3-Amino-5-Methylisoxazole supplier

Name
3-Amino-5-methylisoxazole
EINECS 214-013-6
CAS No. 1072-67-9
Article Data22
CAS DataBase
Density 1.167 g/cm³
Solubility soluble in water
Melting Point 59-63 °C
Formula C₄H₆N₂O
Boiling Point 235.9 °C at 760 mmHg
Molecular Weight 98.1044
Flash Point 96.5 °C
Transport Information
Appearance slightly yellow flakes
Safety 22-24/25-47-37/39-26-16-26/37/39/47-36
Risk Codes 5-36/37/38-11-36/37/38/5-20/21/22
Molecular Structure
Hazard Symbols F,Xi
Synonyms Isoxazole,3-amino-5-methyl- (6CI,7CI,8CI);5-Methyl-1,2-oxazol-3-amine;5-Methyl-3-aminoisoxazole;5-Methyl-3-isoxazolamine;5-Methyl-3-isoxazolylamine;NSC 159134;3-amino-5-methylisooxzole;
PSA 52.05000
LogP 1.14640

Synthetic route

: C11H13N3O2S

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
Stage #1: C11H13N3O2S With hydroxylamine hydrochloride; potassium carbonate In water at 85℃; for 2h; Stage #2: With hydrogenchloride In water for 1h;	80%

: 4368-06-3
3-hydroxybutanenitrile

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
Stage #1: 3-hydroxybutanenitrile With hydroxylamine hydrochloride; potassium carbonate In water at 20 - 60℃; for 3h; Stage #2: With iron(III) chloride In toluene Reagent/catalyst; Temperature; Reflux;	77%

: 91377-59-2
2-(5-methyl-1,2-oxazol-3-yl)-1H-isoindole-1,3(2H)-dione

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 3h; Heating;	75.1%

: 108790-08-5, 127461-31-8
C4H4N2O2S

: 1165952-91-9
cyclohexa-1,3-diene

A: 1072-67-9
5-methylisoxazol-3-ylamine

: exo-3-(5-methylisoxazol-3-yl)-2λ4-thia-3-azabicyclo[2.2.2]oct-5-ene 2 oxide

: (1RS,2SR,4SR)-(2-oxo-2λ4-thia-3-azabicyclo[2.2.2]oct-5-en-3-yl)phosphonic acid diphenyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 22h; hetero-Diels-Alder reaction;	A n/a B n/a C 64%

...Expand

: 100143-11-1
(5-methyl-isoxazol-3-yl)-carbamic acid benzyl ester

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium hydroxide

: 92087-97-3
(5-methyl-isoxazol-3-yl)-carbamic acid ethyl ester

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium hydroxide

: 4786-20-3
but-2-enenitrile

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
(i) Br2, MeOH, (ii) aq. NaOH, NH2CONHOH; Multistep reaction;

: 106124-31-6
(Z)-4-(5-Methyl-isoxazol-3-ylamino)-pent-3-en-2-one

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 3h; Heating; Yield given;

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: C10H10ClN3O3S

C: 4-amino-3-chloro-N-(5-methyl-isoxazol-3-yl)-benzenesulphonamide

Conditions

Conditions	Yield
With sodium hypochlorite; borate buffer at 25℃; pH=9; Kinetics; Further Variations:; pH-values; Reagents; Solvents;

...Expand

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: C10H13N3O4S

C: C10H13N3O5S

D: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; water; sodium chloride; sodium hydroxide pH=9.5; Catalytic behavior; Mechanism; Kinetics; pH-value; Reagent/catalyst; Inert atmosphere;

...Expand

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: 98-10-2
benzenesulfonamide

C: 533-73-3
1,2,4-Trihydroxybenzene

D: 547-44-4
N-((4-aminophenyl)sulfonyl)carbamimidic acid

E: 20759-40-4
3-hydroxybenzenesulfonamide

F: 4-amino-N-(4-hydroxy-5-methylisoxazol-3-yl)benzenesulfonamide

G: N-(4,5-dihydroxy-5-methyl-4,5-dihydroisoxazol-3-yl)-4-hydroxybenzenesulfonamide

H: N-(4,5-dihydroxy-5-methyl-4,5-dihydroisoxazol-3-yl)benzenesulfonamide

I: (Z)-N-((2-oxopropylidene)carbamoyl)methanesulfonamide

J: 3,4-dihydroxy-N-(5-methylisoxazol-3-yl)benzenesulfonamide

K: 3,4-dihydroxy-N-(4-hydroxy-5-methylisoxazol-3-yl)benzenesulfonamide

L: 4-amino-3-hydroxy-N- (5-methylisoxazol-3-yl)benzenesulfonamide

M: 4-amino-3-hydroxy-N-(4-hydroxy-5-methylisoxazol-3-yl)benzenesulfonamide

N: 2-oxo-N-(phenylsulfonyl)acetimidamide

O: 141233-20-7
4-hydroxy-N-(5-methyl-3-isoxazolyl)benzenesulphonamide

P: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Q: 108-95-2
phenol

Conditions

Conditions	Yield
With AgBr-BaMoO4 composite photocatalyst In water for 1.25h; Kinetics; Reagent/catalyst; UV-irradiation;

...Expand

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: 947619-95-6
5-methyl-3-nitrosoisoxazole

C: 4-amino-3-hydroxy-N- (5-methylisoxazol-3-yl)benzenesulfonamide

D: 4-amino-3-hydroxy-N-(4-hydroxy-5-methylisoxazol-3-yl)benzenesulfonamide

E: C4H8N2O

Conditions

Conditions	Yield
With sodium sulfate In water pH=7; Kinetics; pH-value; Reagent/catalyst; Electrochemical reaction;

...Expand

: 18607-98-2
N1-acetylsulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: 947619-95-6
5-methyl-3-nitrosoisoxazole

C: 121-62-0
N-acetylsulfanilic acid

D: 131549-85-4
nitroso derivative of sulfamethoxazole

E: 618-41-7
Benzenesulfinic acid

F: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Conditions

Conditions	Yield
With sodium sulfate In water pH=7; Kinetics; pH-value; Reagent/catalyst; Electrochemical reaction;

...Expand

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: 75079-82-2
3-nitro-5-methylisoxazole

C: 947619-95-6
5-methyl-3-nitrosoisoxazole

D: 4-amino-3-hydroxy-N- (5-methylisoxazol-3-yl)benzenesulfonamide

Conditions

Conditions	Yield
With iron(III) sulfate; sodium hydrogensulfite at 25℃; pH=4; Kinetics; pH-value;

...Expand

: 723-46-6
sulfamethoxazole

A: 5765-44-6
5-methylisoxazole

B: 1072-67-9
5-methylisoxazol-3-ylamine

C: 2592-14-5
1-hydroxy-2-aminobenzene-5-sulfonic acid

D: C9H8N2O4S

E: 141233-20-7
4-hydroxy-N-(5-methyl-3-isoxazolyl)benzenesulphonamide

F: (5-methyl-1,2-oxazol-3-yl)sulfamic acid

G: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: sulfamethoxazole With 0D/1D 50 wt.% AgI/MoO3 Z-scheme heterojunction composite In water for 0.5h; Darkness; Sonication; Stage #2: In water pH=3.92; Kinetics; Catalytic behavior; Reagent/catalyst; Irradiation;

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 635-93-8
5-chlorosalicyclaldehyde

: 88812-64-0
3-(2-hydroxy-8-chlorobenzylideneamino)-5-methylisoxazole

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	88%
In ethanol Heating;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 1761-61-1
5-bromosalicyclaldehyde

: 88812-68-4
4-bromo-2-[(5-methyl-3-isoxazolyl)imino]methylphenol

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	95%
In ethanol Heating;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 120-57-0
piperonal

: 88812-71-9
[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-(5-methyl-isoxazol-3-yl)-amine

Conditions

Conditions	Yield
Heating;	100%
In ethanol; chloroform

: 1072-67-9
5-methylisoxazol-3-ylamine

: 104-87-0
4-methyl-benzaldehyde

: 112633-38-2
(5-Methyl-isoxazol-3-yl)-[1-p-tolyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
Heating;	100%
With 1-methylimidazolium tetrafluoroborate at 30℃; for 0.25h;
In ethanol; chloroform

: 1072-67-9
5-methylisoxazol-3-ylamine

: 104-88-1
4-chlorobenzaldehyde

: 88812-63-9
N-(4-chlorobenzylidene)-5-methylisoxazol-3-amine

Conditions

Conditions	Yield
Heating;	100%
With 1-methylimidazolium tetrafluoroborate at 30℃;
In ethanol; chloroform
In ethanol Reflux;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 89-98-5
2-chloro-benzaldehyde

: 112633-41-7
[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-(5-methyl-isoxazol-3-yl)-amine

Conditions

Conditions	Yield
Heating;	100%
With trimethylsilyl acetate; zinc(II) chloride In N,N-dimethyl-formamide at 100℃; for 8h;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 99-61-6
3-nitro-benzaldehyde

: 88812-66-2
(5-Methyl-isoxazol-3-yl)-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
Heating;	100%
In ethanol; chloroform

: 1072-67-9
5-methylisoxazol-3-ylamine

: 555-16-8
4-nitrobenzaldehdye

: 112633-39-3
(5-Methyl-isoxazol-3-yl)-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-amine

Conditions

Conditions	Yield
Heating;	100%
In ethanol; chloroform
With acetic acid In 1,2-dichloro-ethane at 60℃; for 1.5h;
With tert-butylisonitrile; phenylpropyolic acid In methanol at 20℃; for 24h;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 100-52-7
benzaldehyde

: 112633-37-1
N-benzylidene-5-methylisoxazol-3-amine

Conditions

Conditions	Yield
Heating;	100%
With 1-methylimidazolium tetrafluoroborate at 30℃; for 0.25h;
In ethanol; chloroform
With acetic acid In 1,2-dichloro-ethane at 60℃; for 1.5h;
With magnesium sulfate In ethanol at 20℃;

: 1072-67-9
5-methylisoxazol-3-ylamine

: 123-11-5
4-methoxy-benzaldehyde

: 88812-69-5
[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-(5-methyl-isoxazol-3-yl)-amine

Conditions

Conditions	Yield
Heating;	100%
With piperidine In ethanol for 0.166667h; Reflux;	76%
With 1-methylimidazolium tetrafluoroborate at 30℃;
In ethanol; chloroform

: 1072-67-9
5-methylisoxazol-3-ylamine

: 874-42-0
2,4-dichlorobenzaldeyhde

: 112661-91-3
[1-(2,4-Dichloro-phenyl)-meth-(E)-ylidene]-(5-methyl-isoxazol-3-yl)-amine

Conditions

Conditions	Yield
Heating;	100%
In ethanol; chloroform

: 1072-67-9
5-methylisoxazol-3-ylamine

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 415715-07-0
4-methoxy-2-[(5-methyl-3-isoxazolyl)imino]methylphenol

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	90%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 613-84-3
2-hydroxy-5-methylbenzaldehyde

: 326878-69-7
4-methyl-2-[(5-methyl-3-isoxazolyl)imino]methylphenol

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	90%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 90-02-8
salicylaldehyde

: 112633-43-9
2-((5-methylisoxazol-3-ylimino)methyl)phenol

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	95%
In methanol Reflux;	82%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 90-59-5
3,5-Dibromosalicylaldehyde

: 116808-16-3
C11H8Br2N2O2

Conditions

Conditions	Yield
Reflux;	100%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 88812-65-1
C11H8Cl2N2O2

Conditions

Conditions	Yield
Reflux;	100%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 693-13-0
diisopropyl-carbodiimide

: 1,3-diisopropyl-2-(5-methylisoxazol-3-yl)guanidine

Conditions

Conditions	Yield
[{Me2Si(C5Me4)(NPh)}Y(CH2SiMe3)(thf)2] In tetrahydrofuran at 20℃; for 1h;	99%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 68-11-1
mercaptoacetic acid

: 105-07-7
4-cyanobenzaldehyde

: 1610829-08-7
4-(3-(5-methylisoxazol-3-yl)-4-oxothiazolidin-2-yl)benzonitrile

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	98.7%

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 582-17-2
2,7-Dihydroxynaphthalene

: 459-57-4
4-fluorobenzaldehyde

: 1380601-72-8
C21H17FN2O3

Conditions

Conditions	Yield
at 80℃; for 0.5h; Neat (no solvent);	98%

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 312932-31-3
(1,1,1-trifluoro-2-(trifluoromethyl)-but-2-yl)isocyanate

: 355829-46-8
1-[1,1-bis(trifluoromethyl)propyl]-3-(5-methylisoxazol-3-yl)urea

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 4h;	98%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Conditions

Conditions	Yield
With pyridine at 20℃; for 5h;	97%
	95%
With pyridine at 0℃; for 2h; Inert atmosphere;	90%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 1338361-28-6
C12H12ClN3O

: 915910-20-2
1-(3,4-dimethylphenyl)-5-methyl-N-(5-methylisoxazol-3-yl)-1H-1,2,3-triazole-4-carboxamide

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 70℃;	97%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 108-86-1
bromobenzene

: 71854-24-5
3-anilino-5-methylisoxazole

Conditions

Conditions	Yield
With [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate; tert-butyl XPhos In tert-butyl alcohol at 20℃; for 2h; Inert atmosphere;	97%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 582-17-2
2,7-Dihydroxynaphthalene

: 555-16-8
4-nitrobenzaldehdye

: 1380601-75-1
1-[(5-methylisoxazol-3-ylamino)(4-nitrophenyl)methyl]naphthalene-2,7-diol

Conditions

Conditions	Yield
at 80℃; for 0.5h; Neat (no solvent);	97%

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 19005-93-7
1H-indol-2-ylcarboxaldehyde

: N-((1H-indol-2-yl)methylene)-5-methylisoxazol-3-amine

Conditions

Conditions	Yield
With acetic acid In methanol at 30℃; for 0.2h; Temperature; Sonication;	97%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 830-79-5
2,4,6-trimethoxybenzaldehyde

: N-(2,4,6-trimethoxybenzylidene)-5-methylisoxazol-3-amine

Conditions

Conditions	Yield
With acetic acid In methanol at 30℃; for 0.2h; Temperature; Sonication;	97%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 437-81-0
2,6-difluorobenzaldehyde

: 68-11-1
mercaptoacetic acid

: 1350308-04-1
2-(2,6-difluorophenyl)-3-(5-methylisoxazol-3-yl)thiazolidin-4-one

Conditions

Conditions	Yield
In toluene Reflux;	96.7%

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 83-38-5
2,6-dichlorobenzaldehyde

: 68-11-1
mercaptoacetic acid

: 1350308-03-0
2-(2,6-dichlorophenyl)-3-(5-methylisoxazol-3-yl)thiazolidin-4-one

Conditions

Conditions	Yield
In toluene Reflux;	96.5%

...Expand

: 1072-67-9
5-methylisoxazol-3-ylamine

: 78-39-7
Triethyl orthoacetate

: ethyl N-(5-methylisoxazol-3-yl)acetimidate

Conditions

Conditions	Yield
for 1.5h; Heating;	96%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 94-05-3
ethyl (ethoxymethylene)cyanoacetate

: 219619-78-0
ethyl 2-cyano-3-(5-methylisoxazol-3-ylamino)acrylate

Conditions

Conditions	Yield
In ethanol for 1.5h; Reflux;	96%

3-Amino-5-Methylisoxazole Chemical Properties

Molecular Formula:C₄H₆N₂O
Molar mass:98.10324g/mol
Structure of 3-Amino-5-methylisoxazole(1072-67-9):

Synonyms of 3-Amino-5-methylisoxazole(1072-67-9):3-Isoxazolamine, 5-methyl-;Isoxazole, 3-amino-5-methyl-;5-Methyl-3-aminoisoxazole;3-Methyl-5-aminoisoxazole;5-methylisoxazol-3-amine;5-Methyl-3-isoxazolamine
Density:1.167 g/cm³
Flash Point:96.5 °C
Boiling Point:235.9 °C at 760 mmHg
Index of Refraction:1.524
Vapour Pressure:0.0487 mmHg at 25°C
Melting point:59-63°C
Solubility:Soluble in alcohol, ether, vapor volatile with water
Water solubility:soluble
Appearance:White crystals
storage temp:Refrigerator

3-Amino-5-Methylisoxazole Uses

3-Amino-5-methylisoxazole(1072-67-9) is pharmaceutical intermediates,and can be used for the production of sulfonamide.

3-Amino-5-Methylisoxazole Production

3-Amino-5-methylisoxazole(1072-67-9) can be derived from the degradation of 5 - methylisoxazole -3 - carboxamide.

3-Amino-5-Methylisoxazole Toxicity Data With Reference

1.Oral, mus: LD50 = 3060-4060 mg/kg (24H) Oral, mus: LD50 = 2409-3271 mg/kg (10D)
2.Carcinogenicity:3-Amino-5-methylisoxazole(1072-67-9)- Not listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65.

3-Amino-5-Methylisoxazole Safety Profile

Hazard Codes:Xi-F,Xi,F,Xn
Risk Statements:
5: Heating may cause an explosion
10: Flammable
11: Highly Flammable
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
16: Keep away from sources of ignition - No smoking
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
47: Keep at temperature not exceeding ... E C (to be specified by the manufacturer)

3-Amino-5-Methylisoxazole Specification

Stability and Reactivity of 3-Amino-5-methylisoxazole(1072-67-9):
Conditions to Avoid:Incompatible materials, temperatures above 65°C, ignition sources,light.
Chemical Stability:Stable under normal pressures and temperatures.
Incompatibilities with Other Materials:Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.

Product Name

3-Amino-5-methylisoxazole

Synthetic route

3-Amino-5-Methylisoxazole Chemical Properties

3-Amino-5-Methylisoxazole Uses

3-Amino-5-Methylisoxazole Production

3-Amino-5-Methylisoxazole Toxicity Data With Reference

3-Amino-5-Methylisoxazole Safety Profile

3-Amino-5-Methylisoxazole Specification

Related Products

Hot Products