Conditions | Yield |
---|---|
With hydrogen In ethanol; water at 25℃; under 760.051 Torr; for 3h; Autoclave; | 99.9% |
With iron(III)-acetylacetonate; hydrazine hydrate In methanol at 150℃; Microwave irradiation; Green chemistry; | 99% |
With iron(III)-acetylacetonate; hydrazine hydrate In methanol at 150℃; for 0.0333333h; Microwave irradiation; chemoselective reaction; | 99% |
Conditions | Yield |
---|---|
With 3-azapentane-1,5-diamine at 140℃; for 24h; Sealed tube; | 96% |
With Arthrobacter sp. N2 In various solvent(s) pH=6.6; Kinetics; | |
With phosphate buffer at 70℃; pH=7.2; Kinetics; Activation energy; Further Variations:; Reagents; pH-values; Temperatures; various reaction time; | |
With dihydrogen peroxide In water Irradiation; |
(3,4-Dichloro-phenyl)-carbamic acid benzyl ester
m,p-dichloroaniline
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction; | 89% |
3,3',4,4'-tetrachloroazobenzene
m,p-dichloroaniline
Conditions | Yield |
---|---|
With ethanol; iron; calcium chloride at 60℃; for 0.416667h; | 87% |
With ammonium bromide; aluminium In methanol for 0.333333h; sonication; | 85% |
3,4-dichlophenylboronic acid
m,p-dichloroaniline
Conditions | Yield |
---|---|
With N-Bromosuccinimide; CYANAMID; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 1h; chemoselective reaction; | 85% |
With N-Bromosuccinimide; N-methoxylamine hydrochloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; | 84% |
N-(3,4-dichlorophenyl)acetamide
A
3,4-dichloro-N-ethylaniline
B
m,p-dichloroaniline
Conditions | Yield |
---|---|
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h; | A n/a B 75% |
1-chloro-4-nitroso-benzene
C11H13Cl2NO2
A
3,3',4,4'-Tetrachloroazoxybenzene
B
3,4,4'-Trichloroazoxybenzene
C
m,p-dichloroaniline
Conditions | Yield |
---|---|
With diethylamine In methanol at 25℃; | A 16.5% B 74% C 7% |
m,p-dichloroaniline
Conditions | Yield |
---|---|
Stage #1: (3,4-dichlorophenyl)zinc(II) iodide With CuCl*2LiCl In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: With 3,3’-di-tert-butyl oxaziridine In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; | 65% |
C11H13Cl2NO2
A
3,3',4,4'-Tetrachloroazoxybenzene
B
3,4,4'-Trichloroazoxybenzene
C
3',4',4-Trichloroazoxybenzene
D
m,p-dichloroaniline
Conditions | Yield |
---|---|
With diethylamine; N-(4-chlorophenyl)hydroxylamine In methanol at 25℃; | A 6.8% B 10.9% C 7.7% D 55% |
3,4-dichloro-N-methylaniline
m,p-dichloroaniline
Conditions | Yield |
---|---|
With piperidine; dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile at -78℃; for 40h; Sealed tube; Inert atmosphere; Irradiation; | 45% |
4-bromo-1,2-dichlorobenzene
m,p-dichloroaniline
Conditions | Yield |
---|---|
With copper(I) oxide; ammonia; water |
triethanolamine
3,4-dichloronitrobenzene
A
2-chloro-4-nitrophenol
B
m,p-dichloroaniline
C
3,3',4,4'-tetrachloroazobenzene
Conditions | Yield |
---|---|
With hydrogenchloride; tin |
Conditions | Yield |
---|---|
With acetic acid Durch Chlorieren und Destillation des Reaktionsproduktes mit Natronlauge; | |
With acetic acid Durch Chlorieren; |
6-amino-2,3-dichlorobenzoic acid
m,p-dichloroaniline
Conditions | Yield |
---|---|
beim Erhitzen ueber den Schmelzpunkt; |
Conditions | Yield |
---|---|
With acetic acid Verseifen des Reaktionsproduktes; | |
With acetic acid und Verseifung des Reaktionsproduktes; |
1,2-dichloro-3-iodo-5-nitro-benzene
m,p-dichloroaniline
Conditions | Yield |
---|---|
With ammonium sulfide; ethanol |
3,4-dichloronitrobenzene
2,2'-iminobis[ethanol]
A
2-chloro-4-nitrophenol
B
m,p-dichloroaniline
C
3,3',4,4'-tetrachloroazobenzene
Conditions | Yield |
---|---|
With lithium amide; ammonia at -50℃; | |
With ammonia; sodium amide at -50℃; |
3,4-dichloronitrobenzene
sodium n-propoxide
benzene
A
3,3',4,4'-Tetrachloroazoxybenzene
B
m,p-dichloroaniline
3,4-dichloronitrobenzene
sodium ethanolate
benzene
A
3,3',4,4'-Tetrachloroazoxybenzene
B
m,p-dichloroaniline
N-3,4-dichlorophenylalanine
A
carbon dioxide
B
m,p-dichloroaniline
C
1,4--2,5-dimethyl-3,6-diketopiperazine
Conditions | Yield |
---|---|
at 120℃; for 8h; Product distribution; sealed ampul; different reaction times and temperature; |
1,3-bis(3,4-dichlorophenyl)urea
A
phenyl isocyanate
B
m,p-dichloroaniline
Conditions | Yield |
---|---|
at 150 - 220℃; Thermodynamic data; ΔH; heat of dissociation; |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 83℃; for 24h; Irradiation; further reagents, further conditions; |
C11H13Cl2NO2
A
3,3',4,4'-Tetrachloroazoxybenzene
B
m,p-dichloroaniline
C
3,3',4,4'-tetrachloroazobenzene
Conditions | Yield |
---|---|
With diethylamine In methanol at 25℃; for 48h; Product distribution; Rate constant; Mechanism; other reagent: NEt3; |
C11H13Cl2NO2
A
3,3',4,4'-Tetrachloroazoxybenzene
B
N-(3,4-dichlorophenyl)-hydroxylamine
C
m,p-dichloroaniline
D
3,3',4,4'-tetrachloroazobenzene
Conditions | Yield |
---|---|
With diethylamine In methanol at 25℃; Yields of byproduct given; |
n-propyl-3,4-dichlorophenyltriazene
A
Propane-1-diazonium
B
m,p-dichloroaniline
Conditions | Yield |
---|---|
With potassium chloride; tris hydrochloride In acetonitrile at 25℃; different pH-s, other reagents; |
β-D-galactopyranosylmethyl 3,4-dichlorophenyltriazene
A
2,6-anhydro-L-glycero-L-galacto-heptitol
B
m,p-dichloroaniline
Conditions | Yield |
---|---|
With Mg(2+)-free lacZ-β-galactosidase; sodium EDTA buffer at 25℃; Rate constant; |
(3,4-Dichloranilino)phenyl-acetonitril
A
hydrogen cyanide
B
benzaldehyde
C
m,p-dichloroaniline
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 1h; Product distribution; Heating; further reagents: 1.) H2O/MeOH, reflux, 2.) 0.1 mol/l H2SO4 in MeOH, reflux, 3.) pepsin reagent solution, 37 deg C, 4.) pancreatin-NaHCO3 reagent solution, 37 deg C; | |
With water In methanol at 20℃; Rate constant; Kinetics; Thermodynamic data; other temperatures: 40 deg C, 60 deg C; |
Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
With silica-supported aluminum chloride at 60℃; for 8h; Michael addition; Neat (no solvent); | 100% |
3-aminobutyric acid
m,p-dichloroaniline
3-(3,4-dichloroanilino) butyric acid
Conditions | Yield |
---|---|
With potassium phosphate; copper(I) bromide In N,N-dimethyl-formamide at 40 - 50℃; Ullmann Condensation; | 100% |
hexakis[(4-formyl-2-methoxy)phenoxy]cyclotriphosphazene
m,p-dichloroaniline
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 24h; | 100% |
m,p-dichloroaniline
4-Nitrobenzenesulfonyl chloride
N-(3,4-dichlorophenyl)-4-nitrobenzenesulfonamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; Inert atmosphere; | 99.6% |
With pyridine In dichloromethane at 20℃; Inert atmosphere; | 99.6% |
With sodium hydroxide |
chloroacetyl chloride
m,p-dichloroaniline
2-chloro-N-(3,4-dichlorophenyl)acetamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 99% |
With sodium hydrogencarbonate In 1,4-dioxane for 0.5h; | 98% |
With sodium hydroxide In benzene for 1h; | 89% |
Conditions | Yield |
---|---|
at 90℃; for 1h; | 99% |
for 0.5h; Heating; | 98% |
With mesoporous silica SBA-15 functionalized with acidic [HNMP]ZnCl3 based deep eutectic solvent In neat (no solvent) at 20℃; | 98% |
acrylic acid methyl ester
m,p-dichloroaniline
methyl 2-bromo-3-(3,4-dichlorophenyl)propanoate
Conditions | Yield |
---|---|
With hydrogen bromide; copper(I) bromide; sodium nitrite In acetone 1.) -5 deg C, 0.5 h, 2.) 25 deg C, 0.5 h; | 99% |
Stage #1: m,p-dichloroaniline With hydrogen bromide; sodium nitrite In water; acetone at -5℃; for 0.5h; Stage #2: acrylic acid methyl ester With copper(I) bromide In water; acetone at -5 - 20℃; for 0.5h; | 14.2 g |
methylphosphinyl chloride
m,p-dichloroaniline
N-(3,4-Dichlorophenyl)-P-(α-chloro-2-tolyl)-P-methylphosphinamide
Conditions | Yield |
---|---|
In diethyl ether | 99% |
m,p-dichloroaniline
1,3-bis-(3,4-dichloro-phenyl)-triazene
Conditions | Yield |
---|---|
With SHNC In water for 16h; Ambient temperature; | 99% |
benzyl chloroformate
m,p-dichloroaniline
(3,4-Dichloro-phenyl)-carbamic acid benzyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water at 0 - 20℃; for 16h; | 99% |
(6S)-4-methoxy-6-[(2,2,2-trifluoroacetyl)amino]-5,6,7,8-tetrahydronaphthalene-1-sulfonyl chloride
m,p-dichloroaniline
Conditions | Yield |
---|---|
Stage #1: (6S)-4-methoxy-6-[(2,2,2-trifluoroacetyl)amino]-5,6,7,8-tetrahydronaphthalene-1-sulfonyl chloride; m,p-dichloroaniline With pyridine In tetrahydrofuran; dichloromethane for 2h; Stage #2: With sodium hydroxide In tetrahydrofuran; dichloromethane; water for 10h; Stage #3: With ammonium chloride In tetrahydrofuran; dichloromethane; water pH=~ 9; | 99% |
2-Bromoacetyl bromide
m,p-dichloroaniline
2-bromo-N-(3,4-dichloro-phenyl)-acetamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; | 99% |
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere; | 75% |
With triethylamine In dichloromethane at 20℃; for 3h; |
4-methyl-benzoyl chloride
m,p-dichloroaniline
N-(3,4-dichlorophenyl)-4-methylbenzamide
Conditions | Yield |
---|---|
With pyridine Reflux; | 99% |
Conditions | Yield |
---|---|
With copper acetylacetonate; sodium hydroxide; N,N`-dimethylethylenediamine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 5h; Reagent/catalyst; | 98.1% |
potassium cyanide
4-hydroxy-benzaldehyde
m,p-dichloroaniline
(3,4-Dichloro-phenylamino)-(4-hydroxy-phenyl)-acetonitrile
Conditions | Yield |
---|---|
With acetic acid In water Heating; | 98% |
Conditions | Yield |
---|---|
for 0.00277778h; Green chemistry; | 98% |
Ethoxycarbonyl isothiocyanate
m,p-dichloroaniline
Conditions | Yield |
---|---|
In acetone at 20 - 40℃; for 12.33h; | 98% |
4-Methoxycarbonylbenzoyl chloride
m,p-dichloroaniline
N-(3,4-Dichloro-phenyl)-terephthalamic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; triethylamine In tetrahydrofuran at 10 - 40℃; Cooling with ice; Inert atmosphere; | 97.5% |
With sodium hydrogencarbonate; triethylamine In tetrahydrofuran at 10 - 40℃; Inert atmosphere; | 97.5% |
With sodium hydrogencarbonate; triethylamine In tetrahydrofuran at 10 - 40℃; Cooling with ice; Inert atmosphere; | 23.87 g |
methyl chloroformate
m,p-dichloroaniline
methyl N-(3,4-dichlorophenyl)carbamate
Conditions | Yield |
---|---|
With N,N-dimethyl acetamide at 5 - 20℃; for 0.75h; | 97% |
With pyridine In ethyl acetate at 20℃; for 2h; | 88% |
maleic anhydride
m,p-dichloroaniline
N-(3,4-dichloro-phenyl)-maleamic acid
Conditions | Yield |
---|---|
In chloroform for 7h; | 97% |
In diethyl ether at 20℃; for 16.0833h; | 87% |
In chloroform at 20℃; |
ethyl bromoacetate
m,p-dichloroaniline
ethyl 2-((3,4-dichlorophenyl)amino)acetate
Conditions | Yield |
---|---|
Stage #1: ethyl bromoacetate; m,p-dichloroaniline With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 20 - 90℃; for 19h; Stage #2: With sodium carbonate In 1-methyl-pyrrolidin-2-one; water at 20℃; for 0.166667h; | 97% |
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 90℃; | 97% |
With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine at 90℃; for 12h; | 74% |
With potassium carbonate Reflux; |
methyl 2-diazo-2-(2-ethynylphenyl)acetate
m,p-dichloroaniline
methyl 2-(3,4-dichlorophenyl)-3-methyl-2H-isoindole-1-carboxylate
Conditions | Yield |
---|---|
With tetrakis(actonitrile)copper(I) hexafluorophosphate In dichloromethane at 20℃; for 0.166667h; | 97% |
4-chloro-2-(isopropylamino)-6-phenylpyrimidine
m,p-dichloroaniline
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 100℃; | 97% |
Conditions | Yield |
---|---|
In ethanol for 0.5h; | 97% |
In ethanol at 20℃; |
[Rh(2-(CH2-PtBu2)-6-(CH2-NEt2)C5H2N)N2]
m,p-dichloroaniline
[Rh(2-(CH2-PtBu2)-6-(CH2-NEt2)C5H3N)(m-Cl-p-Cl-NHC6H3)]
Conditions | Yield |
---|---|
(under N2, Schlenk); Rh-complex placed in NMR tube, benzene-d6 or THF soln. of m,p-dichloroaniline added, heated at 60°C for 3 h; elem. anal.; | A n/a B 97% |
Conditions | Yield |
---|---|
With acetic acid at 25 - 30℃; for 6h; Green chemistry; | 97% |
With nano-CuFe2O4-chitosan In ethanol at 20℃; for 2h; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With reduced graphene oxide In water at 80℃; for 0.0833333h; Green chemistry; | 97% |
In acetic acid at 70℃; for 0.333333h; | 91% |
The 3,4-Dichloroaniline, with the CAS registry number 95-76-1,is also known as 1-Amino-3,4-Dichlorobenzene; 3,4-Dichlorobenzenamine; 3,4-DCA. It belongs to the product categories of Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks.Its EINECS number is 202-448-4. This chemical's molecular formula is C6H5Cl2N and molecular weight is 162.02. What's more,Its systematic name is 3,4-Dichloroaniline.It is a brown solid which is which is stable,combustible and incompatible with strong oxidizing agents,acids,acid chlorides,acid anhydrides, but it is darkens in storage.
The characteristics of 3,4-Dichloroaniline are as follows:
(1)ACD/LogP: 2.51; (2)ACD/LogD (pH 5.5): 2.51; (3)ACD/LogD (pH 7.4): 2.51; (4)ACD/BCF (pH 5.5): 47.33; (5)ACD/BCF (pH 7.4): 47.44; (6)ACD/KOC (pH 5.5): 549.97; (7)ACD/KOC (pH 7.4): 551.34; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 26.02 ; (12)Index of Refraction: 1.613; (13)Molar Refractivity: 40.27 cm3; (14)Molar Volume: 115.6 cm3; (15)Polarizability: 15.96 ×10-24 cm3; (16)Surface Tension: 48.3 dyne/cm; (17)Density: 1.401 g/cm3; (18)Flash Point: 118.2 °C; (19)Enthalpy of Vaporization: 51.01 kJ/mol; (20)Boiling Point: 271.8 °C at 760 mmHg; (21)Vapour Pressure: 0.0063 mmHg at 25°C; (22)Exact Mass: 160.979905; (23)MonoIsotopic Mass: 160.979905; (24)Topological Polar Surface Area: 26; (25)Heavy Atom Count: 9; (26)Complexity: 97.1.
You can still convert the following datas into molecular structure:
(1)SMILES:Nc1cc(Cl)c(Cl)cc1;
(2)Std. InChI:InChI=1S/C6H5Cl2N/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2;
(3)Std. InChIKey:SDYWXFYBZPNOFX-UHFFFAOYSA-N.
Production of 3,4-Dichloroaniline:
1,2-dichloro-4-nitro-benzene could react to produce 3,4-Dichloroaniline, with the following condition: reagent: NaHS/Al2O3; reation time: 4 min; yield: 80%; other condition: microwave irradiation.
Use of 3,4-Dichloroaniline is as below:
chloroacetyl chloride could react with 3,4-Dichloroaniline to produce chloro-acetic acid-(3,4-dichloro-anilide), with the following condition: reagent:benzene
As to its usage, it is widely applied in many ways. It could be used in the intermediate in pharmaceutics, pesticide, and dye. If used in pesticide, it could be the intermediate for propanil, diuron, linuron, swep and so on. And it could also be used as the intermediate for bioactivity.
Safety information of 3,4-Dichloroaniline:
When dealing with this chemical, you should be cautious and then take some measures to protect yourself. For one thing, this chemical is toxic. It may at low levels cause damage to health, and if by inhalation, in contact with skin and if swallowed, it will bring damage to our health. Besides, it may cause sensitisation by skin contact, and it also has risk of serious damage to eyes. For another thing, it is dangerous for the environment. It may present an immediate or delayed danger to one or more components of the environment; And being toxic to aquatic organisms, it may cause long-term adverse effects in the aquatic environment.Therefore, you should take the following instructions while using. Wear suitable protective clothing, gloves and eye/face protection. If in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; If in case of accident or if you feel unwell, seek medical advice immediately (show the label where possible); After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer). While keep it, this material and its container must be disposed of as hazardous waste , and then avoid releasing to the environment, with refering to special instructions/safety data sheet.
Below are the toxicity information of 3,4-Dichloroaniline:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 237mg/kg (237mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
cat | LD50 | skin | 700mg/kg (700mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(5), Pg. 29, 1969. | |
guinea pig | LD50 | oral | 675mg/kg (675mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(4), Pg. 8, 1968. |
mouse | LD50 | intraperitoneal | 310mg/kg (310mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Labo-Pharma-Problemes et Techniques. Vol. 27, Pg. 306, 1979. |
mouse | LD50 | oral | 740mg/kg (740mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(5), Pg. 29, 1969. | |
rabbit | LD50 | oral | 675mg/kg (675mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(4), Pg. 8, 1968. |
rabbit | LDLo | skin | 300mg/kg (300mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0571586, |
rat | LCLo | inhalation | 65mg/m3/4H (65mg/m3) | Office of Toxic Substances Report. Vol. OTS, | |
rat | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Labo-Pharma-Problemes et Techniques. Vol. 27, Pg. 306, 1979. |
rat | LD50 | oral | 545mg/kg (545mg/kg) | Office of Toxic Substances Report. Vol. OTS, |
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