 207-826-2
  • CAS No. 496-72-0
  • Article Data90
  • CAS DataBase
  • Density 1.107 g/cm3
  • Solubility 16 g/L (20 °C) in water
  • Melting Point 87-89 °C(lit.)
  • Formula C7H10N2
  • Boiling Point 262.3 °C at 760 mmHg
  • Molecular Weight 122.17
  • Flash Point 132.1 °C
  • Transport Information UN 2811
  • Appearance off-white small blocks
  • Safety 26-37/39-61-36/37/39
  • Risk Codes 20/21/22-36/37/38-52/53-40-36-22
  • Molecular Structure Molecular Structure of 496-72-0 (3,4-Diaminotoluene)
  • Hazard Symbols HarmfulXn
  • Synonyms Toluene-3,4-diamine(7CI,8CI);1,2-Diamino-4-methylbenzene;2-Amino-4-methylaniline;2-Amino-5-methylaniline;3,4-Diamino-1-methylbenzene;3,4-Tolylenediamine;4-Methyl-1,2-benzenediamine;4-Methyl-1,2-diaminobenzene;4-Methyl-1,2-phenylenediamine;4-Methyl-2-aminoaniline;4-Methyl-o-phenylenediamine;1,2-Benzenediamine,4-methyl-;
  • PSA 52.04000
  • LogP 2.32180

Synthetic route

4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With hydrogen; nickel In methanol at 65 - 75℃; for 1h; Autoclave; Inert atmosphere;97%
With aluminum oxide; hydrazine hydrate; iron(III) chloride at 111℃; for 0.1h; Irradiation; microwave;96%
With hydrazine hydrate In ethanol at 70℃; for 4h; chemoselective reaction;94%
3,4-Dinitrotoluene
610-39-9

3,4-Dinitrotoluene

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol at 20℃; for 48h;96.6%
With hydrogen In methanol at 50℃; under 1500.15 Torr; for 0.25h; Inert atmosphere;88%
With 5 wt% ruthenium/carbon; hydrogen; sodium nitrite In isopropyl alcohol at 150℃; under 62256.2 Torr; for 4h; Temperature; Autoclave;
5-methylbenzo[c][1,2,5]thiadiazole
1457-93-8

5-methylbenzo[c][1,2,5]thiadiazole

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With methanol; samarium diiodide In tetrahydrofuran at 20℃; for 0.333333h;91%
With magnesium In methanol at 45 - 60℃; for 1.83333h;86%
2-nitro-5,5'-dimethylazobenzene

2-nitro-5,5'-dimethylazobenzene

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With formic acid; zinc In methanol at 20℃; for 24h; Inert atmosphere;90%
5-methyl-2-nitroaniline
578-46-1

5-methyl-2-nitroaniline

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With tetrahydroxydiboron; water at 80℃; for 8h;86%
With tetrahydroxydiboron; 5%-palladium/activated carbon; water In acetonitrile at 50℃; for 24h;80%
With hydrogenchloride; tin
5-methylbenzofuroxan
19164-41-1

5-methylbenzofuroxan

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With ammonium sulfate; magnesium In methanol Ambient temperature;80%
With Saccharomyces cerevisiae BY In methanol at 20℃; for 6.5h; pH=7.0; aq. buffer; Enzymatic reaction;80%
2-nitro-4,4'-dimethylazobenzene

2-nitro-4,4'-dimethylazobenzene

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With formic acid; zinc In methanol at 20℃; for 10h; Inert atmosphere;76%
2-amino-4-methylacetanilide
53476-34-9

2-amino-4-methylacetanilide

A

2,5-dimethylbenzimidazole
1792-41-2

2,5-dimethylbenzimidazole

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
Erhitzen;
(4-amino-3-nitrophenyl)methanol
63189-97-9

(4-amino-3-nitrophenyl)methanol

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With hydrogenchloride; tin
(E)-1-(4-methyl-2-nitrophenyl)-2-(p-tolyl)diazene

(E)-1-(4-methyl-2-nitrophenyl)-2-(p-tolyl)diazene

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With hydrogenchloride; tin
bis-(4-methyl-2-nitro-phenyl)-diazene

bis-(4-methyl-2-nitro-phenyl)-diazene

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With hydrogenchloride; tin
bis-(4-methyl-2-p-tolylazo-phenyl)-diazene

bis-(4-methyl-2-p-tolylazo-phenyl)-diazene

A

p-toluidine
106-49-0

p-toluidine

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
bei reduktiver Spaltung;
4-methyl-2-p-tolylazo-aniline
58010-91-6

4-methyl-2-p-tolylazo-aniline

A

p-toluidine
106-49-0

p-toluidine

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
durch Reduktionsmittel;
4-methyl-2-p-tolylazo-aniline
58010-91-6

4-methyl-2-p-tolylazo-aniline

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
bei der Reduktion;
4,4'-dimethyl-2-nitro-ONN-azoxybenzene
102276-78-8

4,4'-dimethyl-2-nitro-ONN-azoxybenzene

A

p-toluidine
106-49-0

p-toluidine

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C

C14H17N3

C14H17N3

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; tin(ll) chloride for 2h; Title compound not separated from byproducts;
...Expand
4,4'-dimethyl-2,3'-dinitro-ONN-azoxybenzene
102276-79-9

4,4'-dimethyl-2,3'-dinitro-ONN-azoxybenzene

A

4-methylbenzene-1,3-diamine
95-80-7

4-methylbenzene-1,3-diamine

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C

C14H16N4O

C14H16N4O

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; tin(ll) chloride for 3h; Title compound not separated from byproducts;
...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

5-Methyl-benzo[1,2,5]selenadiazole
1123-91-7, 37159-63-0

5-Methyl-benzo[1,2,5]selenadiazole

tin dichloride

tin dichloride

A

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

B

selenium

selenium

...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

5-Methyl-benzo[1,2,5]selenadiazole
1123-91-7, 37159-63-0

5-Methyl-benzo[1,2,5]selenadiazole

tin

tin

A

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

B

selen(o) hydrogen

selen(o) hydrogen

...Expand
anhydro-<3-nitro-4-amino-benzyl alcohol

anhydro-<3-nitro-4-amino-benzyl alcohol

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
With hydrogenchloride; tin
ethanol
64-17-5

ethanol

4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

sodium amalgam

sodium amalgam

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

tin

tin

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

...Expand
4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

zinc

zinc

alcoholic KOH-solution

alcoholic KOH-solution

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

...Expand
ethanol
64-17-5

ethanol

acetic acid
64-19-7

acetic acid

2-(2-(4-methyl-2-nitrophenyl)hydrazono)-3-oxo-N-phenylbutanamide
26128-86-9

2-(2-(4-methyl-2-nitrophenyl)hydrazono)-3-oxo-N-phenylbutanamide

zinc dust

zinc dust

A

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

B

3.6-dimethyl-dihydropyrazine-dicarboxylic acid-(2.5)-dianilide

3.6-dimethyl-dihydropyrazine-dicarboxylic acid-(2.5)-dianilide

...Expand
4-methyl-2-p-tolylazo-aniline
58010-91-6

4-methyl-2-p-tolylazo-aniline

A

p-toluidine
106-49-0

p-toluidine

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C

2-p-tolyl-5-methyl-benztriazole

2-p-tolyl-5-methyl-benztriazole

Conditions
ConditionsYield
at 300℃;
...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

(4-methyl-2-nitro-phenylhydrazono)-phenyl-acetonitrile
69864-29-5

(4-methyl-2-nitro-phenylhydrazono)-phenyl-acetonitrile

tin

tin

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C

benzoic acid
65-85-0

benzoic acid

...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

3,4-Dinitrotoluene
610-39-9

3,4-Dinitrotoluene

tin (II)-chloride

tin (II)-chloride

A

5-methyl-2-nitroaniline
578-46-1

5-methyl-2-nitroaniline

B

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C

4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

Conditions
ConditionsYield
at 7℃;
...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

(4-amino-3-nitrophenyl)methanol
63189-97-9

(4-amino-3-nitrophenyl)methanol

tin

tin

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Conditions
ConditionsYield
durch laengeres Behandeln;
...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

ethanol
64-17-5

ethanol

trichloro-acetic acid-(4-methyl-2-nitro-anilide)
339590-78-2

trichloro-acetic acid-(4-methyl-2-nitro-anilide)

tin

tin

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

bis-(4-methyl-2-nitro-phenyl)-diazene

bis-(4-methyl-2-nitro-phenyl)-diazene

tin

tin

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

...Expand
glycolic Acid
79-14-1

glycolic Acid

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

(5-methyl-1H-benzimidazole-2-yl)methanol
20034-02-0

(5-methyl-1H-benzimidazole-2-yl)methanol

Conditions
ConditionsYield
With hydrogenchloride In water for 3h; Reflux;100%
With hydrogenchloride In water for 6h; Reflux;83%
With phosphoric acid at 130℃; for 3h;72%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

benzil
134-81-6

benzil

2,3-diphenyl-6-methylquinoxaline
16107-85-0

2,3-diphenyl-6-methylquinoxaline

Conditions
ConditionsYield
at 100℃; for 0.25h;100%
With gallium(III) triflate In ethanol at 20℃; for 0.0833333h;100%
With aluminum oxide at 20℃; for 0.166667h; neat (no solvent);100%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

dimethylglyoxal
431-03-8

dimethylglyoxal

2,3,6-trimethylquinoxaline
17635-21-1

2,3,6-trimethylquinoxaline

Conditions
ConditionsYield
With zirconium(IV) chloride In methanol at 20℃; for 0.0833333h;100%
With silica-supported stannous chloride In methanol at 20℃; for 0.0333333h;99%
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 0.1h; Reflux;99%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

1,2-bis(4-methoxyphenyl)-1,2-ethanedione
1226-42-2

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

2,3-bis-(4-methoxy-phenyl)-6-methyl-quinoxaline

2,3-bis-(4-methoxy-phenyl)-6-methyl-quinoxaline

Conditions
ConditionsYield
at 80℃; for 1h; solid-state reaction;100%
With zirconium(IV) chloride In methanol at 20℃; for 0.5h;100%
With aluminum oxide at 20℃; for 0.166667h; neat (no solvent);99%
furil
492-94-4

furil

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2,3-di(furan-2-yl)-6-methyl-quinoxaline

2,3-di(furan-2-yl)-6-methyl-quinoxaline

Conditions
ConditionsYield
With gallium(III) triflate In ethanol at 20℃; for 0.166667h;100%
With amberlyst-15 In water at 70℃; for 0.183333h;99%
With aluminum oxide at 20℃; for 0.166667h; neat (no solvent);99%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

6-methyl-1H-benzo[d]imidazole
614-97-1

6-methyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With zirconium(IV) chloride In methanol at 20℃; for 3h;100%
With sulfonated rice husk ash In neat (no solvent) at 60℃; for 0.116667h;95%
With nano-Ni(II)/Y zeolite catalyst In neat (no solvent) at 60℃; for 1.33333h; Green chemistry;83%
With silica tungstic acid at 80℃; for 0.2h; Neat (no solvent);80%
With iron oxide In neat (no solvent) at 80℃; for 0.6h; Green chemistry;77%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

Trichloroacetyl isocyanate
3019-71-4

Trichloroacetyl isocyanate

A

2,2,2-trichloro-N-(5-methyl-1H-benzimidazol-2-yl)acetamide

2,2,2-trichloro-N-(5-methyl-1H-benzimidazol-2-yl)acetamide

B

2,2,2-trichloro-N-(6-methyl-1H-benzimidazol-2-yl)acetamide

2,2,2-trichloro-N-(6-methyl-1H-benzimidazol-2-yl)acetamide

Conditions
ConditionsYield
In dichloromethane at -10 - 20℃; Overall yield = 88 %;A 100%
B n/a
...Expand
C12H15IO2
1083427-54-6

C12H15IO2

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

C31H36I2N2O2

C31H36I2N2O2

Conditions
ConditionsYield
In ethanol at 80℃; for 8h; Inert atmosphere;100%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

furoin
552-86-3

furoin

2,3-di(furan-2-yl)-6-methyl-quinoxaline

2,3-di(furan-2-yl)-6-methyl-quinoxaline

Conditions
ConditionsYield
With [P4-VP]-PdNPs In N,N-dimethyl-formamide at 120℃; for 0.0133333h; Reflux;99%
With morpholine; iron(III) chloride In ethanol at 80℃; for 1.5h;94%
With 5% ruthenium on carbon; oxygen In water at 75℃; for 24h;89%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

5-methyl-1,3-dihydro-2H-benzimidazol-2-one
5400-75-9

5-methyl-1,3-dihydro-2H-benzimidazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 15h;99%
In tetrahydrofuran; dichloromethane at 20℃; for 8h;89%
In tetrahydrofuran at 20℃;82%
indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

7-methyl-11H-indeno[1,2-b]quinoxalin-11-one

7-methyl-11H-indeno[1,2-b]quinoxalin-11-one

Conditions
ConditionsYield
In water at 30℃; for 0.00972222h; Irradiation; Sonication; Green chemistry;99%
With bismuth(lll) trifluoromethanesulfonate In water at 20℃; for 0.1h;91%
In ethanol for 2h; Heating;
4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

5‐methyl‐2‐(4‐nitrophenyl)‐1H‐benzo[d]imidazole
69570-93-0

5‐methyl‐2‐(4‐nitrophenyl)‐1H‐benzo[d]imidazole

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 20℃; for 0.833333h;99%
With silica-bound phosphoric acid In water at 70℃; for 0.00416667h;95%
With oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 24h; Sealed tube; Green chemistry;94%
1,10-phenanthroline-5,6-dione
27318-90-7

1,10-phenanthroline-5,6-dione

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

7-methyldipyrido[3,2-a:2’,3’-c]phenazine
205367-28-8

7-methyldipyrido[3,2-a:2’,3’-c]phenazine

Conditions
ConditionsYield
With sulfated titania (TiO2-SO42-) In ethanol at 20℃; for 0.133333h;99%
With sulfated TiO2-P25 (Degussa titania) for 0.0333333h; Microwave irradiation; Neat (no solvent);99%
With sulfate loaded TiO2 for 0.0333333h; Microwave irradiation; Neat (no solvent);99%
cyclohexanone
108-94-1

cyclohexanone

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

8'-methyl-1',2',3',4',10',11a'-hexahydrospiro[cyclohexane-1,11'-dibenzo[b,e][1,4]diazepine]

8'-methyl-1',2',3',4',10',11a'-hexahydrospiro[cyclohexane-1,11'-dibenzo[b,e][1,4]diazepine]

Conditions
ConditionsYield
With iodine In acetonitrile at 25℃; for 0.0333333h;99%
at 26 - 30℃; for 3.5h; Ionic liquid;95%
With salicylic acid at 20℃; for 1h;92%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2,5-dimethylbenzimidazole
1792-41-2

2,5-dimethylbenzimidazole

Conditions
ConditionsYield
With nano-Ni(II)/Y zeolite catalyst In neat (no solvent) at 60℃; for 0.766667h; Green chemistry;99%
With [PVP-SO3H] HSO4 at 60℃; for 0.0666667h;96%
With ammonium chloride In water Inert atmosphere; Reflux; Green chemistry;95%
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2-(2-chloro-phenyl)-5-methyl-1(3)H-benzoimidazole
14225-76-4

2-(2-chloro-phenyl)-5-methyl-1(3)H-benzoimidazole

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 20℃; for 0.666667h;99%
With air In 1,4-dioxane at 100℃; for 20h;90%
With methanesulfonic acid; silica gel In neat (no solvent) at 90℃; for 6h; Green chemistry;82%
With TCCA In 1,4-dioxane; acetonitrile at 20℃; for 1.83333h;80%
1,2-di(4-methylphenyl)-1,2-ethanedione
3457-48-5

1,2-di(4-methylphenyl)-1,2-ethanedione

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

6-methyl-2,3-di-p-tolylquinoxaline
16107-87-2

6-methyl-2,3-di-p-tolylquinoxaline

Conditions
ConditionsYield
With Cs(cetyltrimethylammonium)2PW12O40 In neat (no solvent) at 80℃; for 0.166667h; Green chemistry;99%
With zirconium tetrakis(dodecyl sulfate) In water at 20℃; for 0.583333h;95%
at 120℃; for 0.0666667h; Microwave irradiation;95%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2-(4-hydroxyphenyl)-5-methylbenzimidazole

2-(4-hydroxyphenyl)-5-methylbenzimidazole

Conditions
ConditionsYield
With sodium metabisulfite; air In N,N-dimethyl-formamide at 90℃; for 2h;99%
With sodium metabisulfite In ethanol; water at 20℃; for 2h;89%
With sodium disulfite for 0.0133333h; microwave irradiation;85%
With sodium metabisulfite In N,N-dimethyl-formamide at 100℃; for 42h;69%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene
1282523-80-1

N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene

Conditions
ConditionsYield
With iron oxide In ethanol at 20℃; for 0.75h; Green chemistry; chemoselective reaction;99%
With guanidine hydrochloride In ethanol at 35 - 40℃; for 0.333333h;94%
With [H2-cryptand 222](Br3)2 In acetonitrile at 20℃; for 8h; chemoselective reaction;70%
Stage #1: di-tert-butyl dicarbonate With C12H24KO6(1+)*Br3H(1-) In ethanol at 20℃; for 0.0166667h;
Stage #2: 4-methyl-1,2-diaminobenzene In ethanol at 20℃; for 4.25h;		65%
carbon dioxide
124-38-9

carbon dioxide

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

5-methyl-1,3-dihydro-2H-benzimidazol-2-one
5400-75-9

5-methyl-1,3-dihydro-2H-benzimidazol-2-one

Conditions
ConditionsYield
With tetrabutylammonium tungstate In 1-methyl-pyrrolidin-2-one at 139.84℃; under 15001.5 Torr; for 24h; Autoclave;99%
In tetrahydrofuran; water at 20℃; under 7500.75 Torr; for 9h; UV-irradiation;99%
With Sn(IV)-doped DFNS supported CdSnO3 nanoparticles under 11251.1 Torr; for 1h; UV-irradiation;98%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

benzyl alcohol
100-51-6

benzyl alcohol

5-methyl-2-phenyl-1H-1,3-benzimidazole
2963-65-7

5-methyl-2-phenyl-1H-1,3-benzimidazole

Conditions
ConditionsYield
With C19H35Cl2CoN2P; sodium triethylborohydride In toluene at 150℃; for 24h; Molecular sieve; Schlenk technique;99%
With trans-bis(quinoline-2-carboxylato)bis(ethanol)cobalt(II); sodium carbonate In acetonitrile at 20℃; for 2h;90%
With C56H86Cl3IrN2P2Ru Schlenk technique; Inert atmosphere;89%
2-Formylphenoxyacetic acid
6280-80-4

2-Formylphenoxyacetic acid

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2-CHLOROBENZYLAMINE
89-97-4

2-CHLOROBENZYLAMINE

C23H20ClN3O2

C23H20ClN3O2

Conditions
ConditionsYield
With natural silk-supported manganese(II) tetrasulfophthalocyanine In water at 20℃; for 8h; Green chemistry;99%
...Expand
4-Methylbenzyl alcohol
589-18-4

4-Methylbenzyl alcohol

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

5-methyl-2-(4-methylphenyl)-1H-benzimidazole
7118-66-3

5-methyl-2-(4-methylphenyl)-1H-benzimidazole

Conditions
ConditionsYield
With C19H35Cl2CoN2P; sodium triethylborohydride In toluene at 150℃; for 24h; Molecular sieve; Schlenk technique;99%
Stage #1: 4-Methylbenzyl alcohol With N-hydroxyphthalimide; Mo72V30; oxygen In ethyl acetate at 70℃; for 6.5h;
Stage #2: 4-methyl-1,2-diaminobenzene In ethyl acetate		87%
With N-hydroxyphthalimide at 70℃; for 3h;79%
With C13H16MnN2O3S(1+)*Br(1-); potassium hydroxide In neat (no solvent) at 140℃; for 20h;74%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

hexan-1-ol
111-27-3

hexan-1-ol

5-methyl-2-pentyl-1H-benzo[d]imidazole

5-methyl-2-pentyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With C19H35Cl2CoN2P; sodium triethylborohydride In toluene at 150℃; for 24h; Molecular sieve; Schlenk technique;99%
With 1,10-Phenanthroline; potassium tert-butylate; nickel dichloride In toluene at 140℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;45%
1,2-di(thiophen-2-yl)ethyne
23975-15-7

1,2-di(thiophen-2-yl)ethyne

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

6-methyl-2,3-di-2-thiophenylquinoxaline

6-methyl-2,3-di-2-thiophenylquinoxaline

Conditions
ConditionsYield
With dimethyl sulfoxide at 140℃; for 3.5h; Sealed tube;99%
1-naphthaldehyde
66-77-3

1-naphthaldehyde

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

((2-amino-5-methylphenyl)amino)(naphthalen-1-yl)methanol

((2-amino-5-methylphenyl)amino)(naphthalen-1-yl)methanol

Conditions
ConditionsYield
With polyamine dendrimer with glycerol initiated polyepichlorohydrin; air In ethanol at 20℃; for 0.0333333h;99%
benzaldehyde
100-52-7

benzaldehyde

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

5-methyl-2-phenyl-1H-1,3-benzimidazole
2963-65-7

5-methyl-2-phenyl-1H-1,3-benzimidazole

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 20℃; for 0.666667h;98%
With sodium hydrogensulfite In N,N-dimethyl acetamide at 100℃; for 2h;98.9%
With ammonium peroxydisulfate; sodium dodecyl-sulfate In water at 25℃; for 0.3h; Micellar solution;98%
acetic anhydride
108-24-7

acetic anhydride

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

3,4-diacetylaminotoluene
5433-07-8

3,4-diacetylaminotoluene

Conditions
ConditionsYield
With Co3O4 nanoparticles at 20℃; for 0.2h; Green chemistry;98%
In water at 50℃; for 0.133333h;91%
Glyoxal
131543-46-9

Glyoxal

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

6-methylquinoxaline
6344-72-5

6-methylquinoxaline

Conditions
ConditionsYield
With 10 wtpercent sulfated polyborate In neat (no solvent) at 100℃; for 0.05h; Green chemistry;98%
With Polystyrene-Supported AlCl3 In ethanol for 0.2h; Reflux;94%
With potassium fluoride on basic alumina at 20℃; for 1h;92%
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

9,10-phenanthrenequinone
84-11-7

9,10-phenanthrenequinone

11-methyl-dibenzo[a,c]phenazine
4559-60-8

11-methyl-dibenzo[a,c]phenazine

Conditions
ConditionsYield
With calcium hydrogensulfate In ethanol at 20℃; for 0.0833333h;98%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide In neat (no solvent) at 80℃; for 0.133333h;97%
With 1-(propyl-3-sulfonate) 3-methylimidazol(3H)-1-ium phosphotungstate In water at 20℃; for 0.166667h; Reagent/catalyst; Time;97%

3,4-Diaminotoluene Consensus Reports

Reported in EPA TSCA Inventory.

3,4-Diaminotoluene Specification

3,4-Diaminotoluene(CAS NO.496-72-0), its Synonyms are o-Tolamine; Tolamine-3.4; Toluene-3.4-diamine;
1.2-Diamino-4-methylbenzene; 3.4-Diamino-1-methylbenzene; 4-Methyl-1.2-benzenediamine; Methylorthamine; 3-Methylorthamine; 4-Methyl-o-phenylenediamine; o-Toluylenediamine; 3.4-Toluylenediamine. It is off-white small blocks. It is used in the synthesis of colorlant compounds (dyestuffs, pigments, optical brighteners and hair dyes), pesticides, corrosion inhibitors and antioxidants.

Physical properties about 3,4-Diaminotoluene are: (1)ACD/LogP: 0.508; (2)ACD/LogD (pH 5.5): 0.43; (3)ACD/LogD (pH 7.4): 0.51; (4)ACD/BCF (pH 5.5): 1.21; (5)ACD/BCF (pH 7.4): 1.43; (6)ACD/KOC (pH 5.5): 37.99; (7)ACD/KOC (pH 7.4): 44.90; (8)#H bond acceptors: 2; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.636; (12)Molar Refractivity: 39.55 cm3; (13)Molar Volume: 110.269 cm3; (14)Polarizability: 15.679 10-24cm3; (15)Surface Tension: 52.3349990844727 dyne/cm; (16)Density: 1.108 g/cm3; (17)Flash Point: 132.104 °C; (18)Enthalpy of Vaporization: 50.005 kJ/mol; (19)Boiling Point: 262.278 °C at 760 mmHg; (20)Vapour Pressure: 0.0109999999403954 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing and gloves;
3. Avoid release to the environment. Refer to special instructions safety data sheet;
4. Wear suitable protective clothing, gloves and eye/face protection;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C7H10N2/c1-5-2-3-6(8)7(9)4-5/h2-4H,8-9H2,1H3;
(2)InChIKey=DGRGLKZMKWPMOH-UHFFFAOYSA-N;
(3)Smilesc1(c(ccc(c1)C)N)N;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LDLo subcutaneous 100mg/kg (100mg/kg)   Zeitschrift fuer Experimentelle Pathologie und Therapie. Vol. 17, Pg. 59, 1915.

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